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List of works by Judy B de Haan

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation

scientific article published on 01 October 2018

A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy.

scientific article published on 22 March 2016

Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse ⬇️

scientific article published on September 7, 2010

Are reactive oxygen species still the basis for diabetic complications?

scientific article published on July 2015

Changes in the levels of enzymes which modulate the antioxidant balance occur during aging and correlate with cellular damage

scientific article published on 01 May 1995

Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?

scientific article published on 21 February 2014

Corrigendum to "Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium" [Vasc. Pharmacol. 79 (2016) 32-42].

scientific article published on 6 October 2017

Corrigendum to “Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice” [Atherosclerosis 243/2 (2015) 598–608]

scientific article published on 01 November 2016

Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains

scientific article published on April 1, 1992

Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

scientific article published on 16 April 2014

Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis.

scientific article

Does lack of glutathione peroxidase 1 gene expression exacerbate lung injury induced by neonatal hyperoxia in mice?

scientific article

Ebselen by modulating oxidative stress improves hypoxia-induced macroglial Müller cell and vascular injury in the retina

scientific article

Effects of exercise training and RhoA/ROCK inhibition on plaque in ApoE-/- mice.

scientific article published on 22 April 2012

Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide.

scientific article published on February 1996

Ensuring animal welfare while meeting scientific aims using a murine pneumonia model of septic shock.

scientific article published in June 2013

Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death

scientific journal article

Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

scientific article

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

scientific article published on 2 March 2015

Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury

scientific journal article

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity.

scientific article

Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy

scientific journal article

Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium.

scientific article published on 10 November 2015

Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice

scientific article published on 09 April 2007

Lack of the antioxidant glutathione peroxidase-1 (GPx1) exacerbates retinopathy of prematurity in mice.

scientific article

Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet.

scientific article published on 28 February 2006

Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy.

scientific article

Limiting reductive stress for treating in-stent stenosis: the heart of the matter?

scientific article

Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR, and CBR--to two different chromosomes in the marsupial species Macropus eugenii

scientific article published on January 1, 1992

Mice lacking glutathione peroxidase-1 activity show increased TUNEL staining and an accelerated inflammatory response in brain following a cold-induced injury.

scientific article published in September 2002

Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide.

scientific article

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

scientific article published on 05 April 2013

Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide

scientific article

Novel pathways and therapies in experimental diabetic atherosclerosis ⬇️

scientific article published on March 1, 2012

Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy

scientific article published in February 2018

Nrf2 activators as attractive therapeutics for diabetic nephropathy.

scientific article published on November 2011

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications.

scientific article

Oxidative stress in surgery in an ageing population: pathophysiology and therapy.

scientific article published on 23 March 2012

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice.

scientific article published on 26 October 2015

Protective Effect of Inflammasome Activation by Hydrogen Peroxide in a Mouse Model of Septic Shock

scientific article

Recent novel approaches to limit oxidative stress and inflammation in diabetic complications.

scientific article

Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1

scientific journal article

Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse.

scientific article

Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy

scientific article

Targeting Oxidative Stress in Diabetic Complications: New Insights

scientific article published on 19 June 2018

Targeting endothelial dysfunction in vascular complications associated with diabetes

scientific article published on 13 October 2011

The ethical dimension in published animal research in critical care: the dark side of our moon

scientific article published on 13 March 2014

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction.

scientific article published on 03 March 2017

The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy

scientific article published on 21 April 2017

What effect does regular exercise have on oxidative stress in people with Down syndrome? A systematic review with meta-analyses.

scientific article

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