List of works - Cristiano Bolchi

1H NMR spectroscopy in the presence of Mosher acid to rapidly determine the enantiomeric composition of amino acid benzyl esters, chirons susceptible to easy racemization

scientific article published on 17 September 2018

3-(Benzodioxan-2-ylmethoxy)-2,6-difluorobenzamides bearing hydrophobic substituents at the 7-position of the benzodioxane nucleus potently inhibit methicillin-resistant Sa and Mtb cell division.

scientific article

5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity

scientific article

6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.

scientific article

A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro".

scientific article published on 24 November 2015

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.

scientific article

Benzodioxane-benzamides as new bacterial cell division inhibitors

scientific article published on 18 October 2014

Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed as α4β2-Nicotinic Acetylcholine Receptor Agonists

scientific article published on 30 July 2015

Corrigendum to “Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes” [Bioorg. Med. Chem. Lett. 16 (2006) 5610–5615]

scholarly article published in Bioorganic & Medicinal Chemistry Letters

Design, synthesis and binding affinity of acetylcholine carbamoyl analogues

scientific article published on 18 September 2013

Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds

scientific article published on 30 April 2014

From 2-aminomethyl-1,4-benzodioxane enantiomers to unichiral 2-cyano- and 2-carbonyl-substituted benzodioxanes via dichloroamine

scientific article published on 26 June 2014

From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at α4β2 nicotinic acetylcholine receptor.

scientific article published on 21 October 2016

Influence of ionization state on the activation of temocapril by hCES1: a molecular-dynamics study

scientific article published in November 2009

Liver and intestinal protective effects of Castanea sativa Mill. bark extract in high-fat diet rats

scientific article published in PLoS ONE

Modelling of full-length human alpha4beta2 nicotinic receptor by fragmental approach and analysis of its binding modes

scientific article

Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype

scientific article published on 16 December 2020

Novel 5-substituted 3-hydroxyphenyl and 3-nitrophenyl ethers of S-prolinol as α4β2-nicotinic acetylcholine receptor ligands

scientific article published on 27 October 2016

One-step preparation of enantiopure L- or D-amino acid benzyl esters avoiding the use of banned solvents.

scientific article published on 3 March 2017

Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency

scientific article published on 8 September 2007

Potent anti-glioblastoma agents by hybridizing the onium-alkyloxy-stilbene based structures of an alpha7-, alpha9-nAChR antagonist and of a pro-oxidant mitocan

scientific article published on 26 November 2018

Predicting the physicochemical profile of diastereoisomeric histidine-containing dipeptides by property space analysis

scientific article published on 8 May 2012

Preparation of enantiopure methionine, arginine, tryptophan, and proline benzyl esters in green ethers by Fischer-Speier reaction.

scientific article published on 6 June 2018

QSAR study for a novel series of ortho monosubstituted phenoxy analogues of alpha1-adrenoceptor antagonist WB4101.

scientific article

Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of alpha 1 antagonist WB-4101.

scientific article published in September 2004

Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes

scientific article published in 2006

Ten Years of Fentanyl-like Drugs: a Technical-analytical Review

scientific article published on 25 January 2019

Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

scientific article published on 13 July 2011

Unichiral 2-(2'-pyrrolidinyl)-1,4-benzodioxanes: the 2R,2'S diastereomer of the N-methyl-7-hydroxy analogue is a potent α4β2- and α6β2-nicotinic acetylcholine receptor partial agonist

scientific article published on 11 October 2011

WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).

scientific article published in November 2006

α9- and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line

scientific article

List of works by Cristiano Bolchi

1H NMR spectroscopy in the presence of Mosher acid to rapidly determine the enantiomeric composition of amino acid benzyl esters, chirons susceptible to easy racemization

3-(Benzodioxan-2-ylmethoxy)-2,6-difluorobenzamides bearing hydrophobic substituents at the 7-position of the benzodioxane nucleus potently inhibit methicillin-resistant Sa and Mtb cell division.

5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity

6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.

A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro".

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.

Benzodioxane-benzamides as new bacterial cell division inhibitors

Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed as α4β2-Nicotinic Acetylcholine Receptor Agonists

Corrigendum to “Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes” [Bioorg. Med. Chem. Lett. 16 (2006) 5610–5615]

Design, synthesis and binding affinity of acetylcholine carbamoyl analogues

Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds

From 2-aminomethyl-1,4-benzodioxane enantiomers to unichiral 2-cyano- and 2-carbonyl-substituted benzodioxanes via dichloroamine

From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at α4β2 nicotinic acetylcholine receptor.

Influence of ionization state on the activation of temocapril by hCES1: a molecular-dynamics study

Liver and intestinal protective effects of Castanea sativa Mill. bark extract in high-fat diet rats

Modelling of full-length human alpha4beta2 nicotinic receptor by fragmental approach and analysis of its binding modes

Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype

Novel 5-substituted 3-hydroxyphenyl and 3-nitrophenyl ethers of S-prolinol as α4β2-nicotinic acetylcholine receptor ligands

One-step preparation of enantiopure L- or D-amino acid benzyl esters avoiding the use of banned solvents.

Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency

Potent anti-glioblastoma agents by hybridizing the onium-alkyloxy-stilbene based structures of an alpha7-, alpha9-nAChR antagonist and of a pro-oxidant mitocan

Predicting the physicochemical profile of diastereoisomeric histidine-containing dipeptides by property space analysis

Preparation of enantiopure methionine, arginine, tryptophan, and proline benzyl esters in green ethers by Fischer-Speier reaction.

QSAR study for a novel series of ortho monosubstituted phenoxy analogues of alpha1-adrenoceptor antagonist WB4101.

Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of alpha 1 antagonist WB-4101.

Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes

Ten Years of Fentanyl-like Drugs: a Technical-analytical Review

Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

Unichiral 2-(2'-pyrrolidinyl)-1,4-benzodioxanes: the 2R,2'S diastereomer of the N-methyl-7-hydroxy analogue is a potent α4β2- and α6β2-nicotinic acetylcholine receptor partial agonist

WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).

α9- and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line