List of works - Declan Chard

A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis

scientific article

ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI.

scientific article

Abnormalities of cerebral perfusion in multiple sclerosis.

scientific article

Accurate GM atrophy quantification in MS using lesion-filling with co-registered 2D lesion masks

scientific article published on 18 January 2014

Advances in Imaging to Support the Development of Novel Therapies for Multiple Sclerosis

scientific article published on 07 March 2012

An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis.

scientific article published on 2 January 2017

An asymptomatic new lesion on MRI is a relapse and should be treated accordingly - No

scientific article published on 01 November 2019

Antecedent anti-NMDA receptor encephalitis in two patients with multiple sclerosis.

scientific article published on 29 December 2016

Application of a B-spline active surface technique to the measurement of cervical cord volume in multiple sclerosis from three-dimensional MR images

scientific article published on 18 August 2003

Association between pathological and MRI findings in multiple sclerosis

scientific article published on 01 February 2019

Bilateral paroxysmal cephalalgia: a novel indomethacin-responsive primary headache syndrome?

scientific article published on 27 July 2012

Brain atrophy and lesion load predict long term disability in multiple sclerosis

scientific article

Brain atrophy measurements should be used to guide therapy monitoring in MS - Commentary

scientific article published on 22 June 2016

Brain lesion location and clinical status 20 years after a diagnosis of clinically isolated syndrome suggestive of multiple sclerosis.

scientific article published on 30 August 2011

Cervical cord area measurement using volumetric brain magnetic resonance imaging in multiple sclerosis.

scientific article published on 18 November 2014

Characteristics of lesional and extra-lesional cortical grey matter in relapsing-remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study.

scientific article

Clinically isolated syndromes

scientific article published on February 2012

Commentary on Al Hussona et al. 'New-onset seizures as a sole clinical presentation of multiple sclerosis'

scientific article published on 19 June 2018

Commentary on: Neuromyelitis optica spectrum disorder related tonic spams responsive to lacosamide - Authors reply

scientific article published on 24 July 2017

Contralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivo.

scientific article

Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas

scientific article published on 9 October 2017

Cortical lesion counts by double inversion recovery should be part of the MRI monitoring process for all MS patients: no

scientific article published on 01 April 2014

DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime?

scientific article published on 29 April 2015

Deep grey matter volume loss drives disability worsening in multiple sclerosis.

scientific article published on 13 January 2018

Diffusion MRI-based cortical complexity alterations associated with executive function in multiple sclerosis.

scientific article published on 12 December 2012

Diffusion tensor imaging in early relapsing-remitting multiple sclerosis

scientific article published in October 2001

Diffusion tensor imaging of early relapsing-remitting multiple sclerosis with histogram analysis using automated segmentation and brain volume correction.

scientific article published in February 2004

Disability in multiple sclerosis is related to normal appearing brain tissue MTR histogram abnormalities.

scientific article published in December 2003

Distinct influence of different vascular risk factors on white matter brain lesions in multiple sclerosis

scientific article published on 07 February 2020

Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes

scientific article published on 26 February 2004

Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis.

scientific article published on 5 May 2004

Emergence of thalamic magnetization transfer ratio abnormality in early relapsing-remitting multiple sclerosis.

scientific article published in June 2005

Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: A pilot study with application to magnetisation transfer measurements

scientific article published on 28 July 2012

Gray and white matter volume changes in early RRMS: a 2-year longitudinal study.

scientific article published in March 2005

Gray matter atrophy is related to long-term disability in multiple sclerosis

scientific article published on 01 September 2008

Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosis

scientific article published in May 2004

Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal study

scientific article published on 7 April 2005

Grey matter pathology in clinically early multiple sclerosis: evidence from magnetic resonance imaging

scientific article

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

scientific article published on 7 March 2016

Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data

scientific article published on 06 April 2021

In vivo imaging of chronic active lesions in multiple sclerosis

scientific article published on 23 September 2020

Increased functional sensorimotor network efficiency relates to disability in multiple sclerosis

scientific article published on 26 October 2020

Increasing normal-appearing grey and white matter magnetisation transfer ratio abnormality in early relapsing-remitting multiple sclerosis.

scientific article published on 18 April 2005

Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial.

scientific article published in January 2003

Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups

scientific article published on 19 February 2014

Is multiple sclerosis a generalized disease of the central nervous system? An MRI perspective

scientific article published on June 2009

Localization of grey matter atrophy in early RRMS : A longitudinal study

scientific article published on 8 November 2006

Location of brain lesions predicts conversion of clinically isolated syndromes to multiple sclerosis

scientific article

Longitudinal evaluation of clinically early relapsing-remitting multiple sclerosis with diffusion tensor imaging

scientific article published on 20 March 2008

Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica

scientific article

MRI monitoring of pathological changes in the spinal cord in patients with multiple sclerosis

scientific article

MRI only conversion to multiple sclerosis following a clinically isolated syndrome.

scientific article

MS cortical lesions on DIR: not quite what they seem?

scientific article

Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration

scientific article

Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis

scientific article published on 08 April 2019

Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis.

scientific article

Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis.

scientific article published on 29 March 2015

Medical professionalism: the trainees' views

scientific article published on 01 January 2006

Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis.

scientific article published in April 2005

Motor network efficiency and disability in multiple sclerosis

scientific article

Multi-channel registration of fractional anisotropy and T1-weighted images in the presence of atrophy: application to multiple sclerosis

scientific article published on October 2015

Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide

scientific article published on 14 February 2017

New oral drugs for the treatment of multiple sclerosis

scientific article published on 01 September 2016

Normal cerebral perfusion measurements using arterial spin labeling: Reproducibility, stability, and age and gender effects

scientific article published on 01 April 2004

Normal-appearing brain tissue MTR histograms in clinically isolated syndromes suggestive of MS.

scientific article published in July 2002

Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study.

scientific article published on 29 January 2007

Paradoxes in thalamic function and cognition in people with multiple sclerosis: less is more

scientific article published on 23 January 2015

Patterns of white matter damage are non-random and associated with cognitive function in secondary progressive multiple sclerosis.

scientific article published on 14 June 2016

Periventricular magnetisation transfer ratio abnormalities in multiple sclerosis improve after alemtuzumab

Predicting outcome in clinically isolated syndrome using machine learning

scientific article

Predicting the development of multiple sclerosis: is gray matter a missing piece of the puzzle?

scientific article published on 25 May 2011

Prediction of future outcome using Bayesian logic

scientific article published on September 1994

Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study

scientific article published in February 2001

Progression of regional grey matter atrophy in multiple sclerosis.

scientific article published in June 2018

Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis

scientific article published in August 2004

Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis

scientific article

Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction

scientific article published on October 2016

Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes.

scientific article

Regional patterns of grey matter atrophy and magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups: a voxel-based analysis study.

scientific article

Relationship of grey and white matter abnormalities with distance from the surface of the brain in multiple sclerosis

scientific article published on 6 September 2016

Relationship of triple dose contrast enhanced lesions with clinical measures and brain atrophy in early relapsing-remitting multiple sclerosis: a two-year longitudinal study

scientific article published on 29 January 2007

Resolving the clinico-radiological paradox in multiple sclerosis

scientific article published on 12 October 2017

Response to the commentary of Yates RL and DeLuca GC on the study: HLA-DRB1*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis.

scientific article published on 12 August 2016

SVM recursive feature elimination analyses of structural brain MRI predicts near-term relapses in patients with clinically isolated syndromes suggestive of multiple sclerosis

scientific article published on 22 October 2019

Sulcal and gyral crown cortical grey matter involvement in multiple sclerosis: A magnetisation transfer ratio study

scientific article

T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis.

scientific article

T2 lesion location really matters: a 10 year follow-up study in primary progressive multiple sclerosis.

scientific article

TI-relaxation time changes over five years in relapsing-remitting multiple sclerosis

scientific article

The association between olfactory bulb volume, cognitive dysfunction, physical disability and depression in multiple sclerosis.

scientific article published on 19 November 2015

The clinical perspective: How to personalise treatment in MS and how may biomarkers including imaging contribute to this?

scientific article

The grey matter correlates of impaired decision-making in multiple sclerosis.

scientific article published on 8 July 2014

The relationship between cortical lesions and periventricular NAWM abnormalities suggests a shared mechanism of injury in primary-progressive MS.

scientific article published on 04 July 2017

The relationship between lesion and normal appearing brain tissue abnormalities in early relapsing remitting multiple sclerosis

scientific article published in February 2002

The reproducibility and sensitivity of brain tissue volume measurements derived from an SPM-based segmentation methodology.

scientific article published in March 2002

The role of MRI in the evaluation of secondary progressive multiple sclerosis.

scientific article

The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease

scientific article published on 06 August 2020

Upper cervical cord area in early relapsing-remitting multiple sclerosis: cross-sectional study of factors influencing cord size.

scientific article published in April 2006

Visualization of cortical MS lesions with MRI need not be further improved - YES

scientific article published on 28 September 2016

Volumetric reconstruction from printed films: Enabling 30 year longitudinal analysis in MR neuroimaging.

scientific article published on 7 October 2017

What lies beneath grey matter atrophy in multiple sclerosis?

scientific article published in January 2016

What you see depends on how you look: Gray matter lesions in multiple sclerosis.

scientific article published on 19 August 2009

White and gray matter damage in primary progressive MS: The chicken or the egg?

scientific article published on 16 December 2015

White matter tract abnormalities are associated with cognitive dysfunction in secondary progressive multiple sclerosis

scientific article published on 5 January 2016

List of works by Declan Chard

A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis

ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI.

