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List of works by Theodorus H. van der Kwast

3D optical coherence tomography and digital pathology

scholarly article published August 2011

4-year prostate specific antigen progression and diagnosis of prostate cancer in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam.

scientific article published on August 2005

4FISH-IF, a four-color dual-gene FISH combined with p63 immunofluorescence to evaluate NKX3.1 and MYC status in prostate cancer

scientific article published on 2 May 2013

A BRCA1/2 mutation, high breast density and prominent pushing margins of a tumor independently contribute to a frequent false-negative mammography

article

A Prostate Cancer "Nimbosus": Genomic Instability and SChLAP1 Dysregulation Underpin Aggression of Intraductal and Cribriform Subpathologies

scientific article published on 13 May 2017

A contemporary update on pathology standards for bladder cancer: transurethral resection and radical cystectomy specimens

scientific article published on 12 October 2012

A critical analysis of the tumor volume threshold for clinically insignificant prostate cancer using a data set of a randomized screening trial

scientific article

A negative confirmatory biopsy among men on active surveillance for prostate cancer does not protect them from histologic grade progression

scientific article published on 2 May 2013

A new and highly prognostic system to discern T1 bladder cancer substage.

scientific article published on 25 October 2011

A new system for substaging pT1 papillary bladder cancer: a prognostic evaluation

scientific article published in September 2005

A pilot 'window of opportunity' neoadjuvant study of metformin in localised prostate cancer.

scientific article published on 27 May 2014

A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer ⬇️

scientific article published on 13 March 2020

Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model

scientific article

Active surveillance for low-risk prostate cancer

scientific article published in March 2013

Adjuvant Radiotherapy After Surgery for Pathologically Advanced Prostate Cancer

scientific article published on 01 December 2007

Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer

scientific article published on 27 December 2011

Allo-I- J antigens in suppression of DTH to H-2 subregion antigens

scientific article published on 01 May 1982

Altered DNA Methylation Landscapes of Polycomb-Repressed Loci Are Associated with Prostate Cancer Progression and ERG Oncogene Expression in Prostate Cancer

scientific article published on 02 April 2013

An immunohistochemical evaluation of androgen and progesterone receptors in ovarian tumors

scientific article published on 01 January 1993

An interobserver reproducibility study on invasiveness of bladder cancer using virtual microscopy and heatmaps

scientific article published on 16 September 2013

Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of CDKN2A deletions in the FGFR3 pathway

scientific article published on 17 August 2016

Androgen Receptors in Dermal Papilla Cells of Scalp Hair Follicles in Male Pattern Baldness ⬇️

scientific article published on December 26, 1991

Androgen pathway dysregulation in BRCA1-mutated breast tumors

scientific article

Androgen receptor heterogeneity in human prostatic carcinomas visualized by immunohistochemistry

article

Androgen receptor modulation in benign human prostatic tissue and prostatic adenocarcinoma during neoadjuvant endocrine combination therapy

scientific article published on 01 April 1996

Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon.

scientific article published on January 1994

Androgen receptors in endocrine-therapy-resistant human prostate cancer.

scientific article

Androgen-independent expression of adrenomedullin and peptidylglycine α-amidating monooxygenase in human prostatic carcinoma

scientific article published on 01 September 2003

Angiosarcoma of the prostate: a more frequent finding in the future owing to radiotherapy? A literature review with treatment implications based on a case report.

scientific article published on 15 April 2014

Anin vitro model of urothelial regeneration: Effects of growth factors and extracellular matrix proteins

scientific article published on 01 July 1994

Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens

scientific article

Array-based genomic analysis of screen-detected Gleason score 6 and 7 prostatic adenocarcinomas

scientific article published on 01 March 2006

Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge

scientific article published on 13 January 2022

Assessment of intravascular granulomas in testicular seminomas and their association with tumour relapse and dissemination

scientific article published on 20 July 2015

Association between metformin medication, genetic variation and prostate cancer risk

scientific article published on 18 May 2020

Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression

scientific article published on 13 April 2011

Atrophy in prostate needle biopsy cores and its relationship to prostate cancer incidence in screened men.

scientific article

Atypical adenomatous hyperplasia of the prostate: morphologic criteria for its distinction from well-differentiated carcinoma.

scientific article

BCAN Think Tank session 1: Overview of risks for and causes of bladder cancer.

scientific article published in May 2010

Bilateral Exudative Pleuritis, an Unusual Pulmonary Onset of Mixed Connective Tissue Disease

scientific article published on 01 January 1985

Biopsy diagnosis of intraductal carcinoma is prognostic in intermediate and high risk prostate cancer patients treated by radiotherapy.

scientific article published on 08 March 2012

Biopsy undergrading in men with Gleason score 6 and fatal prostate cancer in the European Randomized study of Screening for Prostate Cancer Rotterdam

scientific article published on 7 February 2017

Can PSA density be used to detect prostate cancer?

