List of works - Takahiro Shibata

15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses.

scientific article published on 04 December 2007

15-deoxy-?(12,14)-prostaglandin J2 as a potential TRPV1-dependent atopic dermatitis enhancer.

scientific article published in October 2014

2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct

scientific article published on 22 February 2019

2-Oxo-histidine-containing dipeptides are functional oxidation products

scientific article published on 30 November 2018

A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.

scientific article published on 24 October 2008

A method for detection of 4-hydroxy-2-nonenal adducts in proteins

scientific article published on 30 March 2011

A unique mechanism for thiolation of serum albumins by disulphide molecules

scientific article published on 01 February 2020

Adductome-based identification of biomarkers for lipid peroxidation

scientific article published on 24 March 2017

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).

scientific article

An apoptosis-associated mammary protein deficiency leads to enhanced production of IgM antibodies against multiple damage-associated molecules.

scientific article

An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid.

scientific article

Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins

scientific article published on 05 June 2019

Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146

scientific article

Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo

scientific article published on 25 May 2018

Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke

scientific article published on 16 August 2017

Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor

scientific article published on 07 September 2020

Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile.

scientific article published on 6 December 2014

Glycolaldehyde is an endogenous source of lysine N-pyrrolation

scientific article published on 23 April 2020

Granulatoside A, a starfish steroid glycoside, enhances PC12 cell neuritogenesis induced by nerve growth factor through an activation of MAP kinase

scientific article published on 01 December 2006

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

scientific article

Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue.

scientific article published on 10 August 2017

Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies.

scientific article

Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel

scientific article published on 16 February 2016

Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement.

scientific article published on 13 February 2007

Identification of advanced reaction products originating from the initial 4-oxo-2-nonenal-cysteine Michael adducts.

scientific article

Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein

scientific article published on 27 May 2016

Immunohistochemical detection of 13(R)-hydroxyoctadecadienoic acid in atherosclerotic plaques of human carotid arteries using a novel specific antibody

scientific article

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.

scientific article

Lipid peroxidation generates body odor component trans-2-nonenal covalently bound to protein in vivo

scientific article

Lipid radicals cause light-induced retinal degeneration

scientific article published on 20 September 2017

Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins

scientific article

Metal-catalyzed oxidation of protein-bound dopamine.

scientific article published on December 2006

Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas

scientific article published on 16 July 2019

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

scientific article published on 01 July 2019

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators.

scientific article published on 6 July 2008

Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants

scientific article

Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products

scientific article published on 31 July 2021

Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.

scientific article

Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives.

scientific article published in November 2006

Production of natural IgM antibodies against oxidatively-modified proteins in milk fat globule epidermal growth factor 8 (MFG-E8) deficient mice

scientific article

Prostaglandins from a zoanthid: paclitaxel-like neurite-degenerating and microtubule-stabilizating activities

scientific article published on 01 March 2006

Protein adductomics: A comprehensive analysis of protein modifications by electrophiles

scientific article published on 07 March 2019

Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes

scientific article published in 2017

Structural and functional insights into S-thiolation of human serum albumins.

scientific article published in 2018

Thioredoxin as a molecular target of cyclopentenone prostaglandins.

scientific article

Toll-like receptors as a target of food-derived anti-inflammatory compounds

scientific article

Transthiocarbamoylation of proteins by thiolated isothiocyanates

scientific article

List of works by Takahiro Shibata

15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses.

15-deoxy-?(12,14)-prostaglandin J2 as a potential TRPV1-dependent atopic dermatitis enhancer.

2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct

2-Oxo-histidine-containing dipeptides are functional oxidation products

A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.

A method for detection of 4-hydroxy-2-nonenal adducts in proteins

A unique mechanism for thiolation of serum albumins by disulphide molecules

Adductome-based identification of biomarkers for lipid peroxidation

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).

An apoptosis-associated mammary protein deficiency leads to enhanced production of IgM antibodies against multiple damage-associated molecules.

An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid.

Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins

Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146

Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo

Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke

Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor

Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile.

Glycolaldehyde is an endogenous source of lysine N-pyrrolation

Granulatoside A, a starfish steroid glycoside, enhances PC12 cell neuritogenesis induced by nerve growth factor through an activation of MAP kinase

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue.

Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies.

Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel

Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement.

Identification of advanced reaction products originating from the initial 4-oxo-2-nonenal-cysteine Michael adducts.

Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein

Immunohistochemical detection of 13(R)-hydroxyoctadecadienoic acid in atherosclerotic plaques of human carotid arteries using a novel specific antibody

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.

Lipid peroxidation generates body odor component trans-2-nonenal covalently bound to protein in vivo

Lipid radicals cause light-induced retinal degeneration

Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins

Metal-catalyzed oxidation of protein-bound dopamine.

Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators.

Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants

Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products

Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.

Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-delta(12,14)-PGJ2 derivatives.

Production of natural IgM antibodies against oxidatively-modified proteins in milk fat globule epidermal growth factor 8 (MFG-E8) deficient mice

Prostaglandins from a zoanthid: paclitaxel-like neurite-degenerating and microtubule-stabilizating activities

Protein adductomics: A comprehensive analysis of protein modifications by electrophiles

Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes

Structural and functional insights into S-thiolation of human serum albumins.

Thioredoxin as a molecular target of cyclopentenone prostaglandins.

Toll-like receptors as a target of food-derived anti-inflammatory compounds

Transthiocarbamoylation of proteins by thiolated isothiocyanates