List of works - Jean-Marc Porcher

17alpha-ethinylestradiol disrupts the ontogeny of the forebrain GnRH system and the expression of brain aromatase during early development of zebrafish

scientific article published on July 2010

17α-Ethinylestradiol and nonylphenol affect the development of forebrain GnRH neurons through an estrogen receptors-dependent pathway

scientific article published on 28 April 2011

A critical role of follicle-stimulating hormone (Fsh) in mediating the effect of clotrimazole on testicular steroidogenesis in adult zebrafish.

scientific article published on 28 April 2012

A new ELISA for the three-spined stickleback (Gasterosteus aculeatus L.) spiggin, using antibodies against synthetic peptide.

scientific article published in September 2007

A non-invasive method based on head morphology to sex mature three-spined stickleback (Gasterosteus aculeatus L.) in rearing conditions

scientific article

A novel "Integrated Biomarker Response" calculation based on reference deviation concept

scientific article published on 4 December 2012

A potential biomarker of androgen exposure in European bullhead (Cottus sp.) kidney.

scientific article published on 26 September 2012

A stable fish reporter cell line to study estrogen receptor transactivation by environmental (xeno)estrogens.

scientific article

Acclimation capacity of the three-spined stickleback (Gasterosteus aculeatus, L.) to a sudden biological stress following a polymetallic exposure.

scientific article published on 30 July 2016

Activation of the hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and lipophilicity.

scientific article

Adverse effects in wild fish living downstream from pharmaceutical manufacture discharges

scientific article

An active biomonitoring approach using three-spined stickleback (Gasterosteus aculeatus, L.) to assess the efficiency of a constructed wetland as tertiary treatment of wastewater

Analysis of community-level mesocosm data based on ecologically meaningful dissimilarity measures and data transformation

scientific article

Anti-androgenic activities of environmental pesticides in the MDA-kb2 reporter cell line.

scientific article published on 22 August 2010

Application in a biomonitoring context of three-spined stickleback immunomarker reference ranges

scientific article published in 2021

Applications in environmental risk assessment of leucocyte apoptosis, necrosis and respiratory burst analysis on the European bullhead, Cottus sp

article

Assessment of seasonal variability of biomarkers in three-spined stickleback (Gasterosteus aculeatus L.) from a low contaminated stream: implication for environmental biomonitoring

scientific article published on 5 February 2008

BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.

scientific article

Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in sediments from reference and impacted small rivers.

scientific article published on 17 September 2009

Biochemical effects of nonylphenol polyethoxylate adjuvant, Diquat herbicide and their mixture on the three-spined stickleback (Gasterosteus aculeatus L.)

scientific article published on 25 April 2006

Biological markers as indicators of exposure and pneumoconiotic risk: prospective study

scientific article published on 01 January 1993

Biomarker responses in wild three-spined stickleback (Gasterosteus aculeatus L.) as a useful tool for freshwater biomonitoring: a multiparametric approach

scientific article published on 20 February 2008

Blood antioxidant enzymes as markers of exposure or effect in coal miners

scientific article

Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.

scientific article published on 18 July 2011

Characterization of a genotoxicity biomarker in three-spined stickleback (Gasterosteus aculeatus L.): Biotic variability and integration in a battery of biomarkers for environmental monitoring.

scientific article published on 27 October 2014

Characterization of a soluble form of neutral endopeptidase-24.11 (EC 3.4.24.11) in human serum: enhancement of its activity in serum of underground miners exposed to coal dust particles

scientific article published on 01 November 1996

Characterization of testicular expression of P450 17α-hydroxylase, 17,20-lyase in zebrafish and its perturbation by the pharmaceutical fungicide clotrimazole.

scientific article

Chronic effects of a binary insecticide Acer 35 EC on Nile tilapia Oreochromis niloticus through a multi-biomarker approach

scientific article published on 05 October 2020

Comparison of two reference systems for biomarker data analysis in a freshwater biomonitoring context

scientific article

Copper-induced oxidative stress in three-spined stickleback: relationship with hepatic metal levels.

scientific article published on January 2005

Coupling of OECD standardized test and immunomarkers to select the most environmentally benign ionic liquids option--towards an innovative "safety by design" approach

scientific article published on 20 September 2014

Cyp17a1 and Cyp19a1 in the zebrafish testis are differentially affected by oestradiol

scientific article published on 25 February 2013

DEVELOPMENT AND VALIDATION OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY TO MEASURE VITELLOGENIN IN THE ZEBRAFISH (DANIO RERIO)

article

Decision trees versus support vector machine for classification of androgen receptor ligands.