Can non-malignant biopsy features identify men at increased risk of biopsy-detectable prostate cancer at re-screening after 4 years?

scientific article published on 08 October 2007

Cancer Detection and Cancer Characteristics in the European Randomized Study of Screening for Prostate Cancer (ERSPC) – Section Rotterdam

scientific article published on 16 January 2007

Characterization of Distinct Functions for Growth Factors in Murine Transitional Epithelial Cells in Primary Organotypic Culture

article

Characterization of Heterogeneous Prostate Tumors in Targeted Pten Knockout Mice

scientific article published on 25 January 2016

Characterization of mouse urothelial cell lines in different phases of transitional‐cell carcinogenesis ⬇️

scientific article published on July 30, 1993

Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder

scientific article

Clinical and Pathological Prognostic Factors for Recurrence, Progression and Mortality in Non-Muscle Invasive Bladder Cancer: A Meta-Analysis

Clinicopathologic characteristics of 23 cases of invasive low-grade papillary urothelial carcinoma

scientific article published on August 2012

Clonality of localized and metastatic prostate cancer

scientific article published on 16 February 2016

Combined T2-Weighted and Diffusion-Weighted MRI for Localization of Prostate Cancer

scientific article published on 01 August 2007

Combined microsatellite and FGFR3 mutation analysis enables a highly sensitive detection of urothelial cell carcinoma in voided urine

scientific article published on 01 January 2003

Comparison of incidentally detected prostate cancer with screen-detected prostate cancer treated by prostatectomy

article

Comparison of risk calculators from the Prostate Cancer Prevention Trial and the European Randomized Study of Screening for Prostate Cancer in a contemporary Canadian cohort

article

Comparison of screen detected and clinically diagnosed prostate cancer in the European randomized study of screening for prostate cancer, section rotterdam.

scientific article

Concordance between transrectal ultrasound guided biopsy results and radical prostatectomy final pathology: Are we getting better at predicting final pathology?

scientific article published on January 2014

Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set

scientific article published on 04 November 2018

Consistent Biopsy Quality and Gleason Grading Within the Global Active Surveillance Global Action Plan 3 Initiative: A Prerequisite for Future Studies

scientific article published on 13 September 2018

Constitutional DNA-level aberrations in chromosome 22 in a patient with multiple meningiomas.

scientific article

Contemporary grading for prostate cancer: implications for patient care

scientific article published on 17 October 2012

Copy number alterations of c-MYC and PTEN are prognostic factors for relapse after prostate cancer radiotherapy

article

Correlation of ERG Expression and DNA Methylation Biomarkers with Adverse Clinicopathologic Features of Prostate Cancer

scientific article published on 27 March 2012

Corrigendum to 'EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort Under the Auspices of the EAU-ESMO Guidelines Committees' [European Urology 77 (2020) 223-2

scientific article published on 20 May 2020

Creation and internal validation of a biopsy avoidance prediction tool to aid in the choice of diagnostic approach in patients with prostate cancer suspicion

scientific article

Cribriform growth is highly predictive for postoperative metastasis and disease-specific death in Gleason score 7 prostate cancer

scientific article published on 5 September 2014

Cystoscopy revisited as the gold standard for detecting bladder cancer recurrence: diagnostic review bias in the randomized, prospective CEFUB trial.

scientific article published on January 2010

Cytogenetic heterogeneity and histologic tumor growth patterns in prostatic cancer

scientific article published on 01 September 1995

Cytology and Urinary Markers for the Diagnosis of Bladder Cancer

DNA methylation of HOXD3 as a marker of prostate cancer progression

scientific article published on 08 March 2010

Dataset for reporting of carcinoma of the urethra (in urethrectomy specimens): recommendations from the International Collaboration on Cancer Reporting (ICCR)

scientific article published on 02 July 2019

Defining the threshold for significant versus insignificant prostate cancer.

scientific article published on 28 May 2013

Density separation of spleen cells increases fusion frequency and yield of Ig-producing hybridomas

scientific article published on 01 March 1984

Detection of prostate cancer: a comparative study of the diagnostic efficacy of sextant transrectal versus sextant transperineal biopsy

scientific article published on 01 October 2000

Detection rates of cancer, high grade PIN and atypical lesions suspicious for cancer in the European Randomized Study of Screening for Prostate Cancer ⬇️

scientific article published on November 1, 2010

Detection rates of high-grade prostate cancer during subsequent screening visits. Results of the European Randomized Screening Study for Prostate Cancer

scientific article published on 01 May 2006

Determination of Ki-67 defined growth fraction by monoclonal antibody MIB-i in formalin-fixed, paraffin-embedded prostatic cancer tissues

scientific article published on 01 September 1995

Determination of the Association Between T2-weighted MRI and Gleason Sub-pattern: A Proof of Principle Study.

scientific article published on 14 September 2016

Developmental pattern and regulation by androgens of androgen receptor expression in the urogenital tract of the rat.

scientific article published in September 1995

Diagnostic criteria for ductal adenocarcinoma of the prostate: interobserver variability among 20 expert uropathologists

scientific article published on 3 April 2014

Diagnostic prostate biopsy performed in a non-academic center increases the risk of re-classification at confirmatory biopsy for men considering active surveillance for prostate cancer

scientific article published on 09 December 2014

Diagnostic utility of androgen receptor expression in discriminating poorly differentiated urothelial and prostate carcinoma

scientific article published on 17 June 2013

Different PSA Assays Lead to Detection of Prostate Cancers with Identical Histological Features

scientific article published on 01 August 2002

Different profiles of neuroendocrine cell differentiation evolve in the PC-310 human prostate cancer model during long-term androgen deprivation

scientific article published in March 2002

Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin.

