List of works - Philippe Chavatte

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

scientific article published on 12 May 2009

2D QSAR consensus prediction for high-throughput virtual screening. An application to COX-2 inhibition modeling and screening of the NCI database

scientific article published in January 2004

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

scientific article

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series

scientific article published on 27 October 2010

4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis

scientific article published on 12 October 2012

A computational view of COX-2 inhibition

scientific article

Antioxydant activity of β-carboline derivatives in the LDL oxidation model

scientific article published on 30 March 2011

Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers

scientific article published on 29 March 2008

Characterisation of novel defective thiopurine S-methyltransferase allelic variants.

scientific article

Conformation of the tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 deduced from two-dimensional 1H-NMR and conformational energy calculations is related to its affinity for NK1-receptor.

scientific article published in June 2001

Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

scientific article published on 4 December 2014

Corrigendum to “Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers” [Bioorg. Med. Chem. Lett. 19 18 (2008) 3440]

scholarly article by Amaury Graulich et al published January 2010 in Bioorganic & Medicinal Chemistry Letters

Critical Role of Tyrosine 277 in the Ligand-Binding and Transactivating Properties of Retinoic Acid Receptor α†

scientific article published on 01 March 2000

Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3.

scientific article published on 17 March 2008

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

scientific article published on 19 October 2015

Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands

scientific article published on March 2003

Design, synthesis and biological evaluation of potent FAAH inhibitors

scientific article published on 23 April 2016

Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands

scientific article

Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors

scientific article published on January 2002

Development and validation of a reversed-phase HPLC method for the quantification of paclitaxel in different PLGA nanocarriers

scientific article

Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping.

scientific article published on 16 January 2018

Differences in Binding Sites of Two Melatonin Receptors Help to Explain Their Selectivity to Some Melatonin Analogs: A Molecular Modeling Study

scientific article published on 01 October 2006

Docking study of ligands into the colchicine binding site of tubulin.

scientific article published on December 2004

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

scientific article published on 5 May 2015

Du cannabis aux agonistes sélectifs du récepteur CB2

scientific article published on 28 May 2013

Enantioseparation of pyroglutamide derivatives on polysaccharide based chiral stationary phases by high-performance liquid chromatography and supercritical fluid chromatography: a comparative study

scientific article published on 4 July 2014

Exploring chiral separation of 3-carboxamido-5-aryl isoxazole derivatives by supercritical fluid chromatography on amylose and cellulose tris dimethyl- and chloromethyl phenylcarbamate polysaccharide based stationary phases.

scientific article

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population

scientific article published on 27 July 2011

Homology Modeling of 5-HT2C Receptors

Homology modeling of MT1 and MT2 receptors

scientific article published on 14 December 2007

Homology modelling of the serotoninergic 5-HT2c receptor.

scientific article

Identification of a pharmacophore of SKCa channel blockers

scientific article published in December 2005

Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50.

scientific article published on 12 September 2017

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

scientific article

Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors

scientific article published in June 2002

Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds

scientific article published in December 2005

Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

Molecular modelling of phthalates – PPARs interactions

scientific article published in January 2008

NMR studies of interactions of new CB2 cannabinoid receptor ligands with cyclodextrins hosts. Correlation with micellar electrokinetic chromatography and reversed phase high performance liquid chromatography

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

scientific article published on 06 May 2011

Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists

scientific article published on 02 August 2006

Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.

scientific article published in January 2006

Novel benzopyridothiadiazepines as potential active antitumor agents

scientific article published on November 2005

Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model

scientific article published on 12 August 2010

Pharmacophoric search and 3D-QSAR comparative molecular field analysis studies on agonists of melatonin sheep receptors.

scientific article published in November 1998

Potent and selective farnesyl transferase inhibitors.

scientific article

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.

scientific article published on 7 February 2011

Preclinical studies of a specific PPARγ modulator in the control of skin inflammation

scientific article published on 28 October 2013

Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives.

scientific article

Recent advances in the development of selective CB(2) agonists as promising anti-inflammatory agents.

scientific article published on January 2012

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations

scientific article

Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands

scientific article published on 26 October 2012

Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.

scientific article

Structural insight into PPARgamma ligands binding.

