List of works - William T Festuccia

11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues

scientific article published on 31 July 2007

A comparative perspective on lipid storage in animals

scientific article published in April 2013

A novel peptide that improves metabolic parameters without adverse central nervous system effects.

scientific article published on November 2017

Adaptation to a high protein, carbohydrate-free diet induces a marked reduction of fatty acid synthesis and lipogenic enzymes in rat adipose tissue that is rapidly reverted by a balanced diet.

scientific article published in June 2005

Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.

scientific article published on 5 July 2017

Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice

scientific article published in 2021

Basal adrenergic tone is required for maximal stimulation of rat brown adipose tissue UCP1 expression by chronic PPAR-gamma activation.

scientific article published on 14 April 2010

Brown adipose tissue glyceroneogenesis is activated in rats exposed to cold.

scientific article published on 16 November 2004

Cagaita fruit (Eugenia dysenterica DC.) and obesity: Role of polyphenols on already established obesity

scientific article published on 12 October 2017

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue ⬇️

scientific article published on 18 March 2010

Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity

scientific article published on 08 August 2018

Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice.

scientific article published on 25 February 2016

Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ.

scientific article published on 21 December 2011

Critical review of beige adipocyte thermogenic activation and contribution to whole-body energy expenditure

scientific article published in September 2017

DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

scientific article

Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88.

scientific article published on June 2017

Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide

scientific article published on 01 February 2019

Depletion of Ric-8B leads to reduced mTORC2 activity

scientific article published on 11 May 2020

Depot-specific effects of the PPARgamma agonist rosiglitazone on adipose tissue glucose uptake and metabolism.

scientific article published on 5 February 2009

Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1

scientific article published on 01 February 2007

Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects

scientific article published on 28 August 2019

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

scientific article published on 08 September 2020

Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1

scientific article published on 04 February 2019

Exercise rescues the immune response fine-tuned impaired by peroxisome proliferator-activated receptors γ deletion in macrophages

scientific article published on 21 September 2018

Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice

scientific article published on 28 May 2016

Fish Oil Protects Wild Type and Uncoupling Protein 1-Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure

scientific article published on 17 January 2019

High-fat diet-induced hypertension and autonomic imbalance are associated with an upregulation of CART in the dorsomedial hypothalamus of mice.

scientific article published on June 2016

Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle

scientific article published on 28 August 2019

Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia

scientific article published on 8 December 2009

Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure.

scientific article published on 22 September 2015

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2016.

scientific article published on 5 July 2017

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2018

article

Immunometabolism: molecular mechanisms, diseases, and therapies.

scientific article published on 22 September 2014

Increased glyceroneogenesis in adipose tissue from rats adapted to a high-protein, carbohydrate-free diet: role of dietary fatty acids.

scientific article published in January 2006

Integrated proteomics reveals apoptosis-related mechanisms associated with placental malaria

scientific article published on 21 September 2018

Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice

scientific article published on 28 August 2018

Involvement of adipose tissues in the early hypolipidemic action of PPARgamma agonism in the rat

scientific article published on 14 December 2006

Leukotriene-B4 modulates macrophage metabolism and fat loss in type 1 diabetic mice.

scientific article published on 26 June 2019

Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids

scientific article published on 24 January 2020

Liver lipidome signature and metabolic pathways in non-alcoholic fatty liver disease induced by a high-sugar diet

scientific article published on 02 October 2020

Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion

scientific article

Mechanisms of the depot specificity of peroxisome proliferator-activated receptor gamma action on adipose tissue metabolism

scientific journal article

Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

scientific article published on 23 February 2012

Mild-cold water swimming does not exacerbate white adipose tissue browning and brown adipose tissue activation in mice

scientific article published on 14 October 2020

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

scientific journal article

Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions

scientific article published on 16 March 2015

PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2

scientific journal article

PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats.

scientific article published on 11 March 2014

PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues

article

Palmitoleate attenuates diet induced insulin resistance and hepatic inflammation independently of PPAR-α.

scientific article published on 28 May 2014

Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner

scientific article published on 10 September 2013

Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation.

scientific article

Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-γ-independent M2a polarization of myeloid cells

scientific article published on 29 July 2020

Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status

scientific article published on 24 January 2008

Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice

scientific article published on 24 September 2020

Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet

scientific article published on 18 September 2009

Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases

scientific article published on 26 February 2020

Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

scientific article published on 04 July 2018

Regulation of adiposity by mTORC1.

