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List of works by Angelo Paci

A case of melphalan sustained accumulation in an 80-year old patient.

scientific article published on 22 September 2015

A new nanomedicine based on didanosine glycerolipidic prodrug enhances the long term accumulation of drug in a HIV sanctuary

article

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

scientific article published on 13 February 2017

Acoustic characterization of a new trisacryl contrast agent. Part I: In vitro study

scientific article published on 4 December 2007

Application of an acceptance sampling plan for post-production quality control of chemotherapeutic batches in an hospital pharmacy

scientific article published on 05 June 2006

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer

scientific article published on 17 April 2019

Body composition variation and impact of low skeletal muscle mass in patients with advanced medullary thyroid carcinoma treated with vandetanib: results from a placebo-controlled study

scientific article published on 29 March 2013

Busulfan after HSCT in children and young adults

scientific article published on 01 March 2017

Busulfan pharmacokinetics following intravenous and oral dosing regimens in children receiving high-dose myeloablative chemotherapy for high-risk neuroblastoma as part of the HR-NBL-1/SIOPEN trial.

scientific article published on 26 June 2012

Busulfan-Melphalan followed by autologous stem cell transplantation in patients with high-risk neuroblastoma or Ewing sarcoma: an exposed-unexposed study evaluating the clinical impact of the order of drug administration

scientific article published on 25 April 2016

Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase-mutated intrahepatic cholangiocarcinomas

scientific article published on 20 December 2017

Colchicine is an active treatment for everolimus-induced oral ulcers

scientific article published on 13 October 2017

Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model

scientific article published on 08 October 2012

Contribution of high-performance thin-layer chromatography to a pharmaceutical quality assurance programme in a hospital chemotherapy manufacturing unit

scientific article published on 01 November 2003

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

scientific article published on 02 April 2019

Curcumin dietary supplements and everolimus-based cancer treatment.

scientific article

Dihydropyrimidine déhydrogenase (DPD) deficiency screening and securing of fluoropyrimidine-based chemotherapies: Update and recommendations of the French GPCO-Unicancer and RNPGx networks

scientific article published on 24 February 2018

Dual-mode gradient HPLC procedure for the simultaneous determination of chloroquine and proguanil.

scientific article published on January 2002

Dyslipidemia causes overestimation of plasma mitotane measurements

scientific article published on 10 June 2016

E.F.P.--European Fellowship for Pharmacists Promoting Clinical Pharmacy in Europe

scientific article published on 01 August 2005

Early progression under mitotane and polychemotherapy does not mean failure in adrenocortical carcinoma patient.

scientific article

Efficacy and safety of gefitinib during pregnancy: case report and literature review.

scientific article published on 16 June 2014

Elevated plasma ferritin and busulfan pharmacodynamics during high-dose chemotherapy regimens in children with malignant solid tumors

scientific article published on 28 March 2007

Evaluation of the pharmacokinetic profile and analgesic efficacy of oral morphine after total hip arthroplasty.

scientific article published on 24 May 2006

Familial hematological malignancies: new IDH2 mutation.

scientific article published on 3 September 2016

High-dose mitotane strategy in adrenocortical carcinoma: prospective analysis of plasma mitotane measurement during the first 3 months of follow-up

scientific article published on 02 November 2011

High-performance thin-layer chromatography with a derivatization procedure, a suitable method for the identification and the quantitation of busulfan in various pharmaceutical products.

scientific article published in February 2004

Human pharmacokinetic study of heated intraperitoneal oxaliplatin in increasingly hypotonic solutions after complete resection of peritoneal carcinomatosis.

scientific article

Hyperthermic pelvic perfusion with tumor necrosis factor-α for locally advanced cancers: encouraging results of a phase II study

scientific article published in February 2012

Identification and quantitation of antineoplastic compounds in chemotherapeutic infusion bags by use of HPTLC: application to the vinca-alkaloids.

