List of works - Renate Kirschner-Schwabe

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

scientific article

Aneuploidy in children with relapsed B-cell precursor acute lymphoblastic leukaemia: clinical importance of detecting a hypodiploid origin of relapse

scientific article published on 03 February 2019

Author Correction: The landscape of genomic alterations across childhood cancers

scientific article published in Nature

CD11b is a therapy resistance- and minimal residual disease-specific marker in precursor B-cell acute lymphoblastic leukemia

scientific article published on 12 March 2010

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

scientific article published on 17 January 2018

Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds

scientific article published on 10 December 2009

Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia

scientific article published in August 2006

Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia

scientific article published on 17 September 2013

Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia.

scientific article published in March 2007

High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse

scientific article published on 9 August 2011

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia

scientific article published on 3 February 2017

Identification of novel mutations in X-linked retinitis pigmentosa families and implications for diagnostic testing

scientific article published on 6 June 2008

Improving Stratification for Children With Late Bone Marrow B-Cell Acute Lymphoblastic Leukemia Relapses With Refined Response Classification and Integration of Genetics

scientific article published on 23 October 2019

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

scientific article published on 12 March 2019

Intragenic amplification of : a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

scientific article published on 14 August 2017

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

scholarly article by Alva Rani James et al published 14 January 2019 in Journal of Hematology & Oncology

Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.

scientific article published in June 2009

Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia

scientific article published on 21 September 2016

Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia

scientific article

NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia

scientific article published on 30 March 2017

Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.

scientific article

PDX models recapitulate the genetic and epigenetic landscape of pediatric T-cell leukemia

scientific article published on 01 December 2018

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

scientific article

Prenatal manifestation of pancytopenia in Pearson marrow-pancreas syndrome caused by a mitochondrial DNA deletion

scientific article published in February 2007

Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia ⬇️

scientific article published on June 13, 2012

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

scientific article

Somatic mitochondrial mutations in pilocytic astrocytoma.

scientific article

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

scientific article published on 27 June 2014

The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018

Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment.

scientific article published on 6 May 2011

List of works by Renate Kirschner-Schwabe

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

Aneuploidy in children with relapsed B-cell precursor acute lymphoblastic leukaemia: clinical importance of detecting a hypodiploid origin of relapse

Author Correction: The landscape of genomic alterations across childhood cancers

CD11b is a therapy resistance- and minimal residual disease-specific marker in precursor B-cell acute lymphoblastic leukemia

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds

Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia

Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia

Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia.

High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia

Identification of novel mutations in X-linked retinitis pigmentosa families and implications for diagnostic testing

Improving Stratification for Children With Late Bone Marrow B-Cell Acute Lymphoblastic Leukemia Relapses With Refined Response Classification and Integration of Genetics

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

Intragenic amplification of : a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.

Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia

Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia

NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia

Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.

PDX models recapitulate the genetic and epigenetic landscape of pediatric T-cell leukemia

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

Prenatal manifestation of pancytopenia in Pearson marrow-pancreas syndrome caused by a mitochondrial DNA deletion

Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia ⬇️

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

Somatic mitochondrial mutations in pilocytic astrocytoma.

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

The landscape of genomic alterations across childhood cancers

Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment.