List of works - Graham M Lord

A central role for monocytes in Toll-like receptor-mediated activation of the vasculature

scientific article published in September 2009

A global call for action to include gender in research impact assessment

scientific article published on 19 July 2016

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.

scientific article

A strategy for translation

scientific article published in The Lancet

Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

scientific article

An imaging flow cytometric method for measuring cell division history and molecular symmetry during mitosis.

scientific article published on 2 June 2011

Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.

scientific article published on 13 April 2007

Aristolochic acid nephropathy

scientific article published on 15 June 2012

Assessment of regulatory T-cell function in forthcoming clinical trials of cell therapy.

scientific article published on January 2013

Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres

scientific article published on 20 November 2019

Balancing susceptibility to infection and autoimmunity: a role for leptin?

scientific article published on 01 April 2002

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

scientific article

Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

scientific article published on 21 June 2016

Boosting translational research in the U.K.

scientific article published on September 2016

CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.

scientific article published on 12 December 2014

Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells

scientific article published on September 2009

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system

scientific article

Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation.

scientific article published on 11 April 2013

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

scientific article

Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α

scientific article published on 30 January 2019

Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses

scientific article published on 9 February 2011

Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.

scientific article

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

scientific article

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

scientific article

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

scientific article published on 02 March 2019

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

scientific article published on 25 June 2015

Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression

scientific article published on 17 August 2020

Genetic loci influencing kidney function and chronic kidney disease

scientific article

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

scientific article

Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4.

scientific article

Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis

scientific article

Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

scientific article published on 20 January 2017

How might a diagnostic microRNA signature be used to speed up the diagnosis of sepsis?

scientific article published on 01 April 2014

IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses

scientific article published on 22 January 2016

IMMUNOMODULATORY ROLE OF KERATIN 76 IN ORAL AND GASTRIC CANCER

scholarly article published 21 April 2018

Immune biomarkers: the promises and pitfalls of personalized medicine.

scientific article published on 27 March 2015

Immunomodulatory role of Keratin 76 in oral and gastric cancer

scientific article published in Nature Communications

Immunotherapy

scientific article published on 01 January 1999

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

scholarly article

Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients

scientific article published on 28 July 2016

Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis.

scientific article published in July 2000

Integration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery.

scientific article

Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation.

scientific article

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

scientific article published on 02 December 2019

Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines.

scientific article published in August 2002

Leptin prevents the fall in plasma osteocalcin during starvation in male mice.

scientific article

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

scientific article

Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study

scientific article published in February 2018

Lyoplate-based multiparameter flow cytometry for the analysis of T cell subsets in human immuno-monitoring studies.

scientific article published on 23 November 2011

MAGI2 Mutations Cause Congenital Nephrotic Syndrome

scientific article published on 8 December 2016

Markers of achievement for assessing and monitoring gender equity in translational research organisations: a rationale and study protocol

scientific article

MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function

scientific article published on 21 May 2021

Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension

scientific article published on 11 October 2011

Monocytes control natural killer cell differentiation to effector phenotypes

scientific article published on 9 March 2011

Multiple Cladosporium brain abscesses in a renal transplant patient: aggressive management improves outcome

scientific article published on 01 January 1997

Nephropathy caused by Chinese herbs in the UK

scientific article published on 01 August 1999

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.

scholarly article

Plasma immunoreactive leptin concentration in end-stage renal disease.

scientific article published in August 1997

Preventing aristolochic acid nephropathy.

scientific article published on 13 January 2015

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

scientific article published on 07 January 2020

Regulatory T-cell therapy in Crohn's disease: challenges and advances

scientific article published on 24 January 2020

Relative roles of Th1 and Th17 effector cells in allograft rejection.

scientific article published on February 2009

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis.

scientific article published on May 2001

Response to LTE 19-01163

scientific article published on 05 October 2019

Retinoic Acid Signaling in B Cells Is Required for the Generation of an Effective T-Independent Immune Response

scientific article published on 23 December 2016

Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program

scientific article

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis

scientific article

Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8 effector recruitment to mucosal tissues

scientific article published on 17 May 2019

Spontaneous spinal epidural haematoma: a cautionary tale.

