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List of works by Hiroshi Kimura

A Herpesvirus Specific Motif of Epstein-Barr Virus DNA Polymerase Is Required for the Efficient Lytic Genome Synthesis.

scientific article

A case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications.

scientific article

A distinct subtype of Epstein Barr virus positive T/NK-cell lymphoproliferative disorder: Adult patients with chronic active Epstein Barr virus infection-like features

scientific article published on 14 December 2017

A monoclonal expansion of Epstein–Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation ⬇️

scientific article published on November 26, 2012

A pediatric case of hepatitis B virus subgenotype A2 in Japan

scientific article

Acute retinal necrosis caused by herpes simplex virus type 2 in a 3-year-old Japanese boy.

scientific article published on 3 December 2008

Analysis of circulating human and viral microRNAs in patients with congenital cytomegalovirus infection.

scientific article published on 29 September 2016

Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza

scientific article published on June 2006

Anti-CCR4 monoclonal antibody mogamulizumab for the treatment of EBV-associated T- and NK-cell lymphoproliferative diseases.

scientific article published on 12 August 2014

Anti-tumor effects of suberoylanilide hydroxamic acid on Epstein-Barr virus-associated T cell and natural killer cell lymphoma

scientific article

Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells.

scientific article

Antitumor activity of cyclin-dependent kinase inhibitor alsterpaullone in Epstein-Barr virus-associated lymphoproliferative disorders

scientific article published on 11 December 2019

Antitumor effects of duvelisib on Epstein-Barr virus-associated lymphoma cells.

scientific article published on 9 March 2018

Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases.

scientific article

Association of transforming growth factor-beta1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases.

scientific article published in November 2007

Association of virus infected-T cell in severe hepatitis caused by primary Epstein-Barr virus infection.

scientific article

Auditory and vestibular defects induced by experimental labyrinthitis following herpes simplex virus in mice.

scientific article

BGLF2 Increases Infectivity of Epstein-Barr Virus by Activating AP-1 upon De Novo Infection.

scientific article published on 25 April 2018

Baculovirus expression, purification, and properties of varicella-zoster virus gE, gI, and the complex they form.

scientific article published on November 1998

Bortezomib induces apoptosis in T lymphoma cells and natural killer lymphoma cells independent of Epstein-Barr virus infection.

scientific article published on 4 April 2011

Causes of vertical transmission of hepatitis B virus under the at-risk prevention strategy in Japan.

scientific article published on February 2013

Characterization of a Suppressive Cis-acting Element in the Epstein-Barr Virus LMP1 Promoter.

scientific article published on 22 November 2017

Chronic Active Epstein-Barr Virus Disease.

scientific article published on 22 December 2017

Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation ⬇️

scientific article published on October 23, 2003

Chronic active Epstein-Barr virus infection with dilatation of the Valsalva sinus

scientific article published on 01 December 2006

Clinical and virological characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation

scientific article

Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein-Barr virus infection.

scientific article published on June 2006

Combination therapy with intraventricular interferon-alpha and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay.

scientific article published in August 2003

Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy

scientific article published on 01 August 2010

Comprehensive Analyses of Intraviral Epstein-Barr Virus Protein–Protein Interactions Hint Central Role of BLRF2 in the Tegument Network

scientific article published on 11 July 2022

Congenital cytomegalovirus infection diagnosed by polymerase chain reaction with the use of preserved umbilical cord.

scientific article published in July 2005

Conversion from mycophenolate mofetil to mizoribine for patients with positive polyomavirus type BK in urine.

scientific article published in September 2008

Current research on chronic active Epstein-Barr virus infection in Japan.

scientific article published in April 2014

Defective Epstein-Barr virus in chronic active infection and haematological malignancy

scientific article published on 21 January 2019

Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis.

scientific article published on 7 September 2012

Detection of EBV genomes in plasmablasts/plasma cells and non-B cells in the blood of most patients with EBV lymphoproliferative disorders by using Immuno-FISH.

scientific article

Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss.

scientific article published on 18 June 2008

Diabetic mice show an aggravated course of herpes-simplex virus-induced facial nerve paralysis.

scientific article published in October 2012

Diagnostic testing in Epstein-Barr virus infection.

