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List of works by Ulrich M. Zanger

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.

scientific article

A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

article

A natural CYP2B6 TATA box polymorphism (-82T--> C) leading to enhanced transcription and relocation of the transcriptional start site.

scientific article

A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6

scientific article published on 25 April 2007

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter

scientific article (publication date: 8 November 2002)

A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.

scientific article published in August 2004

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes

scientific article published on 9 February 2009

A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.

scientific article published on October 2006

A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells

scientific article

A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

scientific article

ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation

scientific article published on 16 March 2005

ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression.

scientific article published in September 2013

Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver

scientific article published on 2 January 2008

Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

scientific article published on 18 January 2013

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells

scientific article

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.

scientific article

Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics

Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

scientific article published in August 2002

Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes

scientific article

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6 ⬇️

scientific article published on October 1, 2003

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR.

scientific article published in December 2003

Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver

scientific article published on 17 July 2008

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data

scientific article

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists

scientific article published on 26 August 2015

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

scientific article

Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus

scientific article published on 10 June 2005

Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling

scientific article

Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity

scientific article

Cytochrome P450 2B6: function, genetics, and clinical relevance

scientific article published on January 2012

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry ⬇️

scientific article published on November 15, 2003

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation ⬇️

scientific article published on January 16, 2013

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

scientific article

Detection of single nucleotide polymorphisms in CYP2B6 gene

scientific article published on 01 January 2002

Direct Quantification of Cytochromes P450 and Drug Transporters - A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

scientific article published on 17 January 2018

Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).

scientific article published on 7 January 2013

Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction

scientific article published on 01 January 2002

Distinction between human cytochrome P450 (CYP) isoforms and identification of new phosphorylation sites by mass spectrometry

scientific article published on 2 October 2008

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

scientific article published on 27 November 2017

Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism ⬇️

scientific article published on January 18, 2012

Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study

scientific article

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

scientific article published in October 2009

Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease

scientific article published in October 2002

Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: influence of nongenetic factors and association with gene expression

scientific article published on 3 June 2013

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

scientific article

Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene

scientific article published on 5 May 2007

GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia

scientific article published in January 2005

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis

scientific article

Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites

scientific article published on 22 November 2011

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver

scientific article

Genetic polymorphisms of glutathione S-transferase A1, the major glutathione S-transferase in human liver: consequences for enzyme expression and busulfan conjugation

scientific article published in June 2002

Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations

scientific article

Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz

scientific article published in December 2005

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1 ⬇️

scientific article published on January 11, 2013

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes

scientific article published on 16 March 2016

Highly multiplexed genotyping of thiopurine s-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups

scientific article

Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.

scientific article

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro.

scientific article

Impact of genetic polymorphism in relation to other factors on expression and function of human drug-metabolizing p450s

scientific article published on 01 January 2005

Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events.

scientific article

Inferring statin-induced gene regulatory relationships in primary human hepatocytes

scientific article published on 14 July 2011

Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9.

scientific article

Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease.

scientific article

Influence of omeprazole on multidrug resistance protein 3 expression in human liver

scientific article published in February 2003

Inhibition of human CYP2B6 by N,N',N''-triethylenethiophosphoramide is irreversible and mechanism-based

scientific article published on 15 December 2004

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

scientific article published in October 2002

Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

scientific article

Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.

scientific article

LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods

scientific article

Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity

scientific article published in January 2004

Limited contribution of CYP3A5 to the hepatic 6beta-hydroxylation of testosterone

scientific article published in July 2004

MALDI-TOF mass spectrometry for multiplex genotyping of CYP2B6 single-nucleotide polymorphisms

scientific article

MIRNA-DISTILLER: A Stand-Alone Application to Compile microRNA Data from Databases ⬇️

scientific article published on July 8, 2011

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver

scientific article published in May 2009

Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450.

scientific article published on 27 March 2017

Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels.

scientific article

Molecular Interactions between NAFLD and Xenobiotic Metabolism.

scientific article published on 22 January 2013

Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine

scientific article

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine

scientific article

Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles

scientific article

Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.

scientific article

Mutational analysis of the human dihydropyrimidine dehydrogenase gene by denaturing high-performance liquid chromatography

scientific article published in January 2003

New aspects on mechanisms of chemical carcinogenesis: emphasis on species and gender/sex differences and developmental/aging determinants

scientific article published on 15 October 2008

No activation of human pregnane X receptor by hyperforin-related phloroglucinols

scientific article published on 20 November 2013

Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C.

scientific article published on 8 November 2007

Novel CYP2B6 enzyme variants in a Rwandese population: functional characterization and assessment of in silico prediction tools

scientific article published on 11 March 2013

Omics and Drug Response ⬇️

scientific article published on November 5, 2012

Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.

scientific article published on 3 January 2015

PPARA: a novel genetic determinant of CYP3A4 in vitro and in vivo

scientific article

Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis

scientific article

Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice

scientific article published on 20 November 2015

Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

scientific article

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8.

scientific article published on 4 November 2015

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance

scientific article published on 5 March 2013

Pharmacogenetics – challenges and opportunities ahead ⬇️

scientific article published on August 20, 2010

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem

scientific article published on 25 February 2013

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

scientific article

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance

scientific article published on July 2007

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine ⬇️

scientific article published on October 16, 2003

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms

scientific article published on 3 September 2014

Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes

scientific article

RNA-interference approach to study functions of NADPH : cytochrome P450 oxidoreductase in human hepatocytes

scientific article

Re: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4

scientific article published on 01 April 2002

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

scientific article published on February 2017

Regulation of drug metabolism by the interplay of inflammatory signaling, steatosis, and xeno-sensing receptors in HepaRG cells

scientific article published on 12 January 2018

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers

scientific article published on 29 July 2015

Role of ABC transporters in fluoropyrimidine-based chemotherapy response.

scientific article

Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group

scientific article

Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry

scientific article

Sex is a major determinant of CYP3A4 expression in human liver

scientific article

Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes

scientific article published in May 2007

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia

scientific article published on 23 October 2017

Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained.

scientific article

Targeting nuclear receptors with lentivirus-delivered small RNAs in primary human hepatocytes.

scientific article

The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro

scientific article published on 2 April 2013

The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes

scientific article published on 28 December 2017

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

scientific article published on 12 July 2004

The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver

scientific article published on August 2002

The role of human CYP2C8 and CYP2C9 variants in pioglitazone metabolism in vitro.

scientific article published on 15 July 2009

Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia

scientific article published in March 2005

Three haplotypes associated with CYP2A6 phenotypes in Caucasians

scientific article published in September 2005

Three novel thiopurine S-methyltransferase allelic variants (TPMT*20, *21, *22) - association with decreased enzyme function

scientific article published in September 2006

Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine

scientific article

Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease

scientific article

Unexpected effects of propiconazole, tebuconazole and their mixture on the receptors CAR and PXR in human liver cells

scientific article published on 6 February 2018

V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans

scientific article published on January 2003

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