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List of works by Kristian Bowles

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The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

scientific article published on 17 October 2012
Prediction of acute myeloid leukaemia risk in healthy individuals

scientific article published in Nature
Management of post-transplant lymphoproliferative disorder in adult solid organ transplant recipients - BCSH and BTS Guidelines.

scientific article published on 16 April 2010
Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines.

scientific article published on 16 April 2010
Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

scientific article
Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia

scientific article published on 4 December 2013
NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

scientific article
NF-κB–Inhibited Acute Myeloid Leukemia Cells Are Rescued from Apoptosis by Heme Oxygenase-1 Induction

scientific article published on March 23, 2010
Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

scientific article
Platelet size has diagnostic predictive value in patients with thrombocytopenia.

scientific article
High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors

scientific article published on January 6, 2011
HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells.

scientific article published on 12 January 2006
Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

scientific article published on 11 June 2013
Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1

scientific article published on September 1, 2011
Understanding the role of NRF2-regulated miRNAs in human malignancies.

scientific article published on August 2013
Impact of Hemoglobin Levels and Anemia on Mortality in Acute Stroke: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis

scientific article
CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma

scientific article published on 08 January 2019
Bortezomib induces heme oxygenase-1 expression in multiple myeloma

scientific article published on June 15, 2012
MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia.

scientific article published on 21 November 2016
NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

scientific article
Oxidative stress responses and NRF2 in human leukaemia

scientific article
Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

scientific article
FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism

scientific article published on September 1, 2010
The bone marrow microenvironment - Home of the leukemic blasts

scientific article published on 12 March 2017
Overcoming bortezomib resistance in multiple myeloma.

scientific article
Necrotizing cervical lymphadenopathy caused by Kikuchi-Fujimoto disease

scientific article published on 01 September 2003
Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

scientific article
Anthracycline-based chemotherapy as first-line treatment in adults with malignant posttransplant lymphoproliferative disorder after solid organ transplantation

scientific article published on 01 August 2006
Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

scientific article published on 29 June 2016
Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib: a GIMEMA, ERIC and UK CLL FORUM study.

scientific article published on 19 April 2018
Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

scientific article published on 06 November 2018
Hyponatremia predicts mortality after stroke.

scientific article published on 14 July 2015
The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.

scientific article
Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

scientific article
PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

scientific article published on 10 March 2017
Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.

scientific article published on 11 May 2016
The clinical utility of Multiplate analyser measurement in platelet function testing following stroke and transient ischaemic attack

scientific article published on July 24, 2014
High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

scientific article published on 12 October 2017
Platelet mass has prognostic value in patients with myelodysplastic syndromes

scientific article published on 25 August 2006
Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction

scientific article published on 3 May 2017
Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC.

scientific article
HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

scientific article published on 28 February 2018
Resolution of chronic severe refractory thrombocytopenia after treatment of hypothyroidism.

scientific article
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

scientific article published on 14 November 2019
Discrepancy between impedance and immunofluorescence platelet counting has implications for clinical decision making in patients with idiopathic thrombocytopenia purpura

scientific article
Addition of sodium criterion to SOAR stroke score.

scientific article published on 10 July 2016
Results of a multicentre UK-wide compassionate use programme evaluating the efficacy of idelalisib monotherapy in relapsed, refractory follicular lymphoma

scientific article published on 24 March 2017
PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

scientific article published on 20 July 2018
Long-Term Factors Associated With Falls and Fractures Poststroke.

scientific article published on 3 April 2018
Predicting response to recombinant factor VIIa in non-haemophiliac patients with severe haemorrhage.

scientific article published on 16 August 2006

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