scientific article

Diagnostic values for the viral load in peripheral blood mononuclear cells of patients with chronic active Epstein-Barr virus disease

scientific article published on 17 December 2015

Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection

scientific article

EBV Viral Loads in Diagnosis, Monitoring, and Response Assessment

scientific article published on 12 February 2019

EBV in T-/NK-Cell Tumorigenesis

scientific article published on 01 January 2018

EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases.

scientific article published on 16 November 2011

Editorial: Epstein-Barr Virus-Associated T/NK-Cell Lymphoproliferative Diseases

scientific article published on 10 July 2019

Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients

scientific article published on 7 February 2015

Effectiveness and safety of inactivated influenza vaccination in pediatric liver transplant recipients over three influenza seasons ⬇️

scientific article published on November 26, 2010

Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8(+) T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay.

scientific article

Elevated expression of activation-induced cytidine deaminase in T and NK cells from patients with chronic active Epstein-Barr virus infection

scientific article published on September 1, 2011

Elimination of LMP1-expressing cells from a monolayer of gastric cancer AGS cells

scientific article

Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production.

scientific article published on 13 September 2017

Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting

scientific article published on 13 December 2019

Epstein-Barr virus infection-induced inflammasome activation in human monocytes.

scientific article

Epstein-Barr virus type 2 latently infects T cells, inducing an atypical activation characterized by expression of lymphotactic cytokines.

scientific article

Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: a case report

scientific article published on 3 September 2013

Establishment of anti-Epstein-Barr virus (EBV) cellular immunity by adoptive transfer of virus-specific cytotoxic T lymphocytes from an HLA-matched sibling to a patient with severe chronic active EBV infection.

scientific article published on February 1996

Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay.

scientific article

Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir

scientific article published on 01 January 2000

Expression of tegument protein pp65 of human cytomegalovirus (CMV) and its application to the analysis of viral-specific cellular immunity in CMV-infected individuals.

scientific article published in December 2002

Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6

scientific article published on 01 January 2002

Fatal varicella infection in a girl with systemic lupus erythematosus after oral acyclovir prophylaxis.

scientific article published on 13 January 2006

Flow cytometric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection

scientific article published on 01 October 2003

Ganciclovir therapy for congenital cytomegalovirus infection in six infants

scientific article

Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia.

scientific article published on 03 April 2017

Generation and Characterization of UL21-Null Herpes Simplex Virus Type 1 ⬇️

scientific article published on November 16, 2012

HSV-2-related hemophagocytic lymphohistiocytosis in a fingolimod-treated patient with MS.

scientific article published on 07 June 2016

Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma.

scientific article

Helicobacter pylori infection in patients with idiopathic short stature

scientific article published on 01 June 2002

Hemiconvulsion-hemiplegia syndrome and primary human herpesvirus 7 infection.

scientific article

Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury.

scientific article published on 12 May 2011

Herpes Simplex Virus Requires Poly(ADP-Ribose) Polymerase Activity for Efficient Replication and Induces Extracellular Signal-Related Kinase-Dependent Phosphorylation and ICP0-Dependent Nuclear Localization of Tankyrase 1 ⬇️

scientific article published on October 19, 2011

Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch.

scientific article published on 3 August 2010

Herpes simplex virus induces extensive modification and dynamic relocalisation of the nuclear mitotic apparatus (NuMA) protein in interphase cells.

scientific article

Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0 ⬇️

scientific article published on May 25, 2011

Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16 ⬇️

scientific article published on July 26, 2011

Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles.

scientific article

Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination

scientific article

Human herpesvirus 6-associated encephalopathy in a child with Dravet syndrome

scientific article published on 3 October 2012

Hydroa Vacciniforme Is Associated with Increased Numbers of Epstein–Barr Virus–Infected γδT Cells ⬇️

scientific article published on February 2, 2012

Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases.

scientific article

Identification of Epstein-Barr virus-infected CD27+ memory B-cells in liver or stem cell transplant patients.

scientific article published on 3 August 2011

Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2

scientific article published on 30 April 2012

Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients

scientific article published on 20 April 2011

Impaired cytotoxic T lymphocyte response to Epstein-Barr virus-infected NK cells in patients with severe chronic active EBV infection.

