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List of works by Thomas P Shanley

A Multibiomarker-Based Model for Estimating the Risk of Septic Acute Kidney Injury

scientific article

Acquired infection during neonatal and pediatric extracorporeal membrane oxygenation.

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Association of bleeding and thrombosis with outcome in extracorporeal life support.

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Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells

scientific article published on 21 December 2007

Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells.

scientific article published on 13 March 2009

Characteristics and outcomes of interhospital transfers from level II to level I pediatric intensive care units

scientific article published on 01 November 2006

Citrate modulates lipopolysaccharide-induced monocyte inflammatory responses

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Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit.

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Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass

scientific article published on 11 October 2011

Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine.

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Contribution of MKP-1 regulation of p38 to endotoxin tolerance.

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Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis

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Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock

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Critical pertussis illness in children: a multicenter prospective cohort study.

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Cytokine and adhesion molecule requirements for lung injury induced by anti-glomerular basement membrane antibody ⬇️

scientific article published on August 1, 1998

Developing a clinically feasible personalized medicine approach to pediatric septic shock

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Differential expression of the Nrf2-linked genes in pediatric septic shock.

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Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock

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Do outcomes vary according to the source of admission to the pediatric intensive care unit?

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Effect of IL-10 on neutrophil recruitment and survival after Pseudomonas aeruginosa challenge.

scientific article published on 18 December 2008

Effect of interhospital transfer on resource utilization and outcomes at a tertiary pediatric intensive care unit.

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Elucidating the role of reversible protein phosphorylation in sepsis-induced myocardial dysfunction

scientific article published on July 2009

End-of-Life Practices Among Tertiary Care PICUs in the United States: A Multicenter Study

scientific article

Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease: a mimicker of sepsis in the pediatric intensive care unit.

scientific article published on 2 April 2007

Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells.

scientific article published on November 2006

Extracorporeal life support for severe respiratory failure in children with immune compromised conditions

scientific article published on 01 July 2008

Fatal and Near-Fatal Asthma in Children: The Critical Care Perspective ⬇️

scientific article published on April 10, 2012

Feasibility and perceived benefits of a framework for physician-parent follow-up meetings after a child's death in the PICU.

scientific article published on January 2014

Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy

scientific article

Functional Status of Neonatal and Pediatric Patients After Extracorporeal Membrane Oxygenation.

scientific article published on 17 April 2017

Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human respiratory epithelium.

scientific article published in July 2001

Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome

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Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock

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Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum.

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Going back for more: an evaluation of clinical outcomes and characteristics of readmissions to a pediatric intensive care unit

scientific article published on 01 July 2007

Granulocyte-macrophage-colony-stimulating factor-dependent peritoneal macrophage responses determine survival in experimentally induced peritonitis and sepsis in mice.

scientific article published on October 2008

Heat shock inhibits activation of NF-kappaB in the absence of heat shock factor-1

scientific article published on 01 March 2002

Heat shock inhibits tnf-induced ICAM-1 expression in human endothelial cells via I kappa kinase inhibition

scientific article published in February 2002

Heat shock-mediated regulation of MKP-1.

scientific article published on 15 June 2005

Hyperoxia and Hypocapnia During Pediatric Extracorporeal Membrane Oxygenation: Associations With Complications, Mortality, and Functional Status Among Survivors

scientific article published on 9 January 2018

Hyperoxia prolongs tumor necrosis factor-alpha-mediated activation of NF-kappaB: role of IkappaB kinase.

scientific article published on April 2002

IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease.

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Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray.

scientific article

Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo

scientific article published on 01 October 2004

Improving delivery of continuous renal replacement therapy: impact of a simulation-based educational intervention

scientific article published on 01 October 2013

In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13 ⬇️

scientific article published on November 15, 1997

Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs

scientific article published on 7 December 2015

Inhaled nitric oxide increases endothelin-1 levels: a potential cause of rebound pulmonary hypertension

scientific article published on 01 January 2002

Inherent Risk Factors for Nosocomial Infection in the Long Stay Critically Ill Child Without Known Baseline Immunocompromise: A Post Hoc Analysis of the CRISIS Trial

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Inpatient health care utilization for children dependent on long-term mechanical ventilation

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Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood

scientific article published on 25 February 2014

Interaction Between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial.

scientific article published on 22 September 2016

Interleukin 10 overexpression alters survival in the setting of gram-negative pneumonia following lung contusion

scientific article

Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children

scientific article published on 29 October 2012

Language Analysis as a Window to Bereaved Parents' Emotions During a Parent-Physician Bereavement Meeting

scientific article

Leukocyte subset-derived genomewide expression profiles in pediatric septic shock

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Limiting and Withdrawing Life Support in the PICU: For Whom Are These Options Discussed?

scientific article published on 11 December 2015

MAP Kinase Phosphatase-1 and Septic Shock.

