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List of works by John D Hooper

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Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes

scientific article (publication date: 12 January 2001)
Structure, function and pathophysiology of protease activated receptors.

scientific article published on 26 January 2011
The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment

scientific article published on June 2010
Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen.

scientific article
Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression

scientific article
The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions

scientific article (publication date: 2001)
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

scientific article
Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.

scientific article
Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis

scientific article published on 18 April 2009
Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination.

scientific article
Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.

scientific article
Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues

scientific journal article
Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors

scientific article (publication date: September 2001)
Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.

scientific article
Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle.

scientific article
Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734

scientific article published on 12 October 2011
The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability.

scientific article published on July 2009
Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs).

scientific article published on June 2008
Prevalence of osteoporosis in prostate cancer survivors: a meta-analysis.

scientific article published on 31 October 2013
Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance

scientific article
The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels

scientific article
Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein.

scientific article
Evidence for steroidogenic potential in human prostate cell lines and tissues.

scientific article
The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2.

scientific article
Tissue engineered humanized bone supports human hematopoiesis in vivo

scientific article
The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration

scientific article published on 7 February 2012
Evaluation of antibodies directed against human protease-activated receptor-2.

scientific article published on 31 July 2012
EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface

scientific article published on 31 March 2014
MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target

scientific article published on 11 July 2016
A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

article
Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2.

scientific article
The Emerging Roles of Extracellular Vesicles As Communication Vehicles within the Tumor Microenvironment and Beyond

scientific article published on 08 August 2017
TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma

scientific journal article
Androgen receptor and caveolin-1 in prostate cancer.

scientific article published on October 2009
Prevalence of osteoporosis in prostate cancer survivors II: a meta-analysis of men not on androgen deprivation therapy.

scientific article
Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function

scientific article published in February 2008
A novel transcript from the KLKP1 gene is androgen regulated, down-regulated during prostate cancer progression and encodes the first non-serine protease identified from the human kallikrein gene locus

scientific article published on March 2008
L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution

scientific article published on 01 June 2018
Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer.

scientific article published on 4 February 2016
Expression profiles and functional associations of endogenous androgen receptor and caveolin-1 in prostate cancer cell lines

scientific article published on 24 December 2013
CD169(+) macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer

scientific article published on 27 April 2016
Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia

scientific article published on 14 January 2015
Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo.

scientific article published on 4 August 2013
Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma PC-3 cells is accompanied by inactivation of nuclear factor-kappa B signaling.

scientific article
Expression of CDCA3 Is a Prognostic Biomarker and Potential Therapeutic Target in Non-Small Cell Lung Cancer

scientific article published on 6 May 2017
Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases.

scientific article published on September 2014
The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer

scientific article published on 01 December 2018
Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells

scientific article published on 30 April 2012
Potent Small Agonists of Protease Activated Receptor 2.

scientific article published on 30 November 2015
MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance

scientific article published on 16 February 2017

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