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List of works by Pierre Desreumaux

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

scientific article

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series

scientific article published on 27 October 2010

4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis

scientific article published on 12 October 2012

5-aminosalicylates and colorectal cancer: preventive role in chronic inflammatory bowel disease?

scientific article published in May 2004

5-aminosalicylic acid is an attractive candidate agent for chemoprevention of colon cancer in patients with inflammatory bowel disease

scientific article

764 Results of Andante, a Randomized Clinical Study With an Anti-IL6 Antibody (PF-04236921) in Subjects With Crohn's Disease Who Are Anti-TNF Inadequate Responders

979 Modulating Peroxisome Proliferator-Activated Receptor Gamma (PPARγ): A Potential New Therapeutic Strategy for Lactose Intolerance

A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome

scientific article published on 13 November 2014

AIEC colonization and pathogenicity: influence of previous antibiotic treatment and preexisting inflammation.

scientific article published on 16 February 2012

Abnormalities in Mucin Gene Expression in Crohnʼs Disease

article

Acrylamide induces accelerated endothelial aging in a human cell model

scientific article published on 10 June 2015

Activated eosinophils and interleukin 5 expression in early recurrence of Crohn's disease.

scientific article

Activation of PPARΓ protects against colon inflammation by inhibiting TNFA signaling pathways

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

scientific article published on 01 September 1998

Adalimumab dose escalation is effective and well tolerated in Crohn's disease patients with secondary loss of response to adalimumab

scientific article published on 14 November 2016

Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro

scientific article published on 11 January 2007

Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice

scientific article published on 16 October 2013

Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation

scientific article

Author's reply to Comment on “A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome” by Guillaume Pineton de Chambrun et al. [Digestive and Liver Disease 2015;47:119–24]

scientific article published on 03 February 2015

Autologous stem cell transplantation for autoimmune diseases: recommendations from the SFGM-TC

scientific article published on 10 July 2014

Bacteriophages Targeting Adherent Invasive Escherichia coli Strains as a Promising New Treatment for Crohn's Disease

scientific article published on 27 January 2017

Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA

scientific article

CD28+ intraepithelial lymphocytes with long telomeres are recruited within the inflamed ileal mucosa in Crohn disease

scientific article published on 01 July 2001

CD8+ cytotoxic T cells induce relapsing colitis in normal mice.

scientific article

CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

scientific article published on 24 May 2007

Cannabis : des nouvelles fonctions anti-diarrhéiques et anti-cancéreuses

scientific article published on 01 January 2004

Cerebro-spinal fluid eosinophilia in shunt infections

article

Characterization of ethylcellulose: starch-based film coatings for colon targeting.

scientific article published in October 2009

Chronic stress stimulates organ specific cytokine expression in mice

Colon targeting with bacteria-sensitive films adapted to the disease state.

scientific article published on 4 May 2009

Colonic inflammation in mice is improved by cigarette smoke through iNKT cells recruitment

scientific article

Colonization of Mice byCandida albicansIs Promoted by Chemically Induced Colitis and Augments Inflammatory Responses through Galectin‐3

article

Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

scientific article published on 4 December 2014

Crohn's disease: beyond antagonists of tumour necrosis factor

scientific article

Decreased lymphatic vessel density is associated with postoperative endoscopic recurrence in Crohn's disease

scientific article published in September 2013

Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier

scientific article published on 14 May 2015

Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease

scientific article published on 01 July 1997

Dysbiosis in inflammatory bowel disease

scientific article

Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn's Disease: Report of the TOSCA Study

scientific article published on 16 September 2017

Effect of intrajejunal elemental diet perfusion on local secretion of soluble CD4 and CD8

scientific article published on 01 May 1996

Effects of infliximab therapy on abdominal fat and metabolic profile in patients with Crohn's disease

scientific article published in October 2009

Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

scientific article published on 22 November 2017

Enhanced production of IL-8 in chronic but not in early ileal lesions of Crohn's disease (CD)

scientific article published on 01 November 2000

Enteric microflora in inflammatory bowel disease patients

scientific article published on November 2016

Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease?

scientific article

Enzymatically degraded Eurylon 6 HP-PG: ethylcellulose film coatings for colon targeting in inflammatory bowel disease patients

scientific article published on 4 October 2010

Eosinophilic enteritis

scientific article published on 22 April 2015

Eosinophils in allergic reactions.

scientific article published on December 1996

Epithelial inflammation response induced by Shigella flexneri depends on mucin gene expression

article

Evaluation of therapeutic properties of fermented vegetables extract (OM-X®) in the model of colitis induced by Citrobacter rodentium in mice

Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells

scientific article published on 01 September 2000

Fluorescent imaging in digestive endoscopy

scientific article published in January 2006

Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases

scientific article

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

scientific article

Gene transfer of CD154 and IL12 cDNA induces an anti-leukemic immunity in a murine model of acute leukemia.

scientific article published in September 2002

Genetically related Escherichia coli strains associated with Crohn's disease.

scientific article published on March 2001

Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration

scientific article published on 29 May 2014

Gut: An underestimated target organ for Aluminum

scientific article

Hepatic deficiency of interleukin 10 in chronic hepatitis C

scientific article published on 01 November 2000

Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A.

scientific article published on December 2005

High carriage of adherent invasive E. coli in wildlife and healthy individuals.

scientific article

How NOD2 mutations predispose to Crohn's disease?

scientific article

IL-10 hepatic deficit in hepatitis C virus (HCV) infection

IL-8 in early and chronic ileal lesions of Crohn's disease (CD)

Ige receptor affects fecal flora, bacterial translocation and intestinal inflammation

scholarly article by Sophie Nutten et al published April 2000 in Gastroenterology

Ileal or Anastomotic Location of Lesions Does Not Impact Rate of Postoperative Recurrence in Crohn's Disease Patients Classified i2 on the Rutgeerts Score.

scientific article published on 11 July 2016

Immunobiology of eosinophils in allergy and inflammation.

scientific article published on January 1997

Immunologie du tube digestif et maladie de Crohn

scientific article published on 01 June 2004

Immunoreactivity for interleukin 3 and 5 and granulocyte/macrophage colony-stimulating factor of intestinal mucosa in bronchial asthma.

scientific article

Immunosupressants and MICI

scientific article published in August 2004

Impact of Small Bowel Exploration Using Video-Capsule Endoscopy in the Management of Acute Gastrointestinal Graft-versus-Host Disease

scientific article published on 01 December 2004

Impaired contractile response of mesenteric arteries in Crohn's disease

scientific article published on 01 October 2000

Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis

scientific article published in May 2003

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.

scientific article published on February 2005

Implication of TNF-Related Apoptosis-Inducing Ligand in Inflammatory Intestinal Epithelial Lesions

scientific article published on 01 June 2006

In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice

scientific article published in February 2013

Infectious agents and Crohn's disease

scientific article published on 01 October 1999

Inflammatory alterations in mesenteric adipose tissue in Crohn's disease

scientific article published on 01 July 1999

Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease

scientific article published in July 2001

Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease

scientific article

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

scientific article

Intestinal steroidogenesis

scientific article published on 02 January 2015

Intestinal steroidogenesis controls PPARγ expression in the colon and is impaired during ulcerative colitis

scientific article published on 22 July 2014

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

scholarly article

La tomographie par cohérence optique en gastroentérologie

scientific article published on 01 May 2005

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

scientific article published on 10 December 2006

Laparoscopic surgery reduces peroperative opiold requirement in Crohn's disease

Low ileal IL-10 mRNA levels predict endoscopic recurrence in patients operated on for Crohn's disease (CD)

article published in 2000

Low ileal interleukin 10 concentrations are predictive of endoscopic recurrence in patients with Crohn's disease.

scientific article published on January 2002

L’IL-23R, un nouveau gène de susceptibilité dans les maladies inflammatoires chroniques intestinales

article

L’endoscopie confocale

scientific article published on 01 March 2005

Macrophage collections in gastrointestinal biopsies and metabolic disorders: two unusual case reports

scientific article published on 01 February 2003

Manifestations digestives des allergies alimentaires chez l'adulte

scientific article published on 01 July 1991

Mesenteric adipose tissue: A major source of TNFA in experimental ileitis in rats

Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease

scientific article published on 21 September 2011

Mesenteric fat in Crohn's disease: a pathogenetic hallmark or an innocent bystander?

scientific article published on 6 September 2006

Mixed Adenocarcinoid Tumor and Crohn's Disease

scientific article published on 01 June 1998

Mo1823 Highlighting of Epidemic Areas of Crohn's Disease in a Population-Based Registry Over 22 Years: Genetic or Environmental Cause?

