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List of works by Daniel Merk

A dual modulator of farnesoid X receptor and soluble epoxide hydrolase to counter non-alcoholic steatohepatitis

scientific article published on 28 August 2017

A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL)

scientific article published on 26 November 2018

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

scientific article published on 22 June 2018

Chances and challenges of retinoid X receptor gamma targeting for regenerative multiple sclerosis treatment.

scientific article

Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms

scientific article published on 11 November 2020

Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics

scientific article published on 14 June 2018

Computer-Assisted Selective Optimization of Side-Activities-from Cinalukast to a PPARα Modulator

scientific article published on 27 June 2019

De Novo Design of Bioactive Small Molecules by Artificial Intelligence.

scientific article published on 10 January 2018

Design and Structural Optimization of Dual FXR/PPARδ Activators

scientific article published on 20 July 2020

Design of Natural-Product-Inspired Multitarget Ligands by Machine Learning

scientific article published on 16 May 2019

Development of Nuclear Receptor Modulators

article

Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning

scientific article published on 02 October 2018

Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning

scientific article published on 06 December 2018

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

scientific article published on 17 September 2019

DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators

scientific article published on 25 January 2017

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

scientific article published on 19 November 2019

Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties

scientific article published on 18 April 2015

Innovations in the Treatment of Cystic Fibrosis: Outriders for the Treatment of Diseases with Other Genetic Defects? ⬇️

scientific article published on December 1, 2011

Medicinal chemistry and pharmacological effects of Farnesoid X Receptor (FXR) antagonists

scientific article

New Hope Or Drawbacks: Will Chronic Kidney Disease Be Treatable with Small Molecules In The Near Future? ⬇️

scientific article published on March 1, 2012

Non-agonist inhibitors of Cdk5-dependent phosphorylation of PPAR as insulin sensitizers in the future?

scientific article published on May 1, 2012

Nonacidic Farnesoid X Receptor Modulators

scientific article published on 27 July 2017

Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012).

scientific article published on 04 January 2013

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators

scientific article

Nuclear Receptors As Pharmaceutical Targets: Rise Of FXR And Rebirth Of PPAR? ⬇️

scientific article published on April 1, 2012

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.

scientific article published on 2 March 2017

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

scientific article published on 9 March 2018

Optical control of the nuclear bile acid receptor FXR with a photohormone

scientific article published on 19 November 2019

Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity

scientific article published on 13 October 2014

Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds

scientific article published on 03 August 2018

Prospective de novo drug design with deep interactome learning

scientific article published in 2024

SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound.

scientific article published on 29 January 2016

Scaffold hopping from synthetic RXR modulators by virtual screening and design

scientific article published on 06 June 2018

Scaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation

scientific article published in Scientific Reports

Selective optimization of Pranlukast to farnesoid X receptor modulators

scientific article published on 20 November 2018

Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists

scientific article published on 11 July 2018

Therapeutic applications of the versatile fatty acid mimetic WY14643.

scientific article published on 14 December 2016

Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present).

scientific article published on 15 June 2012

Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation

scientific article published on 15 February 2019

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

scientific article published in Scientific Reports

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