scientific article published on June 2001

Increased T-cell responses to Epstein-Barr virus with high viral load in patients with Epstein-Barr virus-positive diffuse large B-cell lymphoma.

scientific article published on 13 August 2014

Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children ⬇️

scientific article published on September 8, 2011

Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor

scientific article published on 27 January 2016

Initial Characterization of the Epstein⁻Barr Virus BSRF1 Gene Product

article

Interleukin-17A-producing T lymphocytes in chronic active Epstein-Barr virus infection.

scientific article published in February 2013

JAK inhibitors for refractory lymphoma

scientific article published on 31 August 2018

Kinetics of Epstein-Barr virus load and virus-specific CD8+ T cells in acute infectious mononucleosis ⬇️

scientific article published on December 24, 2010

Large deletion of the X-linked lymphoproliferative disease gene detected by fluorescence in situ hybridization.

scientific article published on June 2000

Longitudinal dynamics of Epstein-Barr virus-specific cytotoxic T lymphocytes during posttransplant lymphoproliferative disorder.

scientific article published on 10 August 2000

Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease.

scientific article published on September 2008

Minus strand RNA of hepatitis C virus liver tissues ⬇️

scientific article published on November 1, 1991

Modes of infection and oncogenesis by the Epstein-Barr virus.

scientific article published on 28 February 2014

Monitoring four herpesviruses in unrelated cord blood transplantation

scientific article published on 01 December 2000

Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR.

scientific article published in March 2004

Multicenter evaluation of prototype real-time PCR assays for Epstein-Barr virus and cytomegalovirus DNA in whole blood samples from transplant recipients.

scientific article

NK-cell post-transplant lymphoproliferative disease with chronic active Epstein-Barr virus infection-like clinical findings

scientific article published on 06 August 2019

Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection.

scientific article

Oncolytic activity of HF10 in head and neck squamous cell carcinomas

scientific article published on 03 September 2019

Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer

scientific article published on 2 December 2013

Overview of EBV-Associated T/NK-Cell Lymphoproliferative Diseases

scientific article published on 01 January 2018

Perinatal Cytomegalovirus-Associated Bullae in an Immunocompetent Infant ⬇️

scientific article published on 01 June 2012

Pharmacokinetics and effects of ribavirin following intraventricular administration for treatment of subacute sclerosing panencephalitis

scientific article published on December 2004

Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.

scientific article published on 11 October 2011

Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.

scientific article published on 5 December 2012

Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection.

scientific article published on 17 May 2013

Polymerase chain reaction-proved herpes simplex encephalitis in children.

scientific article published on January 1998

Possibility of Preventive Treatment for EBV-associated NK Cell-lineage Proliferative Disorders ⬇️

scientific article published on March 1, 2003

Presence of Epstein-Barr virus-infected B lymphocytes with thyrotropin receptor antibodies on their surface in Graves' disease patients and in healthy individuals.

scientific article

Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type

scientific article published on 06 June 2012

Prognostic factors for chronic active Epstein-Barr virus infection

scientific article

Prognostic factors in influenza-associated encephalopathy.

scientific article published in May 2008

Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults: overlap with chronic active EBV infection and infantile fulminant EBV T-LPD.

scientific article published on April 2008

Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection.

scientific article

Prospective monitoring of Epstein–Barr virus and other herpesviruses in patients with juvenile idiopathic arthritis treated with methotrexate and tocilizumab ⬇️

scientific article published on November 5, 2011

Prospective monitoring of the Epstein-Barr virus DNA by a real-time quantitative polymerase chain reaction after allogenic stem cell transplantation.

scientific article published in October 2001

Publisher Correction: Defective Epstein-Barr virus in chronic active infection and haematological malignancy

scientific article published on 01 March 2019

Quantitation of cytomegalovirus DNA in lung tissue of bone marrow transplant recipients

scientific article published on 01 August 1992

Quantitative analysis of Epstein-Barr virus (EBV)-related gene expression in patients with chronic active EBV infection.

scientific article published on 30 September 2009

Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in patients with chronic active EBV infection.

