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List of works by Douglas Yee

64Cu-Labeled Gp2 Domain for PET Imaging of Epidermal Growth Factor Receptor

scientific article published on 3 October 2016

A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer

scientific article published on 13 September 2017

A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.

scientific article published on 13 November 2003

A dual-radioisotope hybrid whole-body micro-positron emission tomography/computed tomography system reveals functional heterogeneity and early local and systemic changes following targeted radiation to the murine caudal skeleton.

scientific article published on 23 February 2014

A phase I feasibility study of multi-modality imaging assessing rapid expansion of marrow fat and decreased bone mineral density in cancer patients.

scientific article

A tale of two receptors: insulin and insulin-like growth factor signaling in cancer ⬇️

scientific article published on 10 October 2014

APOBEC3B is an enzymatic source of mutation in breast cancer.

scientific article published on 06 February 2013

Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells Requires Hyperactivation of eIF4F-Mediated Translation.

scientific article published on 2 June 2017

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

scientific article published on June 2004

Adaptive Trials in the Neoadjuvant Setting: A Model to Safely Tailor Care While Accelerating Drug Development

scientific article published on 20 December 2012

Adaptor proteins as targets for cancer prevention.

scientific article published on 23 February 2010

Adding in vivo quantitative 1H MR spectroscopy to improve diagnostic accuracy of breast MR imaging: preliminary results of observer performance study at 4.0 T.

scientific article

Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer.

scientific article published on June 1996

Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells

scientific article

Amplified in Breast Cancer Regulates Transcription and Translation in Breast Cancer Cells

scientific article published on February 2016

Angiotensin Converting Enzyme Inhibitors (ACEI) and doxorubicin pharmacokinetics in women receiving adjuvant breast cancer treatment

scientific article

Angiotensin converting enzyme inhibitors may be protective against cardiac complications following anthracycline chemotherapy.

scientific article published on 8 January 2010

Anti-Insulin-like Growth Factor Therapy in Breast Cancer.

scientific article

Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical T

scientific article published on 23 July 2020

Atypical methylation of the interleukin-8 gene correlates strongly with the metastatic potential of breast carcinoma cells ⬇️

scientific article published on November 17, 2003

CCR 20th Anniversary commentary: stayin' alive-antiapoptotic proteins and breast cancer

scientific article published in February 2015

Characterization of insulin-like growth factor binding proteins (IGFBP) and regulation of IGFBP-4 in bone marrow stromal cells

scientific article published in June 1995

Characterization of insulin-like growth factor binding proteins and regulation of IGFBP3 in human mesangial cells

scientific article published in April 1996

Chemotherapy and Targeted Therapy for Patients With Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer That is Either Endocrine-Pretreated or Hormone Receptor–Negative: ASCO Guideline Update

scientific article published on 29 July 2021

Chemotherapy and targeted therapy for women with human epidermal growth factor receptor 2-negative (or unknown) advanced breast cancer: American Society of Clinical Oncology Clinical Practice Guideline.

scientific article published on 02 September 2014

Cloning, Chromosome Localization, Expression, and Characterization of an Src Homology 2 and Pleckstrin Homology Domain-containing Insulin Receptor Binding Protein hGrb10γ ⬇️

scientific article published on November 14, 1997

Combined effects of tamoxifen and a chimeric humanized single chain antibody against the type I IGF receptor on breast tumor growth in vivo.

scientific article published on November 2003

Correlation of Insulin-Like Growth Factor-Binding Protein-3 Messenger RNA With Protein Expression in Primary Breast Cancer Tissues: Detection of Higher Levels in Tumors With Poor Prognostic Features

scientific article published in May 1996

Crosstalk between IGF1R and estrogen receptor signaling in breast cancer.

scientific article

Crosstalk between the insulin-like growth factors and estrogens in breast cancer.

scientific article

Detection and downregulation of type I IGF receptor expression by antibody-conjugated quantum dots in breast cancer cells

scientific article

Detection of insulin-like growth factor binding proteins (IGFBPs) by ligand blotting in breast cancer tissues

scientific article published in February 1994

Developing Safety Criteria for Introducing New Agents into Neoadjuvant Trials ⬇️

scientific article published on March 7, 2013

Diabetes and Cancer: A Consensus Report

scientific article published on 16 June 2010

Diabetes and cancer: a consensus report.

scientific article

Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells

scientific article published on 15 February 2016

Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer.

scientific article published on February 2006

Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin.

scientific article published on January 2007

Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial

scientific article published on 13 February 2020

Effect of endocrine therapy on growth of T61 human breast cancer xenografts is directly correlated to a specific down-regulation of insulin-like growth factor II (IGF-II).

scientific article published on January 1993

Effects of weight training on quality of life in recent breast cancer survivors: the Weight Training for Breast Cancer Survivors (WTBS) study

scientific article published in May 2006

Eliminating spurious lipid sidebands in 1H MRS of breast lesions.

