List of works - Kyoko Nakagawa-Goto

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks

scientific article published on 18 January 2017

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

scientific article

5'-Chloro-2,2'-dihydroxychalcone and related flavanoids as treatments for prostate cancer

scientific article published on 28 August 2018

A Novel Clerodane Diterpene from Vitex cofassus.

scientific article published on January 2017

A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice

scientific article published on 05 April 2016

A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways

scientific article published on March 2011

A-ring modified betulinic acid derivatives as potent cancer preventive agents

scientific article published on 16 December 2013

Acetophenone Monomers from Acronychia trifoliolata.

scientific article

Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives

scientific article

Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents

scientific article

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

scientific article

Antitubulin effects of aminobenzothiophene-substituted triethylated chromones

scientific article

Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents

scientific article published on December 2011

Antitumor Agents. 280. Multidrug Resistance-Selective Desmosdumotin B Analogues ⬇️

scientific article published on September 23, 2010

Antitumor Agents. 282. 2′-(R)-O-Acetylglaucarubinone, a Quassinoid from Odyendyea gabonensis As a Potential Anti-Breast and Anti-Ovarian Cancer Agent ⬇️

scientific article published on September 24, 2010

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.

scientific article

Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs

scientific article published on 15 June 2007

Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity

scientific article

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.

scientific article published on 29 September 2009

Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents

scientific article

Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents

scientific article

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

scientific article

Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents.

scientific article

Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents ⬇️

scientific article published on November 17, 2010

Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action

scientific article

Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

scientific article

Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents

scientific article published on September 2006

Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents

scientific article

Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents

scientific article published on 4 July 2007

Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents

scientific article

Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.

scientific article

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

scientific article

Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility

scientific article published on 3 February 2012

Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs

scientific article

Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives

scientific article

Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents

scientific article

Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents

scientific article published on 18 May 2009

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

scientific article

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

scientific article published on 29 December 2017

Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis. ⬇️

scientific article published on 3 July 2008

Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents

scientific article published on October 2006

Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents

scientific article

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

scientific article

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents

scientific article published on 10 July 2007

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia

scientific article published on 05 November 2019

Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

scientific article published on 23 April 2013

Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita

scientific article published on 16 July 2018

Novel sesquiterpene lactone analogues as potent anti-breast cancer agents

scientific article published on 25 March 2016

Paliasanines A-E, 3,4-Methylenedioxyquinoline Alkaloids Fused with a Phenyl-14-oxabicyclo[3.2.1]octane Unit from Melochia umbellata var. deglabrata

scientific article published on 18 September 2020

Phenylethylchromones with In Vitro Antitumor Promoting Activity from Aquilaria filaria.

scientific article published on 8 July 2016

Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions

scientific article

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis

scientific article published on 24 September 2019

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

scientific article published on 6 April 2018

Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice

scientific article published on 22 March 2021

Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata

scientific article published on 23 August 2019

Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L ⬇️

scientific article

Synthesis of 4- epi-Parviflorons A, C, and E: Structure-Activity Relationship Study of Antiproliferative Abietane Derivatives

scientific article published on 05 March 2019

Total Synthesis of Antiproliferative Parvifloron F.

scientific article published on 18 January 2018

Triethylated chromones with substituted naphthalenes as tubulin inhibitors.

scientific article published on 25 September 2016

Tumor-Associated Macrophages Induce Migration of Renal Cell Carcinoma Cells via Activation of the CCL20-CCR6 Axis

scientific article published on 30 December 2019

List of works by Kyoko Nakagawa-Goto

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

5'-Chloro-2,2'-dihydroxychalcone and related flavanoids as treatments for prostate cancer

A Novel Clerodane Diterpene from Vitex cofassus.

A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice

A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways

A-ring modified betulinic acid derivatives as potent cancer preventive agents

Acetophenone Monomers from Acronychia trifoliolata.

Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives

Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

Antitubulin effects of aminobenzothiophene-substituted triethylated chromones

Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents

Antitumor Agents. 280. Multidrug Resistance-Selective Desmosdumotin B Analogues ⬇️

Antitumor Agents. 282. 2′-(R)-O-Acetylglaucarubinone, a Quassinoid from Odyendyea gabonensis As a Potential Anti-Breast and Anti-Ovarian Cancer Agent ⬇️

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.

Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs

Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.

Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents

Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents.

Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents ⬇️

Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action

Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents

Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents

Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents

Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents

Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility

Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs

Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives

Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents

Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis. ⬇️

Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents

Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia

Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita

Novel sesquiterpene lactone analogues as potent anti-breast cancer agents

Paliasanines A-E, 3,4-Methylenedioxyquinoline Alkaloids Fused with a Phenyl-14-oxabicyclo[3.2.1]octane Unit from Melochia umbellata var. deglabrata

Phenylethylchromones with In Vitro Antitumor Promoting Activity from Aquilaria filaria.

Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice

Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata

Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L ⬇️

Synthesis of 4- epi-Parviflorons A, C, and E: Structure-Activity Relationship Study of Antiproliferative Abietane Derivatives

Total Synthesis of Antiproliferative Parvifloron F.

Triethylated chromones with substituted naphthalenes as tubulin inhibitors.

Tumor-Associated Macrophages Induce Migration of Renal Cell Carcinoma Cells via Activation of the CCL20-CCR6 Axis