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List of works by Hartmut Kuhn

15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary

scientific article

5-Selenization of salicylic acid derivatives yielded isoform-specific 5-lipoxygenase inhibitors.

scientific article published on 23 December 2009

A role of Gln596 in fine-tuning mammalian ALOX15 specificity, protein stability and allosteric properties

scientific article published on 06 March 2020

A simple method for the preparation of (5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid enantiomers and the corresponding 14,15-dehydro analogues: role of the 16-hydroxy group for the lipoxygenase reaction

scientific article published in July 2002

Affinity labeling of the rabbit 12/15-lipoxygenase using azido derivatives of arachidonic acid

scientific article

Age-related decrease in 15-lipoxygenase contributes to reduced vasorelaxation in rabbit aorta

scientific article published on 30 November 2007

Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog.

scientific article published in May 2003

Applicability of the triad concept for the positional specificity of mammalian lipoxygenases

scientific article published on 21 December 2009

Arachidonic Acid metabolites in the cardiovascular system: the role of lipoxygenase isoforms in atherogenesis with particular emphasis on vascular remodeling

scientific article published on December 2007

Atopic Patients Show Increased Interleukin 4 Plasma Levels but the Degree of Elevation Is Not Sufficient to Upregulate Interleukin-4-Sensitive Genes

scientific article published on 16 May 2019

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants ⬇️

scientific article published on December 12, 2012

Corrigendum to "Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells" [BBA-Mol. Cell Biol. Volume 1863/2, Pages 152-164]

scientific article published on 27 April 2020

Corrigendum to "The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog" [Biochim. Biophys. Acta 1861/1, (2016) 1-11].

scientific article published on 3 November 2016

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

scholarly article by Astrid Borchert published in September 2018

Design and biological evaluation of photo-switchable inhibitors.

scientific article published in January 2006

Differential expression of secretoglobins in normal ovary and in ovarian carcinoma--overexpression of mammaglobin-1 is linked to tumor progression.

scientific article published on 3 March 2014

Discovery of a functional retrotransposon of the murine phospholipid hydroperoxide glutathione peroxidase: chromosomal localization and tissue-specific expression pattern

scientific article

Do lipoxygenases occur in viruses?: Expression and characterization of a viral lipoxygenase-like protein did not provide evidence for the existence of functional viral lipoxygenases

article

Dual role of oxygen during lipoxygenase reactions

scientific article published in May 2005

Eicosanoid biosynthesis in marine mammals

scientific article published on 05 July 2020

Enantioselective substrate specificity of 15-lipoxygenase 1.

scientific article published in December 2004

Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins

scientific article published on 13 July 2016

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.

scientific article

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

scientific article

Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation.

scientific article published on 27 January 2005

Expression regulation of MAO isoforms in monocytic cells in response to Th2 cytokines.

scientific article

Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function

scientific article published on 24 April 2018

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme

scientific article published on 01 January 2020

Functional Characterization of Novel Bony Fish Lipoxygenase Isoforms and Their Possible Involvement in Inflammation

scientific article published in 2022

Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns

scientific article published on 17 December 2018

Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase

scientific article

Functional characterization of genetic enzyme variations in human lipoxygenases

scientific article

Functional characterization of isolated RNA-binding domains of the GRSF1 protein

scientific article published on 26 December 2017

Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1).

scientific article

Functional characterization of novel ALOX15 orthologs representing key steps in mammalian evolution supports the Evolutionary Hypothesis of reaction specificity

scientific article published on 29 December 2018

Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment

scientific article

Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1

scientific article published on 06 July 2020

Interleukin-13 upregulates vasodilatory 15-lipoxygenase eicosanoids in rabbit aorta

scientific article published on 28 August 2003

Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium

scientific article published on 31 October 2003

Is Regioselectivity in the Enzyme-Catalyzed Hydroperoxidation of Arachidonic Acid Necessarily Determined by Hydrogen Abstraction? The Case of Rabbit Leu597Ala/Ile663Ala ALOX15 Mutant.

scientific article

Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens

scientific article

Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms ⬇️

scientific article (publication date: May 2013)

Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene

scientific article

Mammalian ALOX15 orthologs exhibit pronounced dual positional specificity with docosahexaenoic acid

scientific article published on 8 April 2017

Mammalian lipoxygenases and their biological relevance

scientific article

Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15.

scientific article published on 16 August 2013

Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.

scientific article published on 10 May 2011

Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels

scholarly article

Molecular enzymology of lipoxygenases

scientific article published on 27 August 2010

Monoamine Oxidase A Expression Is Vital for Embryonic Brain Development by Modulating Developmental Apoptosis ⬇️

scientific article published on June 22, 2011

Monoamine oxidase-A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells

scientific article

Monoamine oxidases in development ⬇️

scientific article published on July 11, 2012

Mutagenesis of Sequence Determinants of Truncated Porcine ALOX15 Induces Changes in the Reaction Specificity by Altering the Catalytic Mechanism of Initial Hydrogen Abstraction

scientific article

Mutagenesis of triad determinants of rat Alox15 alters the specificity of fatty acid and phospholipid oxygenation

scientific article

Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes

scientific article published on 12 July 2014

Photoactivation of an inhibitor of the 12/15-lipoxygenase pathway

scientific article published in July 2006

Probing conformational changes in lipoxygenases upon membrane binding: fine-tuning by the active site inhibitor ETYA.

scientific article

Redox control in mammalian embryo development

scientific article published on September 2010

Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta

scientific article published on 20 October 2005

Secreted lipoxygenase from Pseudomonas aeruginosa exhibits biomembrane oxygenase activity and induces hemolysis in human red blood cells

scientific article published on 8 September 2015

Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis

scientific journal article

Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells

scientific article

Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept

scientific article published on 31 August 2011

Structural and functional basis of phospholipid oxygenase activity of bacterial lipoxygenase from Pseudomonas aeruginosa

scientific article

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

scientific article

Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)

scientific article

Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure.

scientific article

Structural properties of plant and mammalian lipoxygenases. Temperature-dependent conformational alterations and membrane binding ability.

scientific article published on 12 August 2008

Suicidal inactivation of the rabbit 15-lipoxygenase by 15S-HpETE is paralleled by covalent modification of active site peptides

scientific article published in February 2003

Synthesis of (5Z,8Z,11Z,14Z)-18- and 19-azidoeicosa-5,8,11,14-tetraenoic acids and their [5,6,8,9,11,12,14,15-3H8]-analogues through a common synthetic route.

scientific article

Synthesis of a new seleninic acid anhydride and mechanistic studies into its glutathione peroxidase activity.

scientific article published in January 2008

Systemic deficiency of mouse arachidonate 15-lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype

scientific article published on 12 September 2020

The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding

scientific article

The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity

scientific article published on 13 January 2017

The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs

scientific article published on 17 September 2018

The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog

scientific article published on 6 October 2015

The lipoxygenase pathway of Tupaia belangeri representing Scandentia. Genomic multiplicity and functional characterization of the ALOX15 orthologs in the tree shrew

scientific article published on 29 October 2019

Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development

scientific article published on July 2008

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