List of works - Christian Ottmann

14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban

scientific article published on 01 September 2020

14-3-3: A Case Study in PPI Modulation

scientific article published on 08 June 2018

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.

scientific article published on 16 May 2017

A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action

scientific article published on 11 February 2020

A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

scientific article published on 01 December 2018

A study on the effect of synthetic α-to-β3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins

scientific article published on 01 December 2019

A thermodynamic model for multivalency in 14-3-3 protein-protein interactions

article

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

scientific article published on 15 July 2019

Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ

scientific article published on 03 January 2020

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach

scientific article published on 02 June 2021

Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins

scientific article published on 01 April 2019

Clinical candidates modulating protein-protein interactions: The fragment-based experience

scientific article published on 05 February 2019

Cooperativity basis for small-molecule stabilization of protein-protein interactions

scientific article published on 25 January 2019

Covalent flexible peptide docking in Rosetta

scientific article published on 12 July 2021

Emerging modes-of-action in drug discovery

scientific article published on 25 June 2019

Experimental and Computational Druggability Exploration of the 14-3-3ζ/SOS1pS1161 PPI Interface

scientific article published on 02 November 2020

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

scientific article published in 2021

Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers

scientific article published on 16 November 2020

Fragment-based exploration of the 14-3-3/Amot-p130 interface

scientific article published on 29 December 2021

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening

scientific article published on 6 July 2017

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

scientific article published on 17 May 2018

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization

scientific article published on 10 July 2017

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

scientific article published on 24 December 2019

Locating Large Flexible Ligands on Proteins

scientific article published on 21 December 2017

MMP activation associated Aminopeptidase N reveals a bivalent 14-3-3 binding motif

scientific article published on 27 October 2020

Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation

scientific article published on 12 May 2020

Modulators of 14-3-3 Protein-Protein Interactions ⬇️

scientific article

Multivalent Ligands with Tailor-Made Anion Binding Motif as Stabilizers of Protein-Protein Interactions

scientific article published on 24 September 2019

Protease-Activatable Scaffold Proteins as Versatile Molecular Hubs in Synthetic Signaling Networks

scientific article published on 31 August 2018

Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions

scientific article published on 17 September 2018

Set-up and screening of a fragment library targeting the 14-3-3 protein interface

scientific article published on 22 July 2019

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers

scientific article published on 19 February 2019

Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold