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List of works by Mats Larhed

(11)C-Labeling of a potent hydroxyethylamine BACE-1 inhibitor and evaluation in vitro and in vivo.

scientific article

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

scholarly article by Benjamin Pelcman published in August 2015

A Series of Analogues to the ATR Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

scientific article published on 24 January 2019

A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes.

scientific article published on 24 November 2017

A new highly asymmetric chelation-controlled heck arylation

scientific article published in March 2003

A new regioselective Heck vinylation with enamides. Synthesis and investigation of fluorous-tagged bidentate ligands for fast separation

scientific article

A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-substituted P1/P1' side chains

scientific article

A one-pot isomerization-arylation of 2,3-epoxycyclohexanone under controlled microwave heating

scientific article published in June 2005

A rapid microwave protocol for Heck vinylation of aryl chlorides under air.

scientific article published in January 2003

A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones

scientific article published on 27 May 2009

Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket

scientific article

Aminocarbonylation of 4-iodo-1H-imidazoles with an amino acid amide nucleophile: synthesis of constrained H-Phe-Phe-NH2 analogues

scientific article

Aminocarbonylations employing Mo(CO)6 and a bridged two-vial system: allowing the use of nitro group substituted aryl iodides and aryl bromides

scientific article published on 12 December 2012

An efficient method to perform milliliter-scale PCR utilizing highly controlled microwave thermocycling

scientific article published on 08 March 2004

Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity

scientific article published on October 2005

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

scientific article

Arylboronic acids as versatile coupling partners in fast microwave promoted oxidative Heck chemistry

scientific article published in January 2003

Aspartic protease inhibitors containing tertiary alcohol transition-state mimics

scientific article

Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density

scientific article published on 14 January 2016

Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer

scientific article published on 14 September 2019

Chelation-mediated palladium(II)-catalyzed domino Heck-Mizoroki/Suzuki-Miyaura reactions using arylboronic acids: increasing scope and mechanistic understanding.

scientific article published on 21 March 2011

DXR inhibition by potent mono- and disubstituted fosmidomycin analogues

scientific article

Decarboxylative palladium(II)-catalyzed synthesis of aryl amidines from aryl carboxylic acids: development and mechanistic investigation.

scientific article published on 28 August 2013

Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic

scientific article

Design and synthesis of P1-P3 macrocyclic tertiary-alcohol-comprising HIV-1 protease inhibitors

scientific article

Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase

scientific article

Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β,α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids

scientific article

Dimethylformamide as a carbon monoxide source in fast palladium-catalyzed aminocarbonylations of aryl bromides

scientific article

Dioxygen-promoted regioselective oxidative heck arylations of electron-rich olefins with arylboronic acids

scientific article

Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates

scientific article

Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages

scientific article published on 16 December 2019

Discovery of achiral inhibitors of the hepatitis C virus NS3 protease based on 2(1H)-pyrazinones.

scientific article

ESI-MS detection of proposed reaction intermediates in the air-promoted and ligand-modulated oxidative Heck reaction

scientific article published on 01 November 2006

Easy-to-execute carbonylations: microwave synthesis of acyl sulfonamides using Mo(CO)(6) as a solid carbon monoxide source.

scientific article

Efficient palladium(II) catalysis under air. Base-free oxidative heck reactions at room temperature or with microwave heating

scientific article published on 21 September 2007

Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

scientific article

Fast synthesis of aryl triflates with controlled microwave heating

scientific article

Fast, acid-free, and selective lactamization of lactones in ionic liquids

scientific article published on 01 October 2008

Formamide as a combined ammonia synthon and carbon monoxide source in fast palladium-catalyzed aminocarbonylations of aryl halides

scientific article

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

scientific article published on 15 October 2020

Front Cover: Synthesis of 4H‐Benzo[e][1,3]oxazin‐4‐ones by a Carbonylation–Cyclization Domino Reaction of ortho‐Halophenols and Cyanamide (ChemistryOpen 5/2017).

scientific article published on 6 September 2017

Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors.

scientific article published on 14 June 2009

HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells

scientific article

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

scientific article published on 01 July 2020

High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26.

scientific article published on 10 August 2017

High stereoselectivity in chelation-controlled intermolecular Heck reactions with aryl chlorides, vinyl chlorides and vinyl triflates

scientific article

High-speed heck reactions in ionic liquid with controlled microwave heating

scientific article

High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II.