Abnormalities of cerebral perfusion in multiple sclerosis.

Accurate GM atrophy quantification in MS using lesion-filling with co-registered 2D lesion masks

Advances in Imaging to Support the Development of Novel Therapies for Multiple Sclerosis

An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis.

An asymptomatic new lesion on MRI is a relapse and should be treated accordingly - No

Antecedent anti-NMDA receptor encephalitis in two patients with multiple sclerosis.

Application of a B-spline active surface technique to the measurement of cervical cord volume in multiple sclerosis from three-dimensional MR images

Association between pathological and MRI findings in multiple sclerosis

Bilateral paroxysmal cephalalgia: a novel indomethacin-responsive primary headache syndrome?

Brain atrophy and lesion load predict long term disability in multiple sclerosis

Brain atrophy measurements should be used to guide therapy monitoring in MS - Commentary

Brain lesion location and clinical status 20 years after a diagnosis of clinically isolated syndrome suggestive of multiple sclerosis.

Cervical cord area measurement using volumetric brain magnetic resonance imaging in multiple sclerosis.

Characteristics of lesional and extra-lesional cortical grey matter in relapsing-remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study.

Clinically isolated syndromes

Commentary on Al Hussona et al. 'New-onset seizures as a sole clinical presentation of multiple sclerosis'

Commentary on: Neuromyelitis optica spectrum disorder related tonic spams responsive to lacosamide - Authors reply

Contralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivo.

Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas

Cortical lesion counts by double inversion recovery should be part of the MRI monitoring process for all MS patients: no

DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime?

Deep grey matter volume loss drives disability worsening in multiple sclerosis.

Diffusion MRI-based cortical complexity alterations associated with executive function in multiple sclerosis.

Diffusion tensor imaging in early relapsing-remitting multiple sclerosis

Diffusion tensor imaging of early relapsing-remitting multiple sclerosis with histogram analysis using automated segmentation and brain volume correction.

Disability in multiple sclerosis is related to normal appearing brain tissue MTR histogram abnormalities.

Distinct influence of different vascular risk factors on white matter brain lesions in multiple sclerosis

Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes

Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis.

Emergence of thalamic magnetization transfer ratio abnormality in early relapsing-remitting multiple sclerosis.

Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: A pilot study with application to magnetisation transfer measurements

Gray and white matter volume changes in early RRMS: a 2-year longitudinal study.

Gray matter atrophy is related to long-term disability in multiple sclerosis

Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosis

Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal study

Grey matter pathology in clinically early multiple sclerosis: evidence from magnetic resonance imaging

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data

In vivo imaging of chronic active lesions in multiple sclerosis

Increased functional sensorimotor network efficiency relates to disability in multiple sclerosis

Increasing normal-appearing grey and white matter magnetisation transfer ratio abnormality in early relapsing-remitting multiple sclerosis.

Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial.

Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups

Is multiple sclerosis a generalized disease of the central nervous system? An MRI perspective

Localization of grey matter atrophy in early RRMS : A longitudinal study

Location of brain lesions predicts conversion of clinically isolated syndromes to multiple sclerosis

Longitudinal evaluation of clinically early relapsing-remitting multiple sclerosis with diffusion tensor imaging

Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica

MRI monitoring of pathological changes in the spinal cord in patients with multiple sclerosis

MRI only conversion to multiple sclerosis following a clinically isolated syndrome.

MS cortical lesions on DIR: not quite what they seem?

Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration

Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis

Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis.

Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis.

Medical professionalism: the trainees' views

Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis.

Motor network efficiency and disability in multiple sclerosis

Multi-channel registration of fractional anisotropy and T1-weighted images in the presence of atrophy: application to multiple sclerosis

Neuromyelitis optica spectrum disorder related tonic spasms responsive to lacosamide

New oral drugs for the treatment of multiple sclerosis

Normal cerebral perfusion measurements using arterial spin labeling: Reproducibility, stability, and age and gender effects

Normal-appearing brain tissue MTR histograms in clinically isolated syndromes suggestive of MS.

Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study.

Paradoxes in thalamic function and cognition in people with multiple sclerosis: less is more

Patterns of white matter damage are non-random and associated with cognitive function in secondary progressive multiple sclerosis.

Periventricular magnetisation transfer ratio abnormalities in multiple sclerosis improve after alemtuzumab

Predicting outcome in clinically isolated syndrome using machine learning

Predicting the development of multiple sclerosis: is gray matter a missing piece of the puzzle?

Prediction of future outcome using Bayesian logic

Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study

Progression of regional grey matter atrophy in multiple sclerosis.

Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis

Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis

Reconstructing contralateral fiber tracts: methodological aspects of cerebello-thalamocortical pathway reconstruction

Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes.

Regional patterns of grey matter atrophy and magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups: a voxel-based analysis study.