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Meaning making during parent-physician bereavement meetings after a child's death

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Mechanisms and regulation of the gene-expression response to sepsis.

scientific article published on 17 May 2010

Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis.

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Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury.

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Multiplex serum cytokine immunoassay using nanoplasmonic biosensor microarrays.

scientific article published on 23 March 2015

Multiplexed Nanoplasmonic Temporal Profiling of T-Cell Response under Immunomodulatory Agent Exposure

scientific article published on 22 June 2016

Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge.

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New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

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Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome

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Pediatric intensive care outcomes: development of new morbidities during pediatric critical care.

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Phosphatase inhibition leads to activation of IkappaB kinase in murine macrophages

scientific article published on 01 October 2002

Post-ICU admission fluid balance and pediatric septic shock outcomes: a risk-stratified analysis.

scientific article published on February 2014

Potential Acceptability of a Pediatric Ventilator Management Computer Protocol.

scientific article published on 16 September 2017

Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury.

scientific article published on 16 September 2016

Public participation in, and awareness about, medical research opportunities in the era of clinical and translational research

scientific article published on 14 January 2013

Rapid, automated, parallel quantitative immunoassays using highly integrated microfluidics and AlphaLISA.

scientific article published on 15 June 2015

Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing

scientific article published on October 2013

Refractory hypoxemia caused by hepatopulmonary syndrome: a case report.

scientific article published on 10 December 2014

Regulatory effects of endogenous interleukin-1 receptor antagonist protein in immunoglobulin G immune complex-induced lung injury.

scientific article published on February 1996

Relationship between the functional status scale and the pediatric overall performance category and pediatric cerebral performance category scales.

scientific article

Role of Kupffer cells in gut ischemia/reperfusion-induced hepatic microvascular dysfunction in mice

scientific article published on 01 December 1997

Role of RANTES in experimental cardiac allograft rejection

scientific article published on 01 December 2000

Role of macrophage inflammatory protein-2 in aspiration-induced lung injury

scientific article published on 01 July 2000

Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury. Evidence for alveolar macrophage as source of proteinases

scientific article published on 01 June 1999

Signal transduction overview.

scientific article

Simultaneous Prediction of New Morbidity, Mortality, and Survival Without New Morbidity From Pediatric Intensive Care: A New Paradigm for Outcomes Assessment.

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Study of Protein Phosphatase 2A (PP2A) Activity in LPS-Induced Tolerance Using Fluorescence-Based and Immunoprecipitation-Aided Methodology.

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Temporal and mechanistic effects of heat shock on LPS-mediated degradation of IkappaBalpha in macrophages.

scientific article published on June 2002

Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model.

scientific article published on 29 January 2014

The Accreditation Council for Graduate Medical Education proposed work hour regulations

scientific article published on 01 January 2011

The Missing -Omes: Proposing Social and Environmental Nomenclature in Precision Medicine.

scientific article published on 19 January 2017

The Pediatric Risk of Mortality Score: Update 2015

scientific article published on 21 October 2015

The Role of Tumor Necrosis Factor-α in the Pathogenesis of Aspiration Pneumonitis in Rats

scientific article published on 01 August 1999

The association of immediate post cardiac arrest diastolic hypertension and survival following pediatric cardiac arrest

scientific article published on 06 June 2019

The host response to sepsis and developmental impact

scientific article

The ideal time interval for critical care severity-of-illness assessment

scientific article published on June 2013

The role of cytokines and adhesion molecules in the development of inflammatory injury ⬇️

scientific article published on April 1, 1995

The serine/threonine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling.

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The temporal version of the pediatric sepsis biomarker risk model

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The use of extracorporeal membrane oxygenation in pediatric patients with sickle cell disease.

scientific article published on 29 April 2013

Time for a neonatal-specific consensus definition for sepsis.

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Tracking the impact of the National Institutes of Health Clinical and Translational Science Awards on child health research: developing and evaluating a measurement strategy.

scientific article published on February 2012

Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA

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Tristetraprolin mediates radiation-induced TNF-α production in lung macrophages

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Validating the genomic signature of pediatric septic shock.

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Validation of a gene expression-based subclassification strategy for pediatric septic shock.

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Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population.

scientific article published on 31 July 2014

Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network

scientific article

Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy.

scientific article published on 30 April 2011

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