scientific article

Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1,25-dihydroxyvitamin D in men with prostate cancer and an in vitro model

scientific article

Differential responsiveness to H-2-subregion-coded antigens in graft versus host and host versus graft reactions

scientific article published on 01 January 1981

Differential responsiveness to Mls locus antigens in graft-versus-host and host-versus-graft reactions

scientific article published on 01 May 1980

Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays

scientific article

Discrimination between Nontumor Bladder Tissue and Tumor by Raman Spectroscopy

scientific article published on 01 November 2006

Disease-specific survival of patients with invasive cribriform and intraductal prostate cancer at diagnostic biopsy

scientific article published on 4 March 2016

Dissecting the association between metabolic syndrome and prostate cancer risk: analysis of a large clinical cohort

scientific article published on 14 February 2014

Distinct DNA methylation alterations are associated with cribriform architecture and intraductal carcinoma in Gleason pattern 4 prostate tumors

scientific article published on 9 May 2017

Do neuroendocrine cells in human prostate cancer express androgen receptor?

article

Does PSA velocity predict prostate cancer in pre-screened populations?

scientific article published on 17 January 2006

Domains of the Human Androgen Receptor Involved in Steroid Binding, Transcriptional Activation, and Subcellular Localization ⬇️

scientific article published on October 1, 1991

Downgrading of biopsy based Gleason score in prostatectomy specimens

scientific article published on 29 October 2013

Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis.

scientific article published on 15 March 2016

EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease

scientific article published on 28 October 2010

EAU guidelines on prostate cancer. Part I: screening, diagnosis, and treatment of clinically localised disease

scientific article published on 14 July 2011

EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer.

scientific article published on 25 January 2011

EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer.

scientific article

EAU guidelines on prostate cancer. Part II: treatment of advanced, relapsing, and castration-resistant prostate cancer

scientific article published on 14 July 2011

EAU guidelines on prostate cancer. part 1: screening, diagnosis, and local treatment with curative intent-update 2013.

scientific article published on 06 October 2013

EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort†: Under the Auspices of the EAU-ESMO Guidelines Committees

scientific article published on 19 November 2019

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

scientific article

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate Cancer

scientific article

ERG immunohistochemistry is not predictive for PSA recurrence, local recurrence or overall survival after radical prostatectomy for prostate cancer

scientific article published on 11 November 2011

Editorial Comment on: Collecting Duct Renal Cell Carcinoma: A Matched Analysis of 41 Cases

scientific article published on 01 October 2007

Editorial Comment on: Prevalence of a Tertiary Gleason Grade and Its Impact on Adverse Histopathologic Parameters in a Contemporary Radical Prostatectomy Series

scientific article published on 13 August 2008

Effect of material property heterogeneity on biomechanical modeling of prostate under deformation.

scientific article

Eleven-year outcome of patients with prostate cancers diagnosed during screening after initial negative sextant biopsies.

scientific article published on 6 November 2009

Enhancement by prostaglandin E1 and essential fatty acid deficiency of the passive transfer of delayed hypersensitivity to PPD in rats. Comparison with effects on delayed hypersensitivity to SRBC in mice

scientific article published on 01 January 1979

Epidermal growth factor receptor regulates normal urothelial regeneration

scientific article

Epidermal participation in post-burn hypertrophic scar development

article

Epitope prediction and confirmation for the human androgen receptor: Generation of monoclonal antibodies for multi-assay performance following the synthetic peptide strategy

article

European Association of Urology (EAU) Prognostic Factor Risk Groups for Non-muscle-invasive Bladder Cancer (NMIBC) Incorporating the WHO 2004/2016 and WHO 1973 Classification Systems for Grade: An Update from the EAU NMIBC Guidelines Panel

scientific article published on 05 January 2021

Evaluation and prognostic significance of ACAT1 as a marker of prostate cancer progression

scientific article

Evaluation of ERG and PTEN protein expression in cribriform architecture prostate carcinomas

scientific article published on 26 October 2016

Evaluation of an Aggressive Prostate Biopsy Strategy in Men Younger than 50 Years

scientific article published on 27 July 2018

Evaluation of genetic patterns in different tumor areas of intermediate-grade prostatic adenocarcinomas by high-resolution genomic array analysis

scientific article published in March 2004

Evidence for two candidate tumour suppressor loci on chromosome 9q in transitional cell carcinoma (TCC) of the bladder but no homozygous deletions in bladder tumour cell lines.

scientific article published in May 1999

Expression and prognostic relevance of vascular endothelial growth factor (VEGF) and its receptor (FLT-1) in nephroblastoma.

scientific article published on February 2003

Expression and prognostic value Of CD44 isoforms in nephroblastoma (Wilms tumor)

scientific article published on 01 August 2002

Expression and prognostic value of platelet-derived growth factor-AA and its receptor α in nephroblastoma

scientific article published in November 2010

Expression of platelet-derived growth factor (PDGF) and PDGF receptors in human malignant mesothelioma in vitro and in vivo

scientific article published on 01 February 1996

External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study.

scientific article published on 7 October 2010

Extraprostatic Extension in Core Biopsies Epitomizes High-risk but Locally Treatable Prostate Cancer

scientific article published on 27 May 2018

FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?†

scientific article published on 15 July 2020

FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma

scientific article published in March 2004

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours

scientific article published on 12 January 2007

FGFR3 mutations, but not FGFR3 expression and FGFR3 copy-number variations, are associated with favourable non-muscle invasive bladder cancer.

scientific article

FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

scientific article

False-negative Prostate Needle Biopsies: Frequency, Histopathologic Features, and Follow-up

scientific article published on 01 January 2010

Feasibility of the immunohistochemical detection of endogenous steroids in paraffin-embedded ovarian tumours

scientific article published on 01 May 1990

Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice

scientific article published on 31 March 2014

Fibroblast growth factor receptor 3 mutation analysis on voided urine for surveillance of patients with low-grade non-muscle-invasive bladder cancer.