scientific article published on January 2009

Switching cannabinoid response from CB2 agonists to FAAH inhibitors

scientific article published on 28 January 2014

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

scientific article published on 12 February 2014

Synthesis and Radioligand Binding Studies of Bis-isoquinolinium Derivatives as Small Conductance Ca2+-Activated K+Channel Blockers

scientific article published on 15 September 2007

Synthesis and preliminary pharmacological results on new naphthalene derivatives as 5-HT4 receptor ligands

scientific article published on 01 July 2000

Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.

scientific article published on 25 January 2012

Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands

scientific article

Synthesis of 2,3 and 4,5-Dihydro-hydroxy-isoxazoles and Isoxazoles Under Different pH Conditions

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

scientific article published on 27 February 2012

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.

scientific article published on 21 October 2016

Three-Dimensional Quantitative Structure–Activity Relationship ofMT3 Melatonin Binding Site Ligands: A Comparative Molecular Field Analysis

Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.

scientific article published in September 2001

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

scientific article published on 8 May 2018

Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.

scientific article

List of works by Philippe Chavatte

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

2D QSAR consensus prediction for high-throughput virtual screening. An application to COX-2 inhibition modeling and screening of the NCI database

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series

4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis

A computational view of COX-2 inhibition

Antioxydant activity of β-carboline derivatives in the LDL oxidation model

Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers

Characterisation of novel defective thiopurine S-methyltransferase allelic variants.

Conformation of the tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 deduced from two-dimensional 1H-NMR and conformational energy calculations is related to its affinity for NK1-receptor.

Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

Corrigendum to “Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers” [Bioorg. Med. Chem. Lett. 19 18 (2008) 3440]

Critical Role of Tyrosine 277 in the Ligand-Binding and Transactivating Properties of Retinoic Acid Receptor α†

Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3.

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands

Design, synthesis and biological evaluation of potent FAAH inhibitors

Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands

Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors

Development and validation of a reversed-phase HPLC method for the quantification of paclitaxel in different PLGA nanocarriers

Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping.

Differences in Binding Sites of Two Melatonin Receptors Help to Explain Their Selectivity to Some Melatonin Analogs: A Molecular Modeling Study

Docking study of ligands into the colchicine binding site of tubulin.

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

Du cannabis aux agonistes sélectifs du récepteur CB2

Enantioseparation of pyroglutamide derivatives on polysaccharide based chiral stationary phases by high-performance liquid chromatography and supercritical fluid chromatography: a comparative study

Exploring chiral separation of 3-carboxamido-5-aryl isoxazole derivatives by supercritical fluid chromatography on amylose and cellulose tris dimethyl- and chloromethyl phenylcarbamate polysaccharide based stationary phases.

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population

Homology Modeling of 5-HT2C Receptors

Homology modeling of MT1 and MT2 receptors

Homology modelling of the serotoninergic 5-HT2c receptor.

Identification of a pharmacophore of SKCa channel blockers

Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50.

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors

Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds

Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

Molecular modelling of phthalates – PPARs interactions

NMR studies of interactions of new CB2 cannabinoid receptor ligands with cyclodextrins hosts. Correlation with micellar electrokinetic chromatography and reversed phase high performance liquid chromatography

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists

Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.

Novel benzopyridothiadiazepines as potential active antitumor agents

Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model

Pharmacophoric search and 3D-QSAR comparative molecular field analysis studies on agonists of melatonin sheep receptors.

Potent and selective farnesyl transferase inhibitors.

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.

Preclinical studies of a specific PPARγ modulator in the control of skin inflammation

Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives.

Recent advances in the development of selective CB(2) agonists as promising anti-inflammatory agents.

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations

Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands

Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.

Structural insight into PPARgamma ligands binding.

Switching cannabinoid response from CB2 agonists to FAAH inhibitors

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

Synthesis and Radioligand Binding Studies of Bis-isoquinolinium Derivatives as Small Conductance Ca2+-Activated K+Channel Blockers

Synthesis and preliminary pharmacological results on new naphthalene derivatives as 5-HT4 receptor ligands

Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.

Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands

Synthesis of 2,3 and 4,5-Dihydro-hydroxy-isoxazoles and Isoxazoles Under Different pH Conditions

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.

Three-Dimensional Quantitative Structure–Activity Relationship ofMT3 Melatonin Binding Site Ligands: A Comparative Molecular Field Analysis

Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.