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List of works by Simon F Lacey

A Phase I Study in Adults of Clofarabine Combined with High-Dose Melphalan as Reduced-Intensity Conditioning for Allogeneic Transplantation ⬇️

scientific article published on July 27, 2011

A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor-positive cells

scientific article published on 01 February 2020

A comparative study of Merkel cell, BK and JC polyomavirus infections in renal transplant recipients and healthy subjects ⬇️

scientific article published on July 27, 2010

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

scientific article published in July 2017

Abstract CT105: Safety and feasibility of chimeric antigen receptor modified T cells directed against mesothelin (CART-meso) in patients with mesothelin expressing cancers

scientific article published in August 2015

Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial

scientific article published on 19 March 2018

Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma

scientific article published on 21 February 2019

Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.

scientific article published on 19 April 2018

Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants.

scientific article published on July 2004

Attenuated poxvirus expressing three immunodominant CMV antigens as a vaccine strategy for CMV infection.

scientific article

Attenuated poxviruses generate clinically relevant frequencies of CMV-specific T cells.

scientific article

Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals

scientific article published on 10 November 2020

B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma

scientific article published on 21 March 2019

Biomarkers in T-cell therapy clinical trials ⬇️

scientific article published on February 14, 2013

Biomarkers in chimeric antigen receptor T-cell therapy

scientific article published on 26 April 2018

CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success

article by Kristen B Long et al published 3 December 2018 in Frontiers in Immunology

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

scientific article published on 01 February 2020

CD8+ T cell-mediated suppressive activity inhibits HIV-1 after virus entry with kinetics indicating effects on virus gene expression.

scholarly article

CRISPR-engineered T cells in patients with refractory cancer

scientific article published on 07 February 2020

Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia

scientific article

Characterization of cytotoxic function of CMV-pp65-specific CD8+ T-lymphocytes identified by HLA tetramers in recipients and donors of stem-cell transplants

scientific article

Characterization of host immunity to cytomegalovirus pp150 (UL32).

scientific article

Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice

scientific article

Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

scientific article

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

scientific article published on 10 December 2017

Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer

scientific article

Chimeric antigen receptor T cells for sustained remissions in leukemia

scientific article (publication date: 16 October 2014)

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

scientific article published on September 2015

Clinical evaluation of safety and immunogenicity of PADRE-cytomegalovirus (CMV) and tetanus-CMV fusion peptide vaccines with or without PF03512676 adjuvant

scientific article published on 7 March 2012

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

scientific article

Cross-reactive CTL recognizing two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals

scientific article published on 5 April 2006

Cross-reactivity of T lymphocytes recognizing a human cytotoxic T-lymphocyte epitope within BK and JC virus VP1 polypeptides.

scientific article

Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.

scientific article

Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy: clinicopathological insights

scientific article published on 26 October 2017

Cytomegalovirus immune reconstitution occurs in recipients of allogeneic hematopoietic cell transplants irrespective of detectable cytomegalovirus infection.

scientific article published in November 2005

DNA and low titer, helper-free, recombinant AAV prime-boost vaccination for cytomegalovirus induces an immune response to CMV-pp65 and CMV-IE1 in transgenic HLA A*0201 mice

scientific article

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

scientific article published on 15 July 2020

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

scientific article published on 23 May 2020

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

scientific article published on 30 April 2018

Development of infectious recombinant BK virus ⬇️

scientific article published on August 4, 2011

Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children

scientific article published on 01 October 2020

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

scientific article published in Nature

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

scientific article published on 08 May 2018

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

scientific article

Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer

scientific article published on 21 July 2020

Endothelial Biomarkers Are Associated With Indirect Lung Injury in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome

scientific article published on 04 December 2020

Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.

scientific article published on 11 January 2018

Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma

scientific article published on 23 October 2019

Evaluating the skin in patients undergoing chimeric antigen receptor modified T-cell therapy

scientific article published in November 2016

Ex vivo detection of CD8 T cells specific for H-Y minor histocompatibility antigens in allogeneic hematopoietic stem cell transplant recipients

scientific article

First Trial of CRISPR-Edited T cells in Lung Cancer

scientific article published on 12 June 2020

Functional characterization of BK virus-specific CD4+ T cells with cytotoxic potential in seropositive adults

scientific article published in September 2007

Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ transplant recipients

scientific article published on 11 October 2006

Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual

scientific article published on April 1998

Human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy maintain activated CD8+ T cell subsets as a strong adaptive immune response to cytomegalovirus.

