List of works - José Miguel Vela

5-HT6 receptor signal transduction second messenger systems

scientific article published on January 2010

5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.

scientific article

A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands

scientific article published on 01 January 2006

Antinociception by Sigma-1 Receptor Antagonists: Central and Peripheral Effects.

scientific article published on 27 January 2016

Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats

scientific article published on 24 June 2016

COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature.

scientific article published on March 2009

Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling.

scientific article published in November 2002

Changes in saccharin preference behavior as a primary outcome to evaluate pain and analgesia in acetic acid-induced visceral pain in mice

scientific article

Co-crystals as a new approach to multimodal analgesia and the treatment of pain

scientific article published on 04 September 2019

Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice.

scientific article published in March 2018

Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding

scientific article published on 01 August 1994

Dynamics of microglia in the developing rat brain.

scientific article published in March 2003

Effects of centrally acting analgesics on spinal segmental reflexes and wind-up.

scientific article

Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats

scientific article published on 29 January 2014

Evaluation of formalin-induced pain behavior and glutamate release in the spinal dorsal horn using in vivo microdialysis in conscious rats

scientific article published on 15 September 2012

Expression of purine metabolism-related enzymes by microglial cells in the developing rat brain.

scientific article published in August 1998

Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice

scientific article published on 11 February 2014

Immunohistochemical localization of the sigma1 receptor in Schwann cells of rat sciatic nerve.

scientific article published in May 2004

Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system.

scientific article published in January 2003

Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation.

scientific article

Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells.

scientific article

Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes.

scientific article

Investigational sigma-1 receptor antagonists for the treatment of pain.

scientific article published on 03 June 2015

LPS/IFN-gamma cytotoxicity in oligodendroglial cells: role of nitric oxide and protection by the anti-inflammatory cytokine IL-10.

scientific article published in February 2001

Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance

scientific article published on 21 April 2012

Morphological Characterization of Photochemical Graded Spinal Cord Injury in the Rat

scientific article published on 01 May 2003

Morphology and distribution of microglial cells in the young and adult mouse cerebellum

scientific article published on 01 October 1995

New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain

scientific article

Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain.

scientific article

Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain

scientific article

Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity.

scientific article

Pharmacological sensitivity of reflexive and nonreflexive outcomes as a correlate of the sensory and affective responses to visceral pain in mice

scientific article published on 18 October 2017

Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists.

scientific article published on 18 November 2009

Predicting the antinociceptive efficacy of σ(1) receptor ligands by a novel receptor fluorescence resonance energy transfer (FRET) based biosensor

scientific article published on 20 December 2013

Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice

scientific article

S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice

scientific article published on 01 June 2014

Selective sigma-1 receptor antagonists for the treatment of pain.

scientific article

Sigma 1 receptor: a new therapeutic target for pain.

scientific article published on 13 March 2013

Sigma-1 Receptor and Pain.

scientific article

Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.

scientific article published on 28 April 2013

Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.

scientific article

Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

scientific article published on 07 June 2009

Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands.

scientific article

Synthesis and pharmacological evaluation of a potent and selective σ1 receptor antagonist with high antiallodynic activity.

scientific article published on 20 May 2011

Synthesis and structure-activity relationship study of a new series of selective σ(1) receptor ligands for the treatment of pain: 4-aminotriazoles

scientific article published on 19 February 2015

Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice.

scientific article published on 26 November 2007

The microglial reaction in spinal cords of jimpy mice is related to apoptotic oligodendrocytes.

scientific article

The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats

scientific article published on 18 April 2016

The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control

scientific article published on 18 February 2015

Therapeutic action of cannabinoids in a murine model of multiple sclerosis.

scientific article published in April 2003

Time course of proliferation and elimination of microglia/macrophages in different neurodegenerative conditions.

scientific article published in November 2002

Transplanted olfactory ensheathing cells modulate the inflammatory response in the injured spinal cord

scientific article published on 01 August 2004

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse

scientific article published on 01 March 1998

[Theiler's virus encephalomyelitis infection as a model for multiple sclerosis: cytokines and pathogenic mechanisms]

scientific article published on 01 November 2002

List of works by José Miguel Vela

5-HT6 receptor signal transduction second messenger systems

5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.

A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands

Antinociception by Sigma-1 Receptor Antagonists: Central and Peripheral Effects.

Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats

COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature.

Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling.

Changes in saccharin preference behavior as a primary outcome to evaluate pain and analgesia in acetic acid-induced visceral pain in mice

Co-crystals as a new approach to multimodal analgesia and the treatment of pain

Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice.

Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding

Dynamics of microglia in the developing rat brain.

Effects of centrally acting analgesics on spinal segmental reflexes and wind-up.

Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats

Evaluation of formalin-induced pain behavior and glutamate release in the spinal dorsal horn using in vivo microdialysis in conscious rats

Expression of purine metabolism-related enzymes by microglial cells in the developing rat brain.

Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice

Immunohistochemical localization of the sigma1 receptor in Schwann cells of rat sciatic nerve.

Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system.

Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation.

Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells.

Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes.

Investigational sigma-1 receptor antagonists for the treatment of pain.

LPS/IFN-gamma cytotoxicity in oligodendroglial cells: role of nitric oxide and protection by the anti-inflammatory cytokine IL-10.

Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance

Morphological Characterization of Photochemical Graded Spinal Cord Injury in the Rat

Morphology and distribution of microglial cells in the young and adult mouse cerebellum

New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain

Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain.

Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain

Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity.

Pharmacological sensitivity of reflexive and nonreflexive outcomes as a correlate of the sensory and affective responses to visceral pain in mice

Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists.

Predicting the antinociceptive efficacy of σ(1) receptor ligands by a novel receptor fluorescence resonance energy transfer (FRET) based biosensor

Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice

S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice

Selective sigma-1 receptor antagonists for the treatment of pain.

Sigma 1 receptor: a new therapeutic target for pain.

Sigma-1 Receptor and Pain.

Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.

Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.

Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands.

Synthesis and pharmacological evaluation of a potent and selective σ1 receptor antagonist with high antiallodynic activity.

Synthesis and structure-activity relationship study of a new series of selective σ(1) receptor ligands for the treatment of pain: 4-aminotriazoles

Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice.

The microglial reaction in spinal cords of jimpy mice is related to apoptotic oligodendrocytes.

The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats

The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control

Therapeutic action of cannabinoids in a murine model of multiple sclerosis.

Time course of proliferation and elimination of microglia/macrophages in different neurodegenerative conditions.

Transplanted olfactory ensheathing cells modulate the inflammatory response in the injured spinal cord

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse

[Theiler's virus encephalomyelitis infection as a model for multiple sclerosis: cytokines and pathogenic mechanisms]