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List of works by David M Tarlinton

A gut feeling about plasmablasts

scientific article published on 01 December 2010

A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".

scientific article published in December 2007

A role for Blimp1 in the transcriptional network controlling natural killer cell maturation

scientific article published on 3 December 2010

Absence of MHC class II expression distinguishes fetal from adult B lymphopoiesis in mice

scientific article published on 01 May 1994

Activated Mouse B Cells Lack Expression of Granzyme B

scientific article published on 16 March 2012

Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis

scientific article published on 01 September 1997

Affinity maturation of the primary response by V gene diversification.

scientific article published on January 1998

An Erg-driven transcriptional program controls B cell lymphopoiesis

scientific article published on 15 June 2020

An explanation for the defect in secretion of IgM Mott cells and their predominant occurrence in the Ly-1 B cell compartment

scientific article published on 01 February 1992

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

scientific article published on 31 March 2017

Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger".

scientific article published in October 2005

Antigen presentation by memory B cells: the sting is in the tail.

scientific article published in April 1997

Antigen to the node: B cells go native

scientific article published on 01 April 2007

Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses

scientific journal article

Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation.

scientific article published on 12 October 2017

Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease

scientific article published on 25 April 2012

Atypical chemokine receptor 4 shapes activated B cell fate.

scientific article published on 31 January 2018

Autoimmune regulator controls T cell help for pathogenetic autoantibody production in collagen-induced arthritis

scientific article published in June 2009

B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1

scientific article

B cell memory and the role of apoptosis in its formation.

scientific article published on 07 December 2010

B cell memory in xid mice is long-lived despite reduced memory B cell frequency.

scientific article published in June 1997

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

scientific article

B-cell differentiation in the bone marrow and the periphery.

scientific article published on February 1994

B-cell differentiation: instructive one day, stochastic the next

scientific article published on 01 April 2012

B-cell lymphomas: getting in the zone! ⬇️

scientific article published on September 13, 2012

B1 and B2 cells differ in their potential to switch immunoglobulin isotype.

scientific article published in December 1995

BAFF, IL-4 and IL-21 separably program germinal center-like phenotype acquisition, BCL6 expression, proliferation and survival of CD40L-activated B cells in vitro

scientific article published on 29 July 2019

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

scientific article

Bcl6: Where too much complexity is barely enough ⬇️

scientific article published on August 1, 2011

CD19 differentially regulates BCR signalling through the recruitment of PI3K.

scientific article published on 23 June 2014

CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers

scientific article published on 25 December 2005

CD5 B Cells in the Mouse ⬇️

scientific article published on January 1, 1991

CTLA4Ig alters the course of autoimmune disease development in Lyn-/- mice

article

Congenic nonobese diabetic mouse strains fail to confirm linkage of a marginal zone B lymphocyte phenotype to the Idd11 locus on chromosome 4

scientific article published on 01 January 2006

Continued differentiation during B lymphopoiesis requires signals in addition to cell survival

article

DH element reading frame selection is influenced by an Ig heavy chain transgene, but not by bcl-2.

scientific article published on April 1995

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

scientific article

Determining germinal centre B cell fate.

scientific article published on 16 May 2012

Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene.

scientific article

Direct demonstration of MHC class II surface expression on murine pre-B cells

scientific article published on 01 December 1993

Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination

scientific article published on 24 August 2020

Diversity among memory B cells: origin, consequences, and utility.

scientific article published in September 2013

Do plasma cells contribute to the determination of their lifespan?

scientific article published on 30 April 2020

Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development.

scientific article published on 23 May 2016

Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms

scientific article published on 18 September 2017

Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.

scientific article

Editorial overview: Germinal centers and memory B-cells: from here to eternity

scientific article published in April 2017

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB.

scientific article published on 10 November 2017

Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre.

scientific article published on 08 January 2008

Evolution of B cell responses to Clec9A-targeted antigen

scientific article published on 11 October 2013

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

scientific article

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

scientific article published on 2 February 2014

FcγRIIb controls bone marrow plasma cell persistence and apoptosis

scientific article published on 18 February 2007

Feeling a Little SYK after Mixing BAFF with BCR ⬇️

scientific article published on March 21, 2013

Generation and analysis of Siah2 mutant mice.

scientific article

Genetic evidence for Lyn as a negative regulator of IL-4 signaling

article

Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development.

