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List of works by Sean M. Davidson

116 Matrix metalloproteinase inhibition attenuates reperfusion injury, independently of and additive to mitochondrial permeability transition pore inhibition

16 Matrix metalloproteinase inhibition is a parallel pathway to protection against reperfusion injury, both independent and additive to mitochondrial permeability transition pore inhibition

162 Polymersomes Functionalized with HSP70 – Novel, Synthetic Cardioprotective Nanovesicles

162 Regulated Exosome Secretion by Vascular Smooth Muscle Cells Mediates Vascular Calcification

193 The role of the pi3k-alpha isoform in cardioprotection

253 REMOTE ISCHAEMIC PRECONDITIONING IS MEDIATED VIA THE SDF 1Α/CXCR4 SIGNALLING AXIS

9th Hatter Biannual Meeting: position document on ischaemia/reperfusion injury, conditioning and the ten commandments of cardioprotection

scientific article

A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development

scientific journal article

A needle in a haystack: focus on “Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart”

scientific article published on 01 December 2010

A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies.

scientific article

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

scientific article published on 01 July 2018

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

scientific article published in 2022

Apelin, the potentially therapeutic adipocytokine, protects against myocardial ischemia–reperfusion injury

article published in 2007

Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury

scientific article published on 13 August 2007

Assessing Mitochondrial Potential, Calcium, and Redox State in Isolated Mammalian Cells Using Confocal Microscopy

scientific article published on 01 January 2007

Biologically active constituents of the secretome of human W8B2+ cardiac stem cells.

scientific article

Calcium handling precedes cardiac differentiation to initiate the first heartbeat

scientific article published on 11 October 2016

Calcium microdomains and oxidative stress

scientific article published on 17 October 2006

Can glucagon-like peptide-1 (GLP-1) analogues make neuroprotection a reality?

scientific article published on 01 October 2020

Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro.

scientific article published on 25 August 2017

Cardioprotection mediated by urocortin is dependent on PKCepsilon activation.

scientific article published on 10 March 2005

Cardioprotection – is no the answer? A renewed look at nitric oxide signalling in cardiomyocytes

scientific article published on 01 May 2018

Cardioprotective actions of necrostatin

Cardioprotective actions of the novel adipocytokine visfatin

Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart

scientific article published in 2021

Circulating blood cells and extracellular vesicles in acute cardioprotection

scientific article published on 01 June 2019

Co-dependence of the neural and humoral pathways in the mechanism of remote ischemic conditioning

scientific article published on 23 June 2016

Comparison of small extracellular vesicles isolated from plasma by ultracentrifugation or size-exclusion chromatography: yield, purity and functional potential

Comparison of the effect of two different bone-targeted radiofrequency ablation (RFA) systems alone and in combination with percutaneous vertebroplasty (PVP) on the biomechanical stability of the metastatic spine

scientific article published on 24 July 2015

Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes

scientific article published on 12 October 2017

Correction: Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury.

scientific article published on 26 June 2013

Corrigendum to “Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway” [Biochem. Biophys. Res. Commun. 328 (2005) 442–448]

scholarly article published in Biochemical and Biophysical Research Communications

Cytotoxicity of 5-aza-2'-deoxycytidine in a mammalian cell system

scientific article published on 01 January 1992

DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury.

scientific article published on 27 February 2014

David Garcia-Dorado: a true pioneer in cardiac ischaemia/reperfusion injury

scientific article published on 01 December 2019

De novo cardiomyocytes from within the activated adult heart after injury

scientific article

Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism.

scientific article published on 19 November 2015

Dissecting out the mechanism of cardioprotection by endogenous erthyropoietin using genetic engineering

scientific article published on 14 June 2006

Does Hyperglycemia Reduce Proliferation or Increase Apoptosis?

scientific article published on 14 April 2006

ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure

scientific article published on 01 March 2019

ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies

scientific article

Editorial to: "Building a Bridge to the Future of Cardiovascular Drugs and Therapy".

scientific article published on 13 February 2017

Effects of NO on mitochondrial function in cardiomyocytes: Pathophysiological relevance

scientific article

Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning

scientific article published in Scientific Reports

Endothelial insulin resistance protects the heart against prolonged ischemia-reperfusion injury but does not prevent insulin transport across the endothelium in a mouse Langendorff model

scientific article published on 19 March 2014

Endothelial mitochondria and heart disease

scientific article published on 16 June 2010

Endothelial mitochondria: contributing to vascular function and disease

scientific article published on April 2007

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

scientific article published on 18 March 2011

Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.

scientific article

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.

scientific article published on 29 May 2012

Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model

scientific article published on 22 June 2016

Exogenous SDF-1α Protects Human Myocardium from Hypoxia-Reoxygenation Injury via CXCR4.

scientific article published on 20 October 2015

Exosomes and Cardiovascular Protection.

scientific article published on 29 October 2016

Exosomes and cardioprotection - A critical analysis

scientific article published on 6 November 2017

Exosomes: nanoparticles involved in cardioprotection?

scientific article published on January 2014

Extracellular histones are a target in myocardial ischaemia-reperfusion injury

scientific article published on 01 March 2022

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology.