scientific article

Fixation-dependent immunolocalization shift and immunoreactivity of intracellular growth factors in cartilage

scientific article published on 01 July 2000

Flare-up of delayed-type hypersensitivity initially induced by murine cloned helper T cells

scientific article published on 01 August 1987

Focal laser ablation for prostate cancer followed by radical prostatectomy: validation of focal therapy and imaging accuracy

scientific article

FrequentFGFR3mutations in urothelial papilloma

article

Gene expression profiling of the human prostate zones.

scientific article

Genome-wide germline correlates of the epigenetic landscape of prostate cancer

scientific article published on 07 October 2019

Genomic hallmarks of localized, non-indolent prostate cancer.

scientific article published on 9 January 2017

Genomic, pathological, and clinical heterogeneity as drivers of personalized medicine in prostate cancer

scientific article published on 24 April 2014

Genotype versus phenotype in families with androgen insensitivity syndrome

scientific article (publication date: September 2001)

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories.

scientific article published on 09 January 2017

Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer

scientific article published on April 2017

Gleason Score 7: When Qualitative Change Becomes Quantitative Change

scientific article published on 14 May 2016

Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists

scientific article

Gleason grade patterns in nodal metastasis and corresponding prostatectomy specimens: impact on patient outcome

scientific article published on 09 September 2019

Gleason score, age and screening: Modeling dedifferentiation in prostate cancer

scientific article published on 01 November 2006

Guidelines for processing and reporting of prostatic needle biopsies.

scientific article

Guidelines on processing and reporting of prostate biopsies: the 2013 update of the pathology committee of the European Randomized Study of Screening for Prostate Cancer (ERSPC).

scientific article published on 06 August 2013

Handling and pathology reporting of radical prostatectomy specimens

scientific article published on December 2003

Handling and reporting of pelvic lymphadenectomy specimens in prostate and bladder cancer: a web-based survey by the European Network of Uropathology

scientific article published on 01 April 2019

Hepatic rhabdomyomatous tumor: late sequel of a fetal rhabdomyomatous nephroblastoma

scientific article published on 01 May 1992

High-resolution array CGH identifies novel regions of genomic alteration in intermediate-risk prostate cancer

scientific article published on July 2009

High-resolution array comparative genomic hybridization of chromosome arm 8q: evaluation of genetic progression markers for prostate cancer.

scientific article published on December 2005

Histological and Immunohistochemical Characterization of Joint Inflammation and Flare-up Reactions Induced by Cloned MT4 +,Lyt-2-T cells

scientific article published on 01 September 1990

Histology of joint inflammation induced in rats by cell wall fragments of the anaerobic intestinal bacterium Eubacterium aerofaciens

scientific article published on 01 January 1991

How to combine the molecular profile with the clinicopathological profile of urothelial neoplastic lesions.

scientific article published on September 2008

Human Microtumors Generated in 3D: Novel Tools for Integrated In Situ Studies of Cancer Immunotherapies.

scientific article published on January 2016

Human kallikrein-related peptidase 12: antibody generation and immunohistochemical localization in prostatic tissues.

scientific article published in September 2007

Hyperplasia of epithelium adjacent to transitional cell carcinoma can be induced by growth factors through paracrine pathways.

scientific article published on January 1994

Identification of areas of grading difficulties in prostate cancer and comparison with artificial intelligence assisted grading

scientific article published on 15 June 2020

Identification of patients with prostate cancer who benefit from immediate postoperative radiotherapy: EORTC 22911.

scientific article published on September 2007

Imaging and T Category for Prostate Cancer in the 8th Edition of the Union for International Cancer Control TNM Classification

scientific article published on 12 July 2019

Immunocytochemical staining of proliferating cells in fine needle aspiration smears of primary and metastatic breast tumours ⬇️

scientific article published on May 1, 1988

Immunocytochemistry of malignant mesothelioma: OV632 as a marker of malignant mesothelioma ⬇️

scientific article published on October 1, 1991

Immunohistochemical determination of androgen receptors in relation to oestrogen and progesterone receptors in female breast cancer

scientific article published on October 21, 1992

Immunohistochemistry of ovarian granulosa cell tumours

scientific article published on 01 January 1989

Impact of 5α-Reductase Inhibitors on Men Followed by Active Surveillance for Prostate Cancer

scientific article published on 28 December 2010

Impact of pathology review of stage and margin status of radical prostatectomy specimens (EORTC trial 22911).

scientific article published on 29 August 2006

Impact of the U.S. Preventive Services Task Force recommendations against prostate specific antigen screening on prostate biopsy and cancer detection rates

scientific article published on 3 December 2014

Improving the Rotterdam European Randomized Study of Screening for Prostate Cancer Risk Calculator for Initial Prostate Biopsy by Incorporating the 2014 International Society of Urological Pathology Gleason Grading and Cribriform growth

scientific article

In VitroModulation of Implantation and Intraepithelial Expansion of Bladder Tumor Cells by Epidermal Growth Factor

scientific article published on 01 September 1997

Incidence and follow-up of patients with focal prostate carcinoma in 2 screening rounds after an interval of 4 years

scientific article published on 01 February 2005

Influence of Metabolic Syndrome on Prostate Cancer Stage, Grade, and Overall Recurrence Risk in Men Undergoing Radical Prostatectomy.

scientific article published on 22 March 2016

Influence of the microenvironment on invasiveness of human bladder carcinoma cell lines.