scientific article

Germinal center B and follicular helper T cells: siblings, cousins or just good friends? ⬇️

scientific article published on June 1, 2011

Germinal centers: form and function.

scientific article published in June 1998

Germinal centers: getting there is half the fun.

scientific article published on October 1998

Give and take in the germinal center

scientific article published on 01 June 2010

Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus

scientific article

HIV Vaccines: One Step Closer

scientific article

High Rate of Antibody Secretion Is not Integral to Plasma Cell Differentiation as Revealed by XBP-1 Deficiency

scientific article published on 27 August 2012

Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera

scientific journal article

How intrinsic and extrinsic regulators of plasma cell survival might intersect for durable humoral immunity

scientific article published on 26 June 2020

How many memories does it take to make an SLE flare?

scientific article published on 01 July 2015

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen

scientific article

IL-17 drives germinal center B cells?

scientific article published on 01 February 2008

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

scientific article

IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation.

scientific article

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

scientific article

Inhibition of the B cell by CD22: a requirement for Lyn

scientific article

Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

scientific article published in May 2007

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells.

scientific article published on 29 July 2016

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

scientific article

Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice

scientific article published in October 2013

Kinetics of establishing the memory B cell population as revealed by CD38 expression.

scientific article published in May 1998

Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background.

scientific article published on 4 August 2012

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

scientific article

Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation.

scientific article

Lymph node stromal CCL2 limits antibody responses

scientific article published on 01 March 2020

Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity

scientific article published in March 2018

Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity

scientific journal article

Lyn-dependent signaling regulates the innate immune response by controlling dendritic cell activation of NK cells.

scientific article

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

scientific article published on 25 August 2016

Manipulation of B-cell responses with histone deacetylase inhibitors

scientific article published on 27 April 2015

Mcl-1 is essential for germinal center formation and B cell memory

scientific article

Mcl-1 is essential for the survival of plasma cells

scientific article

Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.

scientific article published on 10 June 2010

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

scientific article published on October 2009

Memory B cells: effectors of long-lived immune responses.

scientific article published on August 2009

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

scientific article published on 01 August 1995

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

scientific article published on 01 October 1995

Multiple routes to B-cell memory

scientific article

Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice

scientific article published on 20 July 2009

Plasma cell development and survival.

scientific article published on September 2010

Plasma cell development: from B-cell subsets to long-term survival niches.

scientific article published on 28 January 2008

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.

scientific article published on 16 March 2018

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

scientific article

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

scientific article published on 22 March 2018

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

scientific article

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

scientific article published in January 2013

Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ

scientific article

Regulation of germinal center responses, memory B cells and plasma cell formation-an update

scientific article

Regulation of memory B-cell survival by the BH3-only protein Puma

scientific article

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

scientific article published on July 2004

Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice.

scientific article published on 2 June 2008

Single cell sorting and cloning.

scientific article

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

scientific article

Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall

scientific article published on 22 June 2015

Targeting plasma cells: are we any closer to a panacea for diseases of antibody-secreting cells?

scientific article published on March 2016

The B-cell response to protein antigens in immunity and transplantation

scientific article published on 01 June 2008

The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity

scientific article

The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.

scientific article

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

scientific article published on 01 April 2002

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

scientific article published on 27 January 2016

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

scientific article

The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

scientific article

The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21

scientific article published on 09 December 2021

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

scientific article published in May 2012

The development of functional B lymphocytes in conditional PU.1 knock-out mice

article

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response ⬇️

scientific article published on June 2, 1997

The generation of antibody-secreting plasma cells.

scientific article

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

scientific article

The phenotype and fate of the antibody-forming cells of the splenic foci

scientific article published on 01 February 1996

The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival

scientific article

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

scientific article

The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

scientific article published on 12 August 2014

The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection.

scientific article published in October 1996

Through a glass less darkly: apoptosis and the germinal center response to antigen ⬇️

scientific article published on May 1, 2012

To affinity and beyond

journal article; published in Nature on 2014-05-28

Transcription factor IRF4 regulates germinal center cell formation through a B cell-intrinsic mechanism

scientific article published on 3 March 2014

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells.

scientific article published on 20 April 2015

bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

scientific article

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

scientific article published on April 2017

c-Myb is required for plasma cell migration to bone marrow after immunization or infection

scientific article published on 15 June 2015

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