scientific article

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.).

scientific article published on 13 August 2014

Determination of a new index of sexual maturity (ISM) in zebra mussel using flow cytometry: interest in ecotoxicology

scientific article published on 31 May 2017

Development and validation of an enzyme-linked immunosorbent assay to measure vitellogenin in the zebrafish (Danio rerio).

scientific article published in August 2002

Development of quantitative vitellogenin-ELISAs for fish test species used in endocrine disruptor screening

scientific article published on 9 October 2003

Digestive enzymes and gut morphometric parameters of threespine stickleback (Gasterosteus aculeatus): Influence of body size and temperature.

scientific article published on 3 April 2018

Distribution of steroid- and dioxin-like activities between sediments, POCIS and SPMD in a French river subject to mixed pressures

scientific article published on 11 January 2013

Dynamic and differential expression of the gonadal aromatase during the process of sexual differentiation in a novel transgenic cyp19a1a-eGFP zebrafish line

scientific article published on 22 June 2017

Ecotoxicity of ethylene glycol monobutyl ether and its acetate

scientific article published in January 2002

Effect of in vivo chronic exposure to clotrimazole on zebrafish testis function.

scientific article published on 23 January 2013

Effect of prochloraz fungicide on biotransformation enzymes and oxidative stress parameters in three-spined stickleback (Gasterosteus aculeatus L.).

scientific article published in January 2008

Effect-directed analysis of endocrine-disrupting compounds in multi-contaminated sediment: identification of novel ligands of estrogen and pregnane X receptors

scientific article published on 26 January 2013

Effects of a chronic exposure to different water temperatures and/or to an environmental cadmium concentration on the reproduction of the threespine stickleback (Gasterosteus aculeatus)

scientific article published on 25 February 2019

Effects of aluminium and bacterial lipopolysaccharide on oxidative stress and immune parameters in roach, Rutilus rutilus L.

scientific article published on 6 July 2014

Effects of bisphenol A on different trophic levels in a lotic experimental ecosystem

scientific article

Effects of chronic exposure to a pharmaceutical mixture on the three-spined stickleback (gasterosteus aculeatus) population dynamics in lotic mesocosms

scientific article published on 01 May 2020

Effects of chronic exposure to cadmium and temperature, alone or combined, on the threespine stickleback (Gasterosteus aculeatus): Interest of digestive enzymes as biomarkers

scientific article published on 12 April 2018

Endocrine disruption in wild populations of chub (Leuciscus cephalus) in contaminated French streams.

scientific article

Erythrocyte antioxidant enzyme activities in coal miners from three French regions

scientific article published on 01 June 1998

Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples

scientific article

Evaluation of an in vitro hsp70 induction test for toxicity assessment of complex mixtures: comparison with chemical analyses and ecotoxicity tests

scientific article published on January 2003

Evaluation of chlorpyrifos effects, alone and combined with lipopolysaccharide stress, on DNA integrity and immune responses of the three-spined stickleback, Gasterosteus aculeatus

scientific article

Evaluation of tumor necrosis factor-alpha (TNF) as an exposure or risk marker in three French coal mining regions

scientific article published on 01 July 1994

Extraction and purification procedures for simultaneous quantification of phenolic xenoestrogens and steroid estrogens in river sediment by gas chromatography/ion trap mass spectrometry.

scientific article

Factory-discharged pharmaceuticals could be a relevant source of aquatic environment contamination: review of evidence and need for knowledge

scientific article published on 03 March 2014

Flow cytometry detection of lysosomal presence and lysosomal membrane integrity in the three-spined stickleback (Gasterosteus aculeatus L.) immune cells: applications in environmental aquatic immunotoxicology

scientific article

Identification of synthetic steroids in river water downstream from pharmaceutical manufacture discharges based on a bioanalytical approach and passive sampling

scientific article

Impact of confinement and food access restriction on the three-spined stickleback (Gasterosteus aculeatus, L.) during caging: a multi-biomarker approach

scientific article published on 21 June 2019

In situ effects of metal contamination from former uranium mining sites on the health of the three-spined stickleback (Gasterosteus aculeatus, L.)

article

In situ experiments to assess effects of constraints linked to caging on ecotoxicity biomarkers of the three-spined stickleback (Gasterosteus aculeatus L.).

scientific article published on 19 November 2015

In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays.

scientific article

Influence of metal (Cd and Zn) waterborne exposure on radionuclide (134Cs, 110Ag, and 57Co) bioaccumulation by rainbow trout (Oncorhynchus mykiss): a field and laboratory study

scientific article published in March 2002

Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances.