scientific article

Infrequent Microsatellite Instability in Urothelial Cell Carcinoma of the Bladder in Young Patients

scientific article published on 04 January 2006

Intermixed normal tissue within prostate cancer: effect on MR imaging measurements of apparent diffusion coefficient and T2--sparse versus dense cancers

article

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling ⬇️

scientific article published on September 10, 2010

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume

scientific article published on 03 September 2010

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease ⬇️

scientific article published on August 27, 2010

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes ⬇️

scientific article published on 03 September 2010

International Validation of a Preoperative Nomogram for Prostate Cancer Recurrence After Radical Prostatectomy

scientific article published on 01 August 2002

Interobserver variability between expert urologic pathologists for extraprostatic extension and surgical margin status in radical prostatectomy specimens

scientific article published in October 2008

Interphase cytogenetics of prostatic adenocarcinoma and precursor lesions: Analysis of 25 radical prostatectomies and 17 adjacent prostatic intraepithelial neoplasias

scientific article published on 01 April 1995

Intraductal Carcinoma of the Prostate: Anonymous to Ominous.

scientific article

Intraductal carcinoma of the prostate: interobserver reproducibility survey of 39 urologic pathologists

scientific article published on 03 September 2014

Intraductal carcinoma of the prostate: precursor or aggressive phenotype of prostate cancer?

scientific article published on 04 September 2012

Is incidentally detected prostate cancer in patients undergoing radical cystoprostatectomy clinically significant?

scholarly article by Roberta Mazzucchelli et al published February 2009 in American Journal of Clinical Pathology

Is prostatectomy for Gleason score 6 a treatment failure?

scientific article published on 09 December 2014

Ki-67 Immunostaining in Uveal Melanoma

scientific article published on 01 October 1990

Large Cell Neuroendocrine Carcinoma of Prostate

scientific article published on 01 June 2006

Le récepteur de type 3 des FGF (FGFR3) : de la chondrodysplasie… au cancer de la vessie

Lesions predictive for prostate cancer in a screened population: First and second screening round findings

scientific article published on 01 November 2004

Limitations in Predicting Organ Confined Prostate Cancer in Patients with Gleason Pattern 4 on Biopsy: Implications for Active Surveillance

scientific article

Long-term follow-up of T1 high-grade bladder cancer after intravesical bacille Calmette-Guérin treatment

scientific article published on 07 September 2010

Long-term use of 5-alpha-reductase inhibitors is safe and effective in men on active surveillance for prostate cancer

scientific article published on 09 March 2020

Longitudinal evaluation of cytogenetic aberrations in prostatic cancer: tumours that recur in time display an intermediate genetic status between non-persistent and metastatic tumours

scientific article published on 01 July 1998

Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: a large multi-institutional study

scientific article published on 10 November 2010

Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract.

scientific article published on June 2007

Low-grade intraductal carcinoma of salivary gland: report of 3 cases with marked apocrine differentiation.

scientific article

Lymph node staging in prostate cancer: perspective for the pathologist

scientific article

Lysosomal localization of secretory prostatic acid phosphatase in human hyperplastic prostate epithelium.

scientific article published on January 1986

MIB-1 (KI-67) Proliferation Index and Cyclin-Dependent Kinase Inhibitor p27Kip1 Protein Expression in Nephroblastoma

scientific article published on 01 January 2004

MR elastography to measure the effects of cancer and pathology fixation on prostate biomechanics, and comparison with T 1, T 2 and ADC.

scientific article published on February 2017

MYH mutations are rare in prostate cancer.

scientific article published on 12 January 2007

Malignant pleural mesothelioma

scientific article published on 01 February 1997

Management and survival of screen-detected prostate cancer patients who might have been suitable for active surveillance.

scientific article

Measurement of peri-prostatic fat thickness using transrectal ultrasonography (TRUS): a new risk factor for prostate cancer

scientific article published on 28 February 2012

Metastatic clear cell renal cell carcinoma presenting as multiple colonic polyps

scientific article published in May 2009

Metastatic disease of screen-detected prostate cancer : characteristics at diagnosis.

scientific article

Metric substage according to micro and extensive lamina propria invasion improves prognostics in T1 bladder cancer

scientific article published on 05 June 2018

Microsatellite analysis of voided-urine samples for surveillance of low-grade non-muscle-invasive urothelial carcinoma: feasibility and clinical utility in a prospective multicenter study (Cost-Effectiveness of Follow-Up of Urinary Bladder Cancer tr

scientific article published on 15 May 2008

Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract

article

Microvascular Invasion in Prostate Cancer: Prognostic Significance in Patients Treated by Radical Prostatectomy for Clinically Localized Carcinoma

scientific article published on 01 January 1998

Microwave-stimulated incubation in immunoelectron microscopy: A quantitative study

scientific article published on 01 June 1988

Migration of B lymphocytes in lymphoid organs of lethally irradiated, thymocyte-reconstituted mice

scientific article published on 01 January 1980

Modern-day prostate cancer is not meaningfully associated with lower urinary tract symptoms: Analysis of a propensity score-matched cohort

scientific article published on January 2017

Modulation of cytokeratin subtype, EGF receptor, and androgen receptor expression during progression of prostate cancer*1 ⬇️

scientific article published on September 1, 1998

Modulation of intraepithelial expansion of human T24 bladder-carcinoma cells in murine urothelium by growth factors and extracellular-matrix components

scientific article published on 01 March 1995

Molecular Grade (FGFR3/MIB-1) and EORTC Risk Scores Are Predictive in Primary Non–Muscle-Invasive Bladder Cancer

scientific article published on 09 June 2010

Molecular and clinical support for a four-tiered grading system for bladder cancer based on the WHO 1973 and 2004 classifications

scientific article

Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome

scientific article published in May 2003

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.

