List of works - Pawel Dokurno

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

scientific article

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity

scientific article

Conformation of cyclodipeptides. factor analysis: a convenient tool for simplifying conformational studies of condensed poly-ring systems: prolyltype cyclopeptides

article published in 1990

Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody

scientific article published on 01 December 1998

Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition

scientific article

Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion ⬇️

scientific article

Crystallization of an antitumour antibody SM3 complexed with a peptide epitope

scientific article published on 01 November 1997

Crystallization of the Fab fragment of the tumour-specific antibody PR1A3.

scientific article published in July 1997

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

scientific article

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

scientific article published on 04 November 2020

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

scientific article

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

scientific article

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

scientific article published on 23 May 2019

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

scientific article

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

Molecular basis of AKAP specificity for PKA regulatory subunits

scientific article published on 01 November 2006

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

scientific article

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

scientific article published on 13 April 2018

Structure of (±)-egenine

Structure of the AAA ATPase p97

scientific article

Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity

scientific article published on 24 July 2019

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

scientific article

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

scientific article

Synthesis, X-ray structure and high-resolution NMR spectroscopy of methyl 3-azido-2,3-dideoxy-alpha-D-arabino-hexopyranoside

scientific article published on 01 January 2000

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

scientific article published on 19 October 2016

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

scientific article

List of works by Pawel Dokurno

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity

Conformation of cyclodipeptides. factor analysis: a convenient tool for simplifying conformational studies of condensed poly-ring systems: prolyltype cyclopeptides

Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody

Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition

Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion ⬇️

Crystallization of an antitumour antibody SM3 complexed with a peptide epitope

Crystallization of the Fab fragment of the tumour-specific antibody PR1A3.

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

Molecular basis of AKAP specificity for PKA regulatory subunits

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

Structure of (±)-egenine

Structure of the AAA ATPase p97

Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

Synthesis, X-ray structure and high-resolution NMR spectroscopy of methyl 3-azido-2,3-dideoxy-alpha-D-arabino-hexopyranoside

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.