scientific article published in January 2003

Individualized Pazopanib Dosing-Letter

scientific article published on 01 December 2016

Induction of glutathione synthesis explains pharmacodynamics of high-dose busulfan in mice and highlights putative mechanisms of drug interaction

scientific article published on 28 November 2006

Influence of the multidrug transporter P-glycoprotein on the intracellular pharmacokinetics of vandetanib.

scientific article published on 28 February 2013

Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer

scientific article published on 21 July 2016

Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence.

scientific article published on 12 January 2018

Irinotecan loaded in eluting beads: preclinical assessment in a rabbit VX2 liver tumor model

scientific article published on 23 February 2012

Lipoprotein-Free Mitotane Exerts High Cytotoxic Activity in Adrenocortical Carcinoma.

scientific article published on 29 June 2015

Liposomal formulation of a glycerolipidic prodrug for lymphatic delivery of didanosine via oral route

scientific article published on 03 June 2007

Liquid chromatography-mass spectrometry assay for quantitation of ifosfamide and its N-deschloroethylated metabolites in rat microsomal medium.

scientific article published on 25 April 2005

Liquid chromatography-tandem mass spectrometry assay of reduced and oxidized glutathione and main precursors in mice liver.

scientific article published on 24 January 2006

Metabolism evaluation of biomimetic prodrugs by in vitro models and mass spectrometry.

scientific article published on 23 May 2009

Microbiological and physicochemical stability of fentanyl and sufentanil solutions for patient-controlled delivery systems.

scientific article published in July 2006

Microbiological and physicochemical stability of oxycodone hydrochloride solutions for patient-controlled delivery systems.

scientific article published on 8 June 2010

Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells ⬇️

scientific article published on May 21, 2013

Mutational profiling of isolated myeloid sarcomas and utility of serum 2HG as biomarker of IDH1/2 mutations

scientific article published on 26 February 2018

Natural history, management and pharmacokinetics of everolimus-induced-oral ulcers: insights into compliance issues.

scientific article

Near infrared spectroscopy and process analytical technology to master the process of busulfan paediatric capsules in a university hospital

scientific article published on 18 April 2006

New dosing nomogram and population pharmacokinetic model for young and very young children receiving busulfan for hematopoietic stem cell transplantation conditioning

scientific article published on 24 July 2020

New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity

scientific article published on 18 November 2008

Nilotinib versus imatinib for GIST

scientific article published on 01 July 2015

Off-patent oral oncology drugs for kids (O3K FP7-project): from bedside to PUMA

scientific article published on 01 October 2012

Organoids as preclinical models to improve intraperitoneal chemotherapy effectiveness for colorectal cancer patients with peritoneal metastases: Preclinical models to improve HIPEC.

scientific article published on 10 August 2017

Oxazaphosphorines: new therapeutic strategies for an old class of drugs

scientific article

Parameters for Stable Water-in-Oil Lipiodol Emulsion for Liver Trans-Arterial Chemo-Eembolization

scientific article published on 2 August 2017

Performance of alfentanil target-controlled infusion in normal and morbidly obese female patients ⬇️

scientific article published on June 24, 2012

Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee

scientific article

Pharmacokinetic Behavior and Appraisal of Intravenous Busulfan Dosing in Infants and Older Children

Pharmacokinetic interaction involving fenofibrate and everolimus

scientific article published on 30 October 2014

Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors

scientific article published on 08 August 2006

Pharmacology of dimethanesulfonate alkylating agents: busulfan and treosulfan.

scientific article

Phase I clinical trial combining imatinib mesylate and IL-2 in refractory cancer patients: IL-2 interferes with the pharmacokinetics of imatinib mesylate

scientific article published on February 2013

Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR(+) NK cell levels correlate with disease outcome

scientific article published on February 2013

Phase I study of temsirolimus in combination with cetuximab in patients with advanced solid tumours.