scientific article published on 25 October 2016

Morphological assessment of radical prostatectomy specimens. A protocol with clinical relevance

Multi-assay performance of a monoclonal antibody directed against the androgen receptor

scientific article published on 01 January 1992

NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer

scientific article

NKX3.1 haploinsufficiency is prognostic for prostate cancer relapse following surgery or image-guided radiotherapy

scientific article published on 2 November 2011

Neoadjuvant radiotherapy for locally advanced and high-risk prostate cancer

scientific article published on 21 December 2010

Nerve outgrowth and neuropeptide expression during the remodeling of human burn wound scars

scientific article published on 01 November 2001

Neuroendocrine cells in the normal, hyperplastic and neoplastic prostate.

scientific article published on January 1995

Nomogram use for the prediction of indolent prostate cancer

scientific article published on 01 November 2007

Non-muscle-invasive bladder cancer surveillance for which cystoscopy is partly replaced by microsatellite analysis of urine: a cost-effective alternative?

scientific article

Non-sentinel lymph node involvement in patients with breast cancer and sentinel node micrometastasis; too early to abandon axillary clearance.

scientific article published in December 2002

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

scientific article published on 23 January 2020

Nonprimary pT1 Nonmuscle Invasive Bladder Cancer Treated With Bacillus Calmette-Guerin is Associated With Higher Risk of Progression Compared to Primary T1 Tumors

scientific article published on 15 May 2010

Not all gleason pattern 4 prostate cancers are created equal: A study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series

scientific article published on 11 May 2015

Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders

scientific article published in December 2002

Novel multiplex MethyLight protocol for detection of DNA methylation in patient tissues and bodily fluids

scientific article published on 21 March 2014

ONECUT2 is a driver of neuroendocrine prostate cancer

scientific article published in Nature Communications

Obesity is associated with larger prostate volume but not with worse urinary symptoms: analysis of a large multiethnic cohort

scientific article

Obesity is associated with risk of progression for low-risk prostate cancers managed expectantly

scientific article published on 18 June 2014

Papillary urothelial neoplasm of low malignant potential (PUN-LMP): Still a meaningful histo-pathological grade category for Ta, noninvasive bladder tumors in 2019?

scientific article published on 05 November 2019

Partial laryngectomy for recurrent glottic carcinoma after radiotherapy.

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Partial remission of parotid gland carcinoma after goserelin

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Pathological stage review is indicated in primary pT1 bladder cancer

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Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer.

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Patients' perceived burden of cystoscopic and urinary surveillance of bladder cancer: a randomized comparison

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Peptidylglycine ?-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate

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Phenotypic and genotypic analysis of large-cell lymphomas, formerly classified as true histiocytic lymphoma: Identification of an unusual group of tumors

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Potentially advanced malignancies detected by screening for prostate carcinoma after an interval of 4 years

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Predicting biochemical recurrence and prostate cancer-specific mortality after radical prostatectomy: comparison of six prediction models in a cohort of patients with screening- and clinically detected prostate cancer

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Predicting favourable prognosis of urothelial carcinoma: gene expression and genome profiling

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Prediction of Indolent Prostate Cancer: Validation and Updating of a Prognostic Nomogram

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Prediction of Progression of Non–Muscle-Invasive Bladder Cancer by WHO 1973 and 2004 Grading and by FGFR3 Mutation Status: A Prospective Study

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Predictive value of four kallikrein markers for pathologically insignificant compared with aggressive prostate cancer in radical prostatectomy specimens: results from the European Randomized Study of Screening for Prostate Cancer section Rotterdam.

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Presence of invasive cribriform or intraductal growth at biopsy outperforms percentage grade 4 in predicting outcome of Gleason score 3+4=7 prostate cancer.

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Prevalence of prostate cancer on autopsy: cross-sectional study on unscreened Caucasian and Asian men.

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Prevalence, Treatment Modalities and Prognosis of Familial Prostate Cancer in a Screened Population

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Primary and secondary delayed-type hypersensitivity to minor histocompatibility antigens in the mouse ⬇️

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Primary cutaneous adenoid cystic carcinoma: case report, immunohistochemistry, and review of the literature.

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Prise en charge de la pièce de prostatectomie radicale. Résultats de la conférence de consensus de la Société internationale d’uropathologie (ISUP)

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Prognostic factors in bladder carcinoma: histologic parameters and expression of a cell cycle-related nuclear antigen (Ki-67).

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Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort

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Prognostic markers in nephroblastoma (Wilms' tumor).

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Prognostic prostate tissue biomarkers of potential clinical use.

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Prognostic significance of substage and WHO classification systems in T1 urothelial carcinoma of the bladder

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Prognostic utility of cell cycle progession score in men with prostate cancer after primary external beam radiation therapy. In regard to Freedland et al.

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Prognostic value of molecular markers, sub-stage and European Organisation for the Research and Treatment of Cancer risk scores in primary T1 bladder cancer.

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Prolonged neoadjuvant combined androgen blockade leads to a further reduction of prostatic tumor volume: three versus six months of endocrine therapy.

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Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic

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Prostate cancer detection with multi-parametric MRI: Logistic regression analysis of quantitative T2, diffusion-weighted imaging, and dynamic contrast-enhanced MRI

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Prostate cancer localization with multispectral MRI using cost-sensitive support vector machines and conditional random fields

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Prostate cancer outcomes of men with biopsy Gleason score 6 and 7 without cribriform or intraductal carcinoma

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Prostate cancer: Draft USPSTF 2017 recommendation on PSA testing - a sea-change?

