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List of works by Sylvaine You

A selective CD28 antagonist and rapamycin synergise to protect against spontaneous autoimmune diabetes in NOD mice

scientific article published on 29 May 2018

Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment

scholarly article

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells

scientific article

CD3 antibodies as unique tools to restore self-tolerance in established autoimmunity their mode of action and clinical application in type 1 diabetes

scientific article published on January 2008

Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet allograft acceptance

scientific article published on 24 September 2014

Control of Immune Response to Allogeneic Embryonic Stem Cells by CD3 Antibody-Mediated Operational Tolerance Induction

scientific article published on 22 October 2015

Delayed Anti-CD3 Therapy Results in Depletion of Alloreactive T Cells and the Dominance of Foxp3+CD4+ Graft Infiltrating Cells ⬇️

scientific article published on June 10, 2013

Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides.

scientific article published in April 2003

Differential Impact of T-bet and IFNγ on Pancreatic Islet Allograft Rejection

scientific article published on 01 September 2018

Differential sensitivity of regulatory and effector T cells to cell death: a prerequisite for transplant tolerance.

scientific article published on 19 May 2015

Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases

scientific article

Engagement of TLR2 Reverses the Suppressor Function of Conjunctiva CD4+CD25+Regulatory T Cells and Promotes Herpes Simplex Virus Epitope-Specific CD4+CD25−Effector T Cell Responses ⬇️

scientific article published on May 17, 2011

Feeding NOD mice with pig splenocytes induces transferable mechanisms that modulate cellular and humoral xenogeneic reactions against pig spleen or islet cells

scientific article published on 01 March 2002

Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection.

scientific article published on 2 May 2007

Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance

scientific article published on 01 February 2011

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

scientific article

Immunoregulatory pathways controlling progression of autoimmunity in NOD mice

scientific article

In vitro xenorecognition of adult pig pancreatic islet cells by splenocytes from nonobese diabetic or non-diabetes-prone mice

scientific article published on 01 September 1998

Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing.

scientific article

Intragraft mechanisms associated with the immunosuppressive versus the tolerogenic effect of CD3 antibodies in a mouse model of islet allografts.

scientific article

Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target

scientific article (publication date: 20 November 2009)

Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice

scientific article published on 13 October 2017

Perifusion analysis of insulin secretion from specific pathogen-free large-white pig islets shows satisfactory functional characteristics for xenografts in humans

scientific article published on June 1, 1998

Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice.

scientific article published in December 2004

Proinsulin: a unique autoantigen triggering autoimmune diabetes.

scientific article

Regulatory mechanisms of immune tolerance in type 1 diabetes and their failures

scientific article published on 20 May 2016

Revisiting the phenotypic and genetic profiling of anergic T cells mediating long-term transplant tolerance.

scientific article published on 30 November 2017

Spleen cells of non-obese diabetic mice fed with pig splenocytes display modified proliferation and reduced aggressiveness in vitro against pig islet cells.

scientific article published on August 1998

TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance

scientific article published on 29 January 2016

The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4+ T cells

scientific article published on 6 March 2017

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

scientific article published on 01 June 2006

Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes

scientific article

Tryptophan catabolism generates autoimmune-preventive regulatory T cells

scientific article published on 10 October 2006

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