List of works - Paul Bowness

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

scientific article

A method for producing monoclonal antibodies to human T-cell-receptor beta-chain variable regions.

scientific article published on November 1993

Aberrant cellular immune responses in humans infected persistently with parvovirus B19

scientific article published in 2005

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

scientific article published on 25 November 2015

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

scientific article published on 25 February 2016

An immunodominant NP<sub>105-113</sub>-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

scientific article published on 01 December 2021

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

scientific article (publication date: 16 February 2010)

Ankylosing spondylitis confers substantially increased risk of clinical spine fractures: a nationwide case-control study.

scientific article published on 24 October 2014

Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway.

scientific article published on 24 October 2008

Anti-tumour necrosis factor therapy in seronegative spondyloarthritis.

scientific article

Autoimmune disease and HTLV-1 infection.

scientific article published in April 1991

Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy

scientific article published on 01 July 2007

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

scientific article

Cell-surface expression and immune receptor recognition of HLA-B27 homodimers

scientific article published on 01 November 2002

Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses

scientific article published on 01 July 1993

Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen

scientific article published on 01 October 2002

Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles.

scientific article

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

scientific article published on February 2014

Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705.

scientific article published in February 2005

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

scientific article

Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue.

scientific article

Detection of broad functional gag-specific CD4+ T cell responses in HIV-1-infected subjects following therapeutic immunization with rMVA expressing an HIV-1 gag immunogen.

scientific article published on 21 December 2006

Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays

scientific article published on February 2012

Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis

scientific article

ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients

scientific article published on 27 April 2015

Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine.

scientific article

Factors affecting TCR-repertoire diversity

scientific article published on 01 January 1994

Fully functional HLA B27-restricted CD4+ as well as CD8+ T cell responses in TCR transgenic mice

scientific article published on 01 January 2004

HLA B27 in health and disease: a double-edged sword?

scientific article

HLA-B27 and disease pathogenesis: new structural and functional insights.

scientific article published on 26 October 1999

HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors.

scientific article published on August 2004

HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.

scientific article

HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats

scientific article (publication date: 2015)

HLA-B27.

scientific article

Hereditary C1q deficiency and systemic lupus erythematosus.

scientific article published on August 1994

High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo.

scientific article

Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells.

scientific article published on June 2007

Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27

scientific article published on 01 October 1994

Importance of a conserved TCR J α-encoded tyrosine for T cell recognition of an HLA B27/ peptide complex

scientific article published on 01 September 1998

Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.

scientific article

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

scientific article

Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide

scientific article published on 01 May 2007

Jekyll and Hyde: the transformation of HLA-B27

scientific article published on 01 June 2000

KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis

scientific article published on 25 February 2013

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

scientific article

Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

scientific article published on March 2003

MHC class I multimers

scientific article

MHC molecules lead many lives. Workshop on MHC Class I Molecules at the interface between Biology & Medicine.

scientific article published on 5 December 2008

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

scientific article published on 21 May 2015

Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells

scientific article published on 01 March 2008

Multiple T cell expansions are found in the blood and synovial fluid of patients with reactive arthritis.

scientific article published in September 1997

Neck pain is a major clinical problem in ankylosing spondylitis, and impacts on driving and safety

scientific article published on 01 March 2005

Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue.

scientific article published on 29 March 2016

Parvovirus 4 infection and clinical outcome in high-risk populations

scientific article

Polymorphisms in the F Pocket of HLA-B27 Subtypes Strongly Affect Assembly, Chaperone Interactions, and Heavy-Chain Misfolding.

scientific article published on 09 October 2016

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.

scientific article published on 11 August 2016

Prevalence of hypothyroidism in patients with polymyalgia rheumatica and giant cell arteritis

scientific article published on 01 October 1991

Prolonged activation of virus-specific CD8+T cells after acute B19 infection

scientific article published in November 2005

Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope

scientific article

RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

scientific article published on 20 November 2015

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope

scientific article

Reduction in Tγδ cell numbers and alteration in subset distribution in systemic lupus erythematosus

scientific article published on 01 November 1991

Selection of T cell receptor variable gene-encoded amino acids on the third binding site loop: a factor influencing variable chain selection in a T cell response

scientific article published on 01 June 1995

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

scientific article published on 30 June 2015

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

scientific article published on 14 December 2021

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

scientific article published on 21 September 2020

Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans

scientific article published in September 2005

T-cell receptors and rheumatic disease: approaches to repertoire analysis ⬇️

scientific article published on January 1, 1992

The arthritis-associated HLA-B27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B27:09.

