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List of works by Sylvie Claeysen

5-HT(4) receptors, a place in the sun: act two.

scientific article published on 20 February 2011

5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

scientific article published on 13 October 2012

5-HT4 receptors: cloning and expression of new splice variants.

scientific article published in December 1998

5-HT4 receptors: gene, transduction and effects on olfactory memory.

scientific article

5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling. ⬇️

scientific article published on 21 March 2007

A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists.

scientific article

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential

scientific article published on 19 June 2019

A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.

scientific article

A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

scientific article published on 18 November 2002

Alzheimer culprits: cellular crossroads and interplay.

scientific article published on 22 May 2012

Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization.

scientific article

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

scientific article

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling

scientific article

Cerebrovascular pathology during the progression of experimental Alzheimer's disease

scientific article published on 7 January 2016

Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease

scientific article published on 24 August 2017

Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase ⬇️

scientific article published on October 20, 1997

Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors

scientific article

Constitutively active mutants of 5-HT4 receptors are they in unique active states?

scientific article

Donecopride, a Swiss army knife with potential against Alzheimer's disease

scientific article published on 27 December 2019

Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2.

scientific article

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease

scientific article published on 24 December 2013

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease

scientific article published on 31 July 2019

Inhibition of glucose-induced insulin secretion by a peripheral-type benzodiazepine receptor ligand (PK11195)

scientific article published on 01 July 2000

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases.

scientific article published on 6 December 2016

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.

scientific article published on August 2006

Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

scientific article published on 06 August 2019

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride

scientific article published on 31 March 2015

Pharmacological profile of engineered 5-HT4 receptors and identification of 5-HT4 receptor-biased ligands ⬇️

scientific article published on November 10, 2012

Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs.

scientific article published on 07 February 2017

Primary culture of mouse dopaminergic neurons

scientific article published on 8 September 2014

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease

scientific article published on 20 February 2020

SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation

scientific article

Serotonin Type 4 Receptor Dimers

scientific article published on 01 January 2013

Serotonin: A New Hope in Alzheimer's Disease?

scientific article published on 26 May 2015

Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.

scientific article

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