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List of works by Frank M Raushel

A Chemoenzymatic Synthesis of the (RP)-Isomer of the Antiviral Prodrug Remdesivir

scientific article published on 10 August 2020

A Common Catalytic Mechanism for Proteins of the HutI Family †

scientific article

A Conserved Glutamate Controls the Commitment to Acyl-Adenylate Formation in Asparagine Synthetase

scientific article published on November 2, 2010

A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase

scientific article

A functional analysis of the allosteric nucleotide monophosphate binding site of carbamoyl phosphate synthetase

scientific article published in April 2002

Access to the carbamate tunnel of carbamoyl phosphate synthetase

scientific article published in May 2004

Annotating Enzymes of Uncertain Function: The Deacylation of d -Amino Acids by Members of the Amidohydrolase Superfamily ,

scientific article

Annotating enzymes of unknown function: N-formimino-L-glutamate deiminase is a member of the amidohydrolase superfamily

scientific journal article

Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking

scientific article published on 2 January 2013

At the periphery of the amidohydrolase superfamily: Bh0493 from Bacillus halodurans catalyzes the isomerization of D-galacturonate to D-tagaturonate

scientific article published on 3 January 2008

Atropselective Hydrolysis of Chiral Binol-Phosphate Esters Catalyzed by the Phosphotriesterase from Sphingobium sp. TCM1

scientific article published on 09 November 2020

Bacterial detoxification of organophosphate nerve agents

scientific article

Biosynthesis of GDP-d-glycero-α-d-manno-heptose for the Capsular Polysaccharide of Campylobacter jejuni

scientific article published on 29 August 2019

Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni

scientific article

Carbamate transport in carbamoyl phosphate synthetase: a theoretical and experimental investigation

scientific article

Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia

scientific article

Catalytic Mechanism and Three-Dimensional Structure of Adenine Deaminase,

scientific article published on February 4, 2011

Catalytic detoxification

scientific article published in Nature

Catalytic mechanisms for phosphotriesterases

scientific article published on 26 April 2012

Catalytic properties of the PepQ prolidase from Escherichia coli

scientific article

Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX.

scientific article published on 14 July 2007

Computational design of enzymes

scientific article

Control of stereoselectivity in phosphotriesterase

scientific article published in January 2004

Correction to Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β-Propeller Protein Fold

scientific article published on 19 August 2016

Cytidine Diphosphoramidate Kinase: An Enzyme Required for the Biosynthesis of the O-Methyl Phosphoramidate Modification in the Capsular Polysaccharides of Campylobacter jejuni

scientific article published on 26 March 2018

Deamination of 6-Aminodeoxyfutalosine in Menaquinone Biosynthesis by Distantly Related Enzymes

scientific article

Deciphering the Aldolase Function of STM3780 from a Bovine Enteric Infection-Related Gene Cluster in Salmonella enterica Serotype Typhimurium

scientific article published on 24 November 2020

Deciphering the Enzymatic Function of the Bovine Enteric Infection-Related Protein YfeJ from Salmonella enterica Serotype Typhimurium

scientific article published on 15 February 2019

Detoxification of organophosphate nerve agents by bacterial phosphotriesterase

scientific article

Differentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents

scientific article published on July 2007

Discovery and Structure Determination of the Orphan Enzyme Isoxanthopterin Deaminase,

scientific article

Discovery of a Cytokinin Deaminase

scientific article published on August 12, 2011

Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni

scientific article published on 26 June 2017

Discovery of a Kojibiose Phosphorylase in Escherichia coli K-12

scientific article published on 30 April 2018

Discovery of a Previously Unrecognized Ribonuclease from Escherichia coli That Hydrolyzes 5'-Phosphorylated Fragments of RNA.

scientific article

Discovery of a bacterial 5-methylcytosine deaminase

scientific article

Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation

scientific article published on 08 October 2013

Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis of both ester bonds to phosphorus

scientific article

Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily

scientific article published on 20 December 2012

Dissection of the conduit for allosteric control of carbamoyl phosphate synthetase by ornithine

scientific article published in April 2002

Effect of linker sequence on the stability of circularly permuted variants of ribonuclease T1.

scientific article

Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site

scientific article

Enzymatic deamination of the epigenetic base N-6-methyladenine

scientific article published on 28 January 2011

Enzymatic neutralization of the chemical warfare agent VX: evolution of phosphotriesterase for phosphorothiolate hydrolysis

scientific article

Enzymatic synthesis of chiral organophosphothioates from prochiral precursors

scientific article

Enzyme-Catalyzed Kinetic Resolution of Chiral Precursors to Antiviral Prodrugs

scientific article published on 10 July 2019

Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents

scientific article published on July 31, 2012

Enzymes with molecular tunnels

scientific article

Evolution of enzymatic activities in the enolase superfamily: N-succinylamino acid racemase and a new pathway for the irreversible conversion of D- to L-amino acids

article

Evolution of function in (β/α)8-barrel enzymes

scientific article published on April 1, 2003

Function discovery and structural characterization of a methylphosphonate esterase

scientific article published on 28 April 2015

Functional Annotation and Three-Dimensional Structure of Dr0930 from Deinococcus radiodurans , a Close Relative of Phosphotriesterase in the Amidohydrolase Superfamily † ‡

scientific article

Functional Annotation of LigU as a 1,3-Allylic Isomerase During the Degradation of Lignin in the Protocatechuate 4,5-Cleavage Pathway from the Soil Bacterium Sphingobium sp. SYK-6.