scientific article published on 26 September 2006

Integrative biomarker response - Threshold (IBR-T): Refinement of IBRv2 to consider the reference and threshold values of biomarkers

scientific article published in 2023

Interest of a multispecies approach in active biomonitoring: Application in the Meuse watershed

scientific article published in 2022

Involvement of fish immunomarkers in environmental biomonitoring approach: Urban and agri-viticultural context

scientific article published on 27 May 2015

Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio).

scientific article

Mixture Concentration-Response Modeling Reveals Antagonistic Effects of Estradiol and Genistein in Combination on Brain Aromatase Gene (cyp19a1b) in Zebrafish.

scientific article published in April 2018

Modelling BPA effects on three-spined stickleback population dynamics in mesocosms to improve the understanding of population effects

scientific article published on 20 July 2019

Modelling historical mesocosm data: Application of a fish bioenergetics model in semi-natural conditions

scientific article published in 2018

Modelling population dynamics in mesocosms using an individual-based model coupled to a bioenergetics model

scientific article published in 2019

Modelling the effect of season, sex, and body size on the three-spined stickleback, Gasterosteus aculeatus, cellular innate immunomarkers: A proposition of laboratory reference ranges

scientific article published on 27 July 2018

Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line.

scientific article published on 24 August 2006

Monitoring estrogenic activities of waste and surface waters using a novel in vivo zebrafish embryonic (EASZY) assay: Comparison with in vitro cell-based assays and determination of effect-based trigger values

scientific article published on 10 June 2019

Monitoring of dioxin-like, estrogenic and anti-androgenic activities in sediments of the Bizerta lagoon (Tunisia) by means of in vitro cell-based bioassays: contribution of low concentrations of polynuclear aromatic hydrocarbons (PAHs).

scientific article

Multi-biomarker approach in wild European bullhead, Cottus sp., exposed to agricultural and urban environmental pressures: practical recommendations for experimental design

scientific article published on 21 January 2012

Parental exposure to methyl methane sulfonate of three-spined stickleback: contribution of DNA damage in male and female germ cells to further development impairment in progeny ⬇️

scientific article published on June 7, 2013

Preliminary investigation of multi-biomarker responses in three-spined stickleback (Gasterosteus aculeatus L.) sampled in contaminated streams

scientific article published on 26 January 2007

Procedures for leukocytes isolation from lymphoid tissues and consequences on immune endpoints used to evaluate fish immune status: A case study on roach (Rutilus rutilus).

scientific article published on 27 December 2017

Rapid analysis of diclofenac and some of its transformation products in the three-spined stickleback, Gasterosteus aculeatus, by liquid chromatography-tandem mass spectrometry

scientific article published on 16 April 2016

Recommendations to design environmental monitoring in the European bullhead, Cottus sp., based on reproductive cycle and immunomarker measurement

scientific article published on 17 January 2015

Relationship between DNA damage in sperm after ex vivo exposure and abnormal embryo development in the progeny of the three-spined stickleback.

scientific article

Relationship between blood antioxidants and occupational exposure to polycyclic aromatic hydrocarbons in coke oven workers ⬇️

scientific article published on 01 September 1998

Reliability evaluation of biomarker reference ranges for mesocosm and field conditions: Cellular innate immunomarkers in Gasterosteus aculeatus

scientific article published on 06 September 2019

Selective activation of zebrafish estrogen receptor subtypes by chemicals by using stable reporter gene assay developed in a zebrafish liver cell line.

scientific article

Study of the chemical derivatization of zearalenone and its metabolites for gas chromatography-mass spectrometry analysis of environmental samples.

scientific article published on 13 March 2008

Toxic effects of a mixture of five pharmaceutical drugs assessed using Fontinalis antipyretica Hedw.

scientific article published in 2021

Triclosan Lacks Anti-Estrogenic Effects in Zebrafish Cells but Modulates Estrogen Response in Zebrafish Embryos.

scientific article published on 12 April 2018

Two-step purification method of vitellogenin from three teleost fish species: rainbow trout (Oncorhynchus mykiss), gudgeon (Gobio gobio) and chub (Leuciscus cephalus)

scientific article published on 01 January 2000

Uranium bioaccumulation and biological disorders induced in zebrafish (Danio rerio) after a depleted uranium waterborne exposure ⬇️

scientific article published on November 18, 2010

Water quality of the Meuse watershed: Assessment using a multi-biomarker approach with caged three-spined stickleback (Gasterosteus aculeatus L.).

scientific article published on 15 October 2020

Wild gudgeons (Gobio gobio) from French rivers are contaminated by microplastics: preliminary study and first evidence

scientific article published on 2 December 2013

List of works by Jean-Marc Porcher

17alpha-ethinylestradiol disrupts the ontogeny of the forebrain GnRH system and the expression of brain aromatase during early development of zebrafish

17α-Ethinylestradiol and nonylphenol affect the development of forebrain GnRH neurons through an estrogen receptors-dependent pathway

A critical role of follicle-stimulating hormone (Fsh) in mediating the effect of clotrimazole on testicular steroidogenesis in adult zebrafish.