scientific article published in July 2003

High-speed synthesis of potent C2-symmetric HIV-1 protease inhibitors by in-situ aminocarbonylations

scientific article published in July 2005

Highly regioselective internal heck arylation of hydroxyalkyl vinyl ethers by aryl halides in water

scientific article

Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening

scientific article

In situ generation of carbon monoxide from solid molybdenum hexacarbonyl. A convenient and fast route to palladium-catalyzed carbonylation reactions

scientific article published on 01 March 2002

In vitro and in vivo evaluation of a (18)F-labeled high affinity NOTA conjugated bombesin antagonist as a PET ligand for GRPR-targeted tumor imaging

scientific article (publication date: 2013)

Increasing rates and scope of reactions: sluggish amines in microwave-heated aminocarbonylation reactions under air.

scientific article published on July 2003

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

scientific article published on 21 November 2014

Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors ⬇️

scientific article published on November 26, 2010

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

scientific article

Masked 3-aminoindan-1-ones by a palladium-catalyzed three-component annulation reaction

scientific article

Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors

Microwave-accelerated homogeneous catalysis in organic chemistry

scientific article

Microwave-accelerated spiro-cyclizations of o-halobenzyl cyclohexenyl ethers by palladium(0) catalysis

scientific article published on 28 June 2007

Microwave-accelerated synthesis of P1'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold

scientific article

Microwave-assisted high-speed PCR.

scientific article

Microwave-assisted synthesis of Weinreb and MAP aryl amides via Pd-catalyzed Heck aminocarbonylation using Mo(CO)6 or W(CO)6

scientific article published on 13 January 2011

Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C.

scientific article

Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

scientific article published in November 2007

Microwave-enhanced aminocarbonylations in water

scientific article published on 01 July 2005

Microwave-enhanced and metal-catalyzed functionalizations of the 4-aryl-dihydropyrimidone template.

scientific article published in July 2005

Microwave-enhanced carbonylative generation of indanones and 3-acylaminoindanones.

scientific article

Microwave-enhanced copper-catalyzed N-arylation of free and protected amino acids in water

scientific article

Microwave-enhanced medicinal chemistry: a high-speed opportunity for convenient preparation of protease inhibitors

scientific article

Microwave-promoted aminocarbonylations of aryl chlorides using Mo(CO)(6) as a solid carbon monoxide source

scientific article published in January 2006

Microwave-promoted and chelation-controlled double arylations of terminal olefinic carbon of vinyl ethers

scientific article

Microwave-promoted palladium(II)-catalyzed C-P bond formation by using arylboronic acids or aryltrifluoroborates

scientific article published in December 2009

Molybdenum Hexacarbonyl Mediated CO Gas-Free Carbonylative Reactions

scholarly article by Luke Odell et al published 10 February 2012 in Synlett

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

scientific article published on 07 November 2020

N-Aryl Isoleucine Derivatives as Angiotensin II AT2 Receptor Ligands

scientific article

N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase

scholarly article by Benjamin Pelcman published in August 2015

Non-peptide AT2-receptor agonists

scientific article published on 15 December 2010

One-pot, two-step, microwave-assisted palladium-catalyzed conversion of aryl alcohols to aryl fluorides via aryl nonaflates

scientific article

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents.

scientific article published on 17 April 2015

Optimizing solubility and permeability of a biopharmaceutics classification system (BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice.

scientific article

Oxidative Heck Reactions using Aryltrifluoroborates and Aryl N-Methyliminodiacetic Acid (MIDA) Boronates

scientific article

Palladium(0)-Catalyzed Carbonylative One-Pot Synthesis of N-Acylguanidines

scientific article

Palladium(II)-catalyzed coupling reactions with a chelating vinyl ether and arylboronic acids: a new Heck/Suzuki domino diarylation reaction.

scientific article published on 5 November 2009

Palladium(II)-catalyzed desulfitative synthesis of aryl ketones from sodium arylsulfinates and nitriles: scope, limitations, and mechanistic studies

scientific article published on 31 October 2014

Protected indanones by a Heck-aldol annulation reaction

scientific article

Rapid and Efficient Conversion of (11) CO2 to (11) CO through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations.

