List of works - Hao Fang

1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation

scientific article published on 15 August 2017

A new boronic acid based fluorescent reporter for catechol

article

Additive- and Photocatalyst-Free Borylation of Arylazo Sulfones under Visible Light

scientific article published on 05 October 2018

Antagonists of IAP proteins: novel anti-tumor agents.

scientific article published on January 2014

Boronic acid-based enzyme inhibitors: a review of recent progress.

scientific article

Computational strategy for bound state structure prediction in structure-based virtual screening: a case study of protein tyrosine phosphatase receptor type O inhibitors

scientific article published on 19 October 2018

Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors

scientific article published on 06 February 2016

Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors

scientific article published on 25 September 2015

Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors.

scientific article published on 28 March 2017

Design, synthesis and biological evaluation of saccharin-based N-hydroxybenzamides as histone deacetylases (HDACs) inhibitors

scientific article published on 11 July 2015

Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors.

scientific article published on 17 June 2015

Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors

scientific article published in February 2014

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors ⬇️

scientific article published on April 21, 2012

Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors

scientific article

Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors

scientific article published on 23 October 2015

Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors

scientific article published on 11 February 2017

Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors.

scientific article published on 14 November 2015

Design, synthesis, and preliminary bioactivity evaluation of N-benzylpyrimidin-2-amine derivatives as novel histone deacetylase inhibitor

scientific article

Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.

scientific article

Discovery of Turn-On Fluorescent Probes for Detecting Bcl-2 Protein

scientific article published on 21 March 2019

Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 Protein

scientific article published on 12 October 2017

Enantioseparation of angiotensin II receptor type 1 blockers: evaluation of 6-substituted carbamoyl benzimidazoles on immobilized polysaccharide-based chiral stationary phases. Unusual temperature behavior

scientific article published on 27 July 2017

Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8.

scientific article

Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening

scientific article published on 12 November 2014

HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells

scientific article published on 06 October 2020

High-performance liquid chromatographic enantioseparation of 3,5-disubstituted hydantoins analogs and temperature-induced reversals of elution orders on a polysaccharide-based chiral stationary phase

scientific article published on 12 June 2014

How to Improve Docking Accuracy of AutoDock4.2: A Case Study Using Different Electrostatic Potentials

scientific article published on 02 January 2013

Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase

scientific article published on 10 August 2016

Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot.

scientific article

Improved antiproliferative activities of a new series of 1,3,4-thiadiazole derivatives against human leukemia and breast cancer cell lines

Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif.

scientific article published on 28 September 2014

Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains.

scientific article published on 18 October 2016

Protein Flexibility in Docking-Based Virtual Screening: Discovery of Novel Lymphoid-Specific Tyrosine Phosphatase Inhibitors Using Multiple Crystal Structures

scientific article published on 17 September 2015

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation

scientific article

The progress of selective fluorescent chemosensors by boronic acid.

scientific article published on January 2012

List of works by Hao Fang

1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation

A new boronic acid based fluorescent reporter for catechol

Additive- and Photocatalyst-Free Borylation of Arylazo Sulfones under Visible Light

Antagonists of IAP proteins: novel anti-tumor agents.

Boronic acid-based enzyme inhibitors: a review of recent progress.

Computational strategy for bound state structure prediction in structure-based virtual screening: a case study of protein tyrosine phosphatase receptor type O inhibitors

Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors

Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors

Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors.

Design, synthesis and biological evaluation of saccharin-based N-hydroxybenzamides as histone deacetylases (HDACs) inhibitors

Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors.

Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors ⬇️

Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors

Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors

Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors

Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors.

Design, synthesis, and preliminary bioactivity evaluation of N-benzylpyrimidin-2-amine derivatives as novel histone deacetylase inhibitor

Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.

Discovery of Turn-On Fluorescent Probes for Detecting Bcl-2 Protein

Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 Protein

Enantioseparation of angiotensin II receptor type 1 blockers: evaluation of 6-substituted carbamoyl benzimidazoles on immobilized polysaccharide-based chiral stationary phases. Unusual temperature behavior

Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8.

Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening

HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells

High-performance liquid chromatographic enantioseparation of 3,5-disubstituted hydantoins analogs and temperature-induced reversals of elution orders on a polysaccharide-based chiral stationary phase

How to Improve Docking Accuracy of AutoDock4.2: A Case Study Using Different Electrostatic Potentials

Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase

Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot.

Improved antiproliferative activities of a new series of 1,3,4-thiadiazole derivatives against human leukemia and breast cancer cell lines

Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif.

Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains.

Protein Flexibility in Docking-Based Virtual Screening: Discovery of Novel Lymphoid-Specific Tyrosine Phosphatase Inhibitors Using Multiple Crystal Structures

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation

The progress of selective fluorescent chemosensors by boronic acid.