scientific article

FAM3A - A mitochondrial route to the stimulation of angiogenesis?

scientific article published on 24 April 2019

FLIP protects cardiomyocytes from apoptosis induced by simulated ischemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA

scientific journal article

Failure of the Adipocytokine, Resistin, to Protect the Heart From Ischemia-Reperfusion Injury

scientific article published on 23 December 2010

Fantastic beasts and how to find them-Molecular identification of the mitochondrial ATP-sensitive potassium channel

scientific article published on 15 October 2019

Flagging flora: heart disease link ⬇️

scientific article published on 07 September 2011

From Protecting the Heart to Improving Athletic Performance - the Benefits of Local and Remote Ischaemic Preconditioning.

scientific article

Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse

scientific article published on 26 June 2008

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

scientific article published on 25 July 2014

High on the hog

scientific article published in Nature

Hsp25 and the p38 MAPK pathway are involved in differentiation of cardiomyocytes.

scientific article

Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway

scientific journal article

Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single- or Two-Photon Confocal Microscopy

scientific article published on 01 January 2018

Imaging Mitochondrial Calcium Signalling with Fluorescent Probes and Single or Two Photon Confocal Microscopy

scientific article published on 01 January 2012

Increased production of functional small extracellular vesicles in senescent endothelial cells

scientific article published on 26 February 2020

Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury

scientific article published on 26 April 2010

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.

scientific article published on 22 September 2015

Innate immunity as a target for acute cardioprotection

scientific article published on 01 June 2019

Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning

scientific article published in 2022

Interaction of the heart and its close and distant neighbours: report of the Meeting of the ESC Working Groups Myocardial Function and Cellular Biology

scientific article published on 16 July 2013

Intrinsic cardiac ganglia and acetylcholine are important in the mechanism of ischaemic preconditioning.

scientific article published on 13 January 2017

Ischaemic Preconditioning Protects Cardiomyocytes from Anthracycline-Induced Toxicity via the PI3K Pathway.

scientific article published on 15 May 2018

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

scientific article

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

scientific article

Leptin, the obesity-related adipocytokine, protects the myocardium against ischaemia–reperfusion injury

Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore

scientific article

Leptin-stimulated inhibition of mitochondrial permeability transition is dependent on presence of functional OB-RB leptin receptor

Letter by Takov et al Regarding Article, "Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice".

scientific article published in May 2017

Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors

scientific journal article

Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.

scientific article

Matrix metalloproteinase inhibition protects CyPD knockout mice independently of RISK/mPTP signalling: a parallel pathway to protection.

scientific article

Melatonin as a cardioprotective therapy following ST-segment elevation myocardial infarction: is it really promising? Reply.

scientific article published in September 2017

Metformin cardioprotects the diabetic heart by inhibiting mPTP opening via the risk pathway

Metformin prevents myocardial reperfusion injury by activating the adenosine receptor.

scientific article

Metformin protects against myocardial reperfusion injury via PI3-kinase-dependent inhibition of mitochondrial permeability transition

Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening

scientific article

Microvesicles and Exosomes in Local and Distant Communication with the Heart

Microvesicles and exosomes: new players in metabolic and cardiovascular disease

scientific article

Mitochondrial DNA damage, oxidative stress, and atherosclerosis: where there is smoke there is not always fire

scientific article

Mitochondrial PINK1--a novel cardioprotective kinase?

scientific article published on 30 September 2008

Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury

scientific article published on 10 March 2020

Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning

scientific article

Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure

scientific article

Mitochondrial pharmacology: energy, injury and beyond.

scientific article published on April 2014

Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation

Molecular regulation of cardiac hypertrophy

scientific article published on 26 February 2008

Monitoring dynamic changes in lymph metabolome of fasting and fed rats by electrospray ionization-ion mobility mass spectrometry (ESI-IMMS).

scientific article

Mouse models of atherosclerosis and their suitability for the study of myocardial infarction

scientific article published on 30 November 2020

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week

scientific article published on 01 January 2019

Myocardial regeneration: expanding the repertoire of thymosin β4 in the ischemic heart

scientific article

Necrostatin: a potentially novel cardioprotective agent?

scientific article published on 31 July 2007

Neural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects.

scientific article

Neuroprotection in Rats Following Ischaemia-Reperfusion Injury by GLP-1 Analogues-Liraglutide and Semaglutide

scientific article published on 01 December 2019

New insights into cardiotoxicity caused by chemotherapeutic agents

scientific article published in November 2017

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.

scientific article

Novel therapeutic strategies for cardioprotection.

scientific article published on 13 May 2014

Optical delivery and monitoring of photodynamic therapy of prostate cancer

Over-expression of the cardioprotective kinase Akt modulates mitochondrial morphology

P439Comparative metabolomics identifies conserved metabolic pathways that control mitochondrial ROS production during ischaemia reperfusion injury

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

scientific article

Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells

scientific article

Plasma exosomes protect the myocardium from ischemia-reperfusion injury.