Mo1898 Continuation or Switch to Another Anti-TNFα After Intestinal Resection in Crohn's Disease Patients Previously Exposed to Anti-TNFα?

Mo1899 Evaluation and Long-Term Benefit of Deep Remission in Crohn's Disease Patients Treated With Infliximab

Mo1900 Combination Therapy With Infliximab and Methotrexate Does Not Improve Crohn's Disease Outcome and Infliximab Tolerance Compared to Infliximab Therapy Alone

Mo1909 Adalimumab Dose Escalation Is Effective and Well Tolerated in Crohn's Disease Patients With Secondary Loss of Response to Adalimumab

Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation.

scientific article published on 18 November 2005

NOD2/CARD15 et maladie de Crohn

scientific article published on 01 June 2005

NOD2: a potential target for regulating liver injury

scientific article published on 28 January 2008

NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation

Narrow band image videoendoscopy in gastroterology

scientific article published in November 2005

Natural history of eosinophilic gastroenteritis

scientific article

Neoboutonia melleri var velutina Prain: in vitro and in vivo hepatoprotective effects of the aqueous stem bark extract on acute hepatitis models

scientific article

Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control

scientific article published on 21 December 2009

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

scientific article published on 06 May 2011

No Evidence for an Involvement of the P38 and JNK Mitogen-Activated Protein in Inflammatory Bowel Diseases

scientific article published on 13 July 2006

No evidence for involvement of the mitogen-activated protein kinase (MAPK) P38 and JNK pathways in human inflammatory bowel diseases and experimental colitis

article

Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis

scientific article

Novel polymeric film coatings for colon targeting: Drug release from coated pellets.

scientific article published on 5 April 2009

Novel polymeric film coatings for colon targeting: how to adjust desired membrane properties

scientific article published on 24 December 2008

Nuclear receptor PPAR and hepatology: pathophysiological and therapeutical aspects

scientific article published in March 2008

O-001 A Multicenter, Double-Blind, Placebo-Controlled Phase3 Study of Ustekinumab, a Human IL-12/23P40 mAB, in Moderate-Service Crohnʼs Disease Refractory to Anti-TFNα

Obesity, visceral fat and Crohn's disease

scientific article published on September 2010

Oral vancomycin induces sustained deep remission in adult patients with ulcerative colitis and primary sclerosing cholangitis

Overexpression of leptin mRNA in the mesenteric adipose tissue of inflammatory bowel disease (IBD)

PPAR-gamma in ulcerative colitis: a novel target for intervention

scientific article

PPARγ

PPARγ agonists as a new class of effective treatment for ulcerative colitis

scientific article published on 01 June 2009

Parallel interleukin 5 synthesis by eosinophils in duodenal and skin lesions of a patient with dermatitis herpetiformis.

scientific article published on July 1995

Patients with Crohn's Disease with High Body Mass Index Present More Frequent and Rapid Loss of Response to Infliximab

scientific article published on 22 August 2017

Peroxisome proliferator-activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut.

scientific article published on 25 September 2017

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

scientific article

Peroxisome proliferator-activated receptor gamma in the colon: inflammation and innate antimicrobial immunity

scientific article

Pouchitis Is Associated with Mucosal Imbalance Between Interleukin-8 and Interleukin-10

scientific article published on 01 August 2000

Preclinical studies of a specific PPARγ modulator in the control of skin inflammation

scientific article published on 28 October 2013

Preliminary study of urinary schistosomiasis in a village in the delta of the Senegal river basin, Senegal

scientific article published on 01 July 1994

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

scientific article published on 01 December 1998

Previous Exposure to Multiple Anti-TNF Is Associated with Decreased Efficiency in Preventing Postoperative Crohn's Disease Recurrence

scientific article published on 30 August 2016

Probiotic Yeast Therapy for Irritable Bowel Syndrome

scientific article published on July 2016

Probiotics in inflammatory bowel disease: a critical review

scientific article published on October 2003

Pyrogenicity and cytokine-inducing properties of Streptococcus pyogenes superantigens: comparative study of streptococcal mitogenic exotoxin Z and pyrogenic exotoxin A.

scientific article published on June 2001

Randomised trial and open-label extension study of an anti-interleukin-6 antibody in Crohn's disease (ANDANTE I and II).

