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List of works by Anna Maria Caccuri

6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer.

scientific article published on February 2008

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib

scientific article

A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.

scientific article published on 12 June 2006

Acidic glutathione transferase from human heart

scientific article published on 01 October 1988

Aggregation of pyrene-labeled microsomal glutathione S-transferase. Effect of concentration

scientific article published on 01 October 1993

Binding and kinetic mechanisms of the Zeta class glutathione transferase

scientific article

Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione S-transferases. Investigation of Ser-9 and Tyr-113 in a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.

scientific article published in November 1997

Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents.

scientific article

Colorimetric and Fluorometric Assays of Glutathione Transferase Based on 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole

scientific article published on 01 May 1994

Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum.

scientific article published on 11 May 2005

Detection of glutathione transferase activity on polyacrylamide gels.

scientific article published in December 1984

Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy

scientific article published on 01 September 1998

GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme

scientific article published on 11 March 2002

Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells

scientific article published on 11 February 2019

Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme

scientific article published on November 2003

Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells. A protection mechanism against excess nitric oxide

scientific article published on 30 December 2006

Glutathione-related enzyme activities in testis of patients with malignant diseases

scientific article published on 01 July 1989

Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases.

scientific article

Inhibition of glutathione transferase pi from human placenta by 1-chloro-2,4-dinitrobenzene occurs because of covalent reaction with cysteine 47

scientific article published on 01 August 1992

Interaction between 1,4-thiazine derivatives and D-amino-acid oxidase

scientific article published on 01 October 1983

Interaction of hemin with placental glutathione transferase

scientific article published on 01 May 1990

Investigation of the active site of human placenta glutathione transferase π by means of a spin-labelled glutathione analogue

scientific article published on 01 August 1992

Ketimine rings: useful detectors of enzymatic activities in solution and on polyacrylamide gel. Detection of L-amino acid oxidase, glutamine transaminase, pantetheinase, and acylase I

scientific article published on 01 September 1987

Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers.

scientific article published on 3 July 2008

Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.

scientific article

N-terminal region of Proteus mirabilis glutathione transferase is not homologous to mammalian and plant glutathione transferases

scientific article published on 01 June 1989

Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione

scientific article published on 2 September 2015

Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo

scientific article

Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma

scientific article published in August 2008

Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome

scientific article published on 23 March 2009

Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate.

scientific article published on 8 August 2005

Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1.

scientific article

Proton release upon glutathione binding to glutathione transferase P1-1: kinetic analysis of a multistep glutathione binding process

scientific article published on 01 March 1998

Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae)

scientific article published on 01 September 1993

Role of glutathione transferases in the mechanism of brostallicin activation.

scientific article

S- aminoethyl- l -cysteine transaminase from bovine brain: purification to homogeneity and assay of activity in different regions of the brain

scientific article published on 01 January 1989

Selenium independent glutathione peroxidase activity associated with cationic forms of glutathione transferase in human heart

scientific article published on 01 September 1986

Shifting Substrate Specificity of Human Glutathione Transferase (from Class Pi to Class Alpha) by a Single Point Mutation

scientific article published on 01 November 1998

Solution Structure of Glutathione Bound to Human Glutathione Transferase P1-1: Comparison of NMR Measurements with the Crystal Structure†

scientific article published on 01 March 1998

Structural flexibility modulates the activity of human glutathione transferase P1-1. Role of helix 2 flexibility in the catalytic mechanism.

scientific article published in July 1996

Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage.

scientific article published in September 2003

Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis

scientific article published on 01 December 2019

Synthesis and structure--activity relationship of new cytotoxic agents targeting human glutathione-S-transferases

scientific article

Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines.

scientific article published on 9 November 2011

Targeting glutathione-S transferase enzymes in musculoskeletal sarcomas: a promising therapeutic strategy.

scientific article published in January 2011

Temperature adaptation of glutathione S-transferase P1-1. A case for homotropic regulation of substrate binding.

scientific article published in July 1999

The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma.

scientific article published on 25 January 2011

The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide

scientific article

Valine 10 May Act as a Driver for Product Release from the Active Site of Human Glutathione Transferase P1-1

scientific article published on 01 December 2000

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