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List of works by David C Huang

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

scientific article published on 01 January 2007

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation

scientific article

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

scientific article published on 12 July 2012

A biosensor of SRC family kinase conformation by exposable tetracysteine useful for cell-based screening.

scientific article published on 15 May 2014

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

scientific article

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

scientific article published on 07 October 2019

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

scientific article

A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

scientific article published on 12 March 2015

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

scientific article

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

scientific article published on 25 September 2018

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

scientific article published on 04 December 2018

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

scientific article published on 31 March 2017

Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases.

scientific article

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

scientific article

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

scholarly article

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.

scientific article published on 10 October 2014

BCL2 inhibition in double hit lymphoma.

scientific article

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

scientific article published on 08 March 2016

BH3 Mimetics for the Treatment of B-Cell Malignancies-Insights and Lessons from the Clinic

scientific article published on 12 November 2020

BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia.

scientific article published in February 2013

BH3-mimetics--the solution to chemoresistance?

scientific article

BH3-only proteins: orchestrating cell death

scientific article published on 09 June 2006

Bax activation by Bim?

scientific article published on 26 June 2009

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

scientific article

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α Production

scientific article published on 01 March 2015

Bcl-2 does not inhibit cell death induced by the physiological Fas ligand: implications for the existence of type I and type II cells

scientific article published on 01 August 2000

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

scientific article published on January 1997

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

scientific article

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

scholarly article

Bim: a novel member of the Bcl-2 family that promotes apoptosis

scientific article published in January 1998

Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199.

scientific article

CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells

scientific article published on 26 September 2018

CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13

scientific article published on 01 March 2006

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

scientific article published on 01 August 2002

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

scientific article published on 24 June 2019

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax.

scientific article

Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing

scientific article published on 11 November 2021

Current challenges and novel treatment strategies in double hit lymphomas

scientific article

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

scientific journal article

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

scientific article published on 14 April 2017

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization

scientific article

Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery.

scientific article

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells

scientific article published on 27 January 2020

Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax.

scientific article

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia

scientific article published on 28 July 2017

Defining the susceptibility of colorectal cancers to BH3-mimetic compounds

scientific article published on 10 September 2020

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

scientific article published on 14 November 2017

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

scientific article

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

scientific article published on 26 June 2013

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

scientific article published on 19 November 2018

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

scientific article published on 23 October 2019

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.

scientific article published on 20 June 2008

Effects of anti-TNF monoclonal antibody infusion in patients with hairy cell leukaemia

scientific article published on 01 June 1992

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

scientific article published on 24 February 2016

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

scientific article published on 20 December 2013

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.

scientific article

Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins.

scientific article published on 24 April 2017

Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis

scientific article published on 30 June 2011

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

scientific article

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells.

scientific article published on 19 May 2005

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

scientific article published on 18 February 2014

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

scientific article

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

scientific article

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.

scientific article published on 14 January 2016

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

scientific article published on 30 September 2016

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

scientific article

How the Bcl-2 family of proteins interact to regulate apoptosis.

scientific article

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos

scientific article published on 18 September 2018

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

scientific article published on 24 May 2016

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

scholarly article

Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma

scientific article published on 16 November 2010

Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.

scientific article

Infection with flaviviruses requires BCLXL for cell survival

scientific article published on 27 September 2018

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

scientific article

KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs

scientific article published on 15 January 2019

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

scientific article

Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells

scientific article published on 18 June 2020

MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex

scientific article published on 24 February 2020

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

scientific article published on 25 August 2016

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication

scientific article

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

scientific article published on July 2009

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

scientific article

Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes.

scientific article published on July 2004

Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737.

scientific article

Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML

scientific article published on 01 March 2020

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

scientific article published on 01 March 2020

Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting

scientific article published on 01 December 2019

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

scientific article published on 13 October 2017

Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

scientific article published on 10 September 2009

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

scientific article published on 27 July 2018

Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies.

scientific article published on October 2011

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

scientific article published on 14 April 2021

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

scientific article published in 2022

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

scientific article published on 5 February 2008

Programmed anuclear cell death delimits platelet life span.

scientific article

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.

scientific article

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

scientific article

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

scientific article

Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

scientific article published on 17 September 2019

Response: Does Bid Play a Role in the DNA Damage Response?

article

Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.

scientific article

Simplified silvestrol analogues with potent cytotoxic activity.

scientific article published on 27 March 2014

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

scientific article

Structural insights into the degradation of Mcl-1 induced by BH3 domains

scientific article

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

scientific article

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

scientific article published on 03 June 2019

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

scientific article published in January 2005

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

scientific article published in August 2017

Synthesis and biological evaluation of a potent salicylihalamide A lactam analogue.

scientific article published on October 2012

Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II.

scientific article published on 5 March 2013

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

scientific article published on 10 April 2015

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

scientific article published on 09 September 2021

Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies

scientific article published on 2 November 2016

Targeting BCL2 for the treatment of lymphoid malignancies

scientific article

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription.

scientific article published on 17 June 2013

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

scientific article published on January 2014

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

scientific article published on 11 April 2016

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

scientific article published on November 2006

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

scientific article published on 01 April 2007

The BH3-mimetic ABT-737 induces mast cell apoptosis in vitro and in vivo: potential for therapeutics.

scientific article published on 16 July 2010

The Bcl-2 family: roles in cell survival and oncogenesis.

scientific article published on November 2003

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

scientific article published on 19 October 2016

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

scientific article published on 01 November 2018

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

scientific article

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

scientific article published on 04 November 2020

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

scientific article published on 18 February 2016

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

scientific article (publication date: May 2001)

Total synthesis of 2''',5'''-diepisilvestrol and its C1''' epimer: key structure activity relationships at C1''' and C2'''

scientific article published on 20 July 2012

Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction

scientific article published on 01 January 2000

VDAC2 enables BAX to mediate apoptosis and limit tumor development

scientific article published in Nature Communications

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

scientific article

Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice.

scientific article

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia.

scientific article

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

scientific article

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