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List of works by William E. Sonntag

A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan.

scientific article

A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolon

scientific article

Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice

scientific article published on 13 July 2016

Accelerated decline in cognition in a mouse model of increased oxidative stress

scientific article published on 22 October 2019

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

scientific article

Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum.

scientific article published on August 2009

Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis.

scientific article published in February 2006

Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span

scientific article published on 24 March 2005

Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats

scientific article published on 01 March 2000

Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.

scientific article published on 4 January 2012

Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.

scientific article

Age-related alterations in retinal neurovascular and inflammatory transcripts

scientific journal article

Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.

scientific article published on 14 August 2013

Age-related decline in peripheral vascular health predicts cognitive impairment.

scientific article published on 27 April 2019

Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.

scientific article published on 18 August 2014

Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency

scientific article published on 10 July 2018

Age-related synaptic changes in sensorimotor cortex of the Brown Norway X fischer 344 rat

scientific article published on 01 July 2000

Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.

scientific article

Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome

scientific article

Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain

scientific journal article

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.

scientific article published on 9 February 2015

Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.

scientific article published on 26 November 2012

Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice

scientific article

Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation

scientific article published on 3 December 2012

Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries

scientific article published on 31 March 2015

Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus.

scientific article published in January 2008

Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1

scientific article

Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells

scientific article published on 13 December 2012

Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. ⬇️

scientific article

Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats.

scientific article published in January 1999

An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe

scientific article

Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats

scientific article

Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease

scientific article published on March 2017

Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents

scientific article published on 6 September 2009

Biomarkers of aging: from primitive organisms to humans

scientific article

Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation

scientific article published on 18 April 2016

Brain and cerebrovascular aging--new mechanisms and insights.

scientific article published in November 2014

CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging

scientific article published on 18 January 2016

Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability

scientific article

Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

scientific article

Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen.

scientific article

Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice

scientific article published on 01 April 2019

Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in mice

scientific article published on 24 December 2010

Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research

scientific article published on 29 April 2019

Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1

scientific article published on 01 January 1988

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.

scientific article published on 9 September 2016

Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence

scientific article

Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

scientific article published on 17 August 2012

Cognitive heterogeneity reveals molecular signatures of age-related impairment

Cognitive performance and age-related changes in the hippocampal proteome.

scientific article published on 14 December 2008

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

scientific article published on 11 October 2011

Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors.

scientific article published in May 1984

Decreased pulsatile release of growth hormone in old male rats

scientific article published on 01 December 1980

Decreases in Cerebral Microvasculature with Age Are Associated with the Decline in Growth Hormone and Insulin-Like Growth Factor 1* ⬇️

scientific article published on August 1, 1997

Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age

scientific article published on 01 October 1995

Dendritic stability in a model of adult-onset IGF-I deficiency

scientific article published on October 2005

Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice

scientific article published on 11 March 2016

Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo

scientific article published on 01 June 1987

Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release

scientific article published on 01 February 1989

Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging

scientific article

Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.

scientific article

Does senescence give rise to disease?

scientific article

Editorial

scientific article published on 20 January 2016

Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats

scientific article published on 01 November 1997

Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats.

scientific article published in August 1995

Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain.

scientific article published in November 1994

Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.

scientific article

Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats

scientific article published on 01 August 1981

Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus.

scientific article published in January 2001

Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury.

scientific article

Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints.

scientific article published in December 2006

Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats

scientific article published on 01 March 1999

Effects of ovariectomy and steroid replacement on hypothalamic lhrh content in aging female rats ⬇️

scientific article published on January 1, 1983

Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats

scientific article

Elevation of Plasma LH in Response to Systemic Injection of -Endorphin Antiserum in Adult Male Rats ⬇️

scientific article published on 01 May 1983

Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease.

scientific article

Endothelial Cell Inflammation and Antioxidant Capacity are Associated With Exercise Performance and Microcirculation in Patients With Symptomatic Peripheral Artery Disease.

scientific article published on 20 January 2015

Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype

scientific article published on 12 August 2021

Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.

scientific article

Ethanol suppresses growth hormone-mediated cellular responses in liver slices

scientific article published on 01 October 1995

Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus

scientific article published on 24 March 2013

Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal

scientific article

Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment.

scientific article

Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus.

scientific article published in July 2005

Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.

scientific article

GeroScience: understanding the interaction of processes of aging and chronic diseases.

scientific article

Greater endothelial apoptosis and oxidative stress in patients with peripheral artery disease

scientific article

Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus

scientific article published on 21 October 2005

Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging

scientific article

Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency.