scientific article

Enhancement of Insulin-Like Growth Factor Signaling in Human Breast Cancer: Estrogen Regulation of Insulin Receptor Substrate-1 Expressionin Vitroandin Vivo

scientific article published in May 1999

Estrogen-related receptor alpha: an orphan finds a family ⬇️

scientific article published on May 10, 2012

Exogenous near-infrared fluorophores and their applications in cancer diagnosis: biological and clinical perspectives.

scientific article

Expression of insulin-like growth factor binding proteins in human breast cancer correlates with estrogen receptor status

scientific article published in June 1993

FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter1

scientific article published in July 1999

Feasibility of single-voxel MRS measurement of apparent diffusion coefficient of water in breast tumors.

scientific article

Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore

scientific article published on 02 June 2009

Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions

scientific article

Fulvestrant regulates epidermal growth factor (EGF) family ligands to activate EGF receptor (EGFR) signaling in breast cancer cells ⬇️

scientific article published on May 18, 2013

Ganitumab and metformin plus standard neoadjuvant therapy in stage 2/3 breast cancer

scientific article published on 05 October 2021

Green Tea Catechin Extract Supplementation Does Not Influence Circulating Sex Hormones and Insulin-Like Growth Factor Axis Proteins in a Randomized Controlled Trial of Postmenopausal Women at High Risk of Breast Cancer

scientific article published on 01 April 2019

Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors

scientific article published on 11 September 2017

How does the estrogen receptor work?

scientific article

How to train your biomarker.

scientific article published on 8 June 2010

IGF system components as prognostic markers in breast cancer.

scientific article published on February 1998

IGF-I regulates redox status in breast cancer cells by activating the amino acid transport molecule xC-.

scientific article

IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.

scientific article published on 14 July 2015

IRS-1 expression and activation are not sufficient to activate downstream pathways and enable IGF-I growth response in estrogen receptor negative breast cancer cells

scientific article published in October 1999

In vitro Sensitivity Testing of Human Bladder Cancers and Cell Lines to TP-40, a Hybrid Protein with selective Targeting and Cytotoxicity

scientific article published in December 1993

In vivo quantification of choline compounds in the breast with 1H MR spectroscopy.

scientific article

Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation

scientific article

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer

scientific article

Insulin Receptor Substrate Suppression by the Tyrphostin NT157 Inhibits Responses to Insulin-Like Growth Factor-I and Insulin in Breast Cancer Cells

scientific article published on 18 September 2018

Insulin Receptor Substrate-1 is the Predominant Signaling Molecule Activated by Insulin-like Growth Factor-I, Insulin, and Interleukin-4 in Estrogen Receptor-positive Human Breast Cancer Cells

scientific article published on 17 April 1998

Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells.

scientific article published on 17 October 2006

Insulin-like Growth Factor Binding Protein Expression in Human Retinal Pigment Epithelial Cells

scientific article published in August 1993

Insulin-like growth factor (IGF)-I controls prostate fibromuscular development: IGF-I inhibition prevents both fibromuscular and glandular development in eugonadal mice

scientific journal article

Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition

scientific article

Insulin-like growth factor binding protein expression in SH-SY5Y neuroblastoma cells.

scientific article published on August 1993

Insulin-like growth factor receptor inhibitors: baby or the bathwater?

scientific article published on 3 July 2012

Insulin-like growth factor-I and cancer risk.

scientific article

Insulin-like growth factors and breast cancer

scientific article published in January 1995

Insulin-like growth factors, insulin, and growth hormone signaling in breast cancer: implications for targeted therapy.

scientific article

Introduction: IGFs and IGFBPs in the normal mammary gland and in breast cancer

scientific article published in 2000

Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer.

scientific article published on 04 July 2011

Longitudinal FDG-PET Revealed Regional Functional Heterogeneity of Bone Marrow, Site-Dependent Response to Treatment and Correlation with Hematological Parameters.

scientific article published on 15 April 2015

Longitudinal assessment of bone loss from diagnostic computed tomography scans in gynecologic cancer patients treated with chemotherapy and radiation ⬇️

scientific article published on August 3, 2010

MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2-Positive and/or Hormone Receptor-Negative Breast Cancers in the I-SPY 2 Trial

scientific article published on 07 February 2019

MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial.

scientific article published on 16 December 2016

Mechanisms of Resistance to Neoadjuvant Chemotherapy in Breast Cancer.

scientific article published in December 2017

Metabolite quantification and high-field MRS in breast cancer

scientific article published on January 2009

MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer

scientific article

Minireview: Were the IGF Signaling Inhibitors All Bad?

scientific article published on 14 September 2015

Mobile Phone Multilevel and Multimedia Messaging Intervention for Breast Cancer Screening: Pilot Randomized Controlled Trial

scientific article published on 7 November 2017

Modulation of the insulin-like growth factor-I system by N-(4-hydroxyphenyl)-retinamide in human breast cancer cell lines.

scientific article

Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression

scientific article published on January 2004

Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells.

scientific article published on March 2006

Neoadjuvant Chemotherapy of Locally Advanced Breast Cancer: Predicting Response with in Vivo1H MR Spectroscopy—A Pilot Study at 4 T

scientific article published in November 2004

Neoadjuvant as Future for Drug Development in Breast Cancer--Response.

scientific article published in January 2016

Of mice and (wo)men: is this any way to test a new drug?

scientific article

Omission of radiation therapy after breast-conserving surgery in the United States: a population-based analysis of clinicopathologic factors.

scientific article published on 27 September 2011

Pharmacodynamic Modeling of Sequence-Dependent Antitumor Activity of Insulin-like Growth Factor Blockade and Gemcitabine ⬇️

scientific article published on November 19, 2011

Pharmacodynamic characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system.

scientific article published on 12 April 2007

Pharmacokinetic profile of recombination human insulin-like growth factor binding protein-1 in athymic mice

scientific article published in January 1996

Phase II trial of 13-cis-retinoic acid plus interferon-α in recurrent head and neck cancer

scientific article published in February 1993

Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.

scientific article

Potential therapeutic strategies to interrupt insulin-like growth factor signaling in breast cancer ⬇️

scientific article published on October 1, 2003

Progesterone and breast cancer.

scientific article

Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes

scientific article

Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2.

scientific article published on September 2008

Prognostic Indicators in Early Breast Cancer ⬇️

scientific article published on March 1, 1993

Prognostic Significance of Insulin-like Growth Factor-Binding Protein Expression in Axillary Lymph Node-Negative Breast Cancer

scientific article published on 7 December 1994

Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives

scientific article published on February 2008

Randomized controlled trial of weight training and lymphedema in breast cancer survivors.

scientific article

Recombinant insulin-like growth factor binding protein-1 inhibits IGF-I, serum, and estrogen-dependent growth of MCF-7 human breast cancer cells.

scientific article published on November 1993

Regulation of Insulin-Like Growth Factor-Binding Protein (IGFBP) Expression by Breast Cancer Cells: Use of IGFBP-1 as as Inhibitor of Insulin-like Growth Factor Action

scientific article published on 2 September 1992

Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines ⬇️

scientific article published on November 1, 2001

Regulation of insulin-like growth factor binding proteins in ovarian cancer cells by oestrogen.

scientific article published on January 1993

STAT6 mediates interleukin-4 growth inhibition in human breast cancer cells

scientific article

Selective activation of insulin receptor substrate-1 and -2 in pleural mesothelioma cells: association with distinct malignant phenotypes.

scientific article

Should diabetic women with breast cancer have their own intervention studies? ⬇️

scientific article published on February 13, 2012

Skeletal remodeling following clinically relevant radiation-induced bone damage treated with zoledronic acid.

scientific article published on 15 November 2011

Spatial and temporal fracture pattern in breast and gynecologic cancer survivors

scientific article

Strain-specific differences in formation of apoptotic DNA ladders in MCF-7 breast cancer cells

scientific article published in September 1999

Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds.

scientific article published on 3 May 2017

Targeting Insulin and Insulin-Like Growth Factor Signaling in Breast Cancer ⬇️

scientific article published on October 10, 2012

Targeting insulin-like growth factor pathways.

scientific article

Targeting the insulin-like growth factor axis as a cancer therapy.

scientific article

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.

scientific article published on 07 October 2016

The IGF System in Mammary Development and Breast Cancer

scientific article published on 22 November 2008

The Minnesota Green Tea Trial (MGTT), a randomized controlled trial of the efficacy of green tea extract on biomarkers of breast cancer risk: study rationale, design, methods, and participant characteristics.

scientific article

The Neoadjuvant Model Is Still the Future for Drug Development in Breast Cancer

scientific article published on 24 February 2015

The alpha2 and alpha3 integrins are required for morphologic differentiation of an intestinal epithelial cell line.

scientific article published on April 2003

The influence of therapeutic radiation on the patterns of bone marrow in ovary-intact and ovariectomized mice

scientific article

The influence of therapeutic radiation on the patterns of bone remodeling in ovary-intact and ovariectomized mice.

scientific article published on 12 January 2013

The insulin-like growth factors and breast cancer — revisited

scientific article published in February 1998

The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival.

scientific article

Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.

scientific article

Use of Insulin-like Growth Factor-I Gene Expression to Distinguish Between Breast and Ovarian Cancer

scientific article published in February 1994

Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density.

scientific article published on 9 December 2016

Utility of high-sensitivity cardiac troponin T in patients receiving anthracycline chemotherapy

scientific article

Validation of marrow fat assessment using noninvasive imaging with histologic examination of human bone samples

scientific article

Vascular function in breast cancer survivors on aromatase inhibitors: a pilot study

scientific article published on 11 August 2017

Water-fat MRI for assessing changes in bone marrow composition due to radiation and chemotherapy in gynecologic cancer patients.

scientific article

Yin Yang gene expression ratio signature for lung cancer prognosis

scientific article

eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.

scientific article

polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice ⬇️

scientific article published on June 1, 1997

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