scientific article published on 23 July 2004

Quantitative analysis of cytomegalovirus load using a real-time PCR assay.

scientific article published in April 2000

Quantitative analysis of herpesvirus load in the lymph nodes of patients with histiocytic necrotizing lymphadenitis using a real-time PCR assay

scientific article published on 01 March 2006

Rapid detection of herpes simplex virus DNA in cerebrospinal fluid: comparison between loop-mediated isothermal amplification and real-time PCR.

scientific article published on 21 May 2005

Rare occurrence ofJAK3mutations in natural killer cell neoplasms in Japan ⬇️

scientific article published on July 29, 2013

Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface

scientific article

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells

scientific article published on 28 November 2018

Relapse of neonatal herpes simplex virus infection

scientific article published on November 2003

Remission of juvenile idiopathic arthritis with primary Epstein-Barr virus infection.

scientific article published on 30 October 2012

Replication of Epstein-Barr virus primary infection in human tonsil tissue explants

scientific article

Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan

scientific article published on 30 July 2013

Role of latent membrane protein 1 in chronic active Epstein-Barr virus infection-derived T/NK-cell proliferation

scientific article published on 3 May 2014

Roles of Epstein-Barr virus BGLF3.5 gene and two upstream open reading frames in lytic viral replication in HEK293 cells

scientific article published on 15 May 2015

S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene Transcription

scientific article published on 03 April 2019

SH2D1A mutations in Japanese males with severe Epstein-Barr virus--associated illnesses

scientific article published in August 2001

Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza

scientific article published on 01 March 2011

Severe hepatitis caused by Epstein-Barr virus without infection of hepatocytes.

scientific article published in July 2001

Simultaneous monitoring by real-time polymerase chain reaction of epstein-barr virus, human cytomegalovirus, and human herpesvirus-6 in juvenile and adult liver transplant recipients.

scientific article published in December 2008

Simultaneous quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay.

scientific article published on 21 March 2007

Successful treatment of neonatal herpes simplex-type 1 infection complicated by hemophagocytic lymphohistiocytosis and acute liver failure.

scientific article

Systemic cytokine responses in patients with influenza-associated encephalopathy

scientific article published on 20 August 2003

T/NK cell type chronic active Epstein-Barr virus disease in adults: an underlying condition for Epstein-Barr virus-associated T/NK-cell lymphoma.

scientific article published on 13 January 2012

The BOLF1 gene is necessary for effective Epstein-Barr viral infectivity

scientific article published on 23 February 2019

The C-Terminus of Epstein-Barr Virus BRRF2 Is Required for its Proper Localization and Efficient Virus Production

scientific article published on 31 January 2017

The Epstein-Barr Virus BDLF4 Gene Is Required for Efficient Expression of Viral Late Lytic Genes.

scientific article published on 22 July 2015

The Epstein-Barr Virus BRRF1 Gene Is Dispensable for Viral Replication in HEK293 cells and Transformation.

scientific article

The Epstein-Barr virus BRRF2 gene product is involved in viral progeny production

scientific article published on 4 June 2015

The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids.

scientific article published on 21 November 2007

The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas.

scientific article

Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells

scientific article published on 08 October 2016

Transmission of cytomegalovirus via breast milk in extremely premature infants.

scientific article

Trial of intraventricular ribavirin therapy for subacute sclerosing panencephalitis in Japan.

scientific article

Unrelated Bone Marrow Transplantation Induced Long-Term Remission in a Patient with Life-Threatening Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis ⬇️

scientific article published on January 1, 2011

Varicella exposure in a neonatal medical centre: successful prophylaxis with oral acyclovir.

scientific article

Varicella-zoster virus glycoproteins E and I expressed in insect cells form a heterodimer that requires the N-terminal domain of glycoprotein I.

scientific article published on July 1997

Vidarabine therapy for severe chronic active Epstein-Barr virus infection.

scientific article published on June 2001

Viral DNA Loads in Various Blood Components of Patients With Epstein-Barr Virus-Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases

scientific article published on 01 September 2019

Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening

scientific article published on 23 January 2015

mTOR inhibitors induce cell-cycle arrest and inhibit tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells.

scientific article published on 10 September 2014

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