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List of works by Jung-Hyun Shim

(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase

scientific article published on 07 August 2008

(3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo.

scientific article published on September 2011

(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity

scientific article published on 06 December 2019

2,4-bis (p-hydroxyphenyl)-2-butenal (HPB242) induces apoptosis via modulating E7 expression and inhibition of PI3K/Akt pathway in SiHa human cervical cancer cells.

scientific article

Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways

scientific article published on 18 September 2020

Althaea rosea Cavanil and Plantago major L. suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase

scientific article

Anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal are mediated by inhibition of the STAT3 pathway

scientific article

Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1.

scientific article published on 22 July 2013

Anti-proliferative properties of kahweol in oral squamous cancer through the regulation specificity protein 1.

scientific article published on 8 September 2014

Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor

scientific article published on 22 February 2017

Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway ⬇️

scientific article published on June 17, 2010

Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1.

scientific article

Apoptotic effects of 7,8-dihydroxyflavone in human oral squamous cancer cells through suppression of Sp1.

scientific article

Beta-Lapachone Suppresses Non-small Cell Lung Cancer Proliferation through the Regulation of Specificity Protein 1.

scientific article published on January 2015

COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer

scientific article

Caspase-3 activation as a key factor for HBx-transformed cell death.

scientific article published on October 2008

Cell growth inhibition by 3-deoxysappanchalcone is mediated by directly targeting the TOPK signaling pathway in colon cancer

scientific article published on 31 December 2018

Chemical regulation of signaling pathways to programmed necrosis

scientific article published on 10 April 2014

Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1

scientific article published on 01 March 2011

Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells

scientific article published on 01 September 2011

Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG)

scientific article

Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT.

scientific article published on 02 October 2014

Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity

scientific article

Cytoprotective effects of esculetin against oxidative stress are associated with the upregulation of Nrf2-mediated NQO1 expression via the activation of the ERK pathway.

scientific article published on 16 December 2016

Deoxypodophyllotoxin, a Lignan from Anthriscus sylvestris, Induces Apoptosis and Cell Cycle Arrest by Inhibiting the EGFR Signaling Pathways in Esophageal Squamous Cell Carcinoma Cells

scientific article published on 18 September 2020

Development of PCR-ELISA for the detection of hepatitis B virus x gene expression and clinical application.

scientific article

Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells.

scientific article published on 20 March 2013

Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma.

scientific article

Downregulation of immune response by the human cytokines Interleukin-32alpha and beta in cell-mediated rejection.

scientific article published on 11 June 2010

Dual inhibition of EGFR and MET by Echinatin retards cell growth and induces apoptosis of lung cancer cells sensitive or resistant to gefitinib

scientific article published on 07 November 2019

Effects of Cellular 11β-hydroxysteroid Dehydrogenase 1 on LPS-induced Inflammatory Responses in Synovial Cell Line, SW982.

scientific article

Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1.

scientific article

Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1

scientific article

Esculetin (6,7-dihydroxycoumarin): a potential cancer chemopreventive agent through suppression of Sp1 in oral squamous cancer cells

scientific article published on 07 October 2014

Esculetin Induces Apoptosis Through EGFR/PI3K/Akt Signaling Pathway and Nucleophosmin Relocalization.

scientific article published on 8 October 2015

Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro

scientific article published on 30 November 2016

HPLC Analysis, Optimization of Extraction Conditions and Biological Evaluation of Corylopsis coreana Uyeki Flos.

scientific article published on 15 January 2016

Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity.

scientific article

Herbacetin suppresses cutaneous squamous cell carcinoma and melanoma cell growth by targeting AKT and ODC.

scientific article

Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells

scientific article published on May 2012

Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation.

scientific article

IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals.

scientific article

Identification and Extraction Optimization of Active Constituents in Seib ex TANAKA Peel and Its Biological Evaluation

scientific article published on 14 February 2019

Identification of the biologically active constituents of Camellia japonica leaf and anti-hyperuricemic effect in vitro and in vivo.

scientific article published on 3 May 2017

In vitro apoptotic effects of methanol extracts of Dianthus chinensis and Acalypha australis L. targeting specificity protein 1 in human oral cancer cells.

scientific article

Inhibition of myeloid cell leukemia-1 by tolfenamic acid induces apoptosis in mucoepidermoid carcinoma.

