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List of works by Takashi Takahashi

A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer.

scientific article

A chemical mismatch cleavage method useful for the detection of point mutations in the p53 gene in lung cancer

scientific article

A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

scientific article published on July 2002

A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation

scientific article

A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer.

scientific article published on July 2006

ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.

scientific article published on December 2005

Aberrant DNA replication in cancer.

scientific article published on 08 August 2012

Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers

scientific article (publication date: 4 April 2002)

Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers.

scientific article published in November 2003

Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.

scientific article published on January 2006

Analysis of beta-tubulin gene alteration in human lung cancer cell lines.

scientific article published in November 2003

Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92

scientific article

Aryl radical involvement in amiodarone-induced pulmonary toxicity: investigation of protection by spin-trapping nitrones.

scientific article published on 9 January 2007

BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.

scientific article published on 9 September 2013

Blood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma

scientific article published on 10 August 2016

Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production

scientific article published on 5 August 2013

Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway.

scientific article

Characterization of high-grade neuroendocrine tumors of the lung in relation to menin mutations.

scientific article

Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways: an international validation study

scientific article

Cloning and characterization of the alternative promoter regions of the human LIMK2 gene responsible for alternative transcripts with tissue-specific expression

scientific article (publication date: 20 August 1999)

Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma

scientific article published on 16 June 2014

Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancers

scientific article

Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells ⬇️

scientific article published on May 23, 2013

Decreased expression of 14-3-3sigma in neuroendocrine tumors is independent of origin and malignant potential.

scientific article published on November 2002

Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.

scientific article

Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation ⬇️

scientific article published on August 1, 1992

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

scientific article (publication date: 6 December 2011)

Differential effect of p53 on the promoters of mouse DNA polymerase beta gene and proliferating-cell-nuclear-antigen gene

scientific article published on 01 April 1994

Differential expression of the c-kit proto-oncogene in germ cell tumours.

scientific article

Differential inactivation of caspase-8 in lung cancers.

scientific article published on January 2002

Disproportionate representation ofKRAS gene mutation in atypical adenomatous hyperplasia, but even distribution ofEGFR gene mutation from preinvasive to invasive adenocarcinomas

article

Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction

scientific article published on 30 July 2019

ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis.

scientific article

Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis

scientific article

Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer.

scientific article published in April 2008

Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation.

scientific article published on 10 January 2014

Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.

scientific article published on 20 March 2006

Expression profiling of genes regulated by TGF-beta: differential regulation in normal and tumour cells.

scientific article published on 11 April 2007

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

scientific article

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

scientific article published on 13 October 2017

Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis

scientific article

Gene expression dose-response changes in microarrays after exposure of human peripheral lung epithelial cells to nickel(II).

scientific article

Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.

scientific article

Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22-->p21.3

scientific article

Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.

scientific article published on March 2006

Helicobacter pylori infection is associated with favorable outcome in advanced gastric cancer patients treated with S-1 adjuvant chemotherapy

scientific article

Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia

scientific article published on February 1992

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma.

scientific article published on 11 January 2010

Hybrid liposomes affect cellular lipid constituents and caveolae structures ⬇️

scientific article published on December 28, 2011

Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data

scientific article

Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.

scientific article published on July 2004

Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster

scientific article

Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer

scientific article

In vitro effects of a recombinant toxin, mSCF-PE40, targeting c-kit receptors ectopically expressed in small cell lung cancers

scientific article published on 01 February 1997

Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas.

scientific article published on 5 July 2017

Inhibition of HSP90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma

scientific article published on 28 December 2020

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells.

scientific article published on 11 November 2010

Inhibitory Effects of Salinomycin on Cell Survival, Colony Growth, Migration, and Invasion of Human Non-Small Cell Lung Cancer A549 and LNM35: Involvement of NAG-1

scientific article (publication date: 2013)

Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins

scientific article

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma

scientific article

K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.

scientific article published on January 2004

LKB1 gene mutations in Japanese lung cancer patients.

scientific article published on 16 August 2007

Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1

scientific article (publication date: July 2007)

Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers.

scientific article published in December 1998

Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features.

scientific article published on 5 June 2014

Lung cancer: an ever increasing store of in-depth basic knowledge and the beginning of its clinical application

scientific article

MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility

scientific article

MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis

scientific article

Maspin expression in normal lung and non-small-cell lung cancers: cellular property-associated expression under the control of promoter DNA methylation.

scientific article published in May 2004

Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells.

scientific article published on 15 November 2010

Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis

scientific article

MicroRNAs in biological processes and carcinogenesis.

scientific article published on 6 October 2006

Molecular cloning of human TAK1 and its mutational analysis in human lung cancer

scientific journal article

Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis.

scientific article

Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications.

scientific article published in December 2004

Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence

scientific article

Mutations of the p53 tumor suppressor gene as clonal marker for multiple primary lung cancers

article

NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma

scientific article

NKX2-1/TTF-1: An Enigmatic Oncogene that Functions as a Double-Edged Sword for Cancer Cell Survival and Progression ⬇️

scientific article published on June 10, 2013

Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer.

scientific article

Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells

scientific article published on 01 July 2007

Phenotypic composition of salivary gland tumors: an application of principal [corrected] component analysis to tissue microarray data.

scientific article

Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction.

scientific article published on March 2004

Protective function of p27(KIP1) against apoptosis in small cell lung cancer cells in unfavorable microenvironments

scientific article

Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex

scientific article (publication date: 2013)

ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1

scientific article published on 4 January 2016

ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma

scientific article published on 20 March 2019

Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma

scientific article published on 12 December 2015

Reduced expression of Dicer associated with poor prognosis in lung cancer patients.

scientific article published in February 2005

Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients.

scientific article

Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

scientific article

Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.

scientific article published on 22 September 2010

Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis.

scientific article

Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses.

scientific article published on 21 April 2009

Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells

scientific article

Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer.

scientific article

SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers

scientific article published on 22 October 2013

Serum glutathione S-transferase-pi level as a tumor marker for non-small cell lung cancer. Potential predictive value in chemotherapeutic response.

scientific article

Seven-Signal Proteomic Signature for Detection of Operable Pancreatic Ductal Adenocarcinoma and Their Discrimination from Autoimmune Pancreatitis ⬇️

scientific article published on May 14, 2012

Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo.

scientific article

TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.

scientific article published on 13 February 2017

Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.

scientific article

Temperature-sensitive mutants of p53 associated with human carcinoma of the lung

scientific article published on 01 January 1992

Tetraspanin CD151 regulates transforming growth factor beta signaling: implication in tumor metastasis.

scientific article published on 22 June 2010

The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells

scientific article published on 20 August 2012

The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells.

scientific article published on 6 August 2010

Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo

scientific article published on 13 July 2012

Thyroid transcription factor-1-regulated microRNA-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells

scientific article

Topographical distributions of allelic loss in individual non-small-cell lung cancers

scientific article published on September 2000

Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.

scientific article

Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages

scientific article (publication date: 2014)

Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth

article

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels

scientific article published on June 2005

hDREF regulates cell proliferation and expression of ribosomal protein genes

scientific article

let-7 and miR-17-92: small-sized major players in lung cancer development

scientific article

let-7 regulates Dicer expression and constitutes a negative feedback loop

scientific article

miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer.

scientific article published on 18 October 2015

miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer.

scientific article

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