scientific article published in October 2017

Regulation of brown adipose tissue recruitment, metabolism and thermogenic function by peroxisome proliferator-activated receptor γ

scientific article

Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation.

scientific article published on 3 May 2009

Sympathetic Regulation of Slc2a4 Gene Expression: Participation of a Putative cAMP Responsive Element (CRE) Site in the Slc2a4 Promoter

scientific article published on 01 January 2019

The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis

scientific article published on 04 October 2019

The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake

scientific article published on 11 February 2009

The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis

scientific article published on 08 August 2019

Tissue-specific postprandial clearance is the major determinant of PPARgamma-induced triglyceride lowering in the rat.

scientific article published on 29 October 2008

Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice

scientific article published on 22 May 2012

Turning up the heat against metabolic syndrome and non-alcoholic fatty liver disease

scientific article published in February 2017

mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function

scientific article published on 28 September 2016

mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold.

scientific article published on 23 November 2016

List of works by William T Festuccia

11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues

A comparative perspective on lipid storage in animals

A novel peptide that improves metabolic parameters without adverse central nervous system effects.

Adaptation to a high protein, carbohydrate-free diet induces a marked reduction of fatty acid synthesis and lipogenic enzymes in rat adipose tissue that is rapidly reverted by a balanced diet.

Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.

Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice

Basal adrenergic tone is required for maximal stimulation of rat brown adipose tissue UCP1 expression by chronic PPAR-gamma activation.

Brown adipose tissue glyceroneogenesis is activated in rats exposed to cold.

Cagaita fruit (Eugenia dysenterica DC.) and obesity: Role of polyphenols on already established obesity

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue ⬇️

Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity

Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice.

Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ.

Critical review of beige adipocyte thermogenic activation and contribution to whole-body energy expenditure

DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88.

Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide

Depletion of Ric-8B leads to reduced mTORC2 activity

Depot-specific effects of the PPARgamma agonist rosiglitazone on adipose tissue glucose uptake and metabolism.

Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1

Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1

Exercise rescues the immune response fine-tuned impaired by peroxisome proliferator-activated receptors γ deletion in macrophages

Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice

Fish Oil Protects Wild Type and Uncoupling Protein 1-Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure

High-fat diet-induced hypertension and autonomic imbalance are associated with an upregulation of CART in the dorsomedial hypothalamus of mice.

Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle

Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia

Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure.

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2016.

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2018

Immunometabolism: molecular mechanisms, diseases, and therapies.

Increased glyceroneogenesis in adipose tissue from rats adapted to a high-protein, carbohydrate-free diet: role of dietary fatty acids.

Integrated proteomics reveals apoptosis-related mechanisms associated with placental malaria

Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice

Involvement of adipose tissues in the early hypolipidemic action of PPARgamma agonism in the rat

Leukotriene-B4 modulates macrophage metabolism and fat loss in type 1 diabetic mice.

Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids

Liver lipidome signature and metabolic pathways in non-alcoholic fatty liver disease induced by a high-sugar diet

Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion

Mechanisms of the depot specificity of peroxisome proliferator-activated receptor gamma action on adipose tissue metabolism

Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

Mild-cold water swimming does not exacerbate white adipose tissue browning and brown adipose tissue activation in mice

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions

PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2

PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats.

PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues

Palmitoleate attenuates diet induced insulin resistance and hepatic inflammation independently of PPAR-α.

Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner

Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation.

Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-γ-independent M2a polarization of myeloid cells

Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status

Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice

Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet

Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases

Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

Regulation of adiposity by mTORC1.

Regulation of brown adipose tissue recruitment, metabolism and thermogenic function by peroxisome proliferator-activated receptor γ

Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation.

Sympathetic Regulation of Slc2a4 Gene Expression: Participation of a Putative cAMP Responsive Element (CRE) Site in the Slc2a4 Promoter

The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis

The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake

The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis

Tissue-specific postprandial clearance is the major determinant of PPARgamma-induced triglyceride lowering in the rat.

Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice

Turning up the heat against metabolic syndrome and non-alcoholic fatty liver disease

mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function

mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold.