List of works - Dominic P Williams

Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex

scientific article

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

scientific article

Acyl glucuronides: the good, the bad and the ugly.

scientific article published on October 2010

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin

scientific article published on February 2004

Application of hepatocyte-like cells to enhance hepatic safety risk assessment in drug discovery

scientific article published on 01 July 2018

Automatic segmentation of anterior segment optical coherence tomography images

scientific article published in May 2013

Bioactivation and inactivation of aflatoxin B1 by human, mouse and rat liver preparations: effect on SCE in human mononuclear leucocytes.

scientific article published in February 1997

Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro

scientific article

Characterisation of the toxic metabolite(s) of naphthalene

article

Characterization of a functional C3A liver spheroid model.

scientific article published on 27 April 2016

Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity.

scientific article published on 26 September 2008

Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies

scientific article

Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats

scientific article

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.

scientific article published on 31 August 2005

Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity ⬇️

scientific article published on August 27, 2010

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

scientific article

Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells

scientific article published on January 2010

Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose-response relationship in murine versus human cell lines and implications for translation into murine models of sepsis

scientific article published on 16 October 2015

Haloarene derivatives of carbamazepine with reduced bioactivation liabilities: 2-monohalo and 2,8-dihalo derivatives

scientific article

Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.

scientific article published in May 2008

Idiosyncratic toxicity: the role of toxicophores and bioactivation

scientific article published on November 2003

Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers ⬇️

scientific article published on July 3, 2013

Investigation of toxic metabolites during drug development

scientific article

Managing the challenge of chemically reactive metabolites in drug development.

scientific article published on April 2011

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

scientific article published on 20 November 2019

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

scientific article

Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals

scientific article published in January 2010

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.

scientific article published on August 2009

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.

scientific article published on December 1998

Modeling hepatic drug metabolism and toxicity: where are we heading?

scientific article

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

retracted scientific article

Nondestructive analysis of automotive paints with spectral domain optical coherence tomography.

scientific article

Novel in vitro and mathematical models for the prediction of chemical toxicity

scientific article

Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone

scientific article

Predicting Drug-Induced Liver Injury with Bayesian Machine Learning

scientific article published on 02 October 2019

Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate.

scientific article published on 22 September 2015

Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

scientific article published in January 2010

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.

scientific article

Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags

scientific article published on 01 March 2006

Reproducing human and cross-species drug toxicities using a Liver-Chip

scientific article published on 01 November 2019

Role of reactive metabolites in drug-induced hepatotoxicity

scientific article published on January 2010

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury

scientific article

The Generation, Detection, and Effects of Reactive Drug Metabolites ⬇️

scientific article published on October 22, 2012

The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore

article

The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo

scientific article published on 12 October 2011

The potential of cytokines as safety biomarkers for drug-induced liver injury ⬇️

scientific article published on 06 August 2010

The role of metabolic activation in drug-induced hepatotoxicity

scientific article

Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity.

scientific article

Toxicophores: investigations in drug safety

scientific article published on 09 June 2006

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science

scientific article published on 01 November 2008

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.

scientific article published on 13 June 2017

List of works by Dominic P Williams

Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

Acyl glucuronides: the good, the bad and the ugly.

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin

Application of hepatocyte-like cells to enhance hepatic safety risk assessment in drug discovery

Automatic segmentation of anterior segment optical coherence tomography images

Bioactivation and inactivation of aflatoxin B1 by human, mouse and rat liver preparations: effect on SCE in human mononuclear leucocytes.

Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro

Characterisation of the toxic metabolite(s) of naphthalene

Characterization of a functional C3A liver spheroid model.

Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity.

Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies

Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.

Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity ⬇️

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells

Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose-response relationship in murine versus human cell lines and implications for translation into murine models of sepsis

Haloarene derivatives of carbamazepine with reduced bioactivation liabilities: 2-monohalo and 2,8-dihalo derivatives

Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.

Idiosyncratic toxicity: the role of toxicophores and bioactivation

Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers ⬇️

Investigation of toxic metabolites during drug development

Managing the challenge of chemically reactive metabolites in drug development.

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.

Modeling hepatic drug metabolism and toxicity: where are we heading?

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Nondestructive analysis of automotive paints with spectral domain optical coherence tomography.

Novel in vitro and mathematical models for the prediction of chemical toxicity

Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone

Predicting Drug-Induced Liver Injury with Bayesian Machine Learning

Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate.

Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.

Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags

Reproducing human and cross-species drug toxicities using a Liver-Chip

Role of reactive metabolites in drug-induced hepatotoxicity

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury

The Generation, Detection, and Effects of Reactive Drug Metabolites ⬇️

The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore

The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo

The potential of cytokines as safety biomarkers for drug-induced liver injury ⬇️

The role of metabolic activation in drug-induced hepatotoxicity

Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity.

Toxicophores: investigations in drug safety

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.