scientific article published on 16 April 2018

Functional Annotation of Two New Carboxypeptidases from the Amidohydrolase Superfamily of Enzymes

scientific article

Functional Characterization of Cj1427, a Unique Ping-Pong Dehydrogenase Responsible for the Oxidation of GDP-d-glycero-α-d-manno-heptose in Campylobacter jejuni

scientific article published on 18 March 2020

Functional Characterization of YdjH, a Sugar Kinase of Unknown Specificity in Escherichia coli K12

scientific article published on 24 July 2019

Functional Characterization of the ycjQRS Gene Cluster from Escherichia coli: A Novel Pathway for the Transformation of d-Gulosides to d-Glucosides

scientific article published on 20 February 2019

Functional Identification and Structure Determination of Two Novel Prolidases from cog1228 in the Amidohydrolase Superfamily,

scientific article

Functional Identification of Incorrectly Annotated Prolidases from the Amidohydrolase Superfamily of Enzymes † ‡

scientific article

Functional and Structural Characterization of the UDP-Glucose Dehydrogenase Involved in Capsular Polysaccharide Biosynthesis from <i>Campylobacter jejuni</i>

scientific article published on 23 February 2021

Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate

scientific article

Functional annotation and three-dimensional structure of an incorrectly annotated dihydroorotase from cog3964 in the amidohydrolase superfamily

scientific article published on 20 December 2012

Functional significance of Glu-77 and Tyr-137 within the active site of isoaspartyl dipeptidase

scientific article

High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli

scientific article (publication date: 6 May 2003)

Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin

scientific article

Inhibitors designed for the active site of dihydroorotase

scientific article

Intermediates in the transformation of phosphonates to phosphate by bacteria

scientific article published on November 16, 2011

Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers

scientific article published on 2 December 2015

Kinetic mechanism of asparagine synthetase from Vibrio cholerae

scientific article published in April 2004

Long-range allosteric transitions in carbamoyl phosphate synthetase

scientific article published on September 2004

Manganese-Induced Substrate Promiscuity in the Reaction Catalyzed by Phosphoglutamine Cytidylyltransferase from Campylobacter jejuni

scientific article published on 09 April 2019

Mechanism and Structure of γ-Resorcylate Decarboxylase.

scientific article published on 28 December 2017

Mechanism for the hydrolysis of organophosphates by the bacterial phosphotriesterase

scientific article

Mechanism for the transport of ammonia within carbamoyl phosphate synthetase determined by molecular dynamics simulations

scientific article published on 26 January 2008

Mechanism of cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium LT2.

scientific article

Mechanism of the dihydroorotase reaction

scientific article published in December 2004

Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli

scientific article published in May 2005

Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template

scientific article

Multiple Reaction Products from the Hydrolysis of Chiral and Prochiral Organophosphate Substrates by the Phosphotriesterase from Sphingobium sp. TCM1

scientific article published on 13 March 2018

N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion

scientific article published on 13 June 2007

On the Catalytic Mechanism of Human ATP Citrate Lyase

scientific article published on June 15, 2012

Operational control of stereoselectivity during the enzymatic hydrolysis of racemic organophosphorus compounds

scientific article

Organophosphate nerve agent toxicity in Hydra attenuata

scientific article published in August 2003

Overcoming the Challenges of Enzyme Evolution To Adapt Phosphotriesterase for V-Agent Decontamination

scientific article published on 01 April 2019

Pa0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine

scientific article published on July 6, 2011

Partial randomization of the four sequential amidation reactions catalyzed by cobyric acid synthetase with a single point mutation

scientific article published on 15 November 2007

Perforation of the tunnel wall in carbamoyl phosphate synthetase derails the passage of ammonia between sequential active sites

scientific article

Positional Isotope Exchange Analysis of the Pantothenate Synthetase Reaction

scientific article published on May 6, 2003

Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC).

scientific article published on 29 March 2008

Potent inhibition of the C-P lyase nucleosidase PhnI by Immucillin-A triphosphate

scientific article

Predicting substrates by docking high-energy intermediates to enzyme structures

scientific article

Prospecting for Unannotated Enzymes: Discovery of a 3′,5′-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily

scientific article

Rescue of the Orphan Enzyme Isoguanine Deaminase

scientific article published on June 7, 2011

Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library

scientific article

STRENDA DB: enabling the validation and sharing of enzyme kinetics data

scholarly article by Neil Swainston published in June 2018

Sensitivity and specificity improvement of an ion sensitive field effect transistors-based biosensor for potato glycoalkaloids detection

scientific article published in February 2006

Standards for Reporting Enzyme Data: The STRENDA Consortium: What it aims to do and why it should be helpful

