List of works - Laura Fumagalli

5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity

scientific article

6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.

scientific article

Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study

scientific article published on 04 March 2020

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.

scientific article

Benzodioxane-benzamides as new bacterial cell division inhibitors

scientific article published on 18 October 2014

Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids

scientific article published on 12 March 2014

Corrigendum to “Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes” [Bioorg. Med. Chem. Lett. 16 (2006) 5610–5615]

scholarly article published in Bioorganic & Medicinal Chemistry Letters

Design, synthesis and binding affinity of acetylcholine carbamoyl analogues

scientific article published on 18 September 2013

Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds

scientific article published on 30 April 2014

Modelling of full-length human alpha4beta2 nicotinic receptor by fragmental approach and analysis of its binding modes

scientific article

Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency

scientific article published on 8 September 2007

Predicting the physicochemical profile of diastereoisomeric histidine-containing dipeptides by property space analysis

scientific article published on 8 May 2012

QSAR study for a novel series of ortho monosubstituted phenoxy analogues of alpha1-adrenoceptor antagonist WB4101.

scientific article

Repositioning Dequalinium as Potent Muscarinic Allosteric Ligand by Combining Virtual Screening Campaigns and Experimental Binding Assays

scientific article published on 19 August 2020

Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of alpha 1 antagonist WB-4101.

scientific article published in September 2004

Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes

scientific article published in 2006

Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

scientific article published on 13 July 2011

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs

scientific article published on 23 April 2020

Unichiral 2-(2'-pyrrolidinyl)-1,4-benzodioxanes: the 2R,2'S diastereomer of the N-methyl-7-hydroxy analogue is a potent α4β2- and α6β2-nicotinic acetylcholine receptor partial agonist

scientific article published on 11 October 2011

WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).

scientific article published in November 2006

List of works by Laura Fumagalli

5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity

6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.

Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.

Benzodioxane-benzamides as new bacterial cell division inhibitors

Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids

Corrigendum to “Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes” [Bioorg. Med. Chem. Lett. 16 (2006) 5610–5615]

Design, synthesis and binding affinity of acetylcholine carbamoyl analogues

Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds

Modelling of full-length human alpha4beta2 nicotinic receptor by fragmental approach and analysis of its binding modes

Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency

Predicting the physicochemical profile of diastereoisomeric histidine-containing dipeptides by property space analysis

QSAR study for a novel series of ortho monosubstituted phenoxy analogues of alpha1-adrenoceptor antagonist WB4101.

Repositioning Dequalinium as Potent Muscarinic Allosteric Ligand by Combining Virtual Screening Campaigns and Experimental Binding Assays

Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of alpha 1 antagonist WB-4101.

Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes

Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs

Unichiral 2-(2'-pyrrolidinyl)-1,4-benzodioxanes: the 2R,2'S diastereomer of the N-methyl-7-hydroxy analogue is a potent α4β2- and α6β2-nicotinic acetylcholine receptor partial agonist

WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).