scientific article published in April 2015

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

scientific article published on 07 April 2016

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

scientific article published on 17 August 2018

Preconditioning and postconditioning: The essential role of the mitochondrial permeability transition pore

Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore

scientific article

Protection From Cardiac Ischemia-Reperfusion Injury by Epigenetic Regulation of NADPH Oxidase

scientific article published on 01 December 2018

Reflections on 40 years of the British Society for Cardiovascular Research (BSCR).

scientific article published on 12 March 2013

Remote ischaemic conditioning reduces infarct size in animal in vivo models of ischaemia-reperfusion injury: a systematic review and meta-analysis

scientific article

Remote ischaemic preconditioning involves signalling through the SDF-1α/CXCR4 signalling axis

scientific article published on 6 August 2013

Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop

scientific article

Response to "Causal reasoning: the 'magical number' three"

scientific article published on September 2009

Rho-kinase mediates reoxygenation-induced cardiomyocyte death and promotes mitochondrial transition pore opening

Role of Caspase 1 in Ischemia/Reperfusion Injury of the Myocardium

scientific article published on 01 September 2019

Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion

scientific article published on 20 November 2017

STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage

scientific article

STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis

scientific article published on 5 November 2003

STAT5 fits the RISK profile for cardioprotection

scientific article published on April 2012

Shining the spotlight on cardioprotection: beyond the cardiomyocyte

scientific article published on 01 June 2019

Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection

scientific article published on 21 October 2005

Silencing PTEN, a negative regulator of the PI3K/AKT pathway, is not sufficient to confer protection against simulated ischaemia and reperfusion

Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation

scientific article published on 23 December 2011

Small extracellular vesicles secreted from human amniotic fluid mesenchymal stromal cells possess cardioprotective and promigratory potential

scientific article published on 07 March 2020

Stem Cell Aging and Age-Related Cardiovascular Disease: Perspectives of Treatment by Ex-vivo Stem Cell Rejuvenation.

scientific article

Stromal cell-derived factor-1α signals via the endothelium to protect the heart against ischaemia-reperfusion injury

scientific article published on 07 February 2019

Stromal derived factor 1α: a chemokine that delivers a two-pronged defence of the myocardium.

scientific article published on April 2014

TPC1 Knockout Knocks Out TPC1.

scientific article published on May 2015

Targeting myocardial ischaemic injury in the absence of reperfusion

scientific article published on 14 October 2020

The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection-evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology

scientific article published on 11 October 2018

The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway

scientific article published on 26 March 2018

The GTN patch: a simple and effective new approach to cardioprotection?

scientific article published on 17 April 2018

The Role of Extracellular DNA and Histones in Ischaemia-Reperfusion Injury of the Myocardium

scientific article published on 01 February 2020

The adipocytokine, resistin, is not cardioprotective despite activating components of the risk pathway

The cannabinoid CB1 receptor antagonist, rimonabant, protects against acute myocardial infarction.

scientific article

The cardioprotective actions of leptin are lost in the Zucker obese (fa/fa) rat.

scientific article

The cardioprotective effect of atorvastatin—Is there a role for the adenosine receptor?

The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage

scientific article published in August 2004

The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection

scientific article published on 01 June 2019

The cytokine storm of COVID-19: a spotlight on prevention and protection

scientific article published on 27 June 2020

The developmental expression of small HSP.

scientific article

The effect of Cyclosporine A on cardiomyocytes differentiation

scientific article published on March 2007

The importance of clinically relevant background therapy in cardioprotective studies

scientific article published on 13 November 2020

The mitochondrial permeability transition pore as a target for cardioprotection in hypertrophic cardiomyopathy.

scientific article

The novel adipocytokine visfatin exerts direct cardioprotective effects

scientific article

The powerful cardioprotective effects of urocortin and the corticotropin releasing hormone (CRH) family

scientific article published on 06 September 2008

The role of PI3Kα isoform in cardioprotection

scientific article published on 17 October 2017

The role of nitric oxide in mitochondria. Focus on “Modulation of mitochondrial Ca2+ by nitric oxide in cultured bovine vascular endothelial cells”

scientific article published on 01 October 2005

The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin

scientific journal article

Title: Therapeutic strategies utilising SDF-1α in ischaemic cardiomyopathy.

scientific article published on 13 October 2017

Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury

scientific article published on 29 October 2010

Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction

scientific article

Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations

scientific article

Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop

scientific article published on 25 September 2012

UK-Russia Researcher Links Workshop: extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 March 2015

scientific article published on 14 May 2015

Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress

scientific article

Urocortin: a few inflammatory remarks.

scientific article

Urocortin: a protective peptide that targets both the myocardium and vasculature

scientific article published on January 2009

Using multiphoton microscopy to examine the response of the heart to ischaemia and reperfusion injury

Vascular smooth muscle cell calcification is mediated by regulated exosome secretion

scientific article published on 23 February 2015

Ventilation strategy has a major influence on remote ischaemic preconditioning in mice

scientific article

miR-19a-3p containing exosomes improve function of ischaemic myocardium upon shock wave therapy

scientific article published on 13 August 2019

β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes.

scientific article

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