List of works - Paul Bowness

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

scientific article

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

scientific article (publication date: 16 February 2010)

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

scientific article

Cell-surface expression and immune receptor recognition of HLA-B27 homodimers

scientific article published on 01 November 2002

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

scientific article published on 21 May 2015

Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

scientific article published on March 2003

Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine.

scientific article

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

scientific article

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

scientific article

Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705.

scientific article published in February 2005

HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors.

scientific article published on August 2004

HLA-B27.

scientific article

Prolonged activation of virus-specific CD8+T cells after acute B19 infection

scientific article published in November 2005

Hereditary C1q deficiency and systemic lupus erythematosus.

scientific article published on August 1994

Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses

scientific article published on 01 July 1993

Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis

scientific article

Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays

scientific article published on February 2012

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

scientific article published on February 2014

HLA B27 in health and disease: a double-edged sword?

scientific article

Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide

scientific article published on 01 May 2007

KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis

scientific article published on 25 February 2013

ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients

scientific article published on 27 April 2015

Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope

scientific article

Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells.

scientific article published on June 2007

Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway.

scientific article published on 24 October 2008

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

scientific article published on 30 June 2015

Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.

scientific article

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

scientific article

HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.

scientific article

The interleukin (IL)-23/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment

scientific article published on 17 June 2015

High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo.

scientific article

Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans

scientific article published in September 2005

Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27

scientific article published on 01 October 1994

The arthritis-associated HLA-B27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B27:09.

scientific article published on 26 June 2013

Ankylosing spondylitis confers substantially increased risk of clinical spine fractures: a nationwide case-control study.

scientific article published on 24 October 2014

Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis.

scientific article

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

scientific article published on 25 November 2015

Jekyll and Hyde: the transformation of HLA-B27

scientific article published on 01 June 2000

Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy

scientific article published on 01 July 2007

The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target

scientific article

Parvovirus 4 infection and clinical outcome in high-risk populations

scientific article

Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles.

scientific article

Importance of a conserved TCR J α-encoded tyrosine for T cell recognition of an HLA B27/ peptide complex

scientific article published on 01 September 1998

Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells

scientific article published on 01 March 2008

Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply

scientific article published on April 26, 2013

The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin

scientific article published on 01 December 2001

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

scientific article published on 09 October 2015

Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen

scientific article published on 01 October 2002

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope

scientific article

Selection of T cell receptor variable gene-encoded amino acids on the third binding site loop: a factor influencing variable chain selection in a T cell response

scientific article published on 01 June 1995

List of works by Paul Bowness

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Cell-surface expression and immune receptor recognition of HLA-B27 homodimers

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine.

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705.

HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors.

HLA-B27.

Prolonged activation of virus-specific CD8+T cells after acute B19 infection

Hereditary C1q deficiency and systemic lupus erythematosus.

Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses

Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis

Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

HLA B27 in health and disease: a double-edged sword?

Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide

KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis

ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients

Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope

Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells.

Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway.

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.

The interleukin (IL)-23/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment

High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo.

Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans

Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27

The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09.

Ankylosing spondylitis confers substantially increased risk of clinical spine fractures: a nationwide case-control study.

Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis.

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

Jekyll and Hyde: the transformation of HLA-B27

Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy

The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target

Parvovirus 4 infection and clinical outcome in high-risk populations

Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles.

Importance of a conserved TCR J α-encoded tyrosine for T cell recognition of an HLA B27/ peptide complex

Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells

Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply

The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope

Selection of T cell receptor variable gene-encoded amino acids on the third binding site loop: a factor influencing variable chain selection in a T cell response

The arthritis-associated HLA-B27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B27:09.