scientific article published on 23 December 2010

Isolinderalactone Induces Cell Death via Mitochondrial Superoxide- and STAT3-Mediated Pathways in Human Ovarian Cancer Cells

scientific article published on 13 October 2020

JAK2 regulation by licochalcone H inhibits the cell growth and induces apoptosis in oral squamous cell carcinoma

scientific article published on 18 September 2018

Janus kinase 2 inhibition by Licochalcone B suppresses esophageal squamous cell carcinoma growth

scientific article published on 06 March 2020

KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression.

scientific article published in January 2010

Kahweol induces apoptosis by suppressing BTF3 expression through the ERK signaling pathway in non-small cell lung cancer cells.

scientific article published on 12 October 2016

Licochalcone A Suppresses Specificity Protein 1 as a Novel Target in Human Breast Cancer Cells.

scientific article published on 12 May 2017

Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway.

scientific article

Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma.

scientific article

Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways

scientific article published on February 2016

Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET

scientific article published on 05 July 2019

Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells by regulation of the JAK2/STAT3 signaling pathway

scientific article published on 20 August 2018

Licochalcone C induces cell cycle G1 arrest and apoptosis in human esophageal squamous carcinoma cells by activation of the ROS/MAPK signaling pathway

scientific article published on 03 February 2020

Licochalcone D Induces ROS-Dependent Apoptosis in Gefitinib-Sensitive or Resistant Lung Cancer Cells by Targeting EGFR and MET

scientific article published on 13 February 2020

Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma

scientific article published on 02 August 2018

Licochalcone H Synthesized by Modifying Structure of Licochalcone C Extracted from Glycyrrhiza inflata Induces Apoptosis of Esophageal Squamous Cell Carcinoma Cells

scientific article published on 09 November 2019

Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma

scientific article published on 8 September 2015

Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway

scientific article published on 10 May 2016

Multifunctional effects of honokiol as an anti-inflammatory and anti-cancer drug in human oral squamous cancer cells and xenograft.

scientific article published on 16 March 2015

Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells

scientific article

Optimization of the Extraction Conditions and Biological Evaluation of H. Lev as an Anti-Hyperuricemic Source

scientific article published on 14 December 2018

Oridonin induces apoptosis in oral squamous cell carcinoma probably through the generation of reactive oxygen species and the p38/JNK MAPK pathway.

scientific article published on 16 March 2018

Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation

scientific article

Phosphorylation of PrxII promotes JNK-dependent apoptosis in adult cloned pig kidney.

scientific article published on 5 June 2014

Picropodophyllotoxin, an Epimer of Podophyllotoxin, Causes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells Through ROS-Mediated JNK/P38 MAPK Pathways ⬇️

scientific article published on 30 June 2020

Protective effect of oxidative stress in HaCaT keratinocytes expressing E7 oncogene.

scientific article

Protein profiling and identification of modulators regulated by human papillomavirus 16 E7 oncogene in HaCaT keratinocytes by proteomics.

scientific article

Proteomic Assessment of the Relevant Factors Affecting Pork Meat Quality Associated with Longissimus dorsi Muscles in Duroc Pigs.

scientific article

Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1).

scientific article published on 25 January 2015

RSK2 mediates muscle cell differentiation through regulation of NFAT3.

scientific article

Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.

scientific article

Regional Differences of Proteins Expressing in Adipose Depots Isolated from Cows, Steers and Bulls as Identified by a Proteomic Approach.

scientific article published on 22 April 2016

Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53.

scientific article

Retrochalcone Echinatin Triggers Apoptosis of Esophageal Squamous Cell Carcinoma via ROS- and ER Stress-Mediated Signaling Pathways

scientific article published on 09 November 2019

Rhein exhibits antitumorigenic effects by interfering with the interaction between prolyl isomerase Pin1 and c-Jun.

scientific article

Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells.

scientific article

Role of transcription factor Sp1 in the 4-O-methylhonokiol-mediated apoptotic effect on oral squamous cancer cells and xenograft.

scientific article published on 15 May 2015

Role of transcription factor Sp1 in the quercetin-mediated inhibitory effect on human malignant pleural mesothelioma

scientific article

Specificity protein 1 is a novel target of 2,4-bis (p-hydroxyphenyl)-2-butenal for the suppression of human oral squamous cell carcinoma cell growth.

scientific article published on 15 January 2014

Structural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2

scientific article

TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2.

scientific article

Targeting ROCK/LIMK/cofilin signaling pathway in cancer

scientific article published on 27 April 2019

The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma.

scientific article published on 18 July 2013

The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation.

scientific article published on 23 January 2009

[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase

scientific article

c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer.

scientific article published on 09 February 2009

β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1.

scientific article published on 20 November 2015

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