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List of works by Toshiro Shirakawa

A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene.

scientific article published on 16 July 2015

A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells.

scientific article published on July 2004

Additional gene therapy with Ad5CMV-p53 enhanced the efficacy of radiotherapy in human prostate cancer cells.

scientific article published in December 2001

Adenoviral-mediated HGF expression inhibits germ cell apoptosis in rats with cryptorchidism

scientific article published on 01 August 2004

Adenovirus-mediated p53 gene transfer to rat testis impairs spermatogenesis

article

Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA combined with cisplatin inhibits cellular growth and induces apoptosis in HPV-positive head and neck cancer cells

scientific article published on 24 May 2018

Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancer.

scientific article published on 5 September 2006

Antibiotic Susceptibilities and Genetic Characteristics of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Stools of Pediatric Diarrhea Patients in Surabaya, Indonesia.

scientific article

Antimicrobial resistance in Salmonella strains clinically isolated in Hyogo, Japan (2009-2012).

scientific article published on January 2014

Antitumor effect of oral cancer vaccine with Bifidobacterium delivering WT1 protein to gut immune system is superior to WT1 peptide vaccine

scientific article

Assessment of proliferating cell nuclear antigen expression and prognosis in patients with renal cell carcinoma with pulmonary metastases

scientific article published on 01 May 1998

Association of VEGF genotype with mRNA level in colorectal adenocarcinomas

scientific article published on 01 December 2004

Association of overexpression of efflux pump genes with antibiotic resistance in Pseudomonas aeruginosa strains clinically isolated from urinary tract infection patients

scientific article published on 8 April 2015

Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2

scientific article

Azithromycin resistance and its mechanism in Neisseria gonorrhoeae strains in Hyogo, Japan.

scientific article

Biosafety studies of carrier cells infected with a replication-competent adenovirus introduced by IAI.3B promoter

scientific article

Blockade of TGF-beta action ameliorates renal dysfunction and histologic progression in anti-GBM nephritis.

scientific article published in July 2003

Clinical trial design for adenoviral gene therapy products.

scientific article published on April 2009

Combination of p53-DC vaccine and rAd-p53 gene therapy induced CTLs cytotoxic against p53-deleted human prostate cancer cells in vitro.

scientific article published on 16 June 2017

Combination with CD/5-FC gene therapy enhances killing of human bladder-cancer cells by radiation.

scientific article published in October 2003

Comparison between phage-open-reading frame typing and automated repetitive-sequence-based PCR for typing MRSA isolates.

scientific article published on 16 April 2014

Determination of the antimicrobial susceptibility and molecular profile of clarithromycin resistance in the Mycobacterium abscessus complex in Japan by variable number tandem repeat analysis.

scientific article published on 18 February 2018

Development of oral cancer vaccine using recombinant Bifidobacterium displaying Wilms' tumor 1 protein

scientific article published on 15 March 2017

Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer ⬇️

scientific article published on July 1, 1998

Does mutation in gyrA and/or parC or efflux pump expression play the main role in fluoroquinolone resistance in Escherichia coli urinary tract infections?: A statistical analysis study

scientific article published on 13 October 2012

Drug-resistant human bladder-cancer cells are more sensitive to adenovirus-mediated wild-type p53 gene therapy compared to drug-sensitive cells.

scientific article

E10A, an adenovirus-carrying endostatin gene, dramatically increased the tumor drug concentration of metronomic chemotherapy with low-dose cisplatin in a xenograft mouse model for head and neck squamous-cell carcinoma.

scientific article

EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients.

scientific article published on 22 September 2005

Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects.

scientific article published in April 2002

Effects of nafamostat mesilate on ADP-induced platelet aggregation and disaggregation in hemodialysis patients

scientific article published in May 2006

Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects

scientific article published on 01 October 2002

Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells.

scientific article

Emergence of fluoroquinolone-resistant strains of Salmonella enterica in Surabaya, Indonesia

scientific article published in August 2009

Establishment of a prostatic small-cell carcinoma cell line (SO-MI).

scientific article published on August 2003

Estrogen levels influence beta-3-adrenoceptor-mediated relaxation of the female rat detrusor muscle.

scientific article

Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E-cadherin and has antitumor effect on human bladder cancer cells in vitro and in vivo.

scientific article published on January 2008

Gene Therapy for Bladder Cancer Using Adenoviral Vector

scientific article published on January 1, 2001

Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines

scientific article published on 01 February 2003

Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention against head and neck cancer-containing HPV16 cell lines ⬇️

scientific article published on May 3, 2013

Gene therapy in prostate cancer: past, present and future.

scientific article published on January 2008

Genetically engineered Bifidobacterium animalis expressing the Salmonella flagellin gene for the mucosal immunization in a mouse model.

scientific article

Genotyping and clinical factors in pediatric diarrhea caused by rotaviruses: one-year surveillance in Surabaya, Indonesia

scientific article

Granulocyte-colony stimulating factor producing urothelial carcinoma of renal pelvis.

scientific article published in May 2005

High Prevalence of Diarrheagenic Escherichia coli among Children with Diarrhea in Kenya

scientific article

Impact and perspective on chronic kidney disease in an Asian developing country: a large-scale survey in North Vietnam

article

Improved bacterial identification directly from urine samples with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

scientific article published on 24 July 2017

In vitro and in vivo inhibitory effect of three Cox-2 inhibitors and epithelial-to-mesenchymal transition in human bladder cancer cell lines.

scientific article

Inhibition mechanism of Gosha-jinki-gan on the micturition reflex in rats.

scientific article published in October 2004

Inhibition of urinary bladder motility by a spinal action of U-50488H in rats.

scientific article published in December 2002

International comparison of causative bacteria and antimicrobial susceptibilities of urinary tract infections between Kobe, Japan and Surabaya, Indonesia

scientific article published on 31 October 2017

Intravenous injection of irradiated tumor cell vaccine carrying oncolytic adenovirus suppressed the growth of multiple lung tumors in a mouse squamous cell carcinoma model.

scientific article

Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer.

scientific article published in December 2007

Long-term outcome of postoperative interferon-alpha adjuvant therapy for non-metastatic renal cell carcinoma.

scientific article published in May 2004

MDR1 up-regulated by apoptotic stimuli suppresses apoptotic signaling

scientific article published on 01 September 2002

Mechanisms of and Risk Factors for Fluoroquinolone Resistance in Clinical Enterococcus faecalis Isolates from Patients with Urinary Tract Infections ⬇️

scientific article published on September 14, 2011

Midkine promoter-based conditionally replicative adenovirus for targeting midkine-expressing human bladder cancer model.

scientific article

Mitochondrial DNA determines androgen dependence in prostate cancer cell lines.

scientific article published on March 2006

Modulation of O-antigen chain length by the wzz gene in Escherichia coli O157 influences its sensitivities to serum complement.

scientific article

Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli in a university teaching hospital.

scientific article

Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 114 clinical isolates of Pseudomonas aeruginosa derived from urinary tract infections and their rapid detection by denaturing high-performance liquid chromatography ⬇️

scientific article published on August 10, 2012

Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 91 clinical isolates of Neisseria gonorrhoeae in Japan.

scientific article published in March 2004

Oral Combination Vaccine, Comprising Bifidobacterium Displaying Hepatitis C Virus Nonstructural Protein 3 and Interferon-α, Induces Strong Cellular Immunity Specific to Nonstructural Protein 3 in Mice

scientific article published on 23 January 2017

Oral administration of genetically modified Bifidobacterium displaying HCV-NS3 multi-epitope fusion protein could induce an HCV-NS3-specific systemic immune response in mice

scientific article published on 21 March 2014

Polymorphism of the interleukin-4, interleukin-13, and signal transducer and activator of transcription 6 genes in Indonesian children with minimal change nephrotic syndrome.

scientific article

Possible role of sonic hedgehog and epithelial-mesenchymal transition in renal cell cancer progression.

scientific article published on 7 August 2013

Post-operative infection and prophylactic antibiotic administration after radical cystectomy with orthotopic neobladder urinary diversion.

scientific article published on 17 January 2012

Potential establishment of lung metastatic xenograft model of androgen receptor-positive and androgen-independent prostate cancer (C4-2B)

scientific article published on 22 August 2012

Presence of a mutation in ponA1 of Neisseria gonorrhoeae in numerous clinical samples resistant to various beta-lactams and other, structurally unrelated, antimicrobials

scientific article published on 01 October 2005

Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer: Initial experience at Kobe University.

scientific article

Quantitative detection of Salmonella enterica serovar Typhi from blood of suspected typhoid fever patients by real-time PCR.

scientific article

Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma

scientific article

Rapid detection and differentiation of Gram-negative and Gram-positive pathogenic bacteria in urine using TaqMan probe.

scientific article

Rapid detection of gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae by denaturing high-performance liquid chromatography.

scientific article published in December 2004

Rapid detection of the fluoroquinolone resistance-associated ParC mutation in Neisseria gonorrhoeae using TaqMan probes.

scientific article

Rapid diagnosis of typhoid fever by PCR assay using one pair of primers from flagellin gene of Salmonella typhi.

scientific article

Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas.

scientific article published in January 2002

Risk factors and mechanisms of fluoroquinolone resistance in 156 Escherichia coli strains clinically isolated from urinary tract infections.

scientific article

Serum testosterone levels in patients with nonmosaic Klinefelter syndrome after testicular sperm extraction for intracytoplasmic sperm injection.

scientific article published in July 2004

Silodosin versus naftopidil in Japanese patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: A randomized multicenter study ⬇️

scientific article published on December 17, 2012

Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial-mesenchymal transition in prostate cancer

scientific article

Study of AZFc partial deletion gr/gr in fertile and infertile Japanese males

article

Susceptibilities of Neisseria gonorrhoeae to fluoroquinolones and other antimicrobial agents in Hyogo and Osaka, Japan

scientific article published on April 2004

The efficiency of in vitro isolation and myogenic differentiation of MSCs derived from adipose connective tissue, bone marrow, and skeletal muscle tissue

scientific article published on 07 March 2012

Ultraviolet light induces Stat3 activation in human keratinocytes and fibroblasts through reactive oxygen species and DNA damage

scientific article

Y chromosome (Yq11) microdeletions in idiopathic azoospermia

scientific article published on 01 March 1997

Y-chromosome microdeletion and phenotype in cytogenetically normal men with idiopathic azoospermia.

scientific article

penA, ponA, porB1, and mtrR Mutations and Molecular Epidemiological Typing of Neisseria gonorrhoeae with Decreased Susceptibility to Cephalosporins.

scientific article published on 12 June 2017

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