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List of works by Giuseppe Pignataro

A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage.

scientific article

Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases.

scientific article

Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia

scientific article published on 15 March 2018

Alcohol increases spontaneous BOLD signal fluctuations in the visual network

scientific article published on 28 June 2010

Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats

scientific article published on 28 October 2019

Antithrombin reduces ischemic volume, ameliorates neurologic deficits, and prolongs animal survival in both transient and permanent focal ischemia.

scientific article

Conjunctival instillation of plasminogen eliminates ocular lesion in B6.129P2-Plgtm1Jld transgenic mice, a model of ligneous conjunctivitis ⬇️

scientific article published on May 16, 2013

Corrigendum to "NCX1 and NCX3: Two new effectors of delayed preconditioning in brain ischemia" [Neurobiol. Dis. 45 (2012) 616-623].

scientific article published on 8 December 2016

Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains

scientific article published on 14 January 2009

Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration

article

Does Na⁺/Ca²⁺ exchanger, NCX, represent a new druggable target in stroke intervention?

scientific article

Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism.

scientific article published on 25 April 2007

Editorial: Mechanisms of Innate Neuroprotection.

scientific article published on 17 May 2016

Effects of bone marrow mesenchymal stem cells (BM-MSCs) on rat pial microvascular remodeling after transient middle cerebral artery occlusion

scientific article

Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.

scientific article

Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits.

scientific article published on January 2013

Glial Na(+) -dependent ion transporters in pathophysiological conditions.

scientific article

HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage

scientific article published on 07 November 2019

HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion.

scientific article

Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT.

scientific article published on 27 January 2016

In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning

scientific article published on 19 September 2007

Involvement of the potassium-dependent sodium/calcium exchanger gene product NCKX2 in the brain insult induced by permanent focal cerebral ischemia.

scientific article published in March 2007

Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets

scientific article published on 07 August 2018

Ionic Transporter Activity in Astrocytes, Microglia, and Oligodendrocytes During Brain Ischemia ⬇️

scientific article published on 03 April 2013

Ionic homeostasis in brain conditioning

scientific article

Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype.

scientific article

MODELS AND METHODS FOR CONDITIONING THE ISCHEMIC BRAIN

scientific article published on 01 October 2018

MicroRNA-103-1 selectively downregulates brain NCX1 and its inhibition by anti-miRNA ameliorates stroke damage and neurological deficits

scientific article published on 23 June 2014

Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Ba

scientific article published on 24 November 2020

NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning ⬇️

scientific article published on January 1, 2013

NCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum

scientific article

NCX1 and NCX3: two new effectors of delayed preconditioning in brain ischemia.

scientific article published on 17 October 2011

NCX1 is a new rest target gene: role in cerebral ischemia

scientific article published on 13 October 2012

NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.

scientific article published on 3 February 2011

Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt

scientific article published on 23 October 2015

Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants.

scientific article published on 22 November 2006

Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion

scientific article published on 14 July 2015

Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.

scientific article published on 17 October 2015

Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options.

scientific article published on 07 June 2011

Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage

scientific article

New perspectives for selective NCX activators in neurodegenerative diseases

scientific article published on 07 February 2020

ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry

scientific article published on 01 May 2019

Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.

scientific article published in April 2006

Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic bra

scientific article published on 5 May 2015

Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives.

scientific article

Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca2+ exchanger 3 downregulation.

scientific article published on 12 February 2018

Protective Effects of Quercetin on Rat Pial Microvascular Changes during Transient Bilateral Common Carotid Artery Occlusion and Reperfusion.

scientific article published on March 2012

Rhythm-specific modulation of the sensorimotor network in drug-naive patients with Parkinson's disease by levodopa

scientific article

Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.

scientific article

Sumoylation of LYS590 of NCX3 f-Loop by SUMO1 Participates in Brain Neuroprotection Induced by Ischemic Preconditioning

scientific article published on 15 March 2016

Synergistic Association of Valproate and Resveratrol Reduces Brain Injury in Ischemic Stroke

scientific article published on 6 January 2018

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window.

scientific article

Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage

scientific article published in January 2008

The 2-oxopyrrolidinacetamide piracetam reduces infarct brain volume induced by permanent middle cerebral artery occlusion in male rats.

scientific article published in September 2002

The NCX3 isoform of the Na+/Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning.

scientific article published on 14 July 2010

Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.

scientific article

Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia.

scientific article published on 7 October 2004

Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors.

scientific article published on 24 August 2017

miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA

scientific article published on 15 January 2020

nNOS and p-ERK involvement in the neuroprotection exerted by remote postconditioning in rats subjected to transient middle cerebral artery occlusion ⬇️

scientific article published on February 27, 2013

ncx1, ncx2, and ncx3 gene product expression and function in neuronal anoxia and brain ischemia.

scientific article published on March 2007

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