scientific article published on 23 October 2015

Rapid palladium-catalyzed synthesis of esters from aryl halides utilizing Mo(CO)(6) as a solid carbon monoxide source

scientific article

Regio- and Stereo-Selective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via Intramolecular Mizoroki-Heck Reaction

scientific article published on 21 February 2020

Regio- and Stereoselective Synthesis of Functionalized Cyclopentene Derivatives via Mizoroki-Heck Reactions.

scientific article

Regiochemical Control and Suppression of Double Bond Isomerization in the Heck Arylation of 1-(Methoxycarbonyl)-2,5-dihydropyrrole

scientific article published on 01 July 1996

Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation

scientific article

Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.

scientific article published on 09 March 2016

Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction.

scientific article

Selective terminal heck arylation of vinyl ethers with aryl chlorides: a combined experimental-computational approach including synthesis of betaxolol

scientific article

Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity

scientific article published on 12 January 2015

Stereoselective synthesis of 3-aminoindan-1-ones and subsequent incorporation into HIV-1 protease inhibitors

scientific article published in February 2006

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

scientific article published on 25 April 2018

Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

scientific article published on 02 June 2020

Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

scientific article

Structural features determining the intestinal epithelial permeability and efflux of novel HIV-1 protease inhibitors

scientific article

Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis

scientific article published on 20 July 2011

Syntheses of new tuberculosis inhibitors promoted by microwave irradiation

scientific article

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

scientific article published on 23 July 2019

Synthesis and characterization of a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging.

scientific article published on 2 July 2013

Synthesis and evaluation of isoleucine derived angiotensin II AT(2) receptor ligands.

scientific article published on 18 December 2013

Synthesis and in vitro evaluation of 5-substituted benzovesamicol analogs containing N-substituted amides as potential positron emission tomography tracers for the vesicular acetylcholine transporter

scientific article

Synthesis and labeling of a piperazine-based library of ¹¹C-labeled ligands for imaging of the vesicular acetylcholine transporter.

scientific article

Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

scientific article published on 13 April 2019

Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation.

scientific article published on 10 October 2017

Synthesis of 11C-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [11C]CO.

scientific article published on 05 October 2016

Synthesis of 4-quinolones via a carbonylative Sonogashira cross-coupling using molybdenum hexacarbonyl as a CO source.

scientific article published on 21 January 2015

Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide ⬇️

scientific article published on 7 September 2017

Synthesis of 4H-Benzo[e][1,3]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho-Halophenols and Cyanamide.

scientific article published on 16 August 2017

Synthesis of Aryl Ketones by Palladium(II)‐Catalyzed Decarboxylative Addition of Benzoic Acids to Nitriles ⬇️

scientific article published on October 11, 2010

Synthesis of P1'-functionalized macrocyclic transition-state mimicking HIV-1 protease inhibitors encompassing a tertiary alcohol

scientific article

Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

scientific article

Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors

scientific article published on 7 October 2011

Synthesis of styrenes by palladium(II)-catalyzed vinylation of arylboronic acids and aryltrifluoroborates by using vinyl acetate

scientific article

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors

scientific article published on 02 March 2020

Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

scientific article

Temperature measurements with two different IR sensors in a continuous-flow microwave heated system

scientific article published on 10 October 2013

The effect of macrocyclic chelators on the targeting properties of the 68Ga-labeled gastrin releasing peptide receptor antagonist PEG2-RM26.

scientific article

The effect of mini-PEG-based spacer length on binding and pharmacokinetic properties of a 68Ga-labeled NOTA-conjugated antagonistic analog of bombesin.

scientific article published on 17 July 2014

The first ligand-modulated oxidative Heck vinylation. Efficient catalysis with molecular oxygen as palladium(0) oxidant

scientific article

Transmetallation Versus β‐Hydride Elimination: The Role of 1,4‐Benzoquinone in Chelation‐Controlled Arylation Reactions with Arylboronic Acids ⬇️

scientific article published on February 28, 2012

Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177 Lu-DOTAGA-PEG2 -RM26.

scientific article published on 11 May 2019

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

scientific article

Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic

scientific article

Ultrafast chemistry: cobalt carbonyl-mediated synthesis of diaryl ketones under microwave irradiation

scientific article published on 01 December 2003

Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

scientific article

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

scientific article published on 7 August 2015

alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases

scientific article published on 3 July 2009

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