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List of works by Frank L. Heppner

A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance

scientific article published on 11 September 2015

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

scientific article

A paucisymptomatic neuromuscular disease mimicking type III 5q-SMA with complex rearrangements in the SMN gene.

scientific article published on 11 December 2013

Abdominal seeding of an atypical teratoid/rhabdoid tumor of the pineal gland along a ventriculoperitoneal shunt catheter

scientific article published on 23 November 2005

An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates.

scientific article published on 24 July 2014

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.

scientific article published in June 2012

Architectural B-cell organization in skeletal muscle identifies subtypes of dermatomyositis.

scientific article

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS.

scientific article published on 19 August 2015

Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus

scientific article published on 19 January 2018

Automated vs. manual cerebrospinal fluid cell counts: a work and cost analysis comparing the Sysmex XE-5000 and the Fuchs-Rosenthal manual counting chamber.

scientific article published on 13 June 2011

Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3

scientific article published on 07 January 2019

Breaking up (amyloid) is hard to do.

scientific article

CNS myeloid cells critically regulate heat hyperalgesia

scientific article published on 21 May 2018

Calcified myocardial necrosis in pediatric patients after cardiopulmonary resuscitation.

scientific article published on 22 December 2012

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.

scientific article published on 31 October 2017

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

scientific article published on July 2008

Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP.

scientific article published on April 2005

Combined temozolomide and sunitinib treatment leads to better tumour control but increased vascular resistance in O6-methylguanine methyltransferase-methylated gliomas ⬇️

scientific article published on March 14, 2013

Conserved size and periodicity of pyramidal patches in layer 2 of medial/caudal entorhinal cortex.

scientific article published on 30 July 2015

Current concepts and controversies in prion immunopathology

scientific article published on January 2004

DNA methylation-based classification of central nervous system tumours

scientific article published on 14 March 2018

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

scientific article published on 27 February 2005

Detection of kappa and delta opioid receptors in skin--outside the nervous system.

scientific article published on 21 October 2005

Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19

scientific article published in 2023

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Early and rapid engraftment of bone marrow-derived microglia in scrapie.

scientific article published in November 2006

Enhanced acute immune response in IL-12p35-/- mice is followed by accelerated distinct repair mechanisms in Staphylococcus aureus-induced murine brain abscess.

scientific article published on 26 March 2013

Erratum to: MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and

article

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

scientific article published on 23 January 2005

Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases ⬇️

scientific article published on November 8, 2011

Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation.

scientific article published in August 2010

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology

scientific article (publication date: 2013)

Genome wide DNA copy number analysis in cholangiocarcinoma using high resolution molecular inversion probe single nucleotide polymorphism assay.

scientific article

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

scientific article

High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia

scientific article published on 08 July 2016

Immune attack: the role of inflammation in Alzheimer disease.

scientific article published on June 2015

Immune system and peripheral nerves in propagation of prions to CNS.

scientific article published on January 2003

Immune-Mediated Necrotizing Myopathy Is Characterized by a Specific Th1-M1 Polarized Immune Profile ⬇️

scientific article published on October 8, 2012

Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice.

scientific article

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice

scientific article

Impaired Pten expression in human malignant peripheral nerve sheath tumours

scientific article

Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain

scientific article published on 04 August 2018

Inflammatory myopathy with abundant macrophages (IMAM): the immunology revisited.

scientific article published on 18 November 2013

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo

scientific article published on 02 February 2016

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.

scientific article published on 25 November 2012

Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice

scientific article published on 30 January 2020

Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies.

scientific article published on 3 January 2019

Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH).

scientific article published in August 2016

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA).

scientific article published on 5 March 2018

Juvenile autophagic vacuolar myopathy - a new entity or variant?

scientific article published in June 2013

Loss of USP18 in microglia induces white matter pathology

scientific article published on 04 July 2019

Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies

scientific article published on 28 February 2013

MGMT Promoter Methylation and BRAF V600E Mutations Are Helpful Markers to Discriminate Pleomorphic Xanthoastrocytoma from Giant Cell Glioblastoma

scientific article

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.

scientific article published on 9 December 2013

Microglia actions in Alzheimer’s disease.

scientific article published on October 2013

Microglia as dynamic and essential components of the amyloid hypothesis

scientific article published in May 2013

Microglia inflict delayed brain injury after subarachnoid hemorrhage.

scientific article

Microglia/macrophages promote glioma progression ⬇️

scientific article published on December 29, 2010

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice.

scientific article published on 9 April 2010

Modeling multiple sclerosis in laboratory animals.

scientific article published on 03 October 2009

Nuclear actin aggregation is a hallmark of anti-synthetase syndrome-induced dysimmune myopathy.

scientific article published on 6 March 2015

Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.

scientific article

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

scientific article published on 30 November 2020

Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies

scientific article

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib—A Phase II Trial ⬇️

scientific article published on April 6, 2011

Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project

scientific article published on 2 February 2018

Phospho-AXL is widely expressed in glioblastoma and associated with significant shorter overall survival.

scientific article published on 13 June 2017

Pipestem capillaries in necrotizing myopathy revisited ⬇️

scientific article published on October 25, 2012

Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients ⬇️

scientific article published on 05 June 2019

Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance ⬇️

scientific article published on March 15, 2013

Proposal for a New Grading of Moyamoya Disease in Adult Patients ⬇️

scientific article published on May 11, 2011

Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress

scientific article

Proximal weakness in a patient with MALT lymphoma: a case report and discussion of possible pathogenesis.

scientific article published on 19 May 2015

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

scientific article

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors.

scientific article published on 30 December 2015

TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma

scientific article published on 23 March 2021

Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis.

scientific article published on 25 February 2015

The 4q12 amplicon in malignant peripheral nerve sheath tumors: consequences on gene expression and implications for sunitinib treatment

scientific article

The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin

scientific article published on 28 April 2020

The evolution of the anaplastic cerebellar liponeurocytoma: case report and review of the literature

scientific article published on January 2015

The most fulminant course of the Marburg variant of multiple sclerosis-autopsy findings

scientific article published on 2 June 2014

The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

scientific article published in 2024

[CORRECTION] High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.

scientific article published in March 2018

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