scientific article published on 12 June 2017

Phase I study of topotecan in combination with temozolomide (TOTEM) in relapsed or refractory paediatric solid tumours

scientific article

Phase II study of vinorelbine and continuous low doses cyclophosphamide in children and young adults with a relapsed or refractory malignant solid tumour: good tolerance profile and efficacy in rhabdomyosarcoma--a report from the Société Française d

scientific article published on 25 May 2012

Physico-chemical stability of busulfan in injectable solutions in various administration packages

scientific article published on March 2013

Pickering-Emulsion for Liver Trans-Arterial Chemo-Embolization with Oxaliplatin

scientific article published on 21 February 2018

Poly-isoprenylated ifosfamide analogs: Preactivated antitumor agents as free formulation or nanoassemblies

scientific article published on 22 May 2017

Population pharmacokinetics of busulfan in children--letter

scientific article published on 01 May 2012

Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept.

scientific article published on 23 December 2014

Prevention of 5-fluorouracil-induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: The multiparametric approach is not convincing

scientific article published in April 2017

Prognostic markers of survival after combined mitotane- and platinum-based chemotherapy in metastatic adrenocortical carcinoma.

scientific article published on 16 August 2010

Quality control and stability study using HPTLC: applications to cyclophosphamide in various pharmaceutical products

scientific article published on 01 June 2005

Quantification of dimethyl-ifosfamide and its N-deschloropropylated metabolites in mouse plasma by liquid chromatography–tandem mass spectrometry ⬇️

scientific article published on February 13, 2011

Quantitation of isocitrate dehydrogenase (IDH)-induced D and L enantiomers of 2-hydroxyglutaric acid in biological fluids by a fully validated liquid tandem mass spectrometry method, suitable for clinical applications

scientific article published on 23 April 2016

Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics

scientific article

Review of therapeutic drug monitoring of anticancer drugs part two--targeted therapies

scientific article

Safety and efficacy compared between irinotecan-loaded microspheres HepaSphere and DC bead in a model of VX2 liver metastases in the rabbit.

scientific article published on 4 May 2015

Safety and quality assurance of chemotherapeutic preparations in a hospital production unit: acceptance sampling plan and economic impact

scientific article published on 10 May 2011

Safety of raltegravir-based antiretroviral therapy in HIV-infected patients receiving multi-kinase inhibitors

scientific article published on 12 November 2016

Safety, tolerability and antitumour activity of LY2780301 (p70S6K/AKT inhibitor) in combination with gemcitabine in molecularly selected patients with advanced or metastatic cancer: a phase IB dose escalation study.

scientific article

Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography-tandem mass spectrometry in human plasma

scientific article published on 22 August 2007

Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography-tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study

scientific article published on 20 April 2015

Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice.

scientific article published on 12 May 2008

Stability of Melphalan in 0.9% Sodium Chloride Solutions Prepared in Polyvinyl Chloride Bags for Intravenous Injection

scientific article published on 16 July 2015

Stabilization Improves Theranostic Properties of Lipiodol®-Based Emulsion During Liver Trans-arterial Chemo-embolization in a VX2 Rabbit Model

scientific article published on 07 March 2017

Synthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV

article

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

scientific article published on 01 May 2020

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

scientific article published on 12 December 2016

The lack of antitumor effects of o,p'DDA excludes its role as an active metabolite of mitotane for adrenocortical carcinoma treatment

scientific article published on 16 July 2014

Therapeutic Drug Monitoring of Carboplatin in High-Dose Protocol (TI-CE) for Advanced Germ Cell Tumors: Pharmacokinetic Results of a Phase II Multicenter Study

scientific article

Therapeutic drug monitoring in cancer--are we missing a trick?

scientific article

Tyrosine kinase inhibitors and pregnancy: A risk to the fetus?

scientific article

Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules.

scientific article published on 31 August 2017

Validation of a new methodology for characterizing ultrasound contrast agents (UCA)

scientific article published in March 2005

Variation in transplacental transfer of tyrosine kinase inhibitors in the human perfused cotyledon model

scientific article published on 7 April 2015

Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas.

scientific article

What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?

scientific article published on 17 May 2018

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