A new ELISA for the three-spined stickleback (Gasterosteus aculeatus L.) spiggin, using antibodies against synthetic peptide.

A non-invasive method based on head morphology to sex mature three-spined stickleback (Gasterosteus aculeatus L.) in rearing conditions

A novel "Integrated Biomarker Response" calculation based on reference deviation concept

A potential biomarker of androgen exposure in European bullhead (Cottus sp.) kidney.

A stable fish reporter cell line to study estrogen receptor transactivation by environmental (xeno)estrogens.

Acclimation capacity of the three-spined stickleback (Gasterosteus aculeatus, L.) to a sudden biological stress following a polymetallic exposure.

Activation of the hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and lipophilicity.

Adverse effects in wild fish living downstream from pharmaceutical manufacture discharges

An active biomonitoring approach using three-spined stickleback (Gasterosteus aculeatus, L.) to assess the efficiency of a constructed wetland as tertiary treatment of wastewater

Analysis of community-level mesocosm data based on ecologically meaningful dissimilarity measures and data transformation

Anti-androgenic activities of environmental pesticides in the MDA-kb2 reporter cell line.

Application in a biomonitoring context of three-spined stickleback immunomarker reference ranges

Applications in environmental risk assessment of leucocyte apoptosis, necrosis and respiratory burst analysis on the European bullhead, Cottus sp

Assessment of seasonal variability of biomarkers in three-spined stickleback (Gasterosteus aculeatus L.) from a low contaminated stream: implication for environmental biomonitoring

BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.

Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in sediments from reference and impacted small rivers.

Biochemical effects of nonylphenol polyethoxylate adjuvant, Diquat herbicide and their mixture on the three-spined stickleback (Gasterosteus aculeatus L.)

Biological markers as indicators of exposure and pneumoconiotic risk: prospective study

Biomarker responses in wild three-spined stickleback (Gasterosteus aculeatus L.) as a useful tool for freshwater biomonitoring: a multiparametric approach

Blood antioxidant enzymes as markers of exposure or effect in coal miners

Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.

Characterization of a genotoxicity biomarker in three-spined stickleback (Gasterosteus aculeatus L.): Biotic variability and integration in a battery of biomarkers for environmental monitoring.

Characterization of a soluble form of neutral endopeptidase-24.11 (EC 3.4.24.11) in human serum: enhancement of its activity in serum of underground miners exposed to coal dust particles

Characterization of testicular expression of P450 17α-hydroxylase, 17,20-lyase in zebrafish and its perturbation by the pharmaceutical fungicide clotrimazole.

Chronic effects of a binary insecticide Acer 35 EC on Nile tilapia Oreochromis niloticus through a multi-biomarker approach

Comparison of two reference systems for biomarker data analysis in a freshwater biomonitoring context

Copper-induced oxidative stress in three-spined stickleback: relationship with hepatic metal levels.

Coupling of OECD standardized test and immunomarkers to select the most environmentally benign ionic liquids option--towards an innovative "safety by design" approach

Cyp17a1 and Cyp19a1 in the zebrafish testis are differentially affected by oestradiol

DEVELOPMENT AND VALIDATION OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY TO MEASURE VITELLOGENIN IN THE ZEBRAFISH (DANIO RERIO)

Decision trees versus support vector machine for classification of androgen receptor ligands.

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.).

Determination of a new index of sexual maturity (ISM) in zebra mussel using flow cytometry: interest in ecotoxicology

Development and validation of an enzyme-linked immunosorbent assay to measure vitellogenin in the zebrafish (Danio rerio).

Development of quantitative vitellogenin-ELISAs for fish test species used in endocrine disruptor screening

Digestive enzymes and gut morphometric parameters of threespine stickleback (Gasterosteus aculeatus): Influence of body size and temperature.

Distribution of steroid- and dioxin-like activities between sediments, POCIS and SPMD in a French river subject to mixed pressures

Dynamic and differential expression of the gonadal aromatase during the process of sexual differentiation in a novel transgenic cyp19a1a-eGFP zebrafish line

Ecotoxicity of ethylene glycol monobutyl ether and its acetate

Effect of in vivo chronic exposure to clotrimazole on zebrafish testis function.