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Prostate tissue composition and MR measurements: investigating the relationships between ADC, T2, K(trans), v(e), and corresponding histologic features

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Prostate-cancer mortality at 11 years of follow-up

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Prostatic needle biopsies following primary high intensity focused ultrasound (HIFU) therapy for prostatic adenocarcinoma: histopathological features in tumour and non-tumour tissue

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Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma

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Proteomic profiling of androgen-independent prostate cancer cell lines reveals a role for protein S during the development of high grade and castration-resistant prostate cancer

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Quantitative DNA methylation analysis of genes coding for kallikrein-related peptidases 6 and 10 as biomarkers for prostate cancer

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Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression

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Randomized Clinical Trial of Vitamin D3 Doses on Prostatic Vitamin D Metabolite Levels and Ki67 Labeling in Prostate Cancer Patients

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Rare case of recurrent angiokeratoma of Fordyce on penile shaft

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Re: Architectural Heterogeneity and Cribriform Pattern Predict Adverse Clinical Outcome for Gleason Grade 4 Prostatic Adenocarcinoma

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Re: Magnetic Resonance Imaging Underestimation of Prostate Cancer Geometry: Use of Patient-specific Molds to Correlate Images with Whole-mount Pathology

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Re: Should Intervening Benign Tissue Be Included in the Measurement of Discontinuous Foci of Cancer on Prostate Needle Biopsy? Correlation With Radical Prostatectomy Findings

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Re: The Index Lesion and Focal Therapy: An Analysis of the Pathological Characteristics of Prostate Cancer ⬇️

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Real-Time MRI-Guided Focused Ultrasound for Focal Therapy of Locally Confined Low-Risk Prostate Cancer: Feasibility and Preliminary Outcomes

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Reasons for Discontinuing Active Surveillance: Assessment of 21 Centres in 12 Countries in the Movember GAP3 Consortium

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Reconstitution of the thymus dependent area in the spleen of lethally irradiated mice

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Regular Transition Zone Biopsy during Active Surveillance for Prostate Cancer May Improve Detection of Pathological Progression

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Regulation of androgen receptor expression in the human heterotransplantable prostate carcinoma PC-82

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Renal oncocytoma, yet another tumour that does not fit in the dualistic benign/malignant paradigm?

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Reply from authors re: Michael Baum. Screening for prostate cancer: can we learn from the mistakes of the breast screening experience? Eur Urol 2013;64:540-1: screening for prostate cancer: we have learned and are still learning.

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Reply to Anna Orsola, Inés de Torres and Juan Morote’s Letter to the Editor re: Bas W.G. van Rhijn, Theo H. van der Kwast, Sultan S. Alkhateeb, et al. A New and Highly Prognostic System to Discern T1 Bladder Cancer Substage. Eur Urol 2012:61:378?

Reply to Maximilian Burger, Wolfgang Otto, and Arndt Hartmann's Letter to the Editor re: Bas W.G. van Rhijn, Theo H. van der Kwast, Sultan S. Alkhateeb, et al. A New and Highly Prognostic System to Discern T1 Bladder Cancer Substage. Eur Urol 2012;61

Report From the International Society of Urological Pathology (ISUP) Consultation Conference On Molecular Pathology Of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges

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Results of Prostate Cancer Screening in a Unique Cohort at 19yr of Follow-up

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Role of Hormonal Treatment in Prostate Cancer Patients with Nonmetastatic Disease Recurrence After Local Curative Treatment: A Systematic Review.

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Rotterdam Randomized Pilot Studies of Screening for Prostate Cancer—An Overview After 10 Years

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Rule-based versus probabilistic selection for active surveillance using three definitions of insignificant prostate cancer

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SIU-ICUD on bladder cancer: pathology

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SU-E-J-95: Towards Optimum Boundary Conditions for Biomechanical Model Based Deformable Registration Using Intensity Based Image Matching for Prostate Correlative Pathology.

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Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques.

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Salvage radical prostatectomy following primary high intensity focused ultrasound for treatment of prostate cancer.

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Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up.

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Screening for prostate cancer at low PSA range: the impact of digital rectal examination on tumor incidence and tumor characteristics

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Screening for prostate cancer without digital rectal examination and transrectal ultrasound: results after four years in the European Randomized Study of Screening for Prostate Cancer (ERSPC), Rotterdam.

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Screening for prostate cancer: results of the Rotterdam section of the European randomized study of screening for prostate cancer.

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Secondary delayed type hypersensitivity to sheep red blood cells in mice: Dependence on long-lived memory cells ⬇️

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Secondary delayed-type hypersensitivity to sheep red blood cells in mice: a long-lived memory phenomenon

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Select Screening in a Specific High-Risk Population of Patients Suggests a Stage Migration Toward Detection of Non–Muscle-Invasive Bladder Cancer

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SeqControl: process control for DNA sequencing

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Serendipity in detecting disease in low prostate-specific antigen ranges.

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Sex differences in bladder cancer outcomes among smokers with advanced bladder cancer.

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Sex steroid receptor expression in 'carcinoid' tumours of the breast.

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Sexual function of patients under surveillance for bladder cancer

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ShatterProof: operational detection and quantification of chromothripsis

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Should Pathologists Routinely Report Prostate Tumour Volume? The Prognostic Value of Tumour Volume in Prostate Cancer

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Should follow-up biopsies for men on active surveillance for prostate cancer be restricted to limited templates?