scientific article published on 25 April 2006

Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging

scientific article

Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.

scientific article published on 19 October 2011

Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats

scientific article published on 01 January 2006

Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning.

scientific article published in January 2004

Growth hormone, insulin-like growth factor-1 and the aging brain.

scientific article

Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system

scientific article

Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis

scientific article published in October 2002

Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems

scientific article published on 30 August 2005

Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline

scientific article

Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.

scientific article published on 10 February 2012

Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.

scientific article

How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats.

scientific article published on March 2009

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms

scientific article published on 10 August 2015

IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice

scientific article

IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging

scientific article

IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.

scientific article published on 26 August 2016

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.

scientific article

INFLUENCE OF DIABETES ON AMBULATION AND INFLAMMATION IN MEN AND WOMEN WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE

scientific article published on December 2015

Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young and old male rats

scientific article published on 01 January 1981

Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young female rats on the day of estrus and intact and chronically castrated old constant estrous female rats.

scientific article

Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44).

scientific article published in December 1983

Impaired bladder function in aging male rats

scientific article

Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease

scientific article

Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition.

scientific article published on 26 February 2013

Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype

scientific article

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

scientific article published in February 2018

Insulin-like growth factor-1 ameliorates age-related behavioral deficits.

scientific article published in December 1998

Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex.

scientific article published in January 2002

Insulin-like growth factor-1 in CNS and cerebrovascular aging

scientific article published on 02 July 2013

Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals.

scientific article

Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats

scientific article published on 01 April 1995

Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice

scientific article published on 15 July 2020

Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular rad

scientific article published on 20 May 2013

Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain

scientific article published in April 2012

Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain.

scientific article

L-Dopa Restores Amplitude of Growth Hormone Pulses in Old Male Rats to That Observed in Young Male Rats ⬇️

scientific article published on March 1, 1982

L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle

scientific article published on 01 June 1997

Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats

scientific article published on 01 October 2007

Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging

scientific article published on 21 October 2011

Maintenance by L-DOPA treatment of estrous cycles and LH response to estrogen in aging female rats

scientific article published on 01 December 1980

Mechanisms of vascular aging: new perspectives.

scientific article

Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice

scientific article

Microvascular plasticity in aging.

scientific article

Mitochondria and aging in the vascular system.

scientific article published on 17 August 2010

Mitochondrial protection by resveratrol.

scientific article

Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination

scientific article

Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals

scientific article published on 01 May 1995

Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

scientific article published on 01 October 1993

Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.

scientific article published on 7 November 2011

Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging

scientific article

Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8+ tissue-resident memory T cells in a miR-155-dependent fashion

scientific article published on 02 September 2020

Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype

scientific article published on 01 June 2018

Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease

scientific article

Of Worms, Flies, Dwarfs, and Things That Go Bump in the Night ⬇️

scientific article published on October 30, 2002

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice

scientific article published on 20 January 2020

Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.

scientific article published on 15 July 2015

Physical performance and longevity in aged rats

scientific article published on 01 May 2002

Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: evidence supported by structural equation modeling (SEM)

scientific article published on 12 May 2007

Positive Feedback by Ovarian Hormones on Prolactin and LH in Old Versus Young Female Rats

scientific article published on 01 January 1980

Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.

scientific article

Quantification of oxidized levels of specific RNA species using an aldehyde reactive probe

scientific article published on 30 May 2011

RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria

scientific article

Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain

scientific article published on 30 September 2011

Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment.

scientific article published on 20 November 2015

Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin

scientific article published on 01 September 1980

Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease

scientific article published on 01 September 2000

Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint

scientific article

Regulation of Cerebrovascular Aging

Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype?

scientific article published on 10 October 2012

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.

scientific article

Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats

scientific article

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.

scientific article

Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice

scientific article published on 04 October 2013

Role of NADPH oxidase in radiation-induced pro-oxidative and pro-inflammatory pathways in mouse brain.

scientific article published on 7 September 2017

Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

scientific article

Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.

scientific article

Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus.

scientific article published in December 2006

Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I.

scientific article

Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease

scientific article published on 16 August 2013

Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells

scientific article

Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa)

scientific article (publication date: April 2013)

Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?

scientific article (publication date: August 2012)

The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.

scientific article published on 23 February 2017

The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.

scientific article published on 21 September 2016

Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats

scientific article published on April 2013

Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.

scientific article published on 6 February 2018

Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

scientific article

Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats

scientific article

Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets

scientific article published on July 2012

Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia

scientific article

Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications

scientific article published on October 2013

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