Effect of prochloraz fungicide on biotransformation enzymes and oxidative stress parameters in three-spined stickleback (Gasterosteus aculeatus L.).

Effect-directed analysis of endocrine-disrupting compounds in multi-contaminated sediment: identification of novel ligands of estrogen and pregnane X receptors

Effects of a chronic exposure to different water temperatures and/or to an environmental cadmium concentration on the reproduction of the threespine stickleback (Gasterosteus aculeatus)

Effects of aluminium and bacterial lipopolysaccharide on oxidative stress and immune parameters in roach, Rutilus rutilus L.

Effects of bisphenol A on different trophic levels in a lotic experimental ecosystem

Effects of chronic exposure to a pharmaceutical mixture on the three-spined stickleback (gasterosteus aculeatus) population dynamics in lotic mesocosms

Effects of chronic exposure to cadmium and temperature, alone or combined, on the threespine stickleback (Gasterosteus aculeatus): Interest of digestive enzymes as biomarkers

Endocrine disruption in wild populations of chub (Leuciscus cephalus) in contaminated French streams.

Erythrocyte antioxidant enzyme activities in coal miners from three French regions

Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples

Evaluation of an in vitro hsp70 induction test for toxicity assessment of complex mixtures: comparison with chemical analyses and ecotoxicity tests

Evaluation of chlorpyrifos effects, alone and combined with lipopolysaccharide stress, on DNA integrity and immune responses of the three-spined stickleback, Gasterosteus aculeatus

Evaluation of tumor necrosis factor-alpha (TNF) as an exposure or risk marker in three French coal mining regions

Extraction and purification procedures for simultaneous quantification of phenolic xenoestrogens and steroid estrogens in river sediment by gas chromatography/ion trap mass spectrometry.

Factory-discharged pharmaceuticals could be a relevant source of aquatic environment contamination: review of evidence and need for knowledge

Flow cytometry detection of lysosomal presence and lysosomal membrane integrity in the three-spined stickleback (Gasterosteus aculeatus L.) immune cells: applications in environmental aquatic immunotoxicology

Identification of synthetic steroids in river water downstream from pharmaceutical manufacture discharges based on a bioanalytical approach and passive sampling

Impact of confinement and food access restriction on the three-spined stickleback (Gasterosteus aculeatus, L.) during caging: a multi-biomarker approach

In situ effects of metal contamination from former uranium mining sites on the health of the three-spined stickleback (Gasterosteus aculeatus, L.)

In situ experiments to assess effects of constraints linked to caging on ecotoxicity biomarkers of the three-spined stickleback (Gasterosteus aculeatus L.).

In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays.

Influence of metal (Cd and Zn) waterborne exposure on radionuclide (134Cs, 110Ag, and 57Co) bioaccumulation by rainbow trout (Oncorhynchus mykiss): a field and laboratory study

Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances.

Integrative biomarker response - Threshold (IBR-T): Refinement of IBRv2 to consider the reference and threshold values of biomarkers

Interest of a multispecies approach in active biomonitoring: Application in the Meuse watershed

Involvement of fish immunomarkers in environmental biomonitoring approach: Urban and agri-viticultural context

Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio).

Mixture Concentration-Response Modeling Reveals Antagonistic Effects of Estradiol and Genistein in Combination on Brain Aromatase Gene (cyp19a1b) in Zebrafish.

Modelling BPA effects on three-spined stickleback population dynamics in mesocosms to improve the understanding of population effects

Modelling historical mesocosm data: Application of a fish bioenergetics model in semi-natural conditions

Modelling population dynamics in mesocosms using an individual-based model coupled to a bioenergetics model

Modelling the effect of season, sex, and body size on the three-spined stickleback, Gasterosteus aculeatus, cellular innate immunomarkers: A proposition of laboratory reference ranges

Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line.

Monitoring estrogenic activities of waste and surface waters using a novel in vivo zebrafish embryonic (EASZY) assay: Comparison with in vitro cell-based assays and determination of effect-based trigger values

Monitoring of dioxin-like, estrogenic and anti-androgenic activities in sediments of the Bizerta lagoon (Tunisia) by means of in vitro cell-based bioassays: contribution of low concentrations of polynuclear aromatic hydrocarbons (PAHs).

Multi-biomarker approach in wild European bullhead, Cottus sp., exposed to agricultural and urban environmental pressures: practical recommendations for experimental design