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List of works by Brice Korkmaz

A Monoclonal Antibody (MCPR3-7) Interfering with the Activity of Proteinase 3 by an Allosteric Mechanism ⬇️

scientific article published on July 31, 2013

A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.

scientific article

A selective reversible azapeptide inhibitor of human neutrophil proteinase 3 derived from a high affinity FRET substrate

scientific article published on 24 December 2011

A substrate-based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen

scientific article published on 13 June 2011

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome

scientific article published in 2016

Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway

scientific article published on 13 November 2013

Catalytic activity and inhibition of wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils.

scientific article published on 15 May 2009

Competition between elastase and related proteases from human neutrophil for binding to alpha1-protease inhibitor.

scientific article

Crystal structure of greglin, a novel non-classical Kazal inhibitor, in complex with subtilisin

scientific article

Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples

scientific article published on 13 October 2016

Differences in Staining for Neutrophil Elastase and its Controlling Inhibitor SLPI Reveal Heterogeneity among Neutrophils in Psoriasis

scientific article published on 13 January 2020

Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase

scientific article published in 2007

Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates ⬇️

scientific article published on June 13, 2011

Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates

scientific article

EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis.

scientific article

Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of peptidyl di(chlorophenyl)-phosphonate ester inhibitors: a kinetic and molecular modeling analysis.

scientific article published on 14 February 2018

Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin

scientific article published on 29 January 2020

Influence of Charge Distribution at the Active Site Surface on the Substrate Specificity of Human Neutrophil Protease 3 and Elastase

scientific article published in Journal of Biological Chemistry

Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

scientific article published on July 2016

Measurement of Neutrophil Elastase, Proteinase 3, and Cathepsin G Activities using Intramolecularly Quenched Fluorogenic Substrates ⬇️

scientific article published on January 1, 2012

Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates

scientific article published in January 2008

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases ⬇️

scientific article published on December 1, 2010

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

scientific article published on 06 February 2013

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

scientific article published on 16 February 2016

Neutrophils can disarm NK cell response through cleavage of NKp46.

scientific article published in September 2016

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

scientific article

Preservation with α-antitrypsin improves primary graft function of murine lung transplants

scientific article published on 30 March 2018

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

scientific article published on 25 September 2019

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

scientific article published on 11 February 2017

Proteinase 3 phosphonic inhibitors

scientific article published on 13 March 2019

Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia

scientific article published on 08 January 2021

Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense.

scientific article

Relevance of the mouse model as a therapeutic approach for neutrophil proteinase 3-associated human diseases ⬇️

scientific article published on July 23, 2013

Selective Inhibitors of Human Neutrophil Proteinase 3 ⬇️

scientific article published on January 1, 2013

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

scientific article published on 09 April 2019

Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S.

scientific article published on 7 December 2017

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

scientific article published on 26 May 2018

Three Wavelength Substrate System of Neutrophil Serine Proteinases

scientific article published on 08 August 2012

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