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List of works by Mercedes Unzeta

"In vitro" effect of some 5-hydroxy-indolalkylamine derivatives on monoamine uptake system.

scientific article published in January 1998

A Spectrophotometric Method for Determining the Oxidative Deamination of Methylamine by the Amine Oxidases

scientific article published on 01 November 2000

A comparative study of some kinetic and molecular properties of microsomal and mitochondrial monoamine oxidase

scientific article published on 01 September 1988

A comparison between radiometric and fluorimetric methods for measuring SSAO activity

scientific article published on 12 February 2013

A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain

scientific article published in January 2009

A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.

scientific article

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

scientific article published on 28 June 2016

Activation of human lung semicarbazide sensitive amine oxidase by a low molecular weight component present in human plasma

scientific article published in July 2003

Amine oxidase activities in bovine lung

scientific article

Amine oxidase activities in chemically-induced mammary cancer in the rat

article published in 1990

Amine oxidase activities in rat breast cancer induced experimentally with 7,12-dimethylbenz(α)anthracene

scientific article published on 01 July 1991

Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives

scientific article published on 15 March 2013

Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells

scientific article

Antioxidant properties of PF9601N, a novel MAO-B inhibitor: assessment of its ability to interact with reactive nitrogen species.

scientific article published on 9 June 2010

CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes.

scientific article published in September 2007

Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids

scientific article

Characterization of A7r5 cell line transfected in a stable form by hSSAO/VAP-1 gene (A7r5 hSSAO/VAP-1 cell line).

scientific article published on 29 March 2007

Characterization of monoamine oxidase activity present in human granulocytes and lymphocytes

scientific article published on 01 August 1989

Contribution of different amine oxidases to the metabolism of dopamine in bovine retina

scientific article

Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

scientific article published on 13 October 2014

Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors

scientific article published on 28 June 2016

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.

scientific article

Determination of monoamine oxidase concentrations in rat liver by inhibitor binding

scientific article published on 01 December 1986

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

scientific article published on 29 April 2014

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

scientific article published on 9 October 2015

Effects of nondenaturating zwitterionic detergent CHAPS, 3-[(3-cholamido propyl) dimethyl ammonio]-1-propanesulfonate, on rat liver mitochondrial and microsomal monoamine oxidase

scientific article published on August 1987

Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia

scientific article published in January 2014

Evidence of a coupled mechanism between monoamine oxidase and peroxidase in the metabolism of tyramine by rat intestinal mitochondria

article

Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity

scientific article published in September 2004

FA-70, a novel selective and irreversible monoamine oxidase-A inhibitor: effect on monoamine metabolism in mouse cerebral cortex

scientific article published on 01 February 2000

Hepatocyte transplants improve liver function and encephalopathy in portacaval shunted rats.

scientific article published on 10 April 2014

Human plasma semicarbazide sensitive amine oxidase (SSAO), beta-amyloid protein and aging

scientific article published in August 2005

Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

scientific article published on 22 September 2009

Immunohistochemical study of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 in the hippocampal vasculature: pathological synergy of Alzheimer's disease and diabetes mellitus

scientific article

Indolalkylamines derivatives as antioxidant and neuroprotective agents in an experimental model of Parkinson's disease.

scientific article

Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6.

scientific article published on 16 January 2013

Inhibition of MAO by substituted tryptamine analogues

scientific article published on 01 January 1990

Inhibition of Monoamine Oxidase from Bovine Retina by β-Carbolines

scientific article published on 01 October 1994

Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives

scientific article published on 01 July 1996

Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liver

scientific article

Interactions between substituted tryptamine analogues, MAO inhibitors and cytochrome P-450

scientific article published on 01 January 1994

Interactions of Monoamine Oxidase Inhibitors, N-Acetylenic Analogues of Tryptamine, with Rat Liver Microsomal Cytochrome P450

scientific article published on 01 May 1994

Investigations of the possible glycosylation of monoamine oxidase B from pig leucocytes

scientific article

Involvement of Ca2+ in dopamine release in striatal rat slices by PF9601N and L-deprenyl.

scientific article published in January 2000

Involvement of SSAO/VAP-1 in oxygen-glucose deprivation-mediated damage using the endothelial hSSAO/VAP-1-expressing cells as experimental model of cerebral ischemia

scientific article

Kinetic Studies of N-Allenic Analogues of Tryptamine as Monoamine Oxidase Inhibitors

scientific article published on 01 July 1996

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

scientific article

Kinetic behaviour of some acetylenic indolalkylamine derivatives and their corresponding parent amines

scientific article published on 01 January 1994

Localization of monoamine oxidase A and B and semicarbazide-sensitive amine oxidase in human peripheral tissues

scientific article published on 01 January 2003

Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain

scientific article published in January 2008

Molecular Determinants of MAO Selectivity in a Series of Indolylmethylamine Derivatives: Biological Activities, 3D-QSAR/CoMFA Analysis, and Computational Simulation of Ligand Recognition

scientific article published on 01 May 2000

Monoamine oxidase activities in lymphocytes and granulocytes taken from pig blood

scientific article published on 01 September 1987

Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in bovine eye

Monoamine oxidase inhibitory potencies and selectivities of 2-[N-(2-propynyl)-aminomethyl]-1-methyl indole derivatives

scientific article

Monoamine oxidase-B activity is not involved in the neuroinflammatory response elicited by a focal freeze brain injury

scientific article

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases

scientific article

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

scientific article published in 2016

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

scientific article published on 30 March 2012

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids

scientific article

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

scientific article published on October 2013

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

scientific article

Neuroprotective Effects of the MAO-B Inhibitor, PF9601N, in anIn VivoModel of Excitotoxicity

scientific article published on 28 April 2014

Neuroprotective aspects of a novel MAO-B inhibitor PF9601N.

