List of works - Amanda Heslegrave

A multi-center study of neurofilament assay reliability and inter-laboratory variability

scientific article published on 19 June 2020

A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer's disease pathology.

scientific article

Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase

scientific article

Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios.

scientific article

Blood Biomarkers for Alzheimer's Disease: Much Promise, Cautious Progress

scientific article

Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate

CSF synaptic protein concentrations are raised in those with atypical Alzheimer's disease but not frontotemporal dementia

scientific article published on 17 December 2019

Cerebrospinal fluid in the differential diagnosis of Alzheimer's disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic

scientific article published on 20 March 2018

Cerebrospinal fluid neurogranin and TREM2 in Huntington's disease

scientific article published on 9 March 2018

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

scientific article published on 16 August 2018

Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration

article

Combined tissue and fluid proteomics with Tandem Mass Tags to identify low-abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study

scientific article published on 4 November 2016

Congenital hyperinsulinism due to mutations in HNF4A and HADH.

scientific article published on September 2010

Correction: The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice

scientific article

Do cerebrospinal fluid transfer methods affect measured amyloid β42, total tau, and phosphorylated tau in clinical practice?

scientific article published on 02 July 2015

Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration

scientific article published on 01 January 2017

Erratum to: Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

scientific article published on 23 February 2016

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease

scientific article published on 12 September 2018

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

scientific article published on 12 April 2019

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

scientific article published on 7 November 2017

Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease

scientific article published in January 2015

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

scientific article published on 01 August 2018

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

scientific article published in December 2015

In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury

scientific article published on 01 September 2019

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease

scientific article

Inflammatory markers of CHMP2B-mediated frontotemporal dementia

scientific article published on 17 August 2018

Interlaboratory validation of cerebrospinal fluid α-synuclein quantification in the diagnosis of sporadic Creutzfeldt-Jakob disease

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

scientific article published on February 2011

Leucine-sensitive hyperinsulinaemic hypoglycaemia in patients with loss of function mutations in 3-Hydroxyacyl-CoA Dehydrogenase

scientific article

Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease

scholarly article by Philip S J Weston et al published 20 February 2019 in Alzheimers Research & Therapy

Molecular biomarkers of Alzheimer's disease: progress and prospects.

scientific article

Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy.

scientific article published on 20 February 2019

Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington's disease

scientific article published on 01 December 2020

Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome

scientific article published on 10 April 2018

Nitric oxide-dependent damage to neuronal mitochondria involves the NMDA receptor.

scientific article published in February 2002

Novel insights into fatty acid oxidation, amino acid metabolism, and insulin secretion from studying patients with loss of function mutations in 3-hydroxyacyl-CoA dehydrogenase.

scientific article published on 18 December 2012

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

scientific article published on 28 November 2019

Plasma tau is increased in frontotemporal dementia.

scientific article published on 13 February 2018

Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest

scientific article published on 13 April 2019

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

scientific article

Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer's disease

scholarly article by Raquel Sánchez-Valle et al published 3 November 2018 in Alzheimers Research & Therapy

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

Stability of blood-based biomarkers of Alzheimer's disease over multiple freeze-thaw cycles

scientific article published on 02 July 2018

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

scientific article published on 01 August 2019

The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study

scientific article published in PLoS ONE

List of works by Amanda Heslegrave

A multi-center study of neurofilament assay reliability and inter-laboratory variability

A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer's disease pathology.

Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase

Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios.

Blood Biomarkers for Alzheimer's Disease: Much Promise, Cautious Progress

Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate

CSF synaptic protein concentrations are raised in those with atypical Alzheimer's disease but not frontotemporal dementia

Cerebrospinal fluid in the differential diagnosis of Alzheimer's disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic

Cerebrospinal fluid neurogranin and TREM2 in Huntington's disease

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration

Combined tissue and fluid proteomics with Tandem Mass Tags to identify low-abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study

Congenital hyperinsulinism due to mutations in HNF4A and HADH.

Correction: The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice

Do cerebrospinal fluid transfer methods affect measured amyloid β42, total tau, and phosphorylated tau in clinical practice?

Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration

Erratum to: Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease

Inflammatory markers of CHMP2B-mediated frontotemporal dementia

Interlaboratory validation of cerebrospinal fluid α-synuclein quantification in the diagnosis of sporadic Creutzfeldt-Jakob disease

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

Leucine-sensitive hyperinsulinaemic hypoglycaemia in patients with loss of function mutations in 3-Hydroxyacyl-CoA Dehydrogenase

Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease

Molecular biomarkers of Alzheimer's disease: progress and prospects.

Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy.

Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington's disease

Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome

Nitric oxide-dependent damage to neuronal mitochondria involves the NMDA receptor.

Novel insights into fatty acid oxidation, amino acid metabolism, and insulin secretion from studying patients with loss of function mutations in 3-hydroxyacyl-CoA dehydrogenase.

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

Plasma tau is increased in frontotemporal dementia.

Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer's disease

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

Stability of blood-based biomarkers of Alzheimer's disease over multiple freeze-thaw cycles

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study