List of works - Xiao Yu

A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1.

scientific article

Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism

scientific article published on 13 October 2016

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.

scientific article published on 09 February 2017

Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W

scientific article

Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells.

scientific article published on 9 November 2014

Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein

scientific article

Crystal Structure and Substrate Specificity of PTPN12

scientific article

Deletion of pancreatic β-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia

scientific article published on 01 May 2019

Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells

scientific article published on 6 August 2015

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells ⬇️

scientific article published on February 22, 2011

Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.

scientific article published on 14 December 2015

FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies

scientific article published on 26 June 2015

FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.

scientific article published on 31 May 2016

Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening

scientific article published on 12 November 2014

H2S induces catecholamine secretion in rat adrenal chromaffin cells

scientific article published on 25 July 2012

Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B

scientific article published on 13 October 2020

Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase

scientific article published on 10 August 2016

Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot.

scientific article

Ligand recognition and biased agonism of the D1 dopamine receptor

scientific article published on 08 June 2022

Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase

scientific article

Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase

scientific article published on 31 October 2013

NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection

scientific article published on 30 October 2020

Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat.

scientific article

Nitric oxide donor protects against acetic acid-induced gastric ulcer in rats via S-nitrosylation of TRPV1 on vagus nerve.

scientific article

Novel role of NOD2 in mediating Ca2+ signaling: evidence from NOD2-regulated podocyte TRPC6 channels in hyperhomocysteinemia

scientific article published on 15 July 2013

Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway.

scientific article published on 20 March 2012

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca(2+)/nNOS/NO/KATP pathway.

scientific article published on 21 January 2015

Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice ⬇️

scientific article

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.

scientific article

Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model.

scientific article published on 28 February 2017

Protein Flexibility in Docking-Based Virtual Screening: Discovery of Novel Lymphoid-Specific Tyrosine Phosphatase Inhibitors Using Multiple Crystal Structures

scientific article published on 17 September 2015

Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression

scientific article

Structural basis of GPBAR activation and bile acid recognition

scientific article published on 22 July 2020

Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2

scientific article published on 22 April 2021

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

scientific article

Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug.

scientific article published on 24 January 2007

The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca(2+)-NOS pathway

scientific article published on 19 August 2016

The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

scientific journal article

The catalytic role of the M2 metal ion in PP2Cα

scientific article

The role of G protein-coupled receptors in cochlear planar cell polarity.

scientific article published on 24 February 2016

The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop

scientific article

Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic β-cells.

scientific article

Understanding cadherin EGF LAG seven-pass G-type receptors.

scientific article

Unsaturated bond recognition leads to biased signal in a fatty acid receptor

scientific article published on 02 March 2023

WIP1 phosphatase is a critical regulator of adipogenesis through dephosphorylating PPARγ serine 112.

scientific article published on 8 February 2017

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.

scientific article published on 7 April 2016

β2-adrenergic receptor and astrocyte glucose metabolism.

scientific article published on 8 March 2012

List of works by Xiao Yu

A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1.

Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.

Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W

Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells.

Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein

Crystal Structure and Substrate Specificity of PTPN12

Deletion of pancreatic β-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia

Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells ⬇️

Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.

FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies

FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.

Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening

H2S induces catecholamine secretion in rat adrenal chromaffin cells

Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B

Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase

Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot.

Ligand recognition and biased agonism of the D1 dopamine receptor

Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase

Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase

NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection

Na+ channel inactivation: a comparative study between pancreatic islet beta-cells and adrenal chromaffin cells in rat.

Nitric oxide donor protects against acetic acid-induced gastric ulcer in rats via S-nitrosylation of TRPV1 on vagus nerve.

Novel role of NOD2 in mediating Ca2+ signaling: evidence from NOD2-regulated podocyte TRPC6 channels in hyperhomocysteinemia

Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway.

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca(2+)/nNOS/NO/KATP pathway.

Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice ⬇️

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.

Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model.

Protein Flexibility in Docking-Based Virtual Screening: Discovery of Novel Lymphoid-Specific Tyrosine Phosphatase Inhibitors Using Multiple Crystal Structures

Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression

Structural basis of GPBAR activation and bile acid recognition

Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug.

The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca(2+)-NOS pathway

The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

The catalytic role of the M2 metal ion in PP2Cα

The role of G protein-coupled receptors in cochlear planar cell polarity.

The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop

Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic β-cells.

Understanding cadherin EGF LAG seven-pass G-type receptors.

Unsaturated bond recognition leads to biased signal in a fatty acid receptor

WIP1 phosphatase is a critical regulator of adipogenesis through dephosphorylating PPARγ serine 112.

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.

β2-adrenergic receptor and astrocyte glucose metabolism.