scientific article published in January 2000

Neuroprotective effect of the monoamine oxidase inhibitor PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] on rat nigral neurons after 6-hydroxydopamine-striatal lesion

scientific article published in August 2002

Neurotransmitter systems and personality measurements: a study in psychosomatic patients and healthy subjects

New2-[(5-Methoxy-1-Methylindolyl)]-Alkylamine Derivatives: the Effect of Branching and Elongation of the Side Chain on Mao Inhibition

scientific article published on 01 July 1998

Novel MAO-B inhibitors: potential therapeutic use of the selective MAO-B inhibitor PF9601N in Parkinson's disease

scientific article published on January 2011

On the primary structure of membrane-bound semicarbazide-sensitive amine oxidase (SSAO).

scientific article

Overexpression of semicarbazide sensitive amine oxidase in the cerebral blood vessels in patients with Alzheimer's disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

scientific article published in March 2002

Overexpression of semicarbazide-sensitive amine oxidase in human myopathies

scientific article (publication date: February 2004)

PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine], a new MAO-B inhibitor, attenuates MPTP-induced depletion of striatal dopamine levels in C57/BL6 mice

scientific article published in February 2003

PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] confers MAO-B independent neuroprotection in ER stress-induced cell death

scientific article published on 4 February 2009

PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress

scientific article

Phosphorylation of histone-like components during spermiogenesis in the sea urchin

scientific article published on 01 November 1972

Plasma VAP-1/SSAO activity predicts intracranial hemorrhages and adverse neurological outcome after tissue plasminogen activator treatment in stroke.

scientific article published on 10 June 2010

Presence of SSAO in human and bovine meninges and microvessels

Prolonged treatment with aminoguanidine strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats.

scientific article published on May 2007

Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors ⬇️

scientific article published on December 13, 2012

Protamines and other basic proteins from spermatozoa of molluscs

scientific article published in August 1973

Protective effect of N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine (PF9601N) on mitochondrial permeability transition

scientific article published on 01 June 2006

Protective effect of N-(2-propynyl)-2-(5-benzyloxyindolyl) methylamine (PF 9601N), a novel MAO-B inhibitor, on dopamine-lesioned PC12 cultured cells.

scientific article published in May 2003

Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.

scientific article published on 12 September 2015

Purification and characterization of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) from bovine lung

scientific article published on April 1998

Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition

scientific article published on June 1999

Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells

scientific article published on April 1998

SSAO/VAP-1 protein expression during mouse embryonic development

article

Semicarbazide-sensitive amine oxidase (SSAO) and its possible contribution to vascular damage in Alzheimer's disease

scientific journal article

Semicarbazide-sensitive amine oxidase (SSAO) from human and bovine cerebrovascular tissues: biochemical and immunohistological characterization.

scientific article published in November 1998

Semicarbazide-sensitive amine oxidase substrates stimulate glucose transport and inhibit lipolysis in human adipocytes.

scientific article published in May 2001

Semicarbazide-sensitive amine oxidases in pig dental pulp

scientific article published in April 2003

Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do.

scientific article

Several aspects on the amine oxidation by semicarbazide-sensitive amine oxidase (SSAO) from bovine lung

scientific article published on 01 January 1994

Sex-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine treatment may be related to differences in monoamine oxidase B

scientific article published on 01 August 1994

Sodium bicarbonate enhances membrane-bound and soluble human semicarbazide-sensitive amine oxidase activity in vitro

scientific article published on 10 September 2007

Soluble semicarbazide sensitive amine oxidase (SSAO) catalysis induces apoptosis in vascular smooth muscle cells

scientific article published on 6 January 2006

Some properties of semicarbazide-sensitive amine oxidase (SSAO) from human cerebrovascular tissues.

scientific article published in April 2001

Studies on the time-dependent activation of microsomal semicarbazide-sensitive amine oxidase

scientific article published on 01 January 1998

Synthesis of 4-methyl-thio-phenyl-propylamine and the evaluation of its interaction with different amine oxidases

scientific article published in January 2004

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease

scientific article published on 26 May 2011

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of [...]

scientific article

The decrease of NAD(P)H has a prominent role in dopamine toxicity

scientific article published on 13 March 2006

The effect of side chain substitution at positions 2 and 3 of the heterocyclic ring of N-acetylenic analogues of tryptamine as monoamine oxidase inhibitors

scientific article published on 01 June 1993

The novel type B MAO inhibitor PF9601N enhances the duration of L-DOPA-induced contralateral turning in 6-hydroxydopamine lesioned rats.

scientific article

The oxidation of dopamine by the semicarbazide-sensitive amine oxidase (SSAO) from rat vas deferens

scientific article published on 01 April 1991

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.

scientific article

Time-dependent activation of the semicarbazide-sensitive amine oxidase (SSAO) from ox lung microsomes.

scientific article published on November 2000

Tissue activity and cellular localization of human semicarbazide-sensitive amine oxidase.

scientific article

VAP-1/SSAO plasma activity and brain expression in human hemorrhagic stroke

scientific article

Vascular cell lines expressing SSAO/VAP-1: a new experimental tool to study its involvement in vascular diseases ⬇️

scientific article (publication date: November 2011)

p53 phosphorylation is involved in vascular cell death induced by the catalytic activity of membrane-bound SSAO/VAP-1.

scientific article

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