scientific article published on 10 July 2001

IMCT-15PILOT STUDY OF T CELLS REDIRECTED TO EGFRvIII WITH A CHIMERIC ANTIGEN RECEPTOR IN PATIENTS WITH EGFRvIII+ GLIOBLASTOMA.

scientific article

Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

scientific article published on 26 January 2016

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

scientific article

Immunization with Th-CTL Fusion Peptide and Cytosine-Phosphate-Guanine DNA in Transgenic HLA-A2 Mice Induces Recognition of HIV-Infected T Cells and Clears Vaccinia Virus Challenge ⬇️

scientific article published on October 15, 2003

Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients

scientific article published on 15 April 2009

In vitro expansion of polyclonal T-cell subsets for adoptive immunotherapy by recombinant modified vaccinia Ankara

scientific article published on April 2006

Increased programmed death-1 molecule expression in cytomegalovirus disease and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation

scientific article published on July 2009

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

scientific article published on 01 October 2018

La Rosa C et al (J Infect Dis 2012; 205:1294–304).

scientific article published in September 2013

Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia

scientific article published on 16 April 2020

Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma

scholarly article by David L Bajor et al published 2018 in OncoImmunology

Low frequency of BK virus in prostatic adenocarcinomas

scientific article

Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy

scientific article published on 2 April 2016

NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.

scientific article

Neural Stem Cell-Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients.

scientific article published on 15 December 2016

Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.

scientific article published on 28 October 2013

Neurotoxicity after CTL019 in a pediatric and young adult cohort

scientific article published on 26 September 2018

Noncytolytic CD8 T cell-mediated suppression of HIV replication

scientific article published on January 1997

Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma

scientific article published on 20 June 2018

Oblimersen and alpha-interferon in metastatic renal cancer: a phase II study of the California Cancer Consortium.

scientific article published on 17 May 2007

Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia

scientific article published on 09 December 2019

PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.

scientific article published on 28 December 2016

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

scientific article published on 10 May 2016

Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers

scientific article published on 30 July 2019

Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice.

scientific article published on 12 July 2002

Programmed death-1 expression in liver transplant recipients as a prognostic indicator of cytomegalovirus disease.

scientific article

Programmed death-1 receptor and interleukin-10 in liver transplant recipients at high risk for late cytomegalovirus disease

scientific article

RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma

scientific article

Recombinant modified vaccinia virus ankara (MVA) expressing wild-type human p53 induces specific antitumor CTL expansion.

scientific article published on 15 August 2011

Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells

scientific article published on 20 July 2018

Relative dominance of HLA-B*07 restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles

scientific article published in April 2003

Relevance of peptide avidity to the T cell receptor for cytomegalovirus-specific ex vivo CD8 T cell cytotoxicity

scientific article published on 9 September 2003

Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients

scientific article published on 20 October 2017

Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial

scientific article published on 08 January 2021

Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

scientific article published on 6 November 2017

Serial treatment of relapsed/refractory multiple myeloma with different BCMA-targeting therapies

scientific article published on 01 August 2019

Simultaneous reconstitution of multiple cytomegalovirus-specific CD8+ cell populations with divergent functionality in hematopoietic stem-cell transplant recipients.

scientific article published on 9 February 2005

Stable HLA antibodies following sustained CD19+ cell depletion implicate a long-lived plasma cell source

scientific article published on 01 September 2020

Status of Cytomegalovirus Prevention and Treatment in 2000.

scientific article

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.

scientific article published on 12 October 2017

Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis

scientific article published on 01 March 2020

The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.

scientific article published on 27 January 2016

The CXC chemokine stromal cell-derived factor 1 is not responsible for CD8+T cell suppression of syncytia-inducing strains of HIV-1 ⬇️

scientific article published on September 2, 1997

The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma

scientific article published on 15 September 2021

The cytological features of CAR(T) cells

scientific article published on 9 September 2016

The effect of single and combined activating killer immunoglobulin-like receptor genotypes on cytomegalovirus infection and immunity after hematopoietic cell transplantation

scientific article published on March 2009

Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of epigenome

scientific article published on 09 June 2020

Treatment of leukemia antigen-loss relapses occurring after CD19-targeted immunotherapies by combination of anti-CD123 and anti-CD19 chimeric antigen receptor T cells.

scientific article published on 4 November 2015

Vaccine-induced control of viral shedding following rhesus cytomegalovirus challenge in rhesus macaques.

scientific article

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