article by Keith F. Tipton et al published May 2014 in Perspectives in Science

Stereoselective Formation of Multiple Reaction Products by the Phosphotriesterase from Sphingobium sp. TCM1

scientific article published on 17 March 2020

Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase

scientific article published on September 2010

Structural Analysis of Cj1427, an Essential NAD-Dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni

scientific article published on 23 March 2020

Structural and Functional Characterization of YdjI, an Aldolase of Unknown Specificity in Escherichia coli K12

scientific article published on 26 July 2019

Structural and Mechanistic Characterization of l -Histidinol Phosphate Phosphatase from the Polymerase and Histidinol Phosphatase Family of Proteins

scientific article

Structural and catalytic diversity within the amidohydrolase superfamily

scientific article

Structural and kinetic studies of sugar binding to galactose mutarotase from Lactococcus lactis

scientific article

Structural characterization and function determination of a nonspecific carboxylate esterase from the amidohydrolase superfamily with a promiscuous ability to hydrolyze methylphosphonate esters

scientific journal article

Structural defects within the carbamate tunnel of carbamoyl phosphate synthetase

scientific article (publication date: 22 October 2002)

Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesterase

scientific article

Structural diversity within the mononuclear and binuclear active sites of N-acetyl-D-glucosamine-6-phosphate deacetylase

scientific article

Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation

scientific article

Structure and Chemical Reaction Mechanism of LigU, an Enzyme That Catalyzes an Allylic Isomerization in the Bacterial Degradation of Lignin

scientific article published on 09 August 2019

Structure and Reaction Mechanism of YcjR, an Epimerase That Facilitates the Interconversion of d-Gulosides to d-Glucosides in <i>Escherichia coli</i>

scientific article published on 28 May 2020

Structure and Reaction Mechanism of the LigJ Hydratase: An Enzyme Critical for the Bacterial Degradation of Lignin in the Protocatechuate 4,5-Cleavage Pathway

scientific article published on 27 September 2018

Structure of Diethyl Phosphate Bound to the Binuclear Metal Center of Phosphotriesterase † ‡

scientific article

Structure of N-formimino-L-glutamate iminohydrolase from Pseudomonas aeruginosa

scientific article

Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β-Propeller Protein Fold

scientific article

Structure, Mechanism, and Substrate Profile for Sco3058: The Closest Bacterial Homologue to Human Renal Dipeptidase,

scientific article

Structure-based activity prediction for an enzyme of unknown function

scientific article

Structure-based function discovery of an enzyme for the hydrolysis of phosphorylated sugar lactones

scientific article

Structure-guided discovery of new deaminase enzymes

scientific journal article

Structures of the Carbon-Phosphorus Lyase Complex Reveal the Binding Mode of the NBD-like PhnK.

scientific article

Substrate Deconstruction and the Nonadditivity of Enzyme Recognition

scientific article

Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase

scientific article published on 30 December 2015

Substrate Profile of the Phosphotriesterase Homology Protein from Escherichia coli

scientific article published on 16 October 2018

Substrate Specificity and Chemical Mechanism for the Reaction Catalyzed by Glutamine Kinase

scientific article published on 06 September 2018

Subunit Interactions within the Carbon-Phosphorus Lyase Complex from Escherichia coli

scientific article published on 19 May 2015

Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies

scientific article published on 14 February 2009

The Discovery of a β-Lactone Synthetase

scientific article published on 15 February 2017

The Enzyme Function Initiative

scientific article

The Hunt for 8-Oxoguanine Deaminase

scientific article

The Mechanism of the Reaction Catalyzed by Uronate Isomerase Illustrates How an Isomerase May Have Evolved from a Hydrolase within the Amidohydrolase Superfamily

scientific article

The catalase activity of diiron adenine deaminase

scientific article published on November 9, 2011

The catalytic mechanism for aerobic formation of methane by bacteria

scientific article published on 24 April 2013

The catalytic mechanism of galactose mutarotase

scientific article (publication date: May 2003)

The enzymatic conversion of phosphonates to phosphate by bacteria

scientific article published on 02 July 2013

The multiple amidation reactions catalyzed by Cobyric acid synthetase from Salmonella typhimurium are sequential and dissociative

scientific article published in January 2007

The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution

scientific article

Theoretical investigation of the reaction mechanism of the dinuclear zinc enzyme dihydroorotase

scientific article published in January 2008

Three-Dimensional Structure and Catalytic Mechanism of Cytosine Deaminase

scientific article

Transition State Analysis of the Reaction Catalyzed by the Phosphotriesterase from Sphingobium sp. TCM1

scientific article published on 19 February 2019

Tunneling of intermediates in enzyme-catalyzed reactions

scientific article

Uronate isomerase: a nonhydrolytic member of the amidohydrolase superfamily with an ambivalent requirement for a divalent metal ion.

scientific article

Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR

scientific article

Virtual screening against metalloenzymes for inhibitors and substrates

scientific article published in September 2005

W. W. "Mo" Cleland: a catalytic life

scientific article published on 10 December 2013

l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota

scientific article