List of works - Stéphane Fourcade

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

scientific article published on 14 October 2008

A novel hypomorphic splice variant in EIF2B5 gene is associated with mild ovarioleukodystrophy

scientific article published on 15 August 2020

ABCD2 alters peroxisome proliferator-activated receptor α signaling in vitro, but does not impair responses to fenofibrate therapy in a mouse model of diet-induced obesity

scientific article

Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

scientific article published on 01 August 2018

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.

scientific article

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

scientific article

Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.

scientific article

Bezafibrate lowers very long‐chain fatty acids in X‐linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation ⬇️

scientific article published on March 24, 2012

Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study

scientific article published on 01 October 2019

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

scientific article

Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation.

scientific article published on 24 February 2018

Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy

scientific article published on 17 November 2011

High-dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy

scientific article published on 08 June 2020

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

scientific article published on 20 April 2013

Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor

scientific article

Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice.

scientific article

Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

scientific article published on 5 October 2017

Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy

scientific article published on 11 February 2019

Mitochondrial dysfunction and oxidative damage cooperatively fuel axonal degeneration in X-linked adrenoleukodystrophy.

scientific article published on 24 September 2013

Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy

scientific article

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease

scientific article

Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy

scientific article

Oxidative stress regulates the ubiquitin-proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy.

scientific article published in March 2013

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

scientific article

PeroxisomeDB: a database for the peroxisomal proteome, functional genomics and disease

scientific article published on 28 November 2006

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

scientific article

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

scientific article

Steroid hormones control circadian Elovl3 expression in mouse liver.

scientific article published on 21 February 2008

Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy

scientific article published on 21 December 2016

The evolutionary origin of peroxisomes: an ER-peroxisome connection.

scientific article

Thyroid hormone induction of the adrenoleukodystrophy-related gene (ABCD2).

scientific article published in June 2003

Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy

scientific article published on 23 February 2010

List of works by Stéphane Fourcade

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

A novel hypomorphic splice variant in EIF2B5 gene is associated with mild ovarioleukodystrophy

ABCD2 alters peroxisome proliferator-activated receptor α signaling in vitro, but does not impair responses to fenofibrate therapy in a mouse model of diet-induced obesity

Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.

Bezafibrate lowers very long‐chain fatty acids in X‐linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation ⬇️

Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation.

Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy

High-dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor

Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice.

Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy

Mitochondrial dysfunction and oxidative damage cooperatively fuel axonal degeneration in X-linked adrenoleukodystrophy.

Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease

Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy

Oxidative stress regulates the ubiquitin-proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy.

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

PeroxisomeDB: a database for the peroxisomal proteome, functional genomics and disease

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

Steroid hormones control circadian Elovl3 expression in mouse liver.

Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy

The evolutionary origin of peroxisomes: an ER-peroxisome connection.

Thyroid hormone induction of the adrenoleukodystrophy-related gene (ABCD2).

Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy