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List of works by Lucio Annunziato

A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage.

scientific article

A new cell-penetrating peptide that blocks the autoinhibitory XIP domain of NCX1 and enhances antiporter activity

scientific article

A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death.

scientific article published in August 2012

A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists.

scientific article published on 5 April 2004

Activation of pre-synaptic M-type K+ channels inhibits [3H]D-aspartate release by reducing Ca2+ entry through P/Q-type voltage-gated Ca2+ channels.

scientific article published on 2 February 2009

Adrenergic receptor systems and unscheduled DNA synthesis in the rat brain

scientific article published on 01 January 1995

Alcohol increases spontaneous BOLD signal fluctuations in the visual network

scientific article published on 28 June 2010

Anoxia-induced NF-kappaB-dependent upregulation of NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons

scientific article published on 22 January 2009

Antithrombin reduces ischemic volume, ameliorates neurologic deficits, and prolongs animal survival in both transient and permanent focal ischemia.

scientific article

Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions.

scientific article published on May 2007

BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential

scientific journal article

Basal and thirst-evoked vasopressin secretion in rats with electrolytic lesion of the medio-ventral septal area.

scientific article published in January 1983

Brain neurotransmitters regulating TRH producing neurons ⬇️

scientific article published on January 1, 1981

Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis

scientific article

Characteristics of dopamine release from isolated nerve endings of the tuberoinfundibular neurones

scientific article published on 01 August 1981

Chemical denervation produces supersensitivity of central serotonergic receptors involved in the control of TSH secretion in the rat

scientific article published on 01 February 1983

Chronic Treatment with Reserpine and Adrenocortical Activation ⬇️

scientific article published on January 1, 1976

Cobalt-sensitive and dihydropyridine-insensitive stimulation of dopamine release from tuberoinfundibular neurons by high extracellular concentrations of barium ions

scientific article published on 01 May 1989

Comparative effects of penfluridol on circling behavior and striatal DOPAC and serum prolactin concentrations in the rat

scientific article published on August 1, 1978

Cu,Zn superoxide dismutase increases intracellular calcium levels via a phospholipase C-protein kinase C pathway in SK-N-BE neuroblastoma cells.

scientific article

Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptor

scientific article published on 27 November 2006

Domperidone antagonizes bromoergocriptine--induced nausea and vomiting without affecting its inhibition of prolactin secretion in puerperal women

scientific article published on 01 January 1987

ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na+ /Ca2+ exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells.

scientific article

Effects of HIV-1 Tat protein on ion secretion and on cell proliferation in human intestinal epithelial cells

article

Endogenous dopamine release from tuberoinfundibular neurons: does calmodulin play any role?

scientific article published in July 1986

Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection.

scientific article

Evidence for a differential interaction of buprenorphine with opiate receptor subtypes controlling prolactin secretion.

scientific article

Expression and function of somatostatin receptor subtype 1 in human growth hormone secreting pituitary tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs.

scientific article published in March 2004

Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system.

scientific article published on November 2003

Felbamate inhibits cloned voltage-dependent Na+ channels from human and rat brain.

scientific article published in December 1996

GDNF selectively induces microglial activation and neuronal survival in CA1/CA3 hippocampal regions exposed to NMDA insult through Ret/ERK signalling.

scientific article

Gadolinium and neomycin block voltage-sensitive Ca2+ channels without interfering with the Na(+)-Ca2+ antiporter in brain nerve endings.

scientific article

Galactosyl derivatives of L-arginine and D-arginine: synthesis, stability, cell permeation, and nitric oxide production in pituitary GH3 cells.

scientific article published on August 2006

HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion.

scientific article

Histamine receptors and antihistamines: from discovery to clinical applications.

scientific article

Histidines 578 and 587 in the S5-S6 linker of the human Ether-a-gogo Related Gene-1 K+ channels confer sensitivity to reactive oxygen species.

scientific article published on 26 December 2001

Ibopamine-induced reduction of serum prolactin level and milk secretion in puerperal women

scientific article published on 01 January 1990

Imatinib-mesylate blocks recombinant T-type calcium channels expressed in human embryonic kidney-293 cells by a protein tyrosine kinase-independent mechanism.

scientific article

In the neuronal cell line SH-SY5Y, oxidative stress-induced free radical overproduction causes cell death without any participation of intracellular Ca(2+) increase.

scientific article

Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndrome

scientific article published on 01 December 1983

Increased ability of apomorphine to reduce serum concentrations of prolactin in rats treated chronically with alpha-methyltyrosine

scientific article published on December 15, 1977

Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes.

scientific article published on 16 April 2007

Involvement of PI3'-K, mitogen-activated protein kinase and protein kinase B in the up-regulation of the expression of nNOSalpha and nNOSbeta splicing variants induced by PRL-receptor activation in GH3 cells.

scientific article published on March 2003

Involvement of the potassium-dependent sodium/calcium exchanger gene product NCKX2 in the brain insult induced by permanent focal cerebral ischemia.

scientific article published in March 2007

Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype.

scientific article

Lack of Evidence for an Inhibitory Role Played by Tuberoinfundibular Dopaminergic Neurons on TSH Secretion in the Rat ⬇️

scientific article published on January 1979

Localization of the site of the haloperidol-induced, prolactin-mediated increase of dopamine turnover in the median eminence: studies in rats with complete hypothalamic deafferentations

scientific article published on 01 January 1978

M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.

scientific article

Macroprolactinoma shrinkage during cabergoline treatment is greater in naive patients than in patients pretreated with other dopamine agonists: a prospective study in 110 patients

scientific article published on 01 June 2000

MicroRNA-103-1 selectively downregulates brain NCX1 and its inhibition by anti-miRNA ameliorates stroke damage and neurological deficits

scientific article published on 23 June 2014

Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.

scientific article published on 26 October 2005

Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging?

scientific article published in September 2002

Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-n-[[(2,4-dimethylbenzyl)-amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) as a pan inhibitor of the Na+-Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in stably

scientific article published on 14 July 2009

NCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum

scientific article

NCX1 and NCX3: two new effectors of delayed preconditioning in brain ischemia.

scientific article published on 17 October 2011

NCX1 expression and functional activity increase in microglia invading the infarct core

scientific article published on 10 September 2009

NCX1 is a new rest target gene: role in cerebral ischemia

scientific article published on 13 October 2012

NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.

scientific article published on 3 February 2011

NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death

scientific journal article

NO-induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn-SOD activity and expression via RAS/ERK1/2 pathway

scientific article published on 06 August 2007

Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory

scientific journal article

Na+/Ca2+ exchanger maintains ionic homeostasis in the peri-infarct area.

scientific article published on 29 March 2007

Neuronal NOS activation during oxygen and glucose deprivation triggers cerebellar granule cell death in the later reoxygenation phase.

scientific article

Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options.

scientific article published on 07 June 2011

Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage

scientific article

Nitric Oxide Stimulates NCX1 and NCX2 but Inhibits NCX3 Isoform by Three Distinct Molecular Determinants ⬇️

scientific article published on December 15, 2010

Novel Cellular Mechanisms for Neuroprotection in Ischemic Preconditioning: A View from Inside Organelles.

scientific article published on 26 May 2015

Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.

scientific article published in April 2006

Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic bra

scientific article published on 5 May 2015

Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives.

scientific article

Possible inhibitory role of histamine H2 receptors in the control of basal TSH secretion in male rats: studies with dimaprit, a selective H2 receptor agonist

scientific article published on 01 January 1987

Possible involvement of Ca++ ions, protein kinase C and Na(+)-H+ antiporter in insulin-induced endogenous dopamine release from tuberoinfundibular neurons

scientific article published on 01 January 1990

Prolactin in CSF selectively increases dopamine turnover in the median eminence

scientific article published on June 12, 1978

Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia

scientific journal article

Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway.

scientific article

Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine.

scientific article

Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment.

scientific article published in April 1986

Regulation of the human ether-a-gogo related gene (HERG) K+channels by reactive oxygen species ⬇️

scientific article published on October 14, 1997

Release of endogenous dopamine from tuberoinfundibular neurons.

scientific article published on July 1984

Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures.

scientific article

Rhythm-specific modulation of the sensorimotor network in drug-naive patients with Parkinson's disease by levodopa

scientific article

Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation.

scientific article

Smoking Selectively Accelerates Carotid Atherosclerosis in Hypertensive Patients

scientific article published on 01 October 2008

Sodium nitroprusside prevents chemical hypoxia-induced cell death through iron ions stimulating the activity of the Na+-Ca2+ exchanger in C6 glioma cells.

scientific article published in April 2000

Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.

scientific article

TSH/cAMP up-regulate sarco/endoplasmic reticulum Ca2+-ATPases expression and activity in PC Cl3 thyroid cells

scientific article published on June 2004

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window.

scientific article

Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage

scientific article published in January 2008

The 2-oxopyrrolidinacetamide piracetam reduces infarct brain volume induced by permanent middle cerebral artery occlusion in male rats.

scientific article published in September 2002

The A1 agonist CCPA reduced bisoxonol-monitored membrane potential depolarization elicited by high K+ in cerebrocortical nerve endings

scientific article published on 01 October 1995

The NCX3 isoform of the Na+/Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning.

scientific article published on 14 July 2010

The Na(+)-Ca++ exchanger in central nerve endings: the relationship between its pharmacological blockade and dopamine release from tuberoinfundibular hypothalamic neurons

scientific article published on March 1, 1992

The dorsal noradrenergic bundle modulates DNA remodeling in the rat brain upon exposure to a spatial novelty.

scientific article published in January 1995

The isolectin IB4 binds RET receptor tyrosine kinase in microglia.

scientific article published on 17 March 2013

The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway.

scientific article

Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia.

scientific article published on 7 October 2004

Zn(2+) slows down Ca(V)3.3 gating kinetics: implications for thalamocortical activity.

scientific article published on 15 August 2007

mGlu1alpha receptors are co-expressed with CB1 receptors in a subset of interneurons in the CA1 region of organotypic hippocampal slice cultures and adult rat brain.

scientific article published on 14 May 2008

ncx1, ncx2, and ncx3 gene product expression and function in neuronal anoxia and brain ischemia.

scientific article published on March 2007

‘Janus face’ of nitric oxide action on plasma membrane and intracellular ionic channels

scientific article published on 01 January 2001

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