scientific article

Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation.

scientific article published on 7 February 2018

Strategies for translational research in the United Kingdom

scientific article published on 01 October 2010

T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

scientific article published on 7 June 2016

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.

scientific article published on January 2012

T-bet as a key regulator of mucosal immunity.

scientific article published on 04 January 2016

T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function

article

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.

scientific article published on 12 July 2005

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

scientific article

T-bet: a bridge between innate and adaptive immunity.

scientific article published on 11 October 2013

The bioenergetics of the immune system.

scientific article

The challenges of stratifying patients for trials in inflammatory bowel disease.

scientific article published on 10 September 2013

The genetic determinants of renal allograft rejection

scientific article published on 28 May 2018

The immune cell transcription factor T-bet: A novel metabolic regulator.

scientific article published on 28 August 2013

The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population

scientific article published on 28 March 2019

The peritoneal fluid concentration of leptin is increased in women with peritoneal but not ovarian endometriosis

scientific article published on 01 June 2001

The transcription T-bet is required for optimal proinflammatory trafficking of CD4+ T cells.

scientific article published on 17 February 2005

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

scientific article published on 24 March 2014

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

scientific article published on 11 October 2012

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

scientific article

The unusual suspects--innate lymphoid cells as novel therapeutic targets in IBD.

scientific article published on May 2015

Transcriptional control of natural killer cell differentiation and function.

scientific article published on 24 August 2011

Transcriptional regulation of the mucosal immune system mediated by T-bet.

scientific article published on 15 September 2010

Translational medicine and the NIHR Biomedical Research Centre concept

scientific article published on 08 August 2008

Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells.

scientific article

microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance

scientific article published on 11 February 2019

List of works by Graham M Lord

A central role for monocytes in Toll-like receptor-mediated activation of the vasculature

A global call for action to include gender in research impact assessment

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.

A strategy for translation

Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

An imaging flow cytometric method for measuring cell division history and molecular symmetry during mitosis.

Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.

Aristolochic acid nephropathy

Assessment of regulatory T-cell function in forthcoming clinical trials of cell therapy.

Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres

Balancing susceptibility to infection and autoimmunity: a role for leptin?

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

Boosting translational research in the U.K.

CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.

Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system

Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation.

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α

Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses

Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression

Genetic loci influencing kidney function and chronic kidney disease

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4.

Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis

Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

How might a diagnostic microRNA signature be used to speed up the diagnosis of sepsis?

IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses

IMMUNOMODULATORY ROLE OF KERATIN 76 IN ORAL AND GASTRIC CANCER

Immune biomarkers: the promises and pitfalls of personalized medicine.

Immunomodulatory role of Keratin 76 in oral and gastric cancer

Immunotherapy

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients

Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis.

Integration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery.

Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation.

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines.

Leptin prevents the fall in plasma osteocalcin during starvation in male mice.

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study

Lyoplate-based multiparameter flow cytometry for the analysis of T cell subsets in human immuno-monitoring studies.

MAGI2 Mutations Cause Congenital Nephrotic Syndrome

Markers of achievement for assessing and monitoring gender equity in translational research organisations: a rationale and study protocol

MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function

Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension

Monocytes control natural killer cell differentiation to effector phenotypes

Multiple Cladosporium brain abscesses in a renal transplant patient: aggressive management improves outcome

Nephropathy caused by Chinese herbs in the UK

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.

Plasma immunoreactive leptin concentration in end-stage renal disease.

Preventing aristolochic acid nephropathy.

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

Regulatory T-cell therapy in Crohn's disease: challenges and advances

Relative roles of Th1 and Th17 effector cells in allograft rejection.

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis.

Response to LTE 19-01163

Retinoic Acid Signaling in B Cells Is Required for the Generation of an Effective T-Independent Immune Response

Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis

Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8 effector recruitment to mucosal tissues

Spontaneous spinal epidural haematoma: a cautionary tale.

Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation.

Strategies for translational research in the United Kingdom

T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.

T-bet as a key regulator of mucosal immunity.

T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

T-bet: a bridge between innate and adaptive immunity.

The bioenergetics of the immune system.