List of works - Ronen Alon

A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets

scientific article

A Sweet Solution: Glycolysis-Dependent Treg Cell Migration.

scientific article published in November 2017

A biochip model of lymphocyte locomotion on confined chemokine tracks.

scientific article published in August 2009

A coupled enzyme assay for measurement of sialidase activity

scientific article published on 01 January 1991

A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells

scientific article published on 24 July 2008

A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.

scientific article published on 20 February 2003

A real time in vitro assay for studying leukocyte transendothelial migration under physiological flow conditions.

scientific article

Activated T lymphocytes and macrophages secrete fibronectin which strongly supports cell adhesion.

scientific article published in May 1992

Affinity cleavage and targeted catalysis of proteins using the avidin-biotin system

scientific article published on 01 December 1990

Affinity cleavage of cell surface antibodies using the avidin-biotin system

scientific article published on 01 September 1993

An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow

scientific journal article

Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions

scientific article published on 18 September 2008

Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.

scientific article published on November 2000

Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.

scientific article published on 3 November 2003

Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation.

scientific article

Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects

scientific article published on 22 January 2014

CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease.

scientific article

CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility.

scientific article published in November 2012

CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma.

scientific article

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

scientific article published on 01 March 2018

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

scientific article published on 08 April 2014

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

scientific article

Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligands

scientific article

Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers.

scientific article published on March 2011

Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts.

scientific article published on 05 July 2012

Chemokine-triggered microtubule polymerization promotes neutrophil chemotaxis and invasion but not transendothelial migration

scientific article published on 25 February 2019

Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.

scientific article published on 17 March 2009

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.

scientific article published on 3 April 2009

Cytokine profile and T cell adhesiveness to endothelial selectins: in vivo induction by a myasthenogenic T cell epitope and immunomodulation by a dual altered peptide ligand

scientific article published on 01 December 2000

Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether.

scientific article

DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.

scientific article published in October 2000

DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration

scientific article

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

scientific article published on 01 February 1999

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis

scholarly article by Tamara Girbl et al published 18 December 2018 in Immunity

Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

scientific article

ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation

scientific article published on 01 March 2020

Elevated nuclear lamin A is permissive for granulocyte transendothelial migration but not for motility through collagen I barriers.

scientific article published on 30 March 2018

Fingerprint of Lung Fluid Ultrafine Particles, a Novel Marker of Acute Lung Inflammation.

scientific article published on 10 June 2015

Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells

scientific article published on January 2007

From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts.

scientific article

Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis

scientific article (publication date: July 2000)

Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation.

scientific article published on 29 January 2015

ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow

scientific article

ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs.

scientific article

Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

scientific article published in Nature Communications

In the hunt for therapeutic targets: mimicking the growth, metastasis, and stromal associations of early-stage lung cancer using a novel orthotopic animal model.

scientific article

Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7

scholarly article by Amiram Ariel et al published October 1997 in European Journal of Immunology

Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics.

scientific article published on February 1999

Inhibition of metastatic cell colonization in murine lungs and tumor-induced morbidity by non-peptidic Arg-Gly-Asp mimetics

scientific article published on 01 December 1993

Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells.

scientific article

Kindlin-3: a new gene involved in the pathogenesis of LAD-III.

scientific article

L-selectin dimerization enhances tether formation to properly spaced ligand

scientific article published on 20 March 2002

LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds ⬇️

scientific article published on October 9, 2003

LAD-III, a novel group of leukocyte integrin activation deficiencies.

scientific article

Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis

scientific article published on 3 August 2010

Learning in motion: pericytes instruct migrating innate leukocytes ⬇️

scientific article published on January 1, 2013

Leukocyte Breaching of Endothelial Barriers: The Actin Link.

scientific article

Leukocyte adhesion deficiency III: a group of integrin activation defects in hematopoietic lineage cells.

scientific article

Leukocyte migration into inflamed tissues.

scientific article

Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments.

scientific article published in January 2017

Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III

scientific article published on 14 September 2012

Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.

scientific article published on 28 January 2016

Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces

scientific journal article

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

scientific article published on 17 April 2005

Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.

scientific article

M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration.

scientific article published on 23 December 2015

Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

scientific article published on 19 January 2018

Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells

publication published on 01 December 2021

Nuclear Deformation During Neutrophil Migration at Sites of Inflammation

scientific article published on 16 November 2018

Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state.

scientific article published on 15 November 2010

Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis

scientific article published on 01 January 2011

Real-Time In Vitro Assay for Studying Chemoattractant- Triggered Leukocyte Transendothelial Migration Under Physiological Flow Conditions

scientific article published on 01 January 2004

Real-time analysis of integrin-dependent transendothelial migration and integrin-independent interstitial motility of leukocytes.

scientific article published on January 2012

RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9.

scientific article

Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes

scientific article published on 01 January 2006

Rolling on N-linked glycans: a new way to present L-selectin binding sites

scientific article published on 01 April 2007

Search for high-mass resonances decaying to dilepton final states in pp collisions at $ \sqrt{s}=7 $ TeV with the ATLAS detector

article

Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.

scientific article

Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines.