scientific article published on 15 December 2017

Recent advances in the development of selective CB(2) agonists as promising anti-inflammatory agents.

scientific article published on January 2012

Resistin-like molecule beta regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice

scientific article

Results of treatment with COX-2 inhibitors and lanreotide in a patient with Menetrier's hypertrophic gastropathy

scientific article

Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis

scientific article

Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases

scientific article

Régulation de l’immunité intestinale par Nod2

scientific article published on 01 November 2004

Rôles de PPAR et PPAR / au cours du cancer colorectal

scientific article published on 01 August 2004

Sa1846 The Expression of the Short Isoform of TSLP in the Colon Is Regulated by the Nuclear Receptor PPARγ and Is Impaired During Ulcerative Colitis

Sa1960 Crohn's Disease Patients With High Body Mass Index Present More Frequent and Rapid Loss of Response to Infliximab

article

Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis

scientific article published in January 2017

Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease

scientific article published on 8 August 2012

Search for evidence of recurring or persistent viruses in Crohn's disease

article

Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease

article

Similar IL-5, IL-3, and GM-CSF syntheses by eosinophils in the jejunal mucosa of patients with celiac disease and dermatitis herpetiformis.

scientific article

Specific targeting of IL-6 signalling pathway: a new way to treat IBD?

scientific article published on October 2000

Streptococcal pyrogenic exotoxin A (SPE A) superantigen induced production of hematopoietic cytokines, IL-12 and IL-13 by human peripheral blood mononuclear cells

scientific article published on 01 November 1997

Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice

scientific article published on September 2003

Su1868 Dissecting the Role of RAGE in Intestinal Fibrosis

Successful induction of tolerance to infliximab in patients with Crohn's disease and prior severe infusion reactions

scientific article published on 01 September 2006

Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells

scientific article

Switching cannabinoid response from CB2 agonists to FAAH inhibitors

scientific article published on 28 January 2014

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

scientific article published on 12 February 2014

Systemic Administration of Agonist Peptide Blocks the Progression of Spontaneous CD8-Mediated Autoimmune Diabetes in Transgenic Mice Without Bystander Damage

scientific article published on 01 July 2000

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

scientific article published on 27 February 2012

The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ.

scientific article published on 10 July 2013

The Expression of the Short Isoform of Thymic Stromal Lymphopoietin in the Colon Is Regulated by the Nuclear Receptor Peroxisome Proliferator Activated Receptor-Gamma and Is Impaired during Ulcerative Colitis

scientific article published on 4 September 2017

The Presence of Adherent-Invasive Escherichia Coli (AIEC) on the Surgical Specimen is a Predictor of Severe Endoscopic Postoperative Recurrence in Ileal Crohn's Disease

The role of PPARγ-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

scientific article

The schistosome glutathione S-transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2-type response with mucosal eosinophils

scientific article

Toxicological consequences of experimental exposure to aluminum in human intestinal epithelial cells.

scientific article published on 16 March 2016

Treatments for Crohn’s Disease–Associated Bowel Damage: A Systematic Review

scientific article published on 23 August 2018

Trough Levels and Antibodies to Infliximab May Not Predict Response to Intensification of Infliximab Therapy in Patients With Inflammatory Bowel Disease

scientific article published on 29 August 2011

Trough Levels and Antibodies to Ustekinumab are not Correlated to Response to Ustekinumab Treatment in Crohn's Disease Patients

Tu1881 HLA B27 Transgenic Rat: A New Animal Model of Postsurgical Ileitis in Inflammatory Bowel Disease

Use of mouse models to evaluate the persistence, safety, and immune modulation capacities of lactic acid bacteria

scientific article

Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease

scientific article (publication date: 17 November 2016)

Variants of NOD1 and NOD2 genes display opposite associations with familial risk of Crohn's disease and anti-saccharomyces cerevisiae antibody levels.

scientific article

Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine

scientific article published on 13 March 2007

Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.

scientific article

Visceral fat and gut inflammation

scientific article published on February 2012

Yersinia pseudotuberculosis anti-inflammatory components reduce trinitrobenzene sulfonic acid-induced colitis in the mouse

scientific article published on April 2004

lnterferon-α in combination with corticosteroids improves systemic mast cell disease

scientific article published on 01 March 1995

micro-Opioid receptor activation prevents acute hepatic inflammation and cell death

scientific article

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