scientific article published on 26 June 2013

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

scientific article published on 09 October 2015

The interleukin (IL)-23/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment

scientific article published on 17 June 2015

The nucleotide sequence of HLA-B2704 reveals a new amino acid substitution in exon 4 which is also present in HLA-B2706.

scientific article published in January 1996

The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target

scientific article

The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin

scientific article published on 01 December 2001

The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis.

scientific article published on January 2009

The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis.

scientific article

The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes.

scientific article

Tracking of peptide-specific CD4+ T-cell responses after an acute resolving viral infection: a study of parvovirus B19.

scientific article published on 30 August 2006

Two birds with one stone: doing metabolomics with your proteomics kit.

scientific article

Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis.

scientific article

List of works by Paul Bowness

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

A method for producing monoclonal antibodies to human T-cell-receptor beta-chain variable regions.

Aberrant cellular immune responses in humans infected persistently with parvovirus B19

Activation-Induced Killer Cell Immunoglobulin-like Receptor 3DL2 Binding to HLA-B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

An immunodominant NP<sub>105-113</sub>-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

Ankylosing spondylitis confers substantially increased risk of clinical spine fractures: a nationwide case-control study.

Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway.

Anti-tumour necrosis factor therapy in seronegative spondyloarthritis.

Autoimmune disease and HTLV-1 infection.

Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

Cell-surface expression and immune receptor recognition of HLA-B27 homodimers

Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses

Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen

Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles.

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705.

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue.

Detection of broad functional gag-specific CD4+ T cell responses in HIV-1-infected subjects following therapeutic immunization with rMVA expressing an HIV-1 gag immunogen.

Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays

Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis

ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients

Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine.

Factors affecting TCR-repertoire diversity

Fully functional HLA B27-restricted CD4+ as well as CD8+ T cell responses in TCR transgenic mice

HLA B27 in health and disease: a double-edged sword?

HLA-B27 and disease pathogenesis: new structural and functional insights.

HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors.

HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.

HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats

HLA-B27.

Hereditary C1q deficiency and systemic lupus erythematosus.

High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo.

Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells.

Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27

Importance of a conserved TCR J α-encoded tyrosine for T cell recognition of an HLA B27/ peptide complex

Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide

Jekyll and Hyde: the transformation of HLA-B27

KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

MHC class I multimers

MHC molecules lead many lives. Workshop on MHC Class I Molecules at the interface between Biology & Medicine.

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells

Multiple T cell expansions are found in the blood and synovial fluid of patients with reactive arthritis.

Neck pain is a major clinical problem in ankylosing spondylitis, and impacts on driving and safety

Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue.

Parvovirus 4 infection and clinical outcome in high-risk populations

Polymorphisms in the F Pocket of HLA-B27 Subtypes Strongly Affect Assembly, Chaperone Interactions, and Heavy-Chain Misfolding.

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.

Prevalence of hypothyroidism in patients with polymyalgia rheumatica and giant cell arteritis

Prolonged activation of virus-specific CD8+T cells after acute B19 infection

Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope

RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope

Reduction in Tγδ cell numbers and alteration in subset distribution in systemic lupus erythematosus

Selection of T cell receptor variable gene-encoded amino acids on the third binding site loop: a factor influencing variable chain selection in a T cell response

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans

T-cell receptors and rheumatic disease: approaches to repertoire analysis ⬇️

The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09.

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

The interleukin (IL)-23/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment

The nucleotide sequence of HLA-B*2704 reveals a new amino acid substitution in exon 4 which is also present in HLA-B*2706.

The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target

The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin

The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis.

The role of natural killer cells, gamma delta T-cells and other innate immune cells in spondyloarthritis.

The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes.

Tracking of peptide-specific CD4+ T-cell responses after an acute resolving viral infection: a study of parvovirus B19.

Two birds with one stone: doing metabolomics with your proteomics kit.

The arthritis-associated HLA-B27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B27:09.

The nucleotide sequence of HLA-B2704 reveals a new amino acid substitution in exon 4 which is also present in HLA-B2706.