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Should we replace the Gleason score with the amount of high-grade prostate cancer?

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Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse

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Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer

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Spatial genomic heterogeneity within localized, multifocal prostate cancer

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Striated muscle in the prostatic apex: does the amount in radical prostatectomy specimens predict postprostatectomy urinary incontinence?

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Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur

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Supervised and unsupervised methods for prostate cancer segmentation with multispectral MRI.

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Surveillance with microsatellite analysis of urine in bladder cancer patients treated by radiotherapy.

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THE PROGNOSTIC VALUE OF PRETREATMENT EXPRESSION OF ANDROGEN RECEPTOR AND BCL-2 IN HORMONALLY TREATED PROSTATE CANCER PATIENTS

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TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.

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TMPRSS2-ERG status is not prognostic following prostate cancer radiotherapy: implications for fusion status and DSB repair

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Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

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Targeting a single mismatched minor histocompatibility antigen with tumor-restricted expression eradicates human solid tumors

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Technical Note: Method to correlate whole-specimen histopathology of radical prostatectomy with diagnostic MR imaging

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The Actual Value of the Surgical Margin Status as a Predictor of Disease Progression in Men with Early Prostate Cancer

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The Benefits and Harms of Different Extents of Lymph Node Dissection During Radical Prostatectomy for Prostate Cancer: A Systematic Review. ⬇️

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The Clinical Genomics of Prostate Cancer

The FGFR3 mutation is related to favorable pT1 bladder cancer

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The Impact of the Use of Aspirin and Other Nonsteroidal Anti-inflammatory Drugs on the Risk of Prostate Cancer Detection on Biopsy

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The Prognostic Value of Neuroendocrine Differentiation in Adenocarcinoma of the Prostate in Relation to Progression of Disease After Endocrine Therapy

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The Trade-off Between Sensitivity and Specificity of Clinical Protocols for Identification of Insignificant Prostate Cancer

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The World Health Organization 1973 classification system for grade is an important prognosticator in T1 non-muscle-invasive bladder cancer

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The contemporary concept of significant versus insignificant prostate cancer

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The development of multiple bladder tumour recurrences in relation to the FGFR3 mutation status of the primary tumour

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The influence of the diagnostic technique on the histopathological diagnosis in malignant mesothelioma

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The pathologist's mean grade is constant and individualizes the prognostic value of bladder cancer grading

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The predictive value of immunohistochemical markers in untreated Wilms' tumour: are they useful?

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The prognostic influence of neuroendocrine cells in prostate cancer: Results of a long-term follow-up study with patients treated by radical prostatectomy

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The value of triple antibody (34βE12 + p63 + AMACR) cocktail stain in radical prostatectomy specimens with crushed surgical margins

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ThePTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion

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Topographical analysis of telomere length and correlation with genomic instability in whole mount prostatectomies.

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Toward Optimal Prediction of Prognosis in T1 Urothelial Carcinoma of the Bladder.

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Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors

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Truncated ETV1, fused to novel tissue-specific genes, and full-length ETV1 in prostate cancer.

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Tumor characteristics in screening for prostate cancer with and without rectal examination as an initial screening test at low PSA (0.0-3.9 ng/ml)

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Tumor heterogeneity of fibroblast growth factor receptor 3 (FGFR3) mutations in invasive bladder cancer: implications for perioperative anti-FGFR3 treatment. ⬇️

scientific article published on 18 April 2016

Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue

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Tumour Features in the Control and Screening Arm of A Randomized Trial of Prostate Cancer

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Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study

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Ultrasound-guided fine needle aspiration cytology of axillary lymph nodes in breast cancer patients. A preoperative staging procedure.

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Ultrastructural and immunohistochemical segregation of gemistocytic subsets.

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Unsupervised segmentation of the prostate using MR images based on level set with a shape prior.

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Urinary DNA Methylation Biomarkers for Noninvasive Prediction of Aggressive Disease in Patients with Prostate Cancer on Active Surveillance

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Urine markers for bladder cancer surveillance: a systematic review

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Uterine artery estrogen receptors in the nonpregnant and pregnant guinea pig

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Utility of Pathology Imagebase for Standardization of Prostate Cancer Grading

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Validation of stem cell markers in clinical prostate cancer: α6-integrin is predictive for non-aggressive disease.

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Validation of the novel International Society of Urological Pathology 2014 five-tier Gleason grade grouping: biochemical recurrence rates for 3+5 disease may be overestimated

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Value of tissue markers p27kip1, MIB-1, and CD44s for the pre-operative prediction of tumour features in screen-detected prostate cancer

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Variability in Diagnostic Opinion Among Pathologists for Single Small Atypical Foci in Prostate Biopsies

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Variant Histology and Clinicopathological Features of Prostate Cancer in Men Younger than 50 Years Treated with Radical Prostatectomy

scientific article published on 24 January 2017

Variation of prostate-specific antigen expression in different tumour growth patterns present in prostatectomy specimens

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Virus specific immune responses after human neoadjuvant adenovirus-mediated suicide gene therapy for prostate cancer.

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Web-based virtual microscopy in teaching and standardizing Gleason grading

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What Is the Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in Excluding Prostate Cancer at Biopsy? A Systematic Review and Meta-analysis from the European Association of Urology Prostate Cancer Guidelines Panel. ⬇️

scientific article published on 20 March 2017

Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors

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Words of wisdom. Re: Modeling grade progression in an active surveillance study

scientific article published in August 2014

Young-age prostate cancer.

scientific article published on 02 April 2015

microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma.

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