scientific article published in June 2001

Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN.

scientific article published in August 2004

Specialized functional properties of the integrin alpha 4 cytoplasmic domain ⬇️

scientific article published on June 1, 1995

Stable contacts of naïve CD4 T cells with migratory dendritic cells are ICAM-1-dependent but dispensable for proliferation in vivo

scientific article published on 01 December 2019

Streptavidin blocks immune reactions mediated by fibronectin-VLA-5 recognition through an Arg-Gly-Asp mimicking site

scientific article published on 01 April 1993

Structural analysis of integrin recognition and the inhibition of integrin-mediated cell functions by novel nonpeptidic surrogates of the Arg-Gly-Asp sequence

scientific article published on 01 February 1993

Suppression of experimental autoimmune myasthenia gravis by inhibiting the signaling between IFN-gamma inducible protein 10 (IP-10) and its receptor CXCR3.

scientific article published on 20 February 2009

Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

scientific article published on 20 January 2015

TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner.

scientific article

TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules

scientific article published on 01 January 2002

Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1

scientific article published on 27 June 2007

Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen

scientific article published on 05 October 2010

The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes

scientific article published on 01 February 1996

The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow.

scientific article published on 7 October 2003

The GPI-linked Ly-6 antigen E48 regulates expression levels of the FX enzyme and of E-selectin ligands on head and neck squamous carcinoma cells.

scientific article

The Kinetics of L-selectin Tethers and the Mechanics of Selectin-mediated Rolling ⬇️

scientific article published on September 8, 1997

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

scientific article

The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes ⬇️

scientific article published on September 29, 1998

Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies

scientific article published on 19 September 2016

Transendothelial migration of effector T cells across inflamed endothelial barriers does not require heparan sulfate proteoglycans.

scientific article published on 8 January 2014

Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots.

scientific article published on 4 December 2011

Trapped versus Soluble Chemokines: Functions in Leukocyte Adhesion and Motility ⬇️

scientific article published on November 24, 2010

Tumor suppressor death-associated protein kinase attenuates inflammatory responses in the lung

scientific article published on 13 October 2011

p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence.

scientific article published in March 2018

List of works by Ronen Alon

A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets

A Sweet Solution: Glycolysis-Dependent Treg Cell Migration.

A biochip model of lymphocyte locomotion on confined chemokine tracks.

A coupled enzyme assay for measurement of sialidase activity

A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells

A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.

A real time in vitro assay for studying leukocyte transendothelial migration under physiological flow conditions.

Activated T lymphocytes and macrophages secrete fibronectin which strongly supports cell adhesion.

Affinity cleavage and targeted catalysis of proteins using the avidin-biotin system

Affinity cleavage of cell surface antibodies using the avidin-biotin system

An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow

Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions

Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.

Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.

Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation.

Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects

CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease.

CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility.

CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma.

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligands

Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers.

Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts.

Chemokine-triggered microtubule polymerization promotes neutrophil chemotaxis and invasion but not transendothelial migration

Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.

Cytokine profile and T cell adhesiveness to endothelial selectins: in vivo induction by a myasthenogenic T cell epitope and immunomodulation by a dual altered peptide ligand

Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether.

DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.

DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis

Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation

Elevated nuclear lamin A is permissive for granulocyte transendothelial migration but not for motility through collagen I barriers.

Fingerprint of Lung Fluid Ultrafine Particles, a Novel Marker of Acute Lung Inflammation.

Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells

From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts.

Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis

Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation.

ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow

ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs.

Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

In the hunt for therapeutic targets: mimicking the growth, metastasis, and stromal associations of early-stage lung cancer using a novel orthotopic animal model.

Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7

Inhibition of L-selectin-mediated leukocyte rolling by synthetic glycoprotein mimics.

Inhibition of metastatic cell colonization in murine lungs and tumor-induced morbidity by non-peptidic Arg-Gly-Asp mimetics

Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells.

Kindlin-3: a new gene involved in the pathogenesis of LAD-III.

L-selectin dimerization enhances tether formation to properly spaced ligand

LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds ⬇️

LAD-III, a novel group of leukocyte integrin activation deficiencies.

Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis

Learning in motion: pericytes instruct migrating innate leukocytes ⬇️

Leukocyte Breaching of Endothelial Barriers: The Actin Link.

Leukocyte adhesion deficiency III: a group of integrin activation defects in hematopoietic lineage cells.

Leukocyte migration into inflamed tissues.

Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments.

Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III

Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.

Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.

M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration.

Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells

Nuclear Deformation During Neutrophil Migration at Sites of Inflammation

Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state.

Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis

Real-Time In Vitro Assay for Studying Chemoattractant- Triggered Leukocyte Transendothelial Migration Under Physiological Flow Conditions

Real-time analysis of integrin-dependent transendothelial migration and integrin-independent interstitial motility of leukocytes.

RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9.

Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes

Rolling on N-linked glycans: a new way to present L-selectin binding sites

Search for high-mass resonances decaying to dilepton final states in pp collisions at $ \sqrt{s}=7 